Download - Case25: 35 y.o. Female. Lesion on the ear. Haemangioma? Lymphoma? Psudolymphoma? Spitz tumour?
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Case25: 35 y.o. Female. Lesion on the ear. Haemangioma? Lymphoma? Psudolymphoma?
Spitz tumour?
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CASE 25- RCCASE 25- RC
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CASE 25 - RC
A.Haemangioma
B. Angiolymphoid hyperplasia with eosinophilia
C. Kaposi’s sarcoma
D.Fibroma
E.Scar
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CASE 25 - RC
A.Haemangioma
B. Angiolymphoid hyperplasia Angiolymphoid hyperplasia with eosinophiliawith eosinophilia
C. Kaposi’s sarcoma
D.Fibroma
E.Scar
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Past Medical HistoryPast Medical History
• Asthma
• Hayfever
• Allergy to cats and dogs
• Urticaria
Drug HistoryDrug History
• Loratidine
• Cetirizine
• Neoclarityn
• Levocetirizine
• Salbutamol inh
• Allergy to penicillin
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Investigations
• FBC
–Eosinophils: 0.39
• IgE
–1667 (0-120)
• U&Es, LFTs, ESR
–normal
• MRI head–No arteriovenous malformation
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ALHE• Aetiology
– Unknown– ?arteriovenous shunts
• Gender– Females > males
• Age– 30-50 y.o.
• Site– Head and neck
• Morphology– Dermal papules, nodules,
plaques– Subcutaneous nodules
Br J Derm 1969, 81:1-15, Br J Derm 1969, 81:804-816, J Am Acad Dermatol 1985, 12:781-796
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Differential Diagnoses
• Inflammatory angiomatous nodules• Pyogenic granuloma• Histiocytoid hemangioma• Kaposi’s sarcoma• Pseudolymphoma (lymphoid hyperplasia)• Cutaneous lymphoma• Kimura disease
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ALHEALHE Kimura’s Kimura’s diseasedisease
PresentationPresentation Superficial papules or Superficial papules or nodules +/or nodules +/or subcutaneous nodulessubcutaneous nodules
Large subcutaneous nodulesLarge subcutaneous nodules
LocalisationLocalisation Head and NeckHead and Neck Head and NeckHead and Neck
PopulationPopulation Third and fourth decadesThird and fourth decades
CaucasianCaucasian
Female > maleFemale > male
Younger ageYounger age
AsianAsian
MaleMale
Regional Lymph Regional Lymph nodesnodes
InfrequentInfrequent PossiblePossible
Skeletal Skeletal involvementinvolvement
NoNo PossiblePossible
Blood eosinophiliaBlood eosinophilia MildMild MarkedMarked
Elevated serum Elevated serum IgEIgE
InfrequentInfrequent FrequentFrequent
Origin of the Origin of the diseasedisease
? Vascular origin ? Vascular origin (endothelial cell)(endothelial cell)
Chronic inflammatory Chronic inflammatory processprocess
Adapted from: Head and Face Medicine 2006, 2:32
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Kimura’s
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Treatment of ALHE
• Surgical excision• Cryotherapy• Curettage and
Electrodessication• Laser (argon, carbon
dioxide, PDL, copper vapor)
• Radiotherapy
• Tacrolimus 0.1% ointment
• Intralesional corticosteroids
• Oral retinoids• Topical imiquimod• Photodynamic therapy• Intralesional bleomycin
Dermatol Surg 2005, 31:713-16, J Dermatolog Treat 2004, 15(5):328-330, Dermatol Surg 2004, 30: 1169-1173,
Dermatology 1998, 197: 189-191, J Am Acad Dermatol. Aug 2003;49 (2 Suppl Case Reports): S195-6,
Clin Exp Dermatol 2009, June 17: Epub…..ahead of print
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Management in our patient
• ‘08: Nd:YAG laser
• ‘08, ‘09: Tacrolimus 0.1% ointment
• ‘09: electrodessication
• ’09: Surgical excision
• ’09: Topical Fluocinolone acetonide
• ’09: Intralesional triamcinolone (40mg/1ml)