Download - Anti ulcer drugs
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Anti- ulcer drugs
Bipul DekaRoll No: 05
Department of Pharmaceutical Sciences, Dibrugarh University
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ULCER
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Cause of peptic Ulcer:
Destruction of the intestinal mucosal lining of the stomach by hydrochloric acid.
Infection with a bacterium called Helicobacter pylori,
Or by long-term use of aspirin or other Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), such as Ibuprofen
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• Therapeutic aims: (a) to relieve pain;
(b) to accelerate healing; and
(c) to prevent ulcer recurrence.
• Therapeutic approaches are threefold : (I) to reduce aggressive forces by lowering H+ output,
(II) to increase protective forces by means of mucoprotectants; and
(III) to eradicate Helicobacter pylori.
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Basic types of Anti-ulcer drugs:I. Lowering of Acid
Concentration
Agents for acid neutralization
Inhibitors of acid production
II. Protective Drugs
III. Eradication of
Helicobacter pylori
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Agents for acid neutralization
•Absorbable Antacids Ex: NaHCO3•Nonabsorbable Antacids Ex: CaCO3
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Inhibitors of acid production:• H2-Antihistaminics
• Proton pump inhibitors
• Cholinoceptor antagonist
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II. Protective Drugs
Sucralfate
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Misoprostol
a semisynthetic prostaglandin derivative with greater stability than natural prostaglandin
Locally released prostaglandins (PGF2α, PGE2) promote mucus production in superficial cellsand inhibit acid secretion ofparietal cells
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III. Eradication of Helicobacter pylori
Plays an important role in the pathogenesis of chronic gastritis and peptic ulcer disease.
The combination of antibacterial drugs and omeprazolehas proved effective.
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References:
“Color Atlas of Pharmacology” by Heinz Lüllmann, Lutz Hein, Klaus Mohr and Detlef Bieger.Goodman & Gilman’s “Manual of Pharmacology & Therapeutics”.“Essentials of Medical Pharmacology” by KD TRIPATHI.“A Textbook of Clinical Pharmacology and Therapeutics” by JAMES M RITTER, LIONEL D LEWIS and TIMOTHY GK MANT.Internet Sources.
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