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  • 8/15/2019 Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4- Phenyl-1,2,3,6-Tetrahydropyridine-Induced E…

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    http://www.ncbi.nlm.nih.gov/pubmed/25967672http://dx.doi.org/10.1016/j.redox.2015.04.011http://www.ncbi.nlm.nih.gov/pubmed/23951401http://dx.doi.org/10.1242/bio.20134853http://www.ncbi.nlm.nih.gov/pubmed/21533133http://dx.doi.org/10.1371/journal.pone.0018506http://www.ncbi.nlm.nih.gov/pubmed/22992073http://dx.doi.org/10.1056/NEJMoa1114287http://www.ncbi.nlm.nih.gov/pubmed/26004161http://dx.doi.org/10.1016/j.jneuroim.2015.04.006http://www.ncbi.nlm.nih.gov/pubmed/20631250http://dx.doi.org/10.1152/ajpcell.00014.2010http://www.ncbi.nlm.nih.gov/pubmed/21308706http://dx.doi.org/10.1002/bmc.1602http://www.ncbi.nlm.nih.gov/pubmed/22992072http://dx.doi.org/10.1056/NEJMoa1206328http://www.ncbi.nlm.nih.gov/pubmed/26188148http://dx.doi.org/10.1016/j.phrs.2015.07.006http://www.ncbi.nlm.nih.gov/pubmed/18342804http://dx.doi.org/10.1016/j.drudis.2007.12.008http://www.ncbi.nlm.nih.gov/pubmed/21297955http://dx.doi.org/10.1371/journal.pone.0016172http://www.ncbi.nlm.nih.gov/pubmed/1837218http://dx.doi.org/10.1016/0006-2952(91)90230-3http://www.ncbi.nlm.nih.gov/pubmed/22922230http://dx.doi.org/10.1093/hmg/dds355http://www.ncbi.nlm.nih.gov/pubmed/25800129http://dx.doi.org/10.1586/14737175.2015.1025755http://www.ncbi.nlm.nih.gov/pubmed/26551700http://dx.doi.org/10.1042/BST20150003http://www.ncbi.nlm.nih.gov/pubmed/23525570http://dx.doi.org/10.1007/s00403-013-1332-yhttp://www.ncbi.nlm.nih.gov/pubmed/26689280http://dx.doi.org/10.1186/s12974-015-0452-zhttp://www.ncbi.nlm.nih.gov/pubmed/18094238http://dx.doi.org/10.1523/JNEUROSCI.3885-07.2007http://www.ncbi.nlm.nih.gov/pubmed/18717629http://dx.doi.org/10.1089/ars.2008.2242http://www.ncbi.nlm.nih.gov/pubmed/20446769http://dx.doi.org/10.1089/ars.2009.3074http://www.ncbi.nlm.nih.gov/pubmed/25793262http://dx.doi.org/10.1371/journal.pone.0120254http://www.ncbi.nlm.nih.gov/pubmed/25565980http://dx.doi.org/10.3389/fnana.2014.00155http://dx.doi.org/10.1021/bk-2015-1200.ch005http://www.ncbi.nlm.nih.gov/pubmed/19059336http://dx.doi.org/10.1016/j.bbadis.2008.11.007http://www.ncbi.nlm.nih.gov/pubmed/22769044http://dx.doi.org/10.1186/1742-2094-9-163

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    http://www.ncbi.nlm.nih.gov/pubmed/23025925http://dx.doi.org/10.1016/j.pneurobio.2012.09.003http://www.ncbi.nlm.nih.gov/pubmed/20667979http://dx.doi.org/10.1096/fj.10-161471http://www.ncbi.nlm.nih.gov/pubmed/19484125http://dx.doi.org/10.1371/journal.pone.0005757http://www.ncbi.nlm.nih.gov/pubmed/2883930http://dx.doi.org/10.1016/0003-9861(87)90085-3http://www.ncbi.nlm.nih.gov/pubmed/25953698http://dx.doi.org/10.1111/bph.13184http://www.ncbi.nlm.nih.gov/pubmed/9426601http://dx.doi.org/10.1023/A:1005838028160http://www.ncbi.nlm.nih.gov/pubmed/26244326http://dx.doi.org/10.1056/NEJMc1506151%23SA2http://www.ncbi.nlm.nih.gov/pubmed/25484350http://dx.doi.org/10.1016/j.cyto.2014.11.006http://www.ncbi.nlm.nih.gov/pubmed/21529244http://dx.doi.org/10.1089/ars.2010.3849http://www.ncbi.nlm.nih.gov/pubmed/17336077http://dx.doi.org/10.1016/j.nbd.2006.12.021http://www.ncbi.nlm.nih.gov/pubmed/23291248http://dx.doi.org/10.1016/j.neuint.2012.12.016http://www.ncbi.nlm.nih.gov/pubmed/25738172http://dx.doi.org/10.1212/NXI.0000000000000076http://www.ncbi.nlm.nih.gov/pubmed/21700211http://dx.doi.org/10.1016/j.chembiol.2011.03.013http://www.ncbi.nlm.nih.gov/pubmed/24139424http://dx.doi.org/10.1016/j.clinthera.2013.08.009http://www.ncbi.nlm.nih.gov/pubmed/17049250http://dx.doi.org/10.1016/j.bmc.2006.09.053http://www.ncbi.nlm.nih.gov/pubmed/22267202http://dx.doi.org/10.1124/jpet.111.190132http://www.ncbi.nlm.nih.gov/pubmed/16823471http://dx.doi.org/10.1172/JCI29178http://www.ncbi.nlm.nih.gov/pubmed/24707183http://dx.doi.org/10.2147/TCRM.S53285http://www.ncbi.nlm.nih.gov/pubmed/18704112http://dx.doi.org/10.1038/jid.2008.197http://www.ncbi.nlm.nih.gov/pubmed/12909459http://dx.doi.org/10.1016/S1471-4906(03)00181-9http://www.ncbi.nlm.nih.gov/pubmed/19127580http://dx.doi.org/10.1002/ana.21461http://www.ncbi.nlm.nih.gov/pubmed/11846609http://dx.doi.org/10.1006/meth.2001.1262http://www.ncbi.nlm.nih.gov/pubmed/25614941http://dx.doi.org/10.3171/2014.11.JNS132348http://www.ncbi.nlm.nih.gov/pubmed/25024611http://dx.doi.org/10.3748/wjg.v20.i26.8572http://www.ncbi.nlm.nih.gov/pubmed/15373936http://dx.doi.org/10.1111/j.1365-2125.2004.02145.xhttp://www.ncbi.nlm.nih.gov/pubmed/21354971http://dx.doi.org/10.1093/brain/awq386http://www.ncbi.nlm.nih.gov/pubmed/21382015http://dx.doi.org/10.1042/AN20100033http://www.ncbi.nlm.nih.gov/pubmed/3997877http://www.ncbi.nlm.nih.gov/pubmed/16968214http://dx.doi.org/10.1146/annurev.pharmtox.46.120604.141046http://www.ncbi.nlm.nih.gov/pubmed/22746536http://dx.doi.org/10.1089/ars.2011.4491http://www.ncbi.nlm.nih.gov/pubmed/25449120http://dx.doi.org/10.1016/j.neuroscience.2014.11.047http://www.ncbi.nlm.nih.gov/pubmed/9240432http://dx.doi.org/10.1006/bbrc.1997.6943http://www.ncbi.nlm.nih.gov/pubmed/26176793http://dx.doi.org/10.1016/j.nbd.2015.07.001http://www.ncbi.nlm.nih.gov/pubmed/16487043http://dx.doi.org/10.1089/ars.2006.8.107