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Trigeminal neuralgia
Speaker: R2 楊芝琳Supervisor: Dr.林嘉祥
1. The clinical journal of pain, 18(1), 20022. Surgical Neurology 66 (2006), 350–3563. JADA, Vol. 135, 2004,1713-17174. 2007;334;201-205 BMJ
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IntroductionIntroductionNeuralgia
Unexplained peripheral nerve pain The most common site: head and neck The most frequently diagnosed form: trigeminatrigemina
l neuralgia (TN)l neuralgia (TN) Fothergill’s disease Tic douloureux (painful jerking) Mean age: 50 y/o Female predominance (male : female = 1:2 ~2:3)
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Characteristics of trigeminal neuralgiaCharacteristics of trigeminal neuralgia
paroxysms of severe, lancinating, electric shock-like bouts of pain restricted to the distribution of the trigeminal nerve Unilaterally (right side) The mandibular (V3) and/or maxillary (V2) br
anch or, rarely, the ophthalmic (V1) branch
Spontaneously attack or triggered by trigger zone & movement of the face
Seconds to minutes
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AnatomyAnatomy
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Pathogenesis of trigeminal neuralgiaPathogenesis of trigeminal neuralgia
Uncertain Traumatic compression of the trigeminal nerv
e by neoplastic (cerebellopontine angle tumor) or vascular anomalies
Infectious agentsHuman herpes simplex virus (HSV)
Demyelinating conditionsMultiple sclerosis (MS)
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Types of Trigeminal Neuralgia
Typical TNAtypical TNPre-TNMultiple sclerosis-related TNTumor-related TNPost-traumatic TN (trigeminal neuropathy)Failed TN
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DiagnosisDiagnosisClassic TNClassic TN
Atypical or mixed TNAtypical or mixed TNA persistent and dull ache between paroxysms or mild sensory loss
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TreatmentTreatment Medical treatment
Carbamazepine (Tegretol) – first line Oxcarbazepine Gabapentin (Neurontin) Lamotrigine Baclofen Phenytoin Clonazepam Valproate Mexiletine Topiramate
Second line
Others
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Mechanism of medical therapy
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Surgical treatment Gasserian ganglion-level procedures
Microvascular decompression (MVD) Ablative treatments
• Radiofrequency thermocoagulation (RFT)
• Glycerol rhizolysis (GR)
• Balloon compression (BC)
• Stereotactic radiosurgery (SRS)
Peripheral procedures Peripheral neurectomy Cryotherapy (cryonanlgesia) Alcohol block
Neuro-destructive procedure
Surgical decompress
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Microvascular decompressionMicrovascular decompression(MVD)(MVD)
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Mechanism of ablation Mechanism of ablation treatmenttreatment
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Radiofrequency thermocoRadiofrequency thermocoagulation (RFT)agulation (RFT)
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CSF flow when entry Mechel’s cave 45~90 sec. cycles of 60~90℃ Perceiving a sharp pinprick as a light touch (hypalgesia) Divisional cutaneous facial flushing
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Glycerol rhizolysis (GR)Glycerol rhizolysis (GR)
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Test dose: 0.1-0.15 ml 0.05~0.1 ml at 3~5 min. intervals Total dose: 0.1~0.4 ml Sensory changes: pain, burning or paresthesia
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Balloon compression Balloon compression (BC)(BC)
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0.5~1 ml of contrast Pear-shape balloon Compression time:
1~7 min.
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Stereotactic radiosurgery Stereotactic radiosurgery (SRS)(SRS)
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Peripheral proceduresPeripheral procedures
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Peripheral neurectomyAlcohol block
0.5~1.5 ml of 80~100% alcohol
Whole branch & smaller peripheral nerve branches
External approach & intraoral method
Cryotherapy Exposed surgically and dire
ct application of a cryoprobe -50~-140℃ 3 cycles of 2 min. with a 5 m
in. thawing period in between
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Ganglion-level proceduresGanglion-level procedures vs. Peripheral proceduresPeripheral proceduresGanglion-level ablative procedures
Similar long-term success rate Varying degrees of sensory loss Balloon compression: least likely to impair
corneal sensation or to cause anesthesia dolorosa
Peripheral procedures High recurrence rates No benefit over ganglion-level procedures Reserved for emergency use
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Flow chart of the current practice of surgery for TN at UCLA.
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ThanksThanks for your for your attention!!attention!!
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(a) Thermal lesion of trigeminal nerve.(a) Thermal lesion of trigeminal nerve. (b) Mislocation of the electrode.(b) Mislocation of the electrode.
(c) Expansion of thermal energy to neighboring neural structures.(c) Expansion of thermal energy to neighboring neural structures.
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