Donor Report July 1, 2013 — June 30, 2014

Dear AICF Friends:

The Board of Directors of the American-Italian Cancer Foundation (AICF) would like to thank the generous donors who made gifts and grants to AICF in fiscal year 2013-14 in support of cancer research, education and the search for a cure.

Your generosity has supported post-doctoral research fellowships at the finest institutions in the country including Columbia University, Massachusetts General Hospital, Memorial Sloan-Kettering, National Institutes of Health (NIH), University of California Berkeley, Boston Children Hospital, The Rockefeller University, Yale University, New York University and others. The research of AICF Fellows is frequently recognized in award-winning scientific journals and several of our brilliant researchers have received awards and recognition from leading medical organizations around the world.

We are also very proud of our Mobile, No-Cost Breast Cancer Screening Program. Your contributions have enabled AICF to recruit, screen, and educate almost 5,000 underprivileged women in New York City this year. AICF serves neglected neighborhoods with low income, limited health education and high incidences of breast cancer.

We are delighted that the 2013 Prize for Scientific Excellence in Medicine, sponsored by the Alexander Bodini Foundation, was presented to two prominent scientists: Joan Massagué, PhD, Chairman, Cancer Biology & Genetics Program, Memorial Sloan-Kettering Cancer Center, and Charles J. Sherr, MD, PhD, Herrick Foundation Chair of the Department of Tumor Cell Biology, St. Jude Children’s Research Hospital.

All of this has been possible because of your generosity, support, and interest. A special thanks to our Board of Directors, the Scientific Advisory Board members, our volunteers and staff.

Thank you,

Daniele D. BodiniChairman

BOARD OF DIRECTORS

Daniele D. Bodini, Chairman

George M. Pavia, Esq., Secretary

Robert F. Agostinelli

Gian Andrea Botta

Alberto Cribiore

Claudio Del Vecchio

Mario D’Urso

Massimo Ferragamo

Mario J. Gabelli

Philip Olivetti

Joseph R. Perella

Ottavio Serena di Lapigio

Honorary MemberH.E. Ambassador of Italy to the United States,

Claudio Bisogniero

FoundersAlessandro di Montezemolo

Umberto Veronesi, MD

SCIENTIFIC ADVISORY BOARD

Executive CommitteeSilvia C. Formenti, MD, Chairman

Claudio Basilico, MD

Riccardo Dalla-Favera, MD

Titia de Lange, PhD

Fabrizio Michelassi, MD, FACS

Larry Norton, MD

John Petrini, PhD

Virgilio Sacchini, MD

MembersJoseph R. Bertino, MD

Paul A. Bunn, Jr., MD

Franco Cavalli, MD

Alberto Costa, MD

José Costa, MD

Vincent T. DeVita, Jr., MD

Pier Paolo Di Fiore, MD, PhD

Thomas J. Fahey, Jr., MD

Luca Gianni, MD

Aron Goldhirsch, MD

John Mendelsohn, MD

Franco Muggia, MD

Michele Pagano, MD

Pier Giuseppe Pelicci, MD, PhD

Gabriella Sozzi, PhD

Andrea Velardi, MD

Roy S. Wiener, MD

$250,000 and overThe Alexander Bodini FoundationThe Council of the City of New York

$100,000- $249,999National Breast Cancer Foundation, Inc.

$50,000- $99,999Acquavella GalleriesThe Del Vecchio Family FoundationGabelli FundsThe Lauder FoundationAmy & Joseph Perella Charitable FundValerie & Michael PuglisiSalvatore Ferragamo USA

$20,000-$49,999Veronica M. Bulgari & Stephen HaimoCastagna Realty Co., Inc.The Dino Olivetti Foundation, Inc.Alexander & Patricia Farman-FarmaianEdward I. HerbstWinston & Strawn LLP

$10,000- $19,999Robert F. AgostinelliAvon Foundation Breast Health Outreach Program E.L. Wiegand FoundationEtro MilanoGeneral Growth Properties Greatergood.orgAlan MnuchinNew York State Department of Health Mr. & Mrs. Lucio A. Noto

Up to $9,999Alley, Maas, Rogers, & Lindsay, PA Vincent J. AmabileAnonymousAon FoundationMr. & Mrs. Dan Arbess

Joanne Derosa ArnoldJoseph F. AzrackBaker & Hostetler, LLP Joseph S. BaldygaBanfi Vintners Foundation Dr. & Mrs. Charles Barbiere, MD, FACCBelkin Burden Wenig & Goldman, LLP Heywood “Woody” BlaufeuxGiancarlo BoccatoFrancesca Bodini & Zack ShermanBollinger InsuranceGian Andrea BottaCouncil Member Gayle Brewer Bronx Community Health Network, Inc.Brunello Cucinelli USA, Inc.Bryan Cave, LLPBulgari Group Thomas & Cynthia BurkeWilliam BurnsBryna ButlerRobert M. Buxton, CFACA Mechanical Mario Calvo-PlateroWilliam CampioneCapital One Bank The Caravetta Heaven’s Helpers FoundationMarco CarboneH.E. Ambassador Sebastiano CardiVivian CardiaMariafrancesca CarliColleen CashmanJohn K. CastleChampions for CharityChandler Construction CompanyJames Bass ChankoAdele Chatfield-TaylorColumbia Bank Columbia University Center for Infection and Immunity Eugenia Comini & Edward BaylissConsulting Engineer Services Alberto Cribiore

3DONORS/ july 1, 2013 — june 30, 2014

2013 Gala Chair Chiara Ferragamo

“Maria, a 62-year-old woman, called AICF to schedule an appointment for her mammogram. She had not had a mammogram or seen a doctor since she moved to the United States three years earlier as an undocumented immigrant. She was nervous because she was feeling pain in her breast, but did not know where to get medical care. One of her friends told her about AICF’s No-Cost Breast Cancer Screening Program and she called to set up an appointment. She was screened just a few days after her call and unfortunately was found to have ACR M (highly suggestive of malignancy, and requiring immediate medical intervention). Maria was recommended for a biopsy, which she did shortly after receiving her screening results. She was diagnosed with Stage-2 breast cancer and is now planning her treatment options. Our Patient Navigator continues to follow up with Maria to ensure the prompt start of her treatment.”

We would like to extend a special thank-you to all of our volunteers and interns:

Chiara Bianchini, Elsa DiRuggiero, Betty Fong, Constance Fontanet, Elizabeth Hilario, Dana Huber, Kiera Laing, Laura Marengo, Ryan Meyer, Orin Neritani, Ann Nguyen, New York Junior League of City of New York (NYJL), Logan Primeau, Nicole Pugliese, Jessica Quinn, Adrianne Ruffler, Nadia White

aicf helps woman detect early breast cancer A Special Note From A Patient: One Of The Many Thank-You Letters AICF Receives

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In Fiscal Year 2013-2014,

we screened 4,324 women

75% had a household income at or below $25,000

74% identify as women of color

47% were uninsured

20% were underinsured

“Lucy, a 48-year-old woman, was screened on our Mobile Care Clinic in partnership with our hub site, The Joseph P Addabbo Family Heath Center. We called Lucy numerous times after her screening to explain her mammogram results and advise her to get additional testing, but we were only able to leave voicemail messages. After twenty days of trying to contact Lucy, she finally answered the phone and informed us that she was aware of her results and need for additional testing; however, she was frustrated because her local clinic had closed after Hurricane Sandy and there were no other nearby testing locations. She was contemplating going to a local hospital, but the wait time for an appointment was two months out. Our Patient Navigator helped her locate alternate locations in Queens and she was able to schedule her diagnostic testing that same weekend. Lucy completed her diagnostic testing and is currently awaiting a surgical consult. During our most recent call with Lucy she shared that if it hadn’t been for AICF urging her to get her additional testing and helping her find a location, she would still be waiting for an appointment and would be unaware of the need for her biopsy. Our Patient Navigator continues to follow up with Lucy and will help her through the health care system if treatment is needed.”

The Critical Importance of Follow-Up

AICF Makes Annual Mammograms Easy to Remember“Mobile Care Clinic patients receive annual breast cancer screening reminders via mail and phone. Recently, our Screening Administrator called Karen to remind her that she was due for her annual mammogram and to schedule an appointment on our Mobile Care Clinic. Karen was excited to receive our reminder call because she had recently moved and misplaced our contact information. Karen informed us that since she relocated, she did not know where to find screening services in her new neighborhood. Karen is uninsured and was in the process of signing up for insurance, but was worried that she would miss her yearly mammogram. Karen shared with us that she had a family history of breast cancer, so annual screenings were very important to her. She thanked us for calling her and is looking forward to participating in our program again.”

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INTERNATIONAL, POST-DOCTORAL RESEARCH FELLOWSHIP PROGRAM 2013-14

Gabelli Funds FellowMemorial Sloan Kettering Cancer CenterMentor: Scott Armstrong, MD, PhD

“One of my projects is aimed at identifying novel therapeutic targets in a specific subgroup of childhood leukemias characterized by some common genomic alterations and a very dismal prognosis. Through the development of two new disease models, I am now testing a new compound in a Phase I clinical experimentation at our institution for other leukemia patients. The project has proceeded very quickly and I am building evidence that a broader range of patients could benefit from this therapeutic approach.”

MAURIZIO FAZIO, MD

LUCA LIGNITTO, PHDDebra & Claudio Del Vecchio FellowNew York University School of MedicineMentor: Michele Pagano, MD

“My experiments are currently focusing on a ubiquitin-ligase named FBXL7. My preliminary data shows that this enzyme is down-regulated in bladder cancer cells. Moreover, I have found that PTPD1, whose levels are markedly increased in human bladder cancer tissues, interacts with and is targeted for degradation by this ligase. My working hypothesis is that FBXL7 supports the expansion of bladder cancer cells through the degradation of PTPD1. I speculate that a drug capable of selectively regulating FBXL7 could be fruitfully employed for the treatment of bladder cancer and also in the other cancers in which FBXL7 expression is affected.”

The Alexander Bodini Foundation FellowYale University School of MedicineMentor: Carla Rothlin

“My experiences as master and PhD student have provided me with a solid background on the mechanisms by which macrophages control inflammation and prevent collateral damage. Inflammation has been described as an enabling characteristic that promotes the acquisition of cancer hallmarks in a wide range of tumors. In this context, macrophage plasticity is a key component not only of inflammation but also of tumor development. As AICF’s fellow, I will focus on the mechanism by which macrophages regulate the inflammatory response: the TAM pathway. My goal is to re-programme macrophages polarization through TAM signalling in order to prevent inflammation-driven cancer.”

LIDIA BOSURGI, PHD

MARCO DEMARIA, PHD

Research for Life ® FellowBuck Institute for Research on AgingMentor: Judith Campisi, PhD

“I’m discovering that the cellular state of senescence is induced upon standard anti-cancer treatment, such as chemotherapy and irradiation, and may be at the root of the deleterious side effects of these therapies. This discovery could be of incredible relevance in designing more efficient and less toxic combinatorial therapies in the future. Very interestingly, I have found that the removal of irradiated or chemotherapy-induced senescent cells in mice is not only delaying cancer progression, but is also rescuing the down-regulated activity of mice with senescence.”

ANNAMARIA MOCCIARO, PHD

Research for Life ® FellowUniversity of California, BerkeleyMentor: Michael Rape, PhD

“Since I joined the lab, I have been involved in a project aimed at the identification of ubiquitination enzymes required for aneuploidy tolerance in human cancer cells, and the characterization of the molecular mechanisms underlying the cellular response to aneuploidy. Recently, I expanded my research and focused on investigating ubiquitination enzymes involved in the differentiation of human embryonic stem cells and in the development of cancer stem cells. Receiving the AICF fellowship allowed me to work on a project that may lead to the discovery of new targets for more selective chemotherapeutics and therefore have a signficant impact in the cancer research field.”

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DONORS/continued

Celina CrosaCutler Minikes & Adelman LLP Meredith DarrowRuth DayAnita T. DazzoPierfederica De IacoBernard De La TourDeRenzo FamilyJoseph DiBenedettoCouncil Member Inez Dickens Damien DimaggioKristin DockeryDolce & Gabbana USAEuropean School of Oncology R. Bradford EvansExperion Design Group Fairman & Associates, Inc. Fameco Real EstateFerrari North America, Inc.Financo, Inc. The First Sharon Baptist ChurchFoa & Son Corporation The Forbes Company, LLCNicolo FoscariLinda Strong FriedmanGianluigi GabettiCouncil Member Daniel Garodnick Genentech Gerald Bland, Inc.Joy A. GermontGIV FoundationGlidden Spina & Partners Goulston & StorrsAnastasia GrazioliJohn & Sheridan GreeniausGuardian Angels Cancer CouncilMr. & Mrs. Joseph GuarigliaCouncil Member Dan HalloranFern HammondAnnafiora Helfrick

The Herbert Irving Comprehensive Cancer CenterHyland Levin LLPIgnarri-Lumis Architects LLP Loretta M. Itri, MD & Raymond P. Warrell, MDCouncil Member Robert Jackson Council Member Letitia James Jeanne S. & Herbert J. Siegel Philanthropic FundG. Randolph JonesKaren KloppLake Contracting LLC Mac LevineVincenzo LordiLouis P. Singer Fund, Inc.Alessandro LuongoCarly LynchMacy’s & Bloomingdale’sStephen S. Madsen, Esq.Dierdre Costa MajorMallah Management LLCLivia Manca di Villahermosa Marcum LLPManuela & Stefano MaroniLavinia MarzottoMichael Matcovich, Jr.Kevin H. & Amanda M. McCarthyRaymond Mikulich & Karen KarlsrudMiller Savarese Associates, Architects Carlo Filippo Mirisola di TorresantoMr. & Mrs. Richard MoranChristian MorettiJennifer MunozThe Noto Family FoundationCouncil Member James Oddo Philip & Bernice OlivettiVincent Pagano, Jr.Council Member Annabel Palma Stephen PalmieriClaudia ParatiPaul Bitts Co. Inc.Pavia & Harcourt LLP

Carlo Perrone Perspecta TrustAndrea PiedimonteGiampaolo Pioli & Claudia VitelliPoten & Partners, Inc Preston High SchoolKevin S. Probel & Melanie SmithCarmela RafaelRemarkable PartnersResidence Resource LTD Elizabeth Right & Michael ReissJuergen RiehmRMD Services, Inc.Sandra RothRoyal Properties, Inc. Maria Pia RuffilliChristina SachsThe Sandra Atlas Bass and Edythe & Sol G. Atlas FoundationMr. & Mrs. Alessandro Saracino Fendi Mr. & Mrs. Ottavio Serena di LapigioValentina ShahPhilip SieversSkadden, Arps, Slate, Meagher & Flom Soluna Holistic Spa Inc.Sons of Italy FoundationSource of Hope FoundationSPC InteriorsSullivan & Cromwell LLPKatrin TheodoliShawn Thomas, CPAThomas Jefferson University - Kimmel Cancer CenterDean VanechAndrea Ventura, MD, PhDJan T. Vilcek, MDAnna VolkPeter WebsterRoy S. Weiner, MDDavid E. WilliamsWPW Family FoundationYum! Brands Foundation, Inc.

in memory ofJoseph S. Baldyga .................................Edith V. Baldyga

The Alexander Bodini Foundation ......Alexander Bodini

William Campione ...............................Ginny Campione

Marco Carbone ................................. Leandro Carbone

Damien Dimaggio ........................... Argentino DeChellis

Annafiora Helfrick ................................... Ennio Grassellini

Heywood “Woody” Blaufeux .................Diego Sferrazza

Carmela Rafael .........................................Yolanda Simio

Gift From:

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screening day sponsors Mr. and Mrs. William Acquavella

Alexander Bodini Foundation

William Campione

Danielle & Anthony Caravetta

Debra & Claudio Del Vecchio

Chiara & Massimo Ferragamo

Gabelli Funds

Joy Germont

Jonathan Goldstein

Mr. and Mrs. Philip Olivetti

Claudia Vitelli & Giampaolo Pioli

Valerie & Michael Puglisi

in honor ofCutler Minikes & Adelman LLP (Richard Adelman) ...............................Daniele D. Bodini

Anna Volk ..............................................Francesca Bodini

WPW Family Foundation ........................Alberto Cribiore

The Lauder Foundation ................ Claudio Del Vecchio

Source of Hope Foundation ............ Chiara Ferragamo

News Anchorwoman First Sharon Baptist Church ........................Robin Roberts

Christina Sachs ................................................. Lisa Rowe

Joy A. Germont ...............................Virgilio Sacchini, MD

Kristin Dockery ...............................The Smaniotto Family

Gift From:

AgripunicaAmericana ManhassetArgiano S.p.A. Società AgricolaMarco BacciBacci Wines Barbetta RestaurantBarboursville Vineyards Barone Ricasoli courtesy of Dreyfus AshbyVincenzo BertucciGuido & Martina BevilacquaVioletta BiticiBorghese, Inc.Paolo, Liana & Alessandro BoselliBradford Renaissance Portraits Corp.Brooks Brothers, Inc.Bruno CerettoBulgari Hotels & Resorts MilanoCa’ del BoscoCaiarossa Srl CanaliCapri Palace Hotel & SpaCarlo Hauner Casa Larga VineyardsCastello di CacchianoCastello Monaci Castelvecchio WineryCastiglion del Bosco CharitybuzzCinzia RoccaCity WineryColavita USAConair Corporation Damilano Barolo

in kind *Daniela VillegasD’Aquino Italian Importing Co., Inc.Dolce & Gabbana Domenico VaccaDonna Distefano Ltd.DonnaChiara Concept WineryEataly & La ScuolaEdible Arrangements of Howard Beach Emilio PucciNeil EmpsonEmpson USA Inc. EtroFattoria Carpineta FontalpinoFelsinaMr. & Mrs. Massimo FerragamoFerrero USAFeudi di San GregorioFuligniFurlaGiuseppe MascarelloLorraine Alexander & Giancarlo GrisiLuigi Seracca GuerrieriHarrys of LondonHenriot, Inc.Hotel Hassler Roma Hub PorteñoIl Borro - Salvatore FerragamoIl Salviatino - Firenzeilly caffé, North AmericaIndagare Travel Investindustrial Inc. & Invest for ChildrenGaetana JaconoEric Albada Jelgersma

Joan KaufmanKramer PortraitsLa Cucina Italiana MagazineLa Locanda Country Hotel La PerlaLavazza Premium Coffees Corp.Lungarno Collection - Hotels, Retreats, VillasLuxury Italian ToursMacelleria Marchesi Antinori SrlMarchesi Mazzei Mario J. GabelliMark Russell Francesco MartinelliMassimo BizzocchiFrancesco MazzeiMelia Villa CapriMillbrook Country House Mionetto USAAlberto MoncadaMonsieur Touton Selection, Ltd.MonteverroFrancesca MorettiPalazzo Manfredi - Relais & ChateauxLivio PanebiancoPanebianco LLCPaola QuadrettiMarcello Malik PigozzoPirelli Tire PomellatoPortolano Products, Inc.Premium Brands, Inc. Principe Corsini

Laudomia PucciPure YogaRelais Santa Croce by Baglioni HotelsRevello FratelliBabe RizzutoGonzalo RobredoRocca delle MacieStefania RocchiRome Luxury SuitesSafilo USA, Inc.Saks Fifth AvenueSalvatore FerragamoSan FeliceSecco Italian BubblesSella & MoscaSINA Fine Italian HotelsSong Saa Private Island, CambodiaSwarovskiTenuta Alfredosa di Raffaella AlbaneseTenuta di BisernoTenuta San GuidoTenuta Sette PontiTerra Moretti Jason TesauroThe Estee Lauder Companies Inc.Olga UrbaniUrbani Tartufi S.r.l. Valle dell’Acate VhernierVie di RomansVilleroy & Boch USARoberto E. WirthYacht Club Costa SmeraldaMaria Cristina Zenobi

AICF’s 2013-14 FellowsPrize winners Charles J. Sherr, MD, PhD and Joan Massagué, PhD with Scientific Advisory Board Vice Chairman Riccardo Dalla-Favera, MD (center)

Laudomia PucciPure YogaRelais Santa Croce by Baglioni HotelsRevello FratelliBabe RizzutoGonzalo RobredoRocca delle MacieStefania RocchiRome Luxury SuitesSafilo USA, Inc.Saks Fifth AvenueSalvatore FerragamoSan FeliceSecco Italian BubblesSella & MoscaSINA Fine Italian HotelsSong Saa Private Island, CambodiaSwarovskiTenuta Alfredosa di Raffaella AlbaneseTenuta di BisernoTenuta San GuidoTenuta Sette PontiTerra Moretti Jason TesauroThe Estee Lauder Companies Inc.Olga UrbaniUrbani Tartufi S.r.l. Valle dell’Acate VhernierVie di RomansVilleroy & Boch USARoberto E. WirthYacht Club Costa SmeraldaMaria Cristina Zenobi

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2013 Benefit Dinner & AuctionsOn Monday, November 11, 2013, the American Italian Cancer Foundation (AICF) held its 33rd Annual Benefit Dinner & Auctions at the Racquet and Tennis Club in New York City.

AICF’s Prize for Scientific Excellence in Medicine was presented to Joan Massagué, PhD and Charles J. Sherr, MD, PhD. The Prize has been established to recognize important discoveries in cancer biology, prevention, diagnosis and/or treatment.

The Alessandro Di Montezemolo Lifetime Achievement Award was received by James G. Niven. This award recognizes outstanding individuals who exemplify the highest standards of commitment to advancing the war against cancer through volunteerism and philanthropy.

Thank you to all of our generous donors and sponsors for making the event a tremendous success!

Executive Director Alessandra Rampogna, AICF Board Chairman Daniele D. Bodini, Regina Pitaro, and AICF Board member Mario J. Gabelli Photo Credit: Photos by: www.studio7nyc.com

Gala Chair Chiara Ferragamo presents Lifetime Achievement Award to James G. Niven

AICF Board member Joseph R. Perella, Lucio Caputo, Alexander Acquavella, Beatrice Stern, James G. Niven, and Fern Hammond

Lucio Caputo, Consul General of Italy in New York Natalia Quintavalle, and AICF Board Member George M. Pavia, Esq

*save the date

Benefit Dinner & Auctions Tuesday, November 11, 2014

The Plaza Hotel, New York City

2014 Gala ChairAlessia Antinori

Marchesi Antinori

Alessandro di Montezemolo Lifetime Achievement AwardJoseph R. Perella

Chairman & Founding PartnerPerella Weinberg Partners

2014 Prize for Scientific Excellence in Medicine James P. Allison, PhD

Professor and Chair, Department of Immunology, The University of Texas MD Anderson Cancer Center

Jedd D. Wolchok, MD, PhD Lloyd J. Old/Virginia & Daniel K. Ludwig Chair in Clinical Investigation,

Chief, Melanoma and Immunotherapeutics Service,Memorial Sloan Kettering Cancer Center

Please call 212.628.9090 or visit www.americanitaliancancer.org to purchase tickets