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An ontological perspective on the UMLS
Final Report CgSB - July 11, 2001
Anita Burgun
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2Lister Hill National Center for Biomedical Communications
MOR (BOSC, May 17, 2001)
Semantic Spaces
TerminologiesMedical Subject HeadingsInternational Classification of DiseasesSNOMED[…]
OntologiesCycWordNetDigital Anatomist[…]
UMLS
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Introduction
Semantics of the relationships between UMLS co-occurring conceptsSemantic GroupingLexical techniques for identifying hyponymic relations among medical terms Ontological features of the biomedical domain
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UMLS Semantic space or ontology?Semantic Network
“a basic ontology for the biomedical domain”Semantic typesRelationshipsSmallDeveloped internallyFully controlled
MetathesaurusConceptsRelationshipsHugeIntegrates vocabularies from other institutionsNot censored
Semantic Space Ontology
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Semantic Network as domain ontology
Re-used in specific medical areas:MENELAS, MAOUSSC, genomics (Yu & al), blood transfusion (Achour & al)
Re-used for specific tasksSemantic tagging of medical documents (MEDTAG)Natural Language Processing (Semantic Interpretation)
Integrated into large-scale ontology librariesONIONS
Addressed some ontological issues, e.g., polysemy
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Semantic Network as domain ontology
Systematic approaches for analyzing the UMLSStructural: object-oriented model (Perl)Semantic: Semantic GroupingOntological
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Overview
Illustrate our work from examples rather than report on all aspects3 aspects:
The principles and the UMLSCompatibility with a general ontology (WordNet)Discussion inspired by the representation of the biomedical domain in several systems (“Blood”)
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The principles and the UMLS
1- Formal properties
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Formal properties
Rigidityproperty that is essential to all the instances.Person (+R). Physician (not R).
Identitythere is a property that is both necessary and sufficient for identifying an instance. Person (+I)
Unityinstances are intrinsic wholes. Person (+U).
Dependencefor all the instances x, necessarily some instance of Z must exist, which is not a part of x, nor a constituent of x (+D). Food (+D)
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Formal properties Rules
Rules(not U) cannot subsume (+U)e.g., Substance cannot subsume Physical Object[…]
Distinction between roles and sortal typesRoles: (Not Rigid) (+Dependent)Sortal types : (+Rigid) (Not Dependent)
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Formal properties Examples
Signs or Symptoms are RolesEye Symptom would belong to the SNMetathesaurus concepts that are assigned only to roles with no sortal Semantic Type represent a numerous set of entities (95% of the Findings, 86% of the Signs or Symptoms are not assigned to another Semantic Type). Which sortal type for : Heart murmur, innocent, Overactive child, or Early waking ?
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The principles and the UMLS
2- The Economy Principle
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The economy principle
R1. Ad hoc precisionThe intent is to establish a set of semantic types, which will be useful for a variety of tasks without introducing undue complexity. The most specific semantic type in the semantic type hierarchy is assigned to the concept.
R2. No hybrid typesInstead of creating a lattice structure, with hybrid types inheriting from two supertypes, the SN has a single inheritance tree structure. As a consequence, a Metathesaurus concept inheriting from two STs is assigned to both types.
R3. No category “other”Rather than proliferating the number of semantic types to encompass multiple additional subcategories, concepts that cannot be categorized by any sibling Semantic Type are simply assigned their common supertype.
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The economy principle and the theory
Intensions and extensionsTaxonomies (isa) are systems in which categories (intensions) are related to one another by means of subordination, or, in class parlance (extensions), systems in which classes are related to one another by means of class inclusion.
Categories and classesWhen a category K has subcategories K1, K2, …. Kn, its extension, the class CK is the union of the classes for each of its subcategories, i.e. CK1, CK2,……CKn.
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Research Device
Manufactured object used primarily in carrying out scientific
research or experimentation
Medical Device
Manufactured object used primarily in the diagnosis, treatment, or prevention of
physiologic or anatomic disorders
Clinical Drug
Pharmaceutical preparation as produced by the manufacturer
Manufactured Object
physical object made by human beings
CMD CRD CCD
CMO
CMD ∪ CRD ∪ CCD
Categories
Classes
≠
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The economy principle and the theory
Disease or Syndrome
Mental DiseaseSomatic Disease
Somatic and Mental Disease
Rule R2: No hybrid typeThus multiple categorization
Vascular Dementia
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The economy principle and the theory
Rule R1: ad hoc precision in hierarchiesThus no “Somatic disease” type
Disease or Syndrome
Mental DiseaseSomatic Disease
Vascular Dementia
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The economy principle and the theory
Rule R3: No “other” typeAssign to the common supertype
Vascular Dementia
Mental Disease“Other” Disease
Disease or Syndrome
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The economy principle and the theory
Disease or Syndrome
Mental Disease
Vascular DementiaDiabetes Mellitus
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Compatibility with general ontologies
The example of WordNet
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Compatibility among ontologies
Compatibility in depthLower levels of ULO/ domain categories(e.g., Disease)
Compatibility in breadthCategories that do not specifically belong to D(e.g., Manufactured Object)
Universal CompatibilityGeneric theories(e.g., time, space)Meta-level categories(e.g., properties, roles)
Upper Level Ontology
Domain Ontology
GeneralOntology
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UMLS and WordNet (general ontology)
WordNetElectronic lexical database (Princeton)General world; 100,000 synsets (clusters of terms)
3 levels Terms: Does the term T from S1 also belong to S2?Concepts: How do terms for concept C in S1 overlap with terms for concept C’ in S2?Semantic classes: How do concepts for class K in S1 overlap with concepts for class K’ in S2?
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UMLS / WordNet Methods
Compatible structures: Clusters of synonymous terms (concepts/ synsets)isa relations
UMLS: categorizationHealth Disorder : Semantic Group Disorder
WordNet: hyponymyHyponyms of selected synsets (Symptom, Ill Health, Disorder (sense 1), Mental retardation, Mental Illness, Defect (sense 1),Abnormalcy)
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UMLS / WordNet Results
Health disorders2% of UMLS conceptsfound in WordNet83% of WordNet synsetsfound in the UMLS
UMLS
WordNet
Same class: 97%
Same class: 48%2%143,991Concepts
Found in WordNetFrom UMLS
77%2,194Terms83%1,379Synsets
Found in UMLSFrom WordNet
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Specific terms
UMLSSpecialized termsTerminology-specific terms
WordNetLay synonyms
infectious mononucleosisglandular feverkissing disease
Infectious MononucleosisGlandular FeverPfeiffer's diseaseMONONUCLEOSISMonocytic anginaGammaherpesviral mononucleosisInfectious mononucleosis, unspecifiedInfective mononucleosis[…]
WordNetUMLS
InfectiousMononucleosis
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Specific concepts
UMLSHealth disorder
Many domain-specific concepts
WordNetHealth disorder
Plant diseasesAstraphobiaCrickSword cut
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Granularity, plesionymy
WordNetUMLS
generalized epilepsygrand mal epilepsy
Epilepsy, Grand MalTonic-Clonic EpilepsySeizure Disorder, Tonic Clonic[…]
Epilepsy, GeneralizedSeizure Disorder, Generalized[…]
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Differing categorization
cavitycariesdental cariestooth decay
Dental CariesDental cavity, NOSTooth cariesDental Decay[…]
WordNetUMLS
Dental Caries
decay
natural process
process
phenomenon
Disease or Syndrome
Pathologic Function
Biologic Function
Natural Phenomenon or Process
Healthdisorder
Healthdisorder
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Representation of the biomedical domainin different systems
Blood
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Objective
Analyze core categories central to the biomedical domain
E.g., anatomy
Study specific views, respective contributions of each system
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Representation of Blood
In general ontologiesCyc Knowledge Representation, common-senseWordNet
In domain ontologiesGALENUMLS
In a specific ontology : Digital AnatomistIn application ontologies : MENELAS
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Cyc
Blood
Mixture
A tangible stuff composed of two or more different constituents which have been mixed. These constituents do not form chemical bonds, and later the mixture may be resolved by some separation event. A mixture has a composition but not a structure
As well as mud, air and carbonate beverage
TangibleThing
#$genls
ExistingStuffType
#$isa
#$genls
The function Separation-Event can apply to it.
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WordNet
Blood
Humorthe four fluids in the body whose balance was believed to determine our emotional and physical state
As well as phlegm, yellow and black bile
EntityPhysical Object
SubstanceBody Substance
Body Fluid
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GALEN
Blood
SoftTissue
As well as Lymphoid Tissue, Integument, and Erectile Tissue
DomainCategoryPhenomenon
Blood has two states, LiquidBlood and CoagulatedBlood
SubstanceTissue
GeneralisedSubstance SubstanceorPhysicalStructure
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UMLS
Blood
Tissue
EntityPhysical Object
Anatomical StructureFully Formed Anatomical Structure
An aggregation of similarly specialized cells and the associated intercellular substance. Tissues are relatively non-localized in comparison to body parts, organs or organ components
Body SubstanceBody Fluid Soft Tissue
Tissue Produces Biologically Active Substance
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Digital Anatomist
Blood
Body Substance
Anatomical EntityPhysical Anatomical Entity
a physical anatomical entity and a substance in gaseous, liquid, semisolid or solid state, with or without the admixture of cells, which is produced by anatomical structures or derived from inhaled and ingested substances that become modified by anatomical structures as they pass into or through the body
As well as saliva, semen, growth hormone, inhaled air, feces, lymph
Tissue is an Organ Part.
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MENELAS
Blood
Body Fluid
EntitySubstratum
Abstract ObjectPhysical Object
Real ObjectMass Object
Tissue
As well as Lymph
Model body_fluid(_x) is [body_fluid: _x]--(attr)-->[viscosity]
Mass Objects are constituted of Countable Objects
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From an example to discussion about…
Knowledge and representations of knowledgeWithin the biomedical domain (core concepts)
Definition of Tissue
Expert knowledge vs. general Humors as microtheories
Upper level categoriesMixtures in Cyc, Mass objects (non countable) in MENELAS
Level of Knowledge to be represented in a DOCoagulated Blood, Liquid Blood in GALEN
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Future Plans
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Future plans
Several projects with CgSB Alignment Metathesaurus/ SN (the descendants of A/ the Metathesaurus concepts assigned to A)Comparing definitions in WordNet and the UMLSFindings?
Formal aspectsN. Guarino
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Acknowledgments
Alexa McCrayOlivier BodenreiderTom Rindflesch