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![Page 1: 1 Complement Pathways - bio.umass.edu · 1 Complement Pathways Complement Activation Proteins are normally inactive - need to be activated (or transient) ... DAF and CRI displace](https://reader030.vdocuments.us/reader030/viewer/2022021521/5bf1776409d3f2706f8bd4c6/html5/thumbnails/1.jpg)
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Complement Pathways
Complement Activation
Proteins are normally inactive -need to be activated (or transient)
Activation - sequential proteolysis
Covalent Attachment - becomestably active after attaching tomicrobe (ab complexes)
Regulation! - important tominimize complement mediateddamage to host cells
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C1 Inhibitor Regulation
![Page 3: 1 Complement Pathways - bio.umass.edu · 1 Complement Pathways Complement Activation Proteins are normally inactive - need to be activated (or transient) ... DAF and CRI displace](https://reader030.vdocuments.us/reader030/viewer/2022021521/5bf1776409d3f2706f8bd4c6/html5/thumbnails/3.jpg)
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Inhibition of C3 Convertase Formation
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Factor I mediated cleavage of C3b