Download - Antacids
![Page 2: Antacids](https://reader031.vdocuments.us/reader031/viewer/2022013004/5681508e550346895dbe8a11/html5/thumbnails/2.jpg)
• http://redpoll.pharmacy.ualberta.ca/drugbank/
Description:The DrugBank database is a unique bioinformatics and cheminformatics
![Page 3: Antacids](https://reader031.vdocuments.us/reader031/viewer/2022013004/5681508e550346895dbe8a11/html5/thumbnails/3.jpg)
• http://www.rxlist.com/script/main/hp.asp
![Page 4: Antacids](https://reader031.vdocuments.us/reader031/viewer/2022013004/5681508e550346895dbe8a11/html5/thumbnails/4.jpg)
![Page 5: Antacids](https://reader031.vdocuments.us/reader031/viewer/2022013004/5681508e550346895dbe8a11/html5/thumbnails/5.jpg)
![Page 6: Antacids](https://reader031.vdocuments.us/reader031/viewer/2022013004/5681508e550346895dbe8a11/html5/thumbnails/6.jpg)
![Page 7: Antacids](https://reader031.vdocuments.us/reader031/viewer/2022013004/5681508e550346895dbe8a11/html5/thumbnails/7.jpg)
![Page 8: Antacids](https://reader031.vdocuments.us/reader031/viewer/2022013004/5681508e550346895dbe8a11/html5/thumbnails/8.jpg)
![Page 10: Antacids](https://reader031.vdocuments.us/reader031/viewer/2022013004/5681508e550346895dbe8a11/html5/thumbnails/10.jpg)
12.2 Antacids• State and Explain how excess acidity
in the stomach can be reduced by the use of different bases.
• Antacids: bases, metal oxides, hydroxides, carbonates, hydrogen carbonates
• Reacts with stomach acid (excess) to adjust the stomach pH to the desired level
![Page 11: Antacids](https://reader031.vdocuments.us/reader031/viewer/2022013004/5681508e550346895dbe8a11/html5/thumbnails/11.jpg)
Purpose of HCl in the stomach
• To suppress growth of harmful bacteria
• To help in digestion by hydrolyzing proteins to amino acids
• Normal pH of stomach acid ~
• 1.2 – 0.3 range,
• Stress also produces more acid
![Page 12: Antacids](https://reader031.vdocuments.us/reader031/viewer/2022013004/5681508e550346895dbe8a11/html5/thumbnails/12.jpg)
Role of antacids
• Neutralizes the excess acids and relives the discomfort
–Excess acid can cause ulcers
![Page 13: Antacids](https://reader031.vdocuments.us/reader031/viewer/2022013004/5681508e550346895dbe8a11/html5/thumbnails/13.jpg)
Examples: Over the Counter
• Al(OH)3 Mg(OH)2 CaCO3
• NaHCO3
![Page 14: Antacids](https://reader031.vdocuments.us/reader031/viewer/2022013004/5681508e550346895dbe8a11/html5/thumbnails/14.jpg)
Alginates
• Antacids are combined with
Alginates• extracted from brown sea weeds
• produces neutralizing layer that prevents acid reflux / acid entering into oesophagus
![Page 15: Antacids](https://reader031.vdocuments.us/reader031/viewer/2022013004/5681508e550346895dbe8a11/html5/thumbnails/15.jpg)
Dimethicone / Antifoaming agent
• Are added to antacids to reduce the surface tension of gas bubbles
• And produce de-foaming action
![Page 16: Antacids](https://reader031.vdocuments.us/reader031/viewer/2022013004/5681508e550346895dbe8a11/html5/thumbnails/16.jpg)
Silicon Chemistry
• The possibilities offered to the formulation chemist by silicone chemistry are endless and yours to explore.
![Page 17: Antacids](https://reader031.vdocuments.us/reader031/viewer/2022013004/5681508e550346895dbe8a11/html5/thumbnails/17.jpg)
Active ingredients of some commercial antacids
• Tums: CaCO3 MgCO3 Mg Si3O8
–For the treatment of gastritis and of ulcers• Rolaids : AlNa(OH)2CO3
• Malox : Al(OH)3 Mg(OH)2
• Alka Seltzer : NaHCO3 , citric acid, aspirin
![Page 18: Antacids](https://reader031.vdocuments.us/reader031/viewer/2022013004/5681508e550346895dbe8a11/html5/thumbnails/18.jpg)
Alka Seltzer : NaHCO3 , citric acid, aspirin
![Page 19: Antacids](https://reader031.vdocuments.us/reader031/viewer/2022013004/5681508e550346895dbe8a11/html5/thumbnails/19.jpg)
Active ingredients of some commercial antacids
• Milk of Magnesia : Mg(OH)2 or MgO/Mg(OH)2 mixture
• Amphogel Al(OH)3
• Di-Gel : CaCO3
![Page 20: Antacids](https://reader031.vdocuments.us/reader031/viewer/2022013004/5681508e550346895dbe8a11/html5/thumbnails/20.jpg)
Action of Antacids
• Mg2Si3O8 + 4 HCl 3 SiO2(s)• 2 H2O (l) + 2 MgCl2(aq)
• Write the reactions for rest of the antacids
• Alkalosis: high doses of antacids• basic stomach• Other problems: body produces
more acids