Download - 10-2 Glycogen (starch) metabolism
![Page 1: 10-2 Glycogen (starch) metabolism](https://reader036.vdocuments.us/reader036/viewer/2022062408/56813507550346895d9c58df/html5/thumbnails/1.jpg)
10-2 Glycogen (starch) metabolism
Figures:
Stryer-5ed; chapter: 21
Lehninger-4ed; chapters: 7, 15, 23
![Page 2: 10-2 Glycogen (starch) metabolism](https://reader036.vdocuments.us/reader036/viewer/2022062408/56813507550346895d9c58df/html5/thumbnails/2.jpg)
![Page 3: 10-2 Glycogen (starch) metabolism](https://reader036.vdocuments.us/reader036/viewer/2022062408/56813507550346895d9c58df/html5/thumbnails/3.jpg)
The structure of starch
amylopectin Branch points occur every 24 to 30 residues!
![Page 4: 10-2 Glycogen (starch) metabolism](https://reader036.vdocuments.us/reader036/viewer/2022062408/56813507550346895d9c58df/html5/thumbnails/4.jpg)
The structure of amylose
![Page 5: 10-2 Glycogen (starch) metabolism](https://reader036.vdocuments.us/reader036/viewer/2022062408/56813507550346895d9c58df/html5/thumbnails/5.jpg)
The structure of glycogen
More branched and compact: branch points occur every 8 to 12 residues!
![Page 6: 10-2 Glycogen (starch) metabolism](https://reader036.vdocuments.us/reader036/viewer/2022062408/56813507550346895d9c58df/html5/thumbnails/6.jpg)
Glycogen (starch)degradation(glycogenolysis)
![Page 7: 10-2 Glycogen (starch) metabolism](https://reader036.vdocuments.us/reader036/viewer/2022062408/56813507550346895d9c58df/html5/thumbnails/7.jpg)
Pyridoxal phosphate cofactor(also in amino acid metabolism)
![Page 8: 10-2 Glycogen (starch) metabolism](https://reader036.vdocuments.us/reader036/viewer/2022062408/56813507550346895d9c58df/html5/thumbnails/8.jpg)
![Page 9: 10-2 Glycogen (starch) metabolism](https://reader036.vdocuments.us/reader036/viewer/2022062408/56813507550346895d9c58df/html5/thumbnails/9.jpg)
![Page 10: 10-2 Glycogen (starch) metabolism](https://reader036.vdocuments.us/reader036/viewer/2022062408/56813507550346895d9c58df/html5/thumbnails/10.jpg)
![Page 11: 10-2 Glycogen (starch) metabolism](https://reader036.vdocuments.us/reader036/viewer/2022062408/56813507550346895d9c58df/html5/thumbnails/11.jpg)
![Page 12: 10-2 Glycogen (starch) metabolism](https://reader036.vdocuments.us/reader036/viewer/2022062408/56813507550346895d9c58df/html5/thumbnails/12.jpg)
![Page 13: 10-2 Glycogen (starch) metabolism](https://reader036.vdocuments.us/reader036/viewer/2022062408/56813507550346895d9c58df/html5/thumbnails/13.jpg)
Glycogen synthesis (glycogenesis)
D-Glucose + ATP D-glucose-6-phosphate + ADP (hexokinase)
Glucose-6-phosphate glucose-1-phosphate (phosphoglucomutase)
Glucose-1-phosphate + UTP UDP-glucose + PPi (UDP-Glc pyrophosphorylase)
![Page 14: 10-2 Glycogen (starch) metabolism](https://reader036.vdocuments.us/reader036/viewer/2022062408/56813507550346895d9c58df/html5/thumbnails/14.jpg)
UDP-glucose is the substrate for glycogen synthesis
ADP-glucose is the substrate for starch synthesis in plants
![Page 15: 10-2 Glycogen (starch) metabolism](https://reader036.vdocuments.us/reader036/viewer/2022062408/56813507550346895d9c58df/html5/thumbnails/15.jpg)
![Page 16: 10-2 Glycogen (starch) metabolism](https://reader036.vdocuments.us/reader036/viewer/2022062408/56813507550346895d9c58df/html5/thumbnails/16.jpg)
![Page 17: 10-2 Glycogen (starch) metabolism](https://reader036.vdocuments.us/reader036/viewer/2022062408/56813507550346895d9c58df/html5/thumbnails/17.jpg)
![Page 18: 10-2 Glycogen (starch) metabolism](https://reader036.vdocuments.us/reader036/viewer/2022062408/56813507550346895d9c58df/html5/thumbnails/18.jpg)
![Page 19: 10-2 Glycogen (starch) metabolism](https://reader036.vdocuments.us/reader036/viewer/2022062408/56813507550346895d9c58df/html5/thumbnails/19.jpg)
![Page 20: 10-2 Glycogen (starch) metabolism](https://reader036.vdocuments.us/reader036/viewer/2022062408/56813507550346895d9c58df/html5/thumbnails/20.jpg)
The cost of converting Glc-6-P into glycogen:
Glucose-6-phosphate glucose-1-phosphate (phosphoglucomutase)
Glucose-1-phosphate + UTP UDP-glucose + PPi (UDP-glucose phosphorylase)
PPi + H2O 2Pi (inorganic pyrophosphatase)
UDP-glucose + glycogen (n) glycogen (n+1) + UDP (glycogensynthase)
UDP + ATP UTP + ADP (nucleoside diphosphate kinase)
Sum: Glc-6-P + ATP + glycogen (n) + H2O glycogen (n+1) + ADP + 2Pi