17th July 2017
Innovate UK Knowledge Transfer Network
Dr Louise Wood
Director of Science, Research and Evidence
Department of Health
@klouisewood
21st Century Health:
Research to Support Personalised Medicine
EC Definition of personalised medicine
Council Conclusions on personalised medicine for
patients (2015/C 421/03)
"Personalised medicine refers to a medical model using
characterisation of individuals’ phenotypes and genotypes
(e.g. molecular profiling, medical imaging, lifestyle data) for
tailoring the right therapeutic strategy for the right person at
the right time, and/or to determine the predisposition to
disease and/or to deliver timely and targeted prevention"
Definition developed by the Advisory group for the H2020 Health, demographic change and well-being challenge
http://www.ema.europa.eu/docs/en_GB/document_library/Presentation/2017/0
5/WC500227976.pdf
The National Institute for
Health Research
The National Institute for Health Research (NIHR):
improving the health and wealth of the nation through
research.
Established by the Department of Health, NIHR:
• funds high quality research to improve health
• trains and supports health researchers
• provides world-class research facilities
• works with the life sciences industry and charities to
benefit all
• involves patients and the public at every step
MedTech developers - NIHR can help
• Is there a need for your technology?
• Find users/patients help improve design
• Where does your technology best fit into patient care
pathways?
• Who are the key opinion leaders and rising stars in the
field?
• What clinical evidence will be needed to help in adoption?
• Help in managing timelines
• Who can help design and deliver my study?
EC Framework for Personalised Medicine
http://www.ema.europa.eu/docs/en_GB/document_library/Presentation/2017
/05/WC500227976.pdf
To work with the NIHR
infrastructure contact the
team at:
Working with the NIHR and NHS
• For support in
undertaking clinical
research in the NHS
Contact the NIHR
Clinical Research
Network Support Team
uk
• 0113 34 34 555
• Web:
www.supportmystudy.nihr
.ac.uk
NIHR –Supported Facilities
7
NIHR Biomedical Research Units
NIHR Health Protection Research Units
NIHR Biomedical Research Centres
NIHR Blood and Transplant Research Units
NIHR Healthcare Technology Co-operatives
NIHR Diagnostic Evidence Co-operatives
NIHR-supported Clinical Research Facilities
NIHR School for Public Health Research
NIHR School for Primary Care Research
NIHR/CR-UK Experimental Cancer Medicine Centres
NIHR Surgical Reconstruction and Microbiology Research Centre
NIHR Collaborations for Leadership in Applied Health Research and Care
Newcastle
Leeds
Sheffield
LeicesterOxford
Bristol
Brighton
Peninsula
London
Bradford
Manchester
Liverpool
Exeter
Southampton
Cambridge
Nottingham
Birmingham
NIHR Inflammatory Respiratory Disease TRC
https://www.nihr.ac.uk/life-sciences-
industry/documents/Brochures%20and
%20flyers/Inflammatory%20Respirator
y%20Disease%20TRC%20flyer.pdf
Diagnostics Evidence Co-operatives
(DECs)
• Act as a catalyst for the generation of high-quality evidence of clinical
validity, clinical utility, cost effectiveness and care pathway benefits of
commercially-supplied IVDs.
NIHR DECs and SBRI
• 10 diagnostics companies secured nearly £2 million
funding by working with NIHR DECs in an Innovate UK
Stratified Medicine SBRI competition.
• Innovate UK provided funding for the development of
new diagnostic products and services for use in
stratified medicine.
• NOCRI worked with Innovate UK to shape the
competition and to help companies partner with the
NIHR Diagnostic Evidence Co-operatives (DECs) to
submit joint applications.
100,000 genomes project
Building a genomic medicine infrastructure
• Illumina - NHS Genomic Medicine
Sequencing Centre in Hinxton
• UK Data Infrastructure for Genomic
Medicine (with MRC)
• NIHR National Biosample Centre - £24
million state-of-the-art facility to store the
samples
• 13 NHS Genomic Medicine Centres in
England to enrol, validate and feedback
to patients
• Genomics England GeCIP
FEASIBILITY
Manage and deliver:
• Early Feedback
• Site Intelligence
• Site Identification
COMMERCIAL
COSTING
TEMPLATES
• Support use
• Manage templates
• Trust, Primary Care
& Device versions
HRA APPROVALS
SYSTEM FOR
GAINING NHS
PERMISSION
• Support use
MODEL
AGREEMENTS
• Support use
STUDY
MANAGEMENT
• Collect & collate
data
• Performance
manage study
Feasibility Set-up Delivery
NIHR Clinical Research Network
Service summary
Clinical Research Network