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Antiretroviral Scale-Up in Resource Limited
Countries: Training the Pharmacists
Alice K. Pau, Pharm.D.
National Institute of Allergy & Infectious Diseases
National Institutes of Health
U.S.A.
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A global view of HIV infection33 million people [30–36 million] living with HIV, 2007
2.2
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Number of people receiving antiretroviral drugs in low- and middle income countries, 2002−2007
Source: Data provided by UNAIDS & WHO, 2008.
end-
2002
end-
2004
end-
2003
end-
2005
0.4
0.8
1.2
1.6
2.2
2.8
Millio
ns
Year
2.4
2.6
3.0
0.0
0.2
0.6
1.0
1.4
1.8
2.0
end-
2007
end-
2006
North Africa and the Middle East
Eastern Europe and Central Asia
East, South and South-East Asia
Latin America and the Caribbean
Sub-Saharan Africa
5.2
3 by 5 Initiative –
reached <50% of
target goal
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Key Challenges in Provision of Antiretrovirals –
Pharmacists’ Perspective
• Increasing number of patients in need of ARVs
• Shortage of pharmacists in many countries, relying on non-pharmacists as dispensers of ARV
• Expansion of pharmacists’ roles – from a “product-oriented” role to a “patient-oriented” role
– is this feasible given the current shortage?
• Need for formal training in HIV pharmacotherapy
• Need time for the training
• Need qualified trainers
• Rapidly emerging safety & efficacy data, new drugs, etc –requires continuous updating
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• Almost all Asian &
South American
countries have > 1
pharmacy school
• Only 18 of 52
African countries
have > 1 pharmacy
school – mostly
richer countries
• In most areas of
Africa, ARV
provision is done by
pharmacist
assistants or
nursing sisters
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Impact of HIV/AIDS on Pharmacist Shortage
• ↓ # of graduates from secondary schools that are qualified to enter into tertiary training programs
• ↓ # of graduates of secondary schools who seek healthcare as career goal
• Pharmacist attrition - HIV/AIDS-related death or early medical retirement
• Migration of pharmacists to resource richer environments
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Human Resources Challenges in the AIDS
Epidemic - Sub Saharan Africa
• Estimated # of patients with HIV = 22.5 million
• Assuming 1 pharmacist takes care of 500 ARV-treated patients
• To assess the human resource needs:
% of pts needing ARV # of pts # of pharmacists
10 % 2,250,000 4,500
25 % 5,625,000 11,250
50 % 11,250,000 22,500
All training plans should take into account human resource capacities & limitations
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Proposed Methods to Meet Human Resource
Challenges
• Increase # of pharmacy schools & students per class
• Provide incentives to keep pharmacists from migration
• Conditional scholarships for current students
• Assure HIV-infected pharmacists & family member are
getting ART & staying healthy
• Train non-pharmacists to fulfill some less technical
pharmacists’ tasks
• Utilize foreign pharmacists from charity organizations
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Training of Pharmacists –
Strategic Planning
• Planning at national and regional levels, based on:
– The epidemics in the region
– Current level of pharmacy support
– Current level of ARV provision
– Projected number of patients entering into care
– Projected pharmacists : patients ratio
– Realistic level of care and commitment
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Training of Pharmacists - Identify Areas of Need
• Who to train? – Pharmacists? Pharmacist Assistants?
• How many need to be trained?
• Who are the trainers?
• Where are the funding sources?
• What mode of training will work best for the intended
audience?
• Define the level of competency
• How to measure competency?
• How to sustain level of competency?
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Funding Sources
• PEPFAR and other agencies from resource richer countries
• Non-governmental organization (e.g. MSF, Treat Asia)
• Local governments
• Academic affiliations (locally or with other countries)
• Pharmaceutical companies
• Competitive grants
• Research programs
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Training Plan
• Identify trainers:
– Existing resources or outsourcing
– Experts in the local area
• Identify trainees
– Pharmacists & pharmacist-assistants in practice
– Training at pharmacy schools
– Other dispensing personnel
• Key to Success: Identify leaders amongst the trainees to carry out future training
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Hurdles in Training Practicing Pharmacists
• Time constraints
• Work- & family-related stress
• Lack of financial incentive for training
• Afraid of complexity of ARV pharmacology
• Afraid to take on a “patient-oriented” role
• Discrimination against HIV-infected patients
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Using Trainers from Outside/Foreign Sources
• Goal: CAPACITY BUILDING, skill sets should be sustainable after the trainers leave the country/region
• The trainers should:
– Engage local area experts in planning and training
– Understand existing systems and limitations
– Be sensitive to and respectful of cultural differences
– Provide long distance clinical mentorship after initial training
– Train local trainers
– Reinforce self learning & lifelong learning
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ARV Dispensing & Counseling
ARV Procurement & Storage
ARV Readiness Assessment
Adherence Counseling
Adverse Effect Monitoring & Management
Drug Info,
Research
Level of Expertise
Level of Necessity
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Basic HIV Training for Pharmacists
HIV Pathogenesis
• Mode of transmission & Prevention strategies
• Time course & consequences of untreated HIV
• HIV/AIDS-related OIs – including prevention and treatment
ARV
• ARV pharmacology & expected outcomes
• Association of adherence & resistance/treatment failure
• Common side effects, detection & management
• National ARV guidelines
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Additional Topics of Training
• Psychosocial Aspects of HIV/AIDS
• Effective Communication Skills – with patients &
other HCW
• Patient confidentiality
• Basic Computer Skills
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Advanced Training for Pharmacists
• Drug information and literature evaluation
• Unique aspects of HIV & ART use in different
populations – children, women, elderly, etc.
• Preparation of information newsletters, patient
education materials
• Preparation and presentation of lectures
• Clinical research training
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Training Format and Tools
• Lectures - live, videotape/conferencing
• On-line, self-paced training
• Newsletter, text, journals
• Practical training at other sites
• Bring trainers to the sites – more time efficient
• Case studies
• Training abroad
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Traditional/Local Medicines & ARV
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Traditional Medicine and ARV
• Use of traditional herbal or other medicines –
common across all cultures
• Potential pharmacokinetic and/or pharmacodynamic
interactions between ARV and traditional medicine
– continue to be an area of concern
• Pharmacists – key persons to identify pts taking
traditional meds and assess for potential adverse
reactions or interactions.
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Training of Non-Pharmacists
• Nurses, pharmacy assistants, community health workers – commonly used in medication dispensing
• Training should include:
– basic knowledge of ARV – how to take the meds, needs for adherence, and common side effects.
• They may play key roles as adherence counselors and peer counselors, and should be relied upon as much as possible where no pharmacists are available
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Keeping Up with Knowledge
• Case discussions with colleagues
• Internal teaching opportunities - drug updates,
journal clubs, case conferences
• Newsletters, journal articles, textbooks
• Internet resources - conference updates, electronic
text, HIV alerts
• Lectures
• Teleconferencing
• Networking with other pharmacists (via listserv, etc)
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Summary
• Training of pharmacists to meet the challenges of ARV scale
up can be a daunting task, esp. in the very resource poor
setting
• Government, pharmacy organizations, academic institutions,
and clinics should recognize the key roles pharmacists can
play and invest on incentives for their training
• Outside sources can provide initial training
• Identifying local trainers and leaders is the key to providing
further training to others entering into the healthcare system
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Pharmacists - Key to ARV Rollout Success