©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
OpenCDS: an Open-Source, Standards-Based, Service-Oriented
Framework for Scalable CDS
OpenCDS: an Open-Source, Standards-Based, Service-Oriented
Framework for Scalable CDS
SOA in Healthcare 2011 ConferenceJuly 13, 2011
Kensaku Kawamoto, MD, PhD
Founder, OpenCDS (www.opencds.org) Co-Chair, HL7 Clinical Decision Support Work Group
Assistant Professor, Duke Center for Health Informatics8/11 - Assistant Prof., Dept. of Biomedical Informatics, Univ. of Utah8/11 - Director, Knowledge Management & Mobilization, Univ. of Utah
SOA in Healthcare 2011 ConferenceJuly 13, 2011
Kensaku Kawamoto, MD, PhD
Founder, OpenCDS (www.opencds.org) Co-Chair, HL7 Clinical Decision Support Work Group
Assistant Professor, Duke Center for Health Informatics8/11 - Assistant Prof., Dept. of Biomedical Informatics, Univ. of Utah8/11 - Director, Knowledge Management & Mobilization, Univ. of Utah
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
Presentation OverviewPresentation Overview
BackgroundClinical decision support (CDS) - definition, examples,
evidence of effectiveness
ProblemNeed for scalable CDS
Potential SolutionStandards-based, open-source CDS services
OpenCDS
Discussion
BackgroundClinical decision support (CDS) - definition, examples,
evidence of effectiveness
ProblemNeed for scalable CDS
Potential SolutionStandards-based, open-source CDS services
OpenCDS
Discussion
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
Presentation OverviewPresentation Overview
BackgroundClinical decision support (CDS) - definition, examples,
evidence of effectiveness
ProblemNeed for scalable CDS
Potential SolutionStandards-based, open-source CDS services
OpenCDS
Discussion
BackgroundClinical decision support (CDS) - definition, examples,
evidence of effectiveness
ProblemNeed for scalable CDS
Potential SolutionStandards-based, open-source CDS services
OpenCDS
Discussion
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
Clinical Decision Support (CDS)Clinical Decision Support (CDS)
The act of providing clinicians, patients and other healthcare stakeholders with pertinent knowledge and/or person-specific information, intelligently filtered or presented at appropriate times, to enhance health and health care (Osheroff, J Am Med Inform Assoc, 2007)
The act of providing clinicians, patients and other healthcare stakeholders with pertinent knowledge and/or person-specific information, intelligently filtered or presented at appropriate times, to enhance health and health care (Osheroff, J Am Med Inform Assoc, 2007)
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
Example Disease Management RemindersExample Disease Management Reminders
Source: Duke University Health System. Lobach DF, Kawamoto K, et al. Medinfo. 2007;861-5.Source: Duke University Health System. Lobach DF, Kawamoto K, et al. Medinfo. 2007;861-5.
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
Example Care Quality ReportingExample Care Quality Reporting
Source: Duke University Health System.Source: Duke University Health System.
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
Example Care Manager AlertExample Care Manager Alert
Source: NC Medicaid. Lobach DF, Kawamoto K, et al. AMIA Annu Symp Proc. 2007;473-7.Source: NC Medicaid. Lobach DF, Kawamoto K, et al. AMIA Annu Symp Proc. 2007;473-7.
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
Example Patient Reminder LetterExample Patient Reminder Letter
Source: NC Medicaid. Lobach DF, Kawamoto K, et al. Proc / AMIA Annual Symp. 2007;473-7.Source: NC Medicaid. Lobach DF, Kawamoto K, et al. Proc / AMIA Annual Symp. 2007;473-7.
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
Example Medication Management ReportExample Medication Management Report
Source: Del Fiol G, Kawamoto K, et al. AMIA Proceedings, 2010.Source: Del Fiol G, Kawamoto K, et al. AMIA Proceedings, 2010.
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
Evidence from systematic reviewsActionable, computer-generated CDS provided
automatically at the point of care significantly improved care quality in >90% of RCTs (Kawamoto, BMJ, 2005)
CDS generally more effective than other QI approaches – including CME, audit and feedback, EBM guideline creation & dissemination, & financial incentives
Examples of effectiveness86% reduction in serious medication errors at Brigham
and Women’s Hospital (Bates, 1999)93.8% compliance with NCEP guidelines vs. 35.2%
compliance in academic cardiology clinic (Stamos, 2001)
Evidence from systematic reviewsActionable, computer-generated CDS provided
automatically at the point of care significantly improved care quality in >90% of RCTs (Kawamoto, BMJ, 2005)
CDS generally more effective than other QI approaches – including CME, audit and feedback, EBM guideline creation & dissemination, & financial incentives
Examples of effectiveness86% reduction in serious medication errors at Brigham
and Women’s Hospital (Bates, 1999)93.8% compliance with NCEP guidelines vs. 35.2%
compliance in academic cardiology clinic (Stamos, 2001)
Evidence of CDS EffectivenessEvidence of CDS Effectiveness
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
Presentation OverviewPresentation Overview
BackgroundCDS - definition, examples, evidence of effectiveness
ProblemNeed for scalable CDS
Potential SolutionStandards-based, open-source CDS services
OpenCDS
Discussion
BackgroundCDS - definition, examples, evidence of effectiveness
ProblemNeed for scalable CDS
Potential SolutionStandards-based, open-source CDS services
OpenCDS
Discussion
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
The ProblemThe Problem
Despite demonstrated effectiveness, CDS is not widely available
The lack of CDS availability is due in part to the tight coupling of CDS capabilities with specific institutions and health IT systems
Despite demonstrated effectiveness, CDS is not widely available
The lack of CDS availability is due in part to the tight coupling of CDS capabilities with specific institutions and health IT systems
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
The NeedThe Need
Application-independent CDS resources that can be efficiently leveraged by diverse healthcare systems and health IT settings to improve patient health
Application-independent CDS resources that can be efficiently leveraged by diverse healthcare systems and health IT settings to improve patient health
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
Presentation OverviewPresentation Overview
BackgroundCDS - definition, examples, evidence of effectiveness
ProblemNeed for scalable clinical decision support (CDS)
Potential SolutionStandards-based, open-source CDS services
OpenCDS
Discussion
BackgroundCDS - definition, examples, evidence of effectiveness
ProblemNeed for scalable clinical decision support (CDS)
Potential SolutionStandards-based, open-source CDS services
OpenCDS
Discussion
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
Rationale for Open, Standards-Based CDS ServicesRationale for Open, Standards-Based CDS Services
Why CDS services?Encapsulates knowledge in highly reusable componentsSupports multiple knowledge representation approachesValidated by several groups
SEBASTIANDOD DDSS-KMRPartners ECRS / CDS Consortium
Why standards-based?To enable interoperability and scalability
Why open source?To foster adoption and collaboration
Why CDS services?Encapsulates knowledge in highly reusable componentsSupports multiple knowledge representation approachesValidated by several groups
SEBASTIANDOD DDSS-KMRPartners ECRS / CDS Consortium
Why standards-based?To enable interoperability and scalability
Why open source?To foster adoption and collaboration
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
CDS Services – Architectural OverviewCDS Services – Architectural Overview
Decision Support Service
Decision Support Service
Knowledge Modules
Knowledge Modules
Institution A Institution A
Client Decision Support Apps
Client Decision Support Apps
Patient Data Sources
Patient Data Sources
Queries for required ptdata
Queries for required ptdata
Institution B Institution B
Client Decision Support Apps
Client Decision Support Apps
Patient Data Sources
Patient Data Sources
Queries for required ptdata
Queries for required ptdata
Conclusions about patientConclusions about patient
Patient data, knowledge modules to use
Patient data, knowledge modules to use
Trigger
Standard Interface:HL7/OMG Decision Support Service Standard
(http://hssp-dss.wikispaces.com)
Standard Data Models:HL7 Virtual Medical Record (vMR) Standard
[ http://wiki.hl7. org/index.php?title= Virtual_Medical_Record_(vMR) ]
Standard Interface:HL7/OMG Decision Support Service Standard
(http://hssp-dss.wikispaces.com)
Standard Data Models:HL7 Virtual Medical Record (vMR) Standard
[ http://wiki.hl7. org/index.php?title= Virtual_Medical_Record_(vMR) ]
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
CDS Services – ExampleCDS Services – Example
Decision Support Service
Decision Support Service
EHR SystemEHR System Patient Data Sources
Patient Data Sources
Pt dataPt
dataCCDCCD
VMRVMREval.
ResultEval.
Result
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
Presentation OverviewPresentation Overview
BackgroundCDS - definition, examples, evidence of effectiveness
ProblemNeed for scalable clinical decision support (CDS)
Potential SolutionStandards-based, open-source CDS services
OpenCDS
Discussion
BackgroundCDS - definition, examples, evidence of effectiveness
ProblemNeed for scalable clinical decision support (CDS)
Potential SolutionStandards-based, open-source CDS services
OpenCDS
Discussion
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
OpenCDSOpenCDS
Goal Facilitate widespread availability of advanced CDS
capabilities through open-source, collaborative development of standards-based DSS infrastructure, tooling, and high-value services
MethodsContribute through Open Health ToolsLeverage open-source JBoss Drools rules engineUse modular architecture, enable iterative refinement,
support multiple knowledge represent. approaches Develop all components required to author, test, and
operationally support standards-compliant DSSs
Goal Facilitate widespread availability of advanced CDS
capabilities through open-source, collaborative development of standards-based DSS infrastructure, tooling, and high-value services
MethodsContribute through Open Health ToolsLeverage open-source JBoss Drools rules engineUse modular architecture, enable iterative refinement,
support multiple knowledge represent. approaches Develop all components required to author, test, and
operationally support standards-compliant DSSs
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
Current OpenCDS CollaboratorsCurrent OpenCDS Collaborators University of Utah HLN Consulting Veterans Health Admin. Intermountain Healthcare Univ. of NC at Chapel Hill Main Line Health Apelon, Inc. Keona Health Mass. General Hospital EBSCO Religent, Inc. IsoDynamic, Inc.
University of Utah HLN Consulting Veterans Health Admin. Intermountain Healthcare Univ. of NC at Chapel Hill Main Line Health Apelon, Inc. Keona Health Mass. General Hospital EBSCO Religent, Inc. IsoDynamic, Inc.
Hospital Universitario Virgen del Rocío, Spain
MaRS Innovation, Canada SmartCare, Africa Emetra AS, Norway Visumpoint, LLC Genesys, LLC Df8health Under active discussions
with several other organizations and individuals
Hospital Universitario Virgen del Rocío, Spain
MaRS Innovation, Canada SmartCare, Africa Emetra AS, Norway Visumpoint, LLC Genesys, LLC Df8health Under active discussions
with several other organizations and individuals
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
Operational Deployment – Online TriageOperational Deployment – Online Triage
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
Key ComponentsKey Components Standard interfaces and data models
Reference implementation of HL7/OMG DSS interfacevMR data modelData mappers (e.g., for CCD vMR)
Reference DSS knowledge management frameworkJBoss Drools and associated authoring/knowledge
management toolsFull-featured terminology supportA “domain specific language” for intuitive knowledge
authoringKnowledge repository and knowledge sharing service
DSS “wrappers” for other CDS engines
Standard interfaces and data modelsReference implementation of HL7/OMG DSS interfacevMR data modelData mappers (e.g., for CCD vMR)
Reference DSS knowledge management frameworkJBoss Drools and associated authoring/knowledge
management toolsFull-featured terminology supportA “domain specific language” for intuitive knowledge
authoringKnowledge repository and knowledge sharing service
DSS “wrappers” for other CDS engines
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
OpenCDS – Sample TopologiesOpenCDS – Sample Topologies
DSS ClientDSS Client
OpenCDS DSS InterfaceOpenCDS DSS Interface
OpenCDSDrools Adapter
OpenCDSDrools Adapter
OpenCDS Drools Engine
OpenCDS Drools Engine
CDS Engine/Service X (e.g., SEBASTIAN,KMR-DDSS, CDSC)
CDS Engine/Service X (e.g., SEBASTIAN,KMR-DDSS, CDSC)
OpenCDS Drools Knowledge
Authoring Platform
OpenCDS Drools Knowledge
Authoring Platform
OpenCDSAdapter XOpenCDSAdapter X
Apelon Distributed Terminology System (DTS)
Apelon Distributed Terminology System (DTS)
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
OpenCDS – Tour and DemoOpenCDS – Tour and Demo
DSS ClientDSS Client
OpenCDS DSS InterfaceOpenCDS DSS Interface
OpenCDSDrools Adapter
OpenCDSDrools Adapter
OpenCDS Drools Engine
OpenCDS Drools Engine
OpenCDS Drools Knowledge
Authoring Platform
OpenCDS Drools Knowledge
Authoring Platform
Apelon Distributed Terminology System (DTS)
Apelon Distributed Terminology System (DTS)
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
Terminology ManagementTerminology Management
External codes converted into internal OpenCDS concept(s) using terminology serviceE.g., ICD9CM 250.42
Diabetes mellitus with renal manifestationsDiabetes mellitusEndocrine disease
Separates terminology management from logic engineering
Uses Apelon DTS, but architecture supports use of other terminology services
External codes converted into internal OpenCDS concept(s) using terminology serviceE.g., ICD9CM 250.42
Diabetes mellitus with renal manifestationsDiabetes mellitusEndocrine disease
Separates terminology management from logic engineering
Uses Apelon DTS, but architecture supports use of other terminology services
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
OpenCDS – Terminology Mgmt. with ApelonOpenCDS – Terminology Mgmt. with Apelon
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
OpenCDS – Terminology Mgmt. with ApelonOpenCDS – Terminology Mgmt. with Apelon
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
Live DemoLive Demo
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
Presentation OverviewPresentation Overview
BackgroundCDS - definition, examples, evidence of effectiveness
ProblemNeed for scalable clinical decision support (CDS)
Potential SolutionStandards-based, open-source CDS services
OpenCDS
Discussion
BackgroundCDS - definition, examples, evidence of effectiveness
ProblemNeed for scalable clinical decision support (CDS)
Potential SolutionStandards-based, open-source CDS services
OpenCDS
Discussion
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
Key Benefits of ApproachKey Benefits of Approach
Builds on robust open-source community and resources
Provides standard architectural framework for integrating various CDS knowledge resources
Supports full life cycle of knowledge authoring, testing, maintenance, and execution
Provides an open-source framework for collaboration and innovation in CDSFreely available under Apache 2.0 license
Builds on robust open-source community and resources
Provides standard architectural framework for integrating various CDS knowledge resources
Supports full life cycle of knowledge authoring, testing, maintenance, and execution
Provides an open-source framework for collaboration and innovation in CDSFreely available under Apache 2.0 license
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
Key Challenges and Potential SolutionsKey Challenges and Potential Solutions
Challenge Potential solutions
Increased effort required to develop and support knowledge resources for use in multiple contexts
Balance generalizability with resource realities Spread knowledge development cost over multiple deployment settings
Bottom line assessment: benefits >> challenges Bottom line assessment: benefits >> challenges
Limited content availability
Provide federal funding for content development Create an interoperable, standards-based market for such knowledge
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
AcknowledgementsAcknowledgements
Research supportNHGRI K01 HG004645 (PI: K. Kawamoto)
University of Utah Dept. of Biomedical Informatics
Numerous OpenCDS collaborators
Research supportNHGRI K01 HG004645 (PI: K. Kawamoto)
University of Utah Dept. of Biomedical Informatics
Numerous OpenCDS collaborators
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
www.opencds.orgwww.opencds.org
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
Thank You!Thank You!
Kensaku Kawamoto, MD, PhD
Kensaku Kawamoto, MD, PhD
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
Backup SlidesBackup Slides
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
NQF Measure 31 for Meaningful UseNQF Measure 31 for Meaningful Use
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
OpenCDS Implementation – Denom.OpenCDS Implementation – Denom.
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
OpenCDS Implementation – NumeratorOpenCDS Implementation – Numerator
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
OpenCDS Implement. – Underlying DetailsOpenCDS Implement. – Underlying Details
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
Testing EnvironmentTesting Environment
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
Batch Regression TestingBatch Regression Testing
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
DSS Invocation - WrapperDSS Invocation - Wrapper
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
DSS Invocation - PayloadDSS Invocation - Payload
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
DSS Response - WrapperDSS Response - Wrapper
©2011, Kensaku Kawamoto©2011, Kensaku Kawamoto
DSS Response - PayloadDSS Response - Payload