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Ant Genomics & the Social Insect Behavior OntologyRCN Lightning Talk 2/25/2011
Christopher D. Smith Ph.D.Assistant Professor Biology
Associate Director, Center for Computing for Life Sciences
Dept. of Biology
San Francisco State University
San Francisco, CA 94132
Office HH518: x52505
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Social Insects Are Excellent Models to Study the Epigenetics of Development & Behavior
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Abouheif & Wray Evolution of the Gene Network Underlying Wing Polyphenism in Ants
Science 12 July 2002:Vol. 297. no. 5579, pp. 249 - 252
JH = Juvenile Hormone
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Wheeler et. al. Expression profiles during honeybee caste determinationGenomeBiology2000, 2(1):research0001.1-0001.6
• Fertile• Stay in nest• Long-lived• Larger
• Sterile• Leave Nest• Short-lived• Aggressive• Smaller, no wings
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‘Covergent’ Behaviors in Ants & Bees
• Extensive literature of natural history & behavior
• Well-developed behavior assays
• MANY genomes, methylomes, developmental timecourses online
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Behaviors can be linked to SNPs
• Africanized bees– Pursue Enemy 10-30x further– More reactive to color, movement– 4-10x stinging– Disengage less– Alert quickly– Larger defense perimeter
• Using comparative annotation we can link ‘Africanized’ SNPs to gene and regulatory annotations
– e.g. Dopamine receptor mutations
• DRD4
– e.g. Serotonin promoter polymorphism
• hSlc6a4,dSerT
Disengagement
Perception
Orientation
1o Discriminationor Identification
AlertRecruitment
Approach
2o Discriminationor IdentificationThreat
ATTACK!
Adapted from Breed & Hunt2004. Annu. Rev. Entolom. 49:271-98
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The Social Insect Behavior Ontology(SIBO)
© SmithLab 2007
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Goal is to use natural language to find chemicals & anatomy associated with behaviors across eusocial insects to gain insight on evolution of eusocial organization
• Anatomy Based on Bolton
• Chemicals linked to CheBI
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2nd Goal: Dissect Genetic & Epigenetic Mechanisms Underlying Behavior Across Taxa
•Most genes associated with human behavioral disease have poorly defined mechanism•We want to RNAi/overexpress candidates in ants and use video tracking to see behavior effects
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http://www.cc.gatech.edu/cpl/projects/gtabas/ NIH: SC2 GM084888