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Reporter:Gong Huiting
Peking Univ. School of Public HealthDepartment of Nutrition and Food Hygiene
Campus Asia Symposium
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CONTENTS
My research project
Our research group
My experience
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Part1 Our research group
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• Department of Nutrition and Food Hygiene
• Professor Wang Peiyu and Professor Zhang Yumei
• 20 students
• Research fields: Nutritional epidemiology、Nutrition and
chronic diseases、Maternal and infant nutrition
Something about our research group
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Our research projects
Follow Up Studies:Maternal and infant
Cross-sectional Studies:Maternal and infant
(cooperated with Nestlé)、Adults
Trials:Lactobacillus paracasei N1115 & Sea buckthorn
puree on Dyslipidemia & Pathoglycemia
Animal Experiments:Exopolysaccharides(EPS)on
healthy and Ulcerative Colitis rats
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Part2 My research project
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Random controlled trial(RCT)
Effects of Sea Buckthorn puree on people
with Prediabetes:
A crossover-controlled trial
Funded by Natural Science Foundation of China(NSFC)
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Sea buckthorn
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Sea buckthorn
Sandy soil and little rainfall
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Sea buckthorn
polysaccharose、dietary fiber、Vitamin、flavonoids、organic acid and so on
Rich in carotenoid and Vitamin C
Spiecies Vitamin C(mg/100g)
European SB 120-315
Alps SB 405-1100
Chinese SB 2500
Lemon 22
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Prediabetes
Impaired glucose regulation
The most important risk factor of type 2
diabetes
Impaired Fasting Glucose &
Impaired Glucose Tolerance
Predia-
betes
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Epidemiology of Prediabetes
Reverse or Progress
6%-10% Impaired Glucose
Tolerance progress into
Type 2 Diabetes every year
We hope Sea Buckthorn can help us preventing the progression of
Prediabetes.
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1Random Controlled TrialCrossover
Double-blindSea buckthorn puree VS.
Placebo
90mL/d
Research Design
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Inclusion criteria
Basic Information
Aged 50-70,male or female
6.1<FPG<7.0mmol/L and/or
5.6%<HbA1c<6.5%。
Prediabetes
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Exclusion criteria
1. Diabetes patients.
2. Who take hypoglycemic agent.
3. Who have impaired liver、thyroid、kidney function or blood
disease.
4. Who have infectious diseases(HIV、hepatitis、tuberculosis .etc.)
5. Active period of gastric ulcer.
6. Who take dietary supplements which could affect this trial.
7. Who have irregular eating habit.
8. Who don’t have the ability to finish our survey, e.g.: confused-
minded people.
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Research Design Choose volunteers
Randomly grouping into AB and BA group according to HbA1c
AB:baseline BA:baseline
survey and takeblood sample after35d of SB puree
survey and takeblood sampleafter 35d ofplacebo
28d wash-out
Crossover,survey and take blood sample after 35d of
placebo/puree
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Survey
International Physical Activity Questionnaire
(IPAQ)
Food Frequency Questionnaire(FFQ)
& 24 hours dietary record
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Blood Sample
75g bread and 1 bag of milk
Fasting Blood Sample 30min、60min、120min after meal
Plasma glucose、insulin、C-peptide、HbA1c;
peripheral blood inflammatory factors:hs-CRP、IL-6、TNF-α
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Some results
Figure 1. changes of FPG during intervention (p=0.045)
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Some results
Figure 2. changes of FPG during wash-out period (p=0.043)
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Part3 My experience
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What I learned in CAMPUS Asia Project——Yonsei Univ.
Scientific Research
Korean Traditional Culture
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• Rigorous and serious scientific research attitude
• Adequate preparation
• Patience
• Combination between physical problems with mentality
and sociology
Scientific research
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Traditional culture
경복궁
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Traditional culture
Carved the seal
of our name in
Korean
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National central museum of South Korea
Korean history
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Thanks for your attention!