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9
1 . How many hexokinases are there? What are the distinct characteristics of glucokinasethat distinguish it from other hexokinases? (total 8 points)
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3. Arachidonic acid (arachidonate) is release from membrane phospholipids. Whichenzyme is responsible for the release? From which position of a phospholipid molecule is ,arachidonate released? What are the two stimuli that are responsible for the release?What is the difference between the two stimuli? (total 12 points)
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5. What makes brown fat brown? What is the physiological function of brown fat? Whatis the protein responsible for this function? How does this protein work? You can draw agraph to help your explanation. (total 9 points)
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7. How is pepsin activated? What is the name of the precursor? Why do we call it anendopeptidase? (total 6 points)
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9. What is the physiological significance that peptides can be administrated directly intoblood? What is the mechanism? (total 6 points)
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1 1' Here is a picture of a purine ring. Please identify the sources of each molecule carbonand nitrogen atom. (total 9 ponts)
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12' What is a transamination reaction? What is the enzyme that is responsible forconverting alanine to pyruvate? What about converting of aspartate to oxaloacetate?(total 6 points) -(v{,,.srrvnrrL"t-1664. v-{e..tr:\ cv\ 13 v..tl;gstr,t*,r\l.t e*" +{,i_ dli-ta.t,.t.v.(/t.l
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14. How does alanine, phenylalanine or isoleucine enter TCA cycle? Please point theintermediates and entuy points in TCA cycle. You can draw a graph to help yourexplanation. (total 6 points)
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16. What are the fates of glucose 6-phosphate in liver? You can draw a graph to help yourexplanation. (total 4 points)
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17. How many types of diabetes are there?their occurrence? (total 10 points) Tw"
What are the causes or factors that lead to?,.r;:* q "! dr;,tnlri./rt d:{fe.,*1,.
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