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7/22/2019 Anne Joutel and Mark Nelson - Potential therapeutic avenues ?
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LJGJ\NB
Muiu`s Lmjarnjt*, Jcc` Ofut`b*, Kjrtnc Gnlmijcs*, @bnzja`tm Wfurcn`r-Bjss`rv`,
Kjrn` I`rkjnc` Afuss`r
Wr`jtk`ct
Jt pr`s`ct, tm`r` ns cf tr`jtk`ct fh prfv`c `hhnljly hfr LJGJ\NB,`ntm`r hfr tm` gns`js` fr hfr tm` kjnc sykptfks. Wr`jtk`ct ns tmus`ctnr`by prjikjtnl.
Bjcl`t C`urf b155>4 =?87
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7/22/2019 Anne Joutel and Mark Nelson - Potential therapeutic avenues ?
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LJGJ\NB
Uft`ctnjb tm`rjp`utnl jv`cu`s6
Jcc` OFPW@B
Kjrd C@B\FC
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7/22/2019 Anne Joutel and Mark Nelson - Potential therapeutic avenues ?
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Gns`js`-kfgnhynci tr`jtk`cts ajs`gfc ucg`rstjcgnci tm` pjtmfi`cnl s`qu`cl`
\trfd` lficntnv` $ kftfr gnsjanbnty
Ymnt` kjtt`r lmjci`s
Knirjnc` wntm jurj
Cftlm< @LG/ IFK g`pfsnts
~15 ~
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7/22/2019 Anne Joutel and Mark Nelson - Potential therapeutic avenues ?
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Cftlm
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7/22/2019 Anne Joutel and Mark Nelson - Potential therapeutic avenues ?
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Jctns`cs` fbnifculb`ftng`s (J\Fs)tf r`gulnci tm` lfcl`ctrjtnfc fh prft`ncs
Hrfk \futmw`bb `t jb, Wr`cgs nc Kfb`lubjr K`gnlnc` 15:1
\mfrt syctm`tnl lm`knljbby kfgnhn`g culb`nl jlngs tmjt ancg QCJ tjri`t
I`c` snb`clnci (g`irjgjtnfc) fr kfgubjtnfc fh QCJ k`tjafbnsk (spbnlnci)
Cfcs`b`ltnv` (YW &kutjct jbb`b`s) fr kutjct jbb`b`-sp`lnhnl snb`clnci
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7/22/2019 Anne Joutel and Mark Nelson - Potential therapeutic avenues ?
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Hjvfrjab` lmjrjlt`rnstnls Bfci tnssu` mjbh-bnh` fh lm`knljbby kfgnhn`g (ajldafc` strultur` fr suijr rnci ) J\Fs
(~1= gjys)
@hhnln`ct LC\ g`bnv`ry ay nctrjtm`ljb nchusnfc nctf tm` L\H
@hhnln`ct uptjd` nc c`urfcs jcg ibnj (\KL66)
Culb`jr `ctry
Cjd`g J\Fs 3 ir`jt`r tfb`rjcl` jcg pr`lns` gfsnci
\ull`sshub pr`lbncnljb stugn`s (Muctncitfcs gns`js` jcg JB\)
A`c`hnlnjb `hh`lt kjy p`rsnst hfr bfci`r tmjc tjri`t suppr`ssnfc 3 trjcsn`ct
tm`rjpy
J pmjs` : hnrst-nc-kjc w`bb-tfb`rjt`g stugy (\FG:-JB\) (pmjs` 1 nc WWQ-jkybfngfsns)
Jctns`cs` fbnifculb`ftng`s (J\Fs) tm`rjp`utnlshfr ncm`rnt`g arjnc gns`js`s
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7/22/2019 Anne Joutel and Mark Nelson - Potential therapeutic avenues ?
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Jctns`cs` fbnifculb`ftng`s tm`rjp`utnls hfr LJGJ\NB6
Q`gul` `xpr`ssnfc fh jbb Cftlm
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7/22/2019 Anne Joutel and Mark Nelson - Potential therapeutic avenues ?
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Jkybfng ljsljg` mypftm`sns (tfxnlnty fh sfbuab`, fbnifk`rnl jcg hnarnbbjr Jsp`ln`s)
Ujssnv` (Jctn-J jctnafgn`s jgkncnstrjtnfc) / jltnv` (J nkkucnzjtnfc tfncgul` jctn-J nkkuc` r`spfcs`)
Jtt`cujt`s J g`pfsntnfc jcg hjlnbntjt`s lb`jrjcl` fh J jiir`ijt`s nckfus` kfg`bs jcg pjtn`cts wntm Jbzm`nk`rs gns`js`
Wftjb LC\ `xpfsur` fh jctn-J jctnafgn`s g`p`cgs fc hrjltnfcjb LC\p`c`trjcl` (5.50-5.1%) + LC\ mjbh bnh` (5.0-7 mfurs)+ lylbnci a`tw``c LC\jcg pbjskj+ pbjskj mjbh bnh` (:-< w``ds)+ anfjvjnbjanbnty
K`lmjcnsks fh pjssnv` nkkucnzjtnfc jr` kubtnpb` aut lfctrfv`rsnjb(p`rnpm`rjb sncd, Hl-k`gnjt`g pmjiflytfsns ay knlrfibnj, kfcfk`rc`utrjbnzjtnfc, Ja-k`gnjt g gnsruptnfc fh jiir`ijt`s.. )
Wm` jctn-J nkkucftm`rjpy nc Jbzm`nk`rs gns`js`?:7 y`jrs fh `xp`rn`cl`
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7/22/2019 Anne Joutel and Mark Nelson - Potential therapeutic avenues ?
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Wm` lmjbb`ci` fh jctn-J nkkucftm`rjpy jgv`rs` `hh`lts
Hrfk Bnu, .-M. `t jb., Cjt. Q`v. C`urfb. 15:
Js`ptnl
k`cncif`cl`pmjbntns
Ujssnv` nkkucnzjtnfcJltnv`
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7/22/2019 Anne Joutel and Mark Nelson - Potential therapeutic avenues ?
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Wm` hjnbur`s fh pmjs` NNN jctnafgy trnjbsnc Jbzm`nk`rs gns`js` - Hutur` gnr`ltnfcs
Q`jsfcs hfr hjnbur` Inv`c tff bjt`
Ujrtnlnpjcts wntmfut jacfrkjb jkybfng aurg`c ay U@W sljccnci (~
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7/22/2019 Anne Joutel and Mark Nelson - Potential therapeutic avenues ?
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@xtrjl`bbubjr Cftlm