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The Pistoia AllianceStrategy, Progress, Momentum
Ramesh Durvasula, PhDDirector, Molecular Sciences & Candidate Optimization
Informatics, Bristol-Myers Squibb
Board Member of Pistoia Alliance
BioITWorld Expo, Boston, April 2011
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Agenda
Industry Drivers
The Origins of Pistoia
The Mission and Strategy of Pistoia
The Initiatives of Pistoia
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What is Core to your Business? What is Critical?
Core?
Cri
tical?
Focus
Staff on
Innovation
Externalize
for Cost
Reduction
Externalize
for
Best
Practices
Reduce
Non-Value
Added Work
1990
2011
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Pistoia MembershipFebruary2011
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The Mission of the Pistoia Alliance
Lowering the barriers to innovation
by improving the interoperability of R&D business processes
via pre-competitive collaborations
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Domains of Action
Biology & Translational
MedicineChemistry
Scientific Collaboration
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The Focus of Each Domain
Big Data, Analytics, Semantics
Supply Chain, Tech Transfer
Vocabularies, Use Cases,
Best Practices
Biology Chemistry
Scientific Collaboration
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The Biology Domain
1. Sequence Services
2. SESL
3. Biology Domain Roadmap
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Sequence Services
Biology Domain
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Sequence Services – the Rationale
“It takes all the running you
can do, to keep in the same
place!” -- Red Queen
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Sequences & Cloud
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SESL
Semantic Enrichment of Scientific Literature
Biology Domain
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Try this at your desk….
Which diseases are correlated to TCF7L2?
Gene/Protein Literature – Full TextLiterature - Abstracts
Inherited diseases Gene expression
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Try it again with Pistoia’s SESL….
Gene naming/synonyms
Gene Function
Literature statistics
Disease co-occurrences
Gene/protein interactions
…all in one report from one
search
HOW? A standard ontology,
data model, query language,
report structure, etc.
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The Deliverables of SESL
A Proof-of-Concept to demonstrate feasibility and clarify requirements
A functional specification for query brokering, result filtering, report generation
A potential for a new Business Model
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The Roadmap of the Domain
Biology Domain
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Breadth of Information Integrated (content)
Co
mp
lexity
of S
erv
ice
-En
ab
lem
en
t
SESL
Sequence
Services
Secure integrated
multi-domain
information services
…
caBIG
SAGE
EATRIS
ELIXIR
Sequences Expression Scientific Literature
Biology Domain Roadmap
Large Scale
Analytics
Multi-
tenant
Security
Hosting &
integration of
private data
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A Reality Check: Setting Expectations
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2020
Our industry needs a Disruptive Innovation. That Disruption...is Pistoia
IF YOU WANT TO GO FAST, GO ALONE
IF YOU WANT TO GO FAR, GO TOGETHER
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Thank you
http://goo.gl/0eytHwww.pistoiaalliance.org