CaseStudy-Pneumaticconveyingofpharmaceuticalingredients
Description: System for receipts preparation to manufacturepharmaceuticalointments
Productname: API and several excipients, such as magnesiumstearate
Productsupply: Bagsanddrums Density: From0.3upto1.03kg/m³ Physicalproperties: Productswithverybadflowingandsticky Systemcapacity: Upto3000l/h Conveyingdistance: 15mDesign:
ATEXandGMPcompliant
Containment:
UptoOEB4
Receivers: Rigidcontainer
Systemconsistingof:
! Drumemptyingstation(preparedtoreceivetheFlexi-vacsystem,toreachOEB5,incaseofAPItransfer)! Bagdumpstation(withflexibleglove-panel,todischargetheAPI)! Dedustingsystem! EZBiopacdischargestation! PCS250withintegratedCIPandsecuritysieving! Fullautomationofthesystem,includingthecontrolofthelifterandthespli-valve.
Thisprojectisacombinedsystem
usingtheflexibletechnologyfromILC
DoverandtheJetsolutionssystems.
ThePCSallowsthepowdertransferof
theseveralcomponentsindense
phase.
Theinstallationisautomatically
controlledbyaPLC.
Theexcipientsaresuckedfromdrums
usingawand;thebagsareemptied
intoabagdumpstationandtheAPIis
dischargedusingtheEZBiopacstation,
whichallowsthetransferwithout
containmentrupture.
Installationconcept
Drumemptying,bagdumpstationsandEZBiopactransfersystem
PCS
Thedrumemptyingstationandthebagdumpstationareusedtotransfertheexcipientinadust-freeoperation.
TheEZBiopacsystemisusedtofeedtheprocesswiththeAPI.Thesystemconsistsofamulti-groovecanister,theEZBiopacwithintegratedo-ring,theseparationcrimptoolandasuctionhopper.WiththeseelementsanOEB5containmentlevelispossible.
Thedifferentelementsareinstalledinaclean-roomandinstalledinmobileframes,toallowtheeasydisplacementbetweenthedifferentrooms.
ThesystemusesHartingplugstoconnecttheseveralstationswithcompressedair,vacuumandelectricalpowerandsignal.
ThePCSisusedtotransfertheproductsindense-phase.
Oneofthemainchallengeswastheverydifferentphysicalpropertiesofeachproduct(flowability,density,etc).ThePCShasanadaptedfiltrationsurfaceandalevelsensor,whichallowthegoodoperationinmultipleproductsconveying.
ThePCSisalsousedasasecuritysieving,ensuringthatonlytheproductwiththerightparticlesizegointotheprocess.
Drumsemptyingstation
Bagdumpstation
PCS250
Securityfilter
Vacuumpump
