BioE
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Design and Manufacture of Plants for the Production of:
BioE
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Bioreactors and FermentersAirlift FermenterAirlift Visual Safety
Fermenter VSFAnaerobic FermenterAutoclavable Fluidized Bed
Reactor AWSAutoclavable Laboratory
Fermenter ALFCell FermenterEnzyme Membrane Reactor
EMRFermenter with Integrated
DownstreamingFermenter for Plant Cell
Cultivation Fluidized Bed Reactor WSHigh Pressure FermenterHigh-Temperature-High-
Pressure Fermenter HTELaboratory Fermenter L1523Laboratory Fermenter NLF22Laboratory Pilot
Fermenter LP351Loop Safety Fermenter LSFMembrane Reactor MFNMR ReactorPhotoreactorPilot Plant FermenterRotaschon FermenterSmall Laboratory
Fermenter KLFSolid State FermenterSurface Cultivation Reactor Visual Safety Fermenter VSF
Up- and Downstream EquipmentCold SterilizationContinuous Sterilization
SystemDispersing MixerDosage SystemMedium Storage Vessel
50–5000 lPerfusion SystemSpiral FilterFeed Vessel
Probes/Measuring systemsAdmittance ProbeAntifoam ProbeExhaust Gas AnalyzerGas Flow MeterIFM - Intelligent Front
ModuleLevel Indicator «Biowatch»Level Measurement ProbepH/Redox ProbepH Interchangeable ProbepO2 probe pO2 Interchangeable ProbePressure TransmitterPt100 Temperature Probe Software for Media
OptimizationTurbditiy ProbeWeighing ProbeWeight Measurement:
Platform, Cell
Sampling and HarvestingContained Sampling SystemDialysis ProbeHarvesting ValvePervaporation ProbeSampling Valve
Agitation SystemDirect DriveDisk TurbineDraught TubeMagnetic DriveTop DriveImpeller
Aeration and ExhaustAutosterile FilterAir FilterBubble-Free AerationControl Valve Flow MeterGas Mixing StationIncineratorReflux CoolerViewing Glass Bursting
Disk Assembly
Vessel AccessoriesBottle Cap with Sterile Filter Bubble Trap CIP Spray BallCIP ValveDosing Valve Foam BreakerHypodermic Needle with
Sterile Case AssemblyIllumination UnitInjector ValveLamella Clarifier Unit Lid Opening DeviceRotor FilterRupture disk Safety ValveSteam TrapSterile Pressure GaugeSterile TrapThermometer Viewing Port
Pumps for Sterile ApplicationsDomp® Double Diaphragm
PumpDouble Piston PumpKobio-Pump Magnetic Circulation PumpPeristaltic PumpPiston Diaphragm Metering
Pump
Components for Sterile LinesDiaphragm ValveMultiple-Diaphragm ValveMemtile: Stainless-Steel
Valve DrivePneumatic Valve DrivePipe-Pt100Sterile ConnectionTRI-Clamp ConnectionVacuum Valve
Fermenter EnergiesCIP-System: Mobil, KitchenClean Steam GeneratorCompressorCoolerHeating CircuitSteam GeneratorThermostat
Powder Handling/MixingCup Hermann Powder
Transfer SystemInversina Tumbler Mixer,
2–500 LitresManual mini-Inversina
tumbler mixer
Amino AcidsAntibioticsBiomass: Probiotics,
Starter Cultures
Measurement and controlBioLogicsBack up
BiopesticidesBiopolymers and LipidsEnzymesEthanol
Data loggingData processingProcess analysis
Process managementProcess optimization Process supervision
Flavors and FragrancesFruit JuicesMonoclonal AntibodiesOrganic Acids
Peptides/Proteins: BloodFactors, Hormones,Growth Factors
Sugar Derivates
VaccinesVitamins
Bioengineering AG Sagenrainstrasse 7 CH-8636 Wald, Switzerland Telephone ++41 55 256 8 111 Fax ++41 55 256 8 [email protected] www.bioengineering.ch
Bioengineering – Experience onlyspecialists can have
Laboratory Pilot Fermenter LP351The link between laboratory and production
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Standard Optional1 Vessel stainless steel 316 L special alloys
grain 240 mirrorpolished
2 Heating circuit closed circuit, galvanized steel, stainless steel 316 L, electrical heat exchanger for steam heater, heat exchanger for cooling
circuits
3 Agitation bottom drive by belt, top drive, magnetic couplingdouble mechanical seal
4 Mechanical seal silicium carbide, steam condensate lubricatedglycerine lubricated
5 Stirrer blade stirrers, baffles airlift, draught tube
6 Inlet air Autosterile filter, ceramic filter separate filter, double filters, absolute filter, gas mixing station
7 Aeration submerse aeration surface aeration, bubble-free aeration
8 Ports standardized lid and side ports flexible location and number special ports
9 Viewing glasses longitudinal and lid viewing flexible location and numberglass with illumination
10 Exhaust air ceramic filter absolute filter, reflux cooler, foam destruction, incinerator
11 Inoculation inoculation port fixed piping, transfer concepts
12 Sampling manual sampling valve pneumatic valve, contained sampling valve, valve with steel bellow, cell-free sampling system
13 Harvest manual harvest valve with steel pneumatic harvest valve, fixedbellows piping, transfer concept
14 Media addition needle connection through lid dosage valve, coupling, fixed piping, transfer concepts
Sterilization manual sterilization of Autosterile automatic sterilization of Autosterilefilter and exhaust air valve filter and exhaust air valve
Double mechanical seal
Magnetic stirrers
The fermenter unit isinstalled on a platform.Easy maintenance andservice work on thefermenter parts arepossible with the openframe construction.
H2
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Product overviewtotal volume working vol. width x depth DN H1 H2 H342 l 28 l 800 x 800 260 1410 860 80050 l 33 l 800 x 800 295 1410 860 80075 l 50 l 800 x 850 345 1430 870 815
Technical dataoperating temperature max. 150° Cmaterial of parts which are in contact with the product 316 Lmotor power 42 l, 50 l 2,2 kW
75l 3 kWspeed max. 1000 min–1
Scale-up or production processes are the field of application for theLaboratory Pilot Fermenter LP351 with total volume 42, 50 or 75 litres.
The straightforward concept in designand construction results in a user-friendly and sturdy high-tech plant.The central in- and outlets for steam,water, air, and waste water, minimizeinstallation time and work.
The flexible installation of Bioengi-neering probes and accessories formedia addition, aeration, sampling,harvest, perfusion, foam destruction,CIP, etc. is guaranteed with thestandardized ports.
The modular design in combinationwith the variety of proven accessoriesenable the performance of biotech-nological processes with enzymes,microorganisms, fungi, algae, plant or animal cells.
Our equipment fulfils the requirednational guidelines and cGMP/FDA-regulations (including IQ and OQ documentation on request).
The stirrer units is driven by belt, thusreducing the fermenter height, sepa-rating the vessel from the motor, andoptimizing the bearing of the free-swinging shaft. The shaft is removedfrom the top and the bearing with the seals is easily disassembled fromthe bottom.
The fermenter is aerated through the Bioengineering Autosterile filter.Without any complicated peripheralconstructions, this filter is in-situsterilizable together with the fer-menter.
The power supply and the measure-ment and control units in the 19”measurement cabinet are separatedfrom the fermenter. The Bioengi-neering IFM controllers combine stateof the art digital technology with a modular set-up. Each measurementor control loop has its own separatemodule, thus enabling easy mainte-nance of single units or the adaptionof the fermenter measurement andcontrols according to actual require-ments. The BioLogics- or BioVisual-software covers all data logging andvisualization requirements. On requestother software systems are available.
