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ONLINE APPENDIX
Online Figure 1 Trial Profile. Of all patients who underwent percutaneous coronary intervention with DES during the study period, 3,224 patients were eligible. A total of 1,811 patients (56%) were enrolled and randomly assigned to the stent types. Two-year follow-up data was obtained from 1,810 patients (one patient withdrew consent). BMS=bare metal stent. DES=drug-eluting stent
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Online Figure 2.
Patient-Reported Chest Pain at 1 and 2-Years (in Patients who Provided Chest Pain Information at Both Times). Patient-reported chest pain classified into 4 scores: 0= no chest pain at all; 1= chest pain only during most severe physical exertion; 2= chest pain at moderate physical effort (during moderate/normal daily activities); 3= chest pain during mild physical exertion or at rest. Panels A and B provide information about the presence and extent (i.e., pain score) of chest pain at 1 and 2-year follow-up in 1,572 patients, who were alive at 2-year follow-up and answered the chest pain questionnaire both times.
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Online Table 1. Supplement II. Outcome of patients in whom longitudinal stent deformation had been observed (all Promus Element stent group).
CaseVessel and segment
Lesion characteristics
ACC/AHA StentProximal/ distal location in stent
Post-dilation of stent performed
Procedural consequences
DAPT use at
Consecutive adverse clinical events until
lesion class
size (mm)
2-year follow-up
2-year follow-up
1 LAD, midbifurcation
C 3.0 x 38 proximal +
additional proximal stent
– –lesion
2 RCA, midsevere
C 2.5 x 32 proximal +
additional proximal stent
– –calcification
3 LAD, prox.
bifurcationC 3.5 x
24 proximal +additional proximal stent
– –lesion
4 LAD, prox.
bifurcationC 2.25 x
16 proximal –additional proximal stent
– –lesion
5 LAD, prox.
severeC 2.25 x
22 proximal +additional proximal stent
– –calcification
6 Left main
bifurcationB2 3.5 x
16 proximal +postdilation
– –lesion of stent
7 RCA, distal
bifurcationC 2.5 x
32 proximal +additional proximal stent
+ –lesion
8 LAD, prox.
moderate calcification C 3.0 x
12 proximal +additional proximal stent
– –
9 RCA, midsevere
C 3.0 x 24 proximal +
postdilation– –
calcification of stent
ACC/AHA=American College of Cardiology/American Heart Association; LAD=left anterior descending artery; Prox.=proximal; RCA=right coronary artery; DAPT=dual antiplatelet therapy. +=yes; –=no.
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Data except results of 2-year follow-up have previously been reported in: von Birgelen C, Sen H, Lam MK, et al. Third-generation zotarolimus-eluting and everolimus-eluting stents in all-comer patients requiring a percutaneous coronary intervention (DUTCH PEERS): A randomised, single-blind, multicentre, non-inferiority trial. Lancet 2014;383:413-23.
Outcome of patients in whom longitudinal stent deformation had been observed (all Promus Element stent group). ACC/AHA=American College of Cardiology/ American Heart Association; LAD=left anterior descending artery; Prox.=proximal; RCA=right coronary artery; DAPT=dual antiplatelet therapy. + = yes; – = no.
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Online Table 2 (Supplement III). Anticoagulant Use at 1 and 2-Year Follow-up.
Total Resolute Integrity ZES
Promus Element EES p value
At 1 year N=1776 N=883 N=883
Ascal 1575 (88.7) 786 (89.0) 789 (88.4) 0.66
P2Y12 inhibitor 437 (24.2) 227 (25.7) 210 (23.5) 0.28
DAPT 1534 (86.4) 765 (86.6) 769 (86.1) 0.75
Vitamin K antagonist 195 (11.0) 90 (10.2) 105 (11.8) 0.29
At 2 years N=1753 N=872 N=881
Ascal 1523 (86.9) 760 (87.2) 763 (86.6) 0.73
P2Y12 inhibitor 205 (11.7) 102 (11.7) 103 (11.7) 1.00
DAPT 157 (9.0) 78 (8.9) 79 (9.0) 0.99
Vitamin K antagonist 214 (12.2) 98 (11.2) 116 (13.2) 0.22
Values are % (n/N). DAPT= dual-antiplatelet therapy. Analysis based on survivors at 1 and 2-year, respectively.