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1Integration of BSL-3 Laboratories into Existing Facilities
Integration of BSL-3 Laboratories into Existing Facilities
51st Annual Biological Safety Conference
Reno, NV October 22, 2008
Scott Sandlin, AIA, CSI, LEED® APPerkins+Will
Houston, Texas
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2Integration of BSL-3 Laboratories into Existing Facilities
Agenda
IntroductionGeneral BSL-3 Design IssuesModular OptionsEquipment ConsiderationsCase Study: ABSL3 Lab for BSL4 Support
• Existing Conditions
• As ConstructedSummary / Questions
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3Integration of BSL-3 Laboratories into Existing Facilities
Before You StartExperience, Understanding
An integrated team and process begins early in the planning phase; document goals and expected outcomes; revisit continuallyFocus is on the process in planning of facility, combining understanding of process with facility designLife Safety a key part of planning and development
Integrated ProcessAll team members “vertically integrated” for project responsibility; streamlines the processDrives the commissioning process, and ensures a well documented end productDelivers facility that meets functional and operational goals
Pre-plumbed stack locations
General BSL-3 Design Issues
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4Integration of BSL-3 Laboratories into Existing Facilities
Summary of Design Features (Secondary Barriers)
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BSL-2 LaboratoryABSL-2 Animal Facility
BSL-3 LaboratoryABSL-3 Animal Facility
BSL-3 Ag AnimalBSL-4 Lab/Animal (Suit)
= Required by BMBL (5th ed.)= Not required by BMBL (5th ed.), however, generally considered as an enhancement
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5Integration of BSL-3 Laboratories into Existing Facilities
General BSL-3 Design Issues
Waste TreatmentHEPA Filter Exhaust ?Location in Building
Life SafetyUtility RoutingMechanical Equipment Room Location
Double door access (vestibule)Negative AirflowPlan to include personnel showerDecontamination
HEPA Filter Caisson
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6Integration of BSL-3 Laboratories into Existing Facilities
Pressure Differential vs. “Airtight”Sealing surface penetrationsPressure Decay test required for BSL-3-Ag
FinishesSeamless flooring optionsWashable/scrubbablesurfaces
Room Layout IssuesDesign for mobile caseworkHigh concentration of BSC’sSubstantial Lab Equipment
Planning for DuctworkAccess to filters, caissons, bioseal valves
General BSL-3 Design Issues
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7Integration of BSL-3 Laboratories into Existing Facilities
Dedicated MEP Systems
Critical Systems Back-UpN+1 Systems RedundancyBack-up Power for Fans
Use of Interstitial Space Highly Recommended
Detailing/Constructability/ Commissioning
“Off-the Shelf” Technology
Energy Conservation/ Sustainability should be a concern
HEPA Filters Above
Effluent decon if desired below
HEPA Filters…Above
General BSL-3 Design Issues
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8Integration of BSL-3 Laboratories into Existing Facilities
Future PlanningConsider locating lab on the upper-most lab floor
Interstitial access or mechanical penthouse is preferable
Consider GLP & Life Safety in locating lab
Consider support space adjacency BSL-2 & Core labs
Pre-plumbed stack locations
General BSL-3 Design Issues
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9Integration of BSL-3 Laboratories into Existing Facilities
Pre-plumbed stack locations
General BSL-3 Design Issues
Interstitial Option: Accessed from Corridor
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10Integration of BSL-3 Laboratories into Existing Facilities
General BSL-3 Design IssuesOperations and Maintenance
Plan for layout & utility systems redundancyLocation for Spares?Add excess electrical capacity for exhaust fans
Environmental ConsiderationsWind Analysis & HVAC Entrainment Study
Exhaust Entrainment Study
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11Integration of BSL-3 Laboratories into Existing Facilities
Future PlanningPlan for vertical exhaust duct runs
Stub stainless steel ductwork in now
Plan for layout & utility systems redundancy
Add excess electrical capacity for exhaust fans
Pre-plumbed stack locations
General BSL-3 Design Issues
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12Integration of BSL-3 Laboratories into Existing Facilities
Modular Lab Option
• Rapid reconfiguration
• Modules are 10’x12’
• Flexibility in HVAC Systems location
Courtesy of Dovetail Biocontainment
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13Integration of BSL-3 Laboratories into Existing Facilities
Layout Opportunities• Right-size the chamber (study
loads, items and run frequency)• Share autoclaves between lab
suites if protocol permits- evaluate system redundancy
needs• Newer designs incorporate water
economizer cycles & crushed door seals.
Pass-thru Sterilizers
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14Integration of BSL-3 Laboratories into Existing Facilities
Pass-thru Sterilizer Design
Utility Opportunities• Re-circulate cooling water, use
bldg. process water instead of domestic cold water (confirm w/ bio-safety protocol)
• Utilize bldg. plant steam vs. local electric steam generation
• Recover and re-circulate jacket condensate
• Utilize building plant compressed air
Pass-thru Sterilizers
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15Integration of BSL-3 Laboratories into Existing Facilities
Biological Safety Cabinet (BSC) selection and optimization
Class II, Type A & B1• Recirculating design utilizing
HEPA filtration:• Up to 30% exhausted via
HEPA into room (A)• 70% returned to work zone (A) Thimble design for exhaust
ducted installation (B1 – 30% recirc.)
Class II, Type B2 & B3• Total exhaust cabinet design
Exhausts conditioned air up to 1200 cu.ft/minute
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16Integration of BSL-3 Laboratories into Existing Facilities
HEPA Filtration on Exhaust
• Exhaust Filtration is not required by BMBL for BSL-3’s
• Filtration is becoming more common due to perceptions of User & community sensitivity
• Consider size and number of filters required
• Select and specify Lower DP HEPA Filters
Bag-in, bag-out HEPA filtration caisson
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17Integration of BSL-3 Laboratories into Existing Facilities
Aerial view of Keiller Building & BSL-4 Addition
Case Study: ABSL-3 Lab for BSL-4 Support
Keiller, Shope Lab & GNL
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19Integration of BSL-3 Laboratories into Existing Facilities
Case Study: ABSL-3 Lab for BSL-4 Support
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20Integration of BSL-3 Laboratories into Existing Facilities
Existing Facility Conditions • Unfinished basement• Low floor to floor height
Case Study: ABSL-3 Lab for BSL-4 Support
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21Integration of BSL-3 Laboratories into Existing Facilities
Low Headroom, Coordination of Underslab Utilities (Waste and Vent!)
Case Study: ABSL-3 Lab for BSL-4 Support
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22Integration of BSL-3 Laboratories into Existing Facilities
Low Headroom, Limitations due to Existing Structure, Equipment Coordination
Case Study: ABSL-3 Lab for BSL-4 Support
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23Integration of BSL-3 Laboratories into Existing Facilities
VFD Exhaust Drives
HEPA Exhaust with Decon Port Exhaust manifold in service closet
Case Study: ABSL-3 Lab for BSL-4 Support
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24Integration of BSL-3 Laboratories into Existing Facilities
Micro Isolator racksPortable isolators and change station
Case Study: ABSL-3 Lab for BSL-4 Support
Finished!
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25Integration of BSL-3 Laboratories into Existing Facilities
Case Study: ABSL-3 Lab for BSL-4 Support
ARC Sink – Utility Station Raised Ceiling for BSC installation
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26Integration of BSL-3 Laboratories into Existing Facilities
Case Study: ABSL-3 Lab for BSL-4 Support
Finished Corridor Animal Room Entry Detail
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27Integration of BSL-3 Laboratories into Existing Facilities
Hire a BSL3-experienced design team with a demonstrated commitment to understanding of how the lab is going to be used and maintained.
Insist on an integrated approach to planning, design and construction.
The devil is in the details: operational and physical!
HVAC system retrofit is often difficult due to space constraints and adjacency issues
Don’t depend on published cost data!
Plan for BSL-3 expansion now if it may be a possibility; route ductwork and provide adequate utility services
Summary