Download - 21 st Birthday Study
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21st Birthday StudyAngela Freeman
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Overview of study… Principal Investigator: Dr. Kerns
Main goal: to study neural effects of extreme drinking in young adults
Single occurrence of extreme drinking occurs on 21st birthday
Young adults may attempt 21 drinks/shots on bday
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Continued…
Does this drinking episode produce any cognitive changes?
Will be using both the functional MRI and structural MRI
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Testing after extreme drinking
fMRI=examining decreased brain activity in the hippocampus as well as the prefrontal cortex
› While completing a long-term memory cognitive task
Structural MRI=studying the decreased brain volume of hippocampus/prefrontal cortex
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Overview of Subjects Goal: 70 participants
Subjects: young adults who are turning 21 years old
Subjects must be celebrating/drinking on 21st birthday
Will participate in three separate interviews
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Screening Must make sure participant is eligible
Initial participant screening form
Would complete screening form via phone
Since conducting a MRI scan must take safety precautions
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Continued… Screened for…
Pacemaker /Mechanical Device
Body piercings
Braces-can distort data
Welding?
Claustrophobic?
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First Interview Responsible for conducting first
interview
Length: 1.5 to 2 hours
Many different interviews› Hangover Symptoms Scale› Lifetime Drinking History› Diagnostic Interview Schedule for DSM-IV
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Hangover Symptoms Scale› Hangover symptoms last 12 months
› Ex. “In the past 12 months when you drank alcohol, how often did you feel more tired than usual the next morning?” Answer options:
1. Never 2. Occasionally 3. About half the time 4. Most of the time 5. Every time I drink alcohol
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Lifetime Drinking History When first phase of drinking
Anymore phases of drinking?
Example: high school, or when first start college
To get an idea of drinking history
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Continued… Start with beginning phase Ask about life events Ask if event was positive, negative, or
neutral How often would drink alcohol/how
much? % of beer, liquor, or wine Drink alone/with others
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Diagnostic Interview Very lengthy Has different sections
› Demographics, Generalized Anxiety Disorder, Depression, Nicotine Dependence
Longest interview Mainly yes/no questions
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MRI training Brain scans held at Brain Imaging Center
Had to become a Level One MR Personnel
› Level 3 or 4 Personnel must accompany me› Would assist the graduate student with
various tasks
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MRI Training Training consisted of:
› Receive tour of the facility Location of emergency buttons and switches
› Certification-safety training quiz
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Scan time! Very important take all metal off!!
Scanner operator must take all metal off
Scanner=almost two hours
Cognitive tasks while in scanner
Show video first› Planet Earth
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First task Imagery task
› See 2 words at a time› Form a mental image› If a excellent image press with right index
finger› If poor image press with right middle finger
After scan will ask about words saw in scanner
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Second task N-Back Task
› See a series of circles on screen› For every circle decide if it was in same
spot three circles ago› Right index finger=same› Right middle finger=different› Measures working memory
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Example
SAME
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After scan Need to complete another cognitive
task
› Basically ask about words saw in scanner Asked participants to form mental image
After this participant done with first scan!
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Interviews 2nd interview
› Ask about birthday celebration What occurred/how much standard drinks
consumed?› Data first 10 participants
Average number of standard drinks=13.2 80%=10 or more drinks 20%=21 or more drinks (max = 28)
› Activities participated in Bar-hopping, dancing, did you embarrass yourself?,
card games› Who celebrate with?
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Third Interview 5 weeks after second scan Final scan Assess how much had to drink previous
5 weeks
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Goals of study Recruit more participants
Goal=70 all together
Analyze brain activity/structure
Discover any changes in brain?
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THE END!!!!!