Download - Age-realted biological changes
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Balamurugan Tangiisuran, PhD Discipline of Clinical Pharmacy
School of Pharmaceutical Sciences Universiti Sains Malaysia [email protected]
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Age-related Physiological Changes and Functional Decline
• Types of Changes Expected with Age: – Overall decline in body system function
– Variable decline in specific organs and systems
– Different presentations of diseases and symptoms
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Age-related Physiological Changes and Functional Decline
• Factors contributing to variations in Functional Decline
–Aging process
–Disease
–Adverse environmental factors
–Adverse lifestyles
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Age-related Physiological Changes and Functional Decline
• System and organs most affected by aging – CV system – Pulmonary system – CNS and brain – Renal system and kidneys – Liver – Immune system – GI system – Endocrine system
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Effects of aging on the CV SYSTEM
• Overall system function – generally sufficient for needs of aging adults
• Heart – Size of heart stays the same – Heart wall thickens with age – Diastolic filling rate decreases, with atrial
contribution to ventricular filling normal – Systolic BP at rest increases, with end systolic
volume and ejection fraction not significantly altered
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Effects of aging on the CV SYSTEM
• Peripheral circulation –Maximal oxygen consumption decreases –Beta-adrenergic modulation decreases,
alpha-adrenergic response normal – Stroke volume increases, counteracting
decreased heart rate
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Effects of aging on the Pulmonary System
• Trachea and Central Airways increase in size, leading to: – More anatomic dead space – Decreased lung weight
• Chest wall thickens, leading to: – Loss of elastic recoil in the lung – Increased closing volume – Decreased maximum expiratory flow – Increased risk for respiratory failure
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Effects of aging on the Central Nervous System and Brain
• Brain mass and cerebral blood flow decreases, leading to: – Decreased coordination – Prolonged reaction time – Impairment of short-term memory – Decreased sensory conduction time – More permeable BBB
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Effects of aging on the Central Nervous System and Brain
• Serotonin system changes affect neuronal functions such as: – Pain – Feeding – Sleep – Sexual behavior – Cardiac regulation – Cognition
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Effects of aging on the Kidneys and Renal SystemKidneys and Renal System
• Anatomic changes: –Kidney size
decreases –Number of
glomeruli decreases
–Renal tubules changes
–Renal vasculature changes
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Effects of aging on the Kidneys and Renal SystemKidneys and Renal System
• Functional changes –Mean ClCr rate decreases –Renal blood flow declines –Conservation of sodium is reduced due to:
• Lower plasma renin activity • Urinary aldosterone excretion
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Effects of aging on the Liver
• Overall function less affected by age than other organs
• Liver size decreases • Hepatic blood flow
decreases, leading to altered metabolic clearance of certain drugs
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Effects of aging on the Immune System
• Cell-mediated responses decrease
• Humoral responses decrease
• Thymus size decreases • T-cell function is altered • B-cells produce less
antibodies
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Effects of aging on the Gastrointestinal System
• Oral cavity: – Traumatic oral
lesions –Xerostomia
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Effects of aging on the Gastrointestinal System
• Stomach – Gastric muscular atrophies – Gastric mucosa thins – Submucosa is infiltrated with elastic fibers – Gastric secretion decreases – pH increases
• once thought to be a consequences of aging, is now thought related to latent H.pylori infections which result in gastric mucosal atrophy and loss of acid producing parietal cells
– Gastric emptying slows
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Effects of aging on the Gastrointestinal System
• Small Intestine and Colon – Nutrition absorption
decreases (e.g., vitamn D, calcium)
– Motility remains intact
– Constipation and fecal incontinence is common
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Effects of aging on the Endocrine system
• Regulatory and feedback mechanism deteriorate
• Binding affinities and receptors decrease
• Glucose tolerance decreases
• Production of sex hormones decreases
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DrDr. . BalamuruganBalamurugan TangiisuranTangiisuran | | School of Pharmaceutical School of Pharmaceutical SciencesSciences
@DrTangiisuran
http://geriatricpharmacy.wordpress.com/