DNA REPAIR MECHANISMS

Luisa María MesaMedicine Student

III semester

INTRODUCTION

As the cell develops lots of mutations:

Induced by:

ChemicalsRadiation

It also develops DNA repair mechanisms:

Substitution, insertion or deletion of bases or

nucleotides, mismatches, strand’s breaks, and

crosslinks.

Base excision repair, nucleotides excision repair, strand breaks repair and mismatch repair.

GENE SWITCH MAY REPAIR DNA, PREVENT

CANCER(2016, FEBRUARY 13TH)

JOURNAL CELL REPORTS

GENE SWITCH MAY REPAIR DNA, PREVENT CANCER

GENE SWITCH MAY REPAIR DNA, PREVENT CANCER

BOTH MOLECULES PLAY AN IMPORTANT ROLE IN DNA

REPAIR

GENE SWITCH MAY REPAIR DNA, PREVENT CANCER

"Our results imply that loss of TET enzymes and 5hmC depletion could contribute significantly to genome instability and inaccurate chromosome segregation,

perhaps explaining the correlation of low 5hmC levels with cancer.”

GENE SWITCH MAY REPAIR DNA, PREVENT CANCER

I think this new finding is important because everyday we discover new

paths that cells take to protect themselves, that give us new ways of treatment specially in cancer. Now as

we know, scientists and doctors have a new enzyme that could help to cure a

defeating illness as cancer. 

STUDY PROVIDES VITAL INFORMATION ABOUT

MECHANISM GOVERNING DNA REPAIR.

(2016, JANUARY 31)

NUCLEIC ACIDS RESEARCH JOURNAL 

STUDY PROVIDES VITAL INFORMATION ABOUT MECHANISM GOVERNING DNA REPAIR

DNA wraps around proteins called histones to form chromatin. Cells can chemically modify histones so they can control the various functions of DNA.

STUDY PROVIDES VITAL INFORMATION ABOUT MECHANISM GOVERNING DNA

REPAIR

STUDY PROVIDES VITAL INFORMATION ABOUT

MECHANISM GOVERNING DNA REPAIR

THE FDA APPROVE A HDAC INHIBITOR IN 2006:  VORINOSTAT (ZOLINZA®)

STUDY PROVIDES VITAL INFORMATION ABOUT MECHANISM GOVERNING DNA REPAIR

This similar study is also important, because it let us understand another way to develop cancer, and could guide future researchers to find new targeted antidotes. This demonstrate how cancer “develops”

new mechanism, and so are we, developing new ways to beat it.

  

MEDICAL UTILITY

MEDICAL UTILITY

It’s important to identify the mechanisms that can cause damages to the DNA, such as

exogenous factors as chemotherapy, UV light, radiation; and endogenous factors as free

radicals; so we can act first, by preventing or modifying the exposure to these damaging

factors.

MEDICAL UTILITY

DNA repair is the first pathway we can use to develop cancer therapies;

because DNA damage is a fundamental problem in life and it’s the main cause of

this illness. When we achieve to fully understand the DNA repair mechanisms,

we would be one step ahead of this disease and it would give multiple

opportunities to people with cancer or another diseases tan involve DNA

damage or damage in the DNA repair mechanism.

Fortunately now, we are improving, and this is

seen at the HDAC inhibitor.

It is also important because it does not

only help with cancer itself, but it helps to

repair the cell after the exposure to the

chemotherapy that the cancer’s patients

experiment.

BIBLIOGRAPHY

• · Study provides vital information about mechanisms governing DNA repair. (2016, January 31). Retrieved February 14, 2016, from http://www.news-medical.net/news/20160131/Study-provides-vital-information-about-mechanisms-governing-DNA-repair.aspx

• · Gene Switch May Repair DNA, Prevent Cancer. (2016, February 13). Retrieved February 14, 2016, from http://www.tasnimnews.com/en/news/2016/02/13/999294/gene-switch-may-repair-dna-prevent-cancer