Download - Apps for rare & neglected diseases
Apps for Rare & Neglected Diseases
Sean EkinsCollaborative Drug Discovery, Inc
Problems can be opportunities
• Smaller research communities• Less investment than Cancer, CV etc• Published data inaccessible to parents• But..• Apps existing for symptoms disease mgmt• Tight knit communities• Willing to collaborate• Try different approaches • Approaches generalizable, cheap, disruptive..
ODDT as an App ExperimentApp for rare and neglected diseases
ShareData and molecules
Inspiration:P4C2011Scio2012
Instigation:PA Dragons Den 2012
Crowdfunding visibilityPublications, posters, talks
biotech
Mol Informatics, 31: 585-597, 2012Drug Discovery Today, In press.
TB Mobile: Appifying data
Not a diagnostic, not a cure for the disease - a research tool
Funded by NIAID 2R42AI088893-02
Same data - different delivery >700 molecules screened versus Mtb and their targets
Similarity searchInfer targets
Problem addressed. Increase in whole cell screening – no idea of target
Logical next steps
• ODDT customizable by 7000 diseases• Imagine each rare disease community as app – with access to
private and public data (DDT)• Make more data available as apps or publish in apps.• Reuse data – mash up – find new ways to use- apps facilitate• e.g. GSK just announced 200 TB cpds to be public• NCATS 58 molecules from Pharmas- no structures
• Show examples of drug discovery by mobile device• Show how hypothesis from one disease can apply elsewhere• Demonstrate repurposing by app
What is needed
• Break down paywalls to papers– Neglected disease apps could increase visibility of
older content to parent advocates and researchers• Breaks down walls to data– Only recent data in PubChem etc..rediscovery of
old drugs published previously for TB..(e.g. PNAS Gold et al.)
• Find sponsors who promote openness (Burroughs Wellcome, small disease charities..)