Lecture 1 Introduction to CHEM 346 September 3rd 2013
346 Organic Chemistry Laboratory Fall 2013
“The Undivided Mind” Imaginary Foundation, 2010
READY FOR RESEARCH
Blackwell et al, J. Chem. Educ. 2006, 83, 1835-1843
UNDERGRADUATE CHEM 344
What is CHEM 346?
- chemical information resources
Part 1 - Learning
- intermediate/advanced lab techniques
- scientific writing
- ethics in scientific research
- new organic chemistry
New organic chemistry & techniques
- 3 “scripted” lab projects
1. Total synthesis of a sulfa-antibiotic - protecting groups - EAS - antibacterial testing
NH2SO
OH2N
Sulfanilamide
What is CHEM 346?
Gerhard Domagk
What is CHEM 346?
New organic chemistry & techniques
- 3 “scripted” lab projects
2. Visible light photocatalysis - ligand synthesis/coordination chemistry - photocatalysis of a Diels-Alder reaction - screening reaction conditions - collating & discussing experimental data
Ru
N
N
NN
N
N
NN
NN
NN
[Ru(bpz)3]2+
2+
R1
R2 R3R2
R1
R4R3
R4+
Diels-Alder
[Ru(bpz)3]2+
Prof. Tehshik Yoon UW-Madison
What is CHEM 346?
New organic chemistry & techniques
- 3 “scripted” lab projects
3. Jacobsen epoxidation - ligand synthesis/coordination chemistry - asymmetric epoxidation of an alkene - mechanistic details
R1
R2
R1
R2O
Jacobsen catalyst
NaOCl
N N
O OMn
Jacobsen catalyst
Cl
Prof. Eric Jacobsen Harvard University
What is CHEM 346?
Chemical information resources
- 2 sessions with chemistry librarian
Scientific writing
Ethics in scientific research
- overview and case studies
- peer review of first draft comments graded final draft
- 3 lab reports written in Organic Letters template
What is CHEM 346?
- chemical information resources
Part 1 - Learning
- intermediate/advanced lab techniques
- scientific writing
- ethics in scientific research
- new organic chemistry
Part II - Applying
- research project/lab placement
- poster presentation
This week
- processing/work-up of NMR data (Kaz)
Today
- training on NMR instrument (Dr. Fry)
- lab drawer check-in B341
Thursday
- begin sulfanilamide lab project
- read lab manual, know what you are doing