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PLEASING CLIENTS AT A MOLECULAR AND CELLULAR LEVEL
AUGUST 7, 2015
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We live in a society exquisitely dependent on science and technology, in which hardly anyone knows anything about science and technology.
– Carl Sagan (1990)
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TOPICS FOR DISCUSSION
Pace of life sciences1
Demands of the domain2
Multi-faceted and interdisciplinary business of science3
Focus on the customer: PDS in biotech4
Industry challenges & beyond5
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SCIENCE DOMAIN: CHAOS & CHANGE
Science TechnologyHypotheses
ThroughputAnalyses
Conclusions
Ideas
Experiments
Data
Algorithms
MethodsAnd everyone is going through the process differently…
Models
Data Management
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• Improvements in technology• Increase in amount of data• Development of algorithms
EVOLVING WITH THE PROCESS
Sample handling
Sample processing
Data storage
Data analysis
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DURATION 10+ YEARS
TECHNOLOGY IS RACING FORWARD, BUT DRUG DEVELOPMENT CYCLE IS LONG
LEAD IDENTIFICATION
PRE-CLINICAL CLINICAL TRIALS
PHASE I PHASE II PHASE III
FDA REVIEW
3-6 YRS 6-7 YRS 1-2 YRS
MANY COMPOUNDS
250 COMPOUNDS
20-100 VOLUNTEERS
100-500 VOLUNTEERS
1,000-5,000 VOLUNTEERS
ONE APPROVED
DRUG
? YRS
TARGET ID &
VALIDATION
Genomics ProteomicsTranscriptomics Epigenomics
ChemistryMetabolomicsToxicity
And all that data has to be “handled”!
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DURATION >10 YEARS
TECHNOLOGY IS RACING FORWARD, BUT CYCLE OF DRUG DEVELOPMENT IS LONG
LEAD IDENTIFICATION
PRE-CLINICAL CLINICAL TRIALS
PHASE I PHASE II PHASE III
FDA REVIEW
3-6 YRS 6-7 YRS 1-2 YRS
MANY COMPOUNDS
250 COMPOUNDS
20-100 VOLUNTEERS
100-500 VOLUNTEERS
1,000-5,000 VOLUNTEERS
ONE APPROVED
DRUG
? YRS
TARGET ID &
VALIDATION
Genomics ProteomicsTranscriptomics Epigenomics
ChemistryMetabolomicsToxicity
LEAD IDENTIFICATION
PRE-CLINICAL
3-6 YRS
MANY COMPOUNDS
250 COMPOUNDS
? YRS
TARGET ID &
VALIDATION
The greatest improvement to this cycle’s efficiency can be achieved
before the clinical phase
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THE LIFE SCIENCES MILIEU
ChemistryEngineering
Regulatory
ClinicalAnimal Sciences
Biology
Informatics
FinanceOperations
IT
Legal
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• Scientists and their habits• Reconciling business & science• Need someone to:
• Keep everyone focused• Suggest methods• Make workflows easy• Do it fast!
FROM SPREADSHEETS TO SYSTEMS: GETTING USERS ONBOARD
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FOCUS ON THE CUSTOMER: DELIVERING ON THE PROMISE OF PDS
DirectionIdentify direction of the business
ScienceNovel technologies speed up the science
TechnologiesBring novel technologies to the business
BusinessScience drives business forward
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SYSTEM TO ACCELERATE & OPTIMIZE DRUG DESIGN
https://www.youtube.com/watch?v=HjB536Glvpw
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• Covers the process
• Open for integration
• With scientific context
• Allows integrated questions to be posed
A PRODUCT: DRUG DESIGN STUDIO
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SYSTEM TO ACCELERATE & OPTIMIZE DRUG DESIGN
https://www.youtube.com/watch?v=vR3nauEkiuI
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For specific business need
To be used across disciplines
With best scientific practices
AT THE END OF THE DAY: PRODUCT BUILT
1
2
3
We have software that captures & searches data.The Question is “What’s next?”
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ONE STEP BEYOND
http://telemedicina.med.muni.cz/
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SOLUTIONS FOR THE BIOTECH BUSINESS
CLIENTWhat do I do with the petabytes of
chemistry, biology, modeling, in-vivo, clinical data?
Provide system for data tracking & integration
How do I search it?Develop search algorithms that allow
omni-directional information flow across disciplines
What can I do with it? Develop analysis algorithms and visualization tools
EPAM
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EXAMPLE: ELECTRONIC NOTEBOOK
• GOOD:
• Searchable• Achievable
• BAD:
• Organization• Data extraction • Visualization
• Need: Different notebooks for different disciplines (modular) with common back end and visualization layer
Biologists
Chemists
Informaticists
Clinicians
Animal Scientists
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Onsite team must speak client’s language
TO ACHIEVE SUCCESS WITH CUSTOMER, REMEMBER:
Business Technology
Science
EPAM Team
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THANKS TO
Thank You!
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