Angiostatin: A Novel Angiogenesis InhibitorThat Mediates the Suppression of Metastases

by a Lewis Lung Carcinoma

Michael S. O’Reilly, Lars Holmgren, Yuen Shing,Catherine Chen, Rosallnd A. Rosenthal,

Marsha Moses, William S. Lane, Yihai Cao, E. Helene Sage, and Judah Folkman

Cell, Vol. 79, 315-328, October 21, 1994

Lung carcinoma implanted subcutaneously into mice.Allow to grow to 1500 mm3

Removed (or not) and wait 15 daysLook for metastases to lung

Same experiment, but now treat with serum or urine from tumor-bearing animal

Named this protein Angiostatin

Surprise! It’s a fragment of Plasminogen

Named this protein Angiostatin

Surprise! It’s a fragment of Plasminogen