DISEASES OF DIFFERENT SYSTEMSPREPARED BY : MUHAMMAD ANAS (2013-AG-2625)

DIGESTIVE SYSTEM

FMD Rinderpest/PPR

BlueTongue

BVD MCF

HostRuminants,Swines

Rinderpesteffect Largeruminants butPPR effectSmallruminants.

Sheep of allages effected.Cattle, goatand dear alsosusceptible.

Cattle, Buffalo,Wild Ruminants,Sheep

Cattle andsusceptible wildruminants

Causative Agent Aphthovirus orRhinovirus

Morbillivirus - Orbivirus BVD Virus Gammaherpesvirus

ClinicalSigns

Pyrexia, Anorexia,Excessive Salivationin Acute phase

(drooling ofsaliva)

*High fever(104-107 °F)Red patchesaround theeyes, mouthand nose andwith dischargeand Frothysaliva .*Four D’s:

DepressionDiarrheaDehydrationDeath

*Dryness ofthe muzzle

*High fever(105° F) andReddening ofnasal and oralmucosaExcessivesalivation

*Watery andmucoiddischarge fromnostrils.

*A “streakyzone” at thejunction ofskin and hoof.

*Abortion,Premature births

*BVD can alsocause respiratorydisease,calledmucosaldisease(MD).

*IntermittentdiarrheaChronic bloat,Loss of bodyweight (WeakCalf Syndrome)Rough skin coat.

Initial clinicalsigns Depression Diarrhea Dyspnea High fever

*Catarrhalconjunctivitis &Rhinitis withmuco-purulentdischarge fromeyes andnose,Cornealopacity

GrossExamination

*Vesicles or blisterson Tongue (anterior2/3 dorsum of thetongue),Dentalpad,Gums,Cheek,Hard and softpalate,Lips,Muzzle,Coronarybands ,Teats, Udder,cornium of dewclawsand interdigitalspaces.

*TIGER HEART(grayish or yellowishstreaking in themyocardium -degeneration andnecrosis)

*Prominentlesions: aroundthe ileo-cecalvalve at thececo-colicjunction and inthe rectum.

*Zebrastriping-Streaks ofcongestionalong the foldsof mucosa

*Edema andcyanosis oflateral andventralsurfaces oftongue

*Tongue,cheeks, lips,dental pad Hypremi

a Edema Cyanosis Multiplehemorrhages*Erosions andulceration ofepithelium

*Erosive lesionsaround thenose,ulcerativestomatitis.

*ThymusregressionGastroenteritis

*Congestion oflarge intestinalmucosa (tigerstrips)

*Cooked brainappearanceOdorresembling thenutrient broth

*White raisedfoci cortex ofkidneys

*Enlargedprescapularlymph node

*Necrotic areasin the omasalepithelium

NERVOUS SYSTEM

Rabies Pseudo-rabies

BSE Scrapie Listeriosis GID

Host MostlyCanines

Cattle,swines

Cattle Sheep andGoat

Ruminants Sheep andrarely incattle

CausativeAgent

Lyssa viruses DNAherpesvirus

Prions Prions Listeriamonocytogenes

Taeniamulticeps(tape worm)

ClinicalSigns

The clinicalsymptomsusuallyappear in oneof two forms:the"DUMB"andthe"FURIOUS"

*"FURIOUS"form(mad-dogsyndrome)Biting andslashing atany movingobject.

*In theDUMB formprofusesalivationand inabilityto swallow.

*Paralysismay followeither the"furious" or"dumb" stageof the disease

In general,signs of CNSdiseaseFever(41-42°C),anorexia, andweight loss.Sneezing anddysponea arefrequentlyseen.

*Mostcommon —apprehensionpelvic limbataxia, andhyperesthesiato touch andsound.

*Generalizedweakness—falling and

recumbencyPruritis, seenin scrapie,but not veryprominentsign.

*Sheep maylead or trailthe rest of theflock

*Sheep mayhave a stargazingappearance.

*Rubbing orscrapingagainst fixedobjects,

*Nibbling,can often beelicited bypalpation ofthe lumbarregion

*Loss ofwool,particularlyover thelateralthorax, flanksandhindquarters.Hyperesthesia.

*Polydipsiaand polyuria

*Encephalitisormeningoencephalitis,Septicemiawith focalhepaticnecrosis,Abortion.

*Headpressing,Facialparalysis,Profusesalivation,animalcircles in onedirectiononly.

*BlindnessMusculartremor andin-coordination

*Excitabilityand collapse,Headpressing,Incompleteparalysis

GrossExamination

Sphericalcytoplasmicinclusionbodies calledNegribodies,present inHippocampus region.

Serousrhinitis,Pulmonaryedema,Necrotic focion liver.Non-suppurativemeningoencephalitis nadNecrotictonsillitis.

Spongiformencephalopathy.vacuolationof graymatterneuropil(spongiosis)and neurons,similar to thelesions seenin scrapie.

Similar toBSE.

Malacia ofmedulla andpons,cloudiness of CSF,Necrosis inthe liver,spleen,endocardium,myocardium.

*Thin walledcyst in thebrain

*Lesion inthe lumbarregion andrarely, in thecervical areaof the spine

RESPIRATORY SYSTEM

T.B HS CBPP CCPP Strangle Glander IBRHost Bovines,Birds Cattle,buffaloe Bovines CAPRINE Equines Equines Bovines

CausativeAgent

Mycobacteriumbovis(M.bovis)M.avium

Pasteurellamultocidamultocida

Mycoplasmamycoidesmycoides

MycoplasmaF38 biotype,M. mycoidescapri

Streptococcusequi

Burkholderiamallei

Bovine herpesvirus-1 (BHV1)

ClinicalSigns

*Fluctuatingfever,moistcough,mayhave dyspnea ortachypnea.Retropharyngeal or other lymphnodes enlarge.

*Abdominalpain, chronicbloat,fecescoated withmucus, puscells, dysphagia(difficulty inswallowing).

*Hypertrophyof upperudder,greenishyellowish colormilk (publichealthimportance)

*Oedema inthe brisketregion*The initialphase istemperatureelevation*Secondphase isrespiratorydistress withprofusesalivation.*In the thirdphase terminalsepticemia.

*Depressio,in-appetenceand feverCoughing

*Animals maybe veryreluctant tomove andstand stifflywith adistinctlyarched back.

*Large jointsmay bedistended andwarm onpalpation

*Mycoplasma F38 straincauseCoughing,laboredrespirationHigh fever,lethargy,anorexiaNasaldischarge -frothyStringysaliva

*M.mycoidescapri causeSepticemia,generalizedinfection andReproductive, GI,respiratorysymptoms

Acutepharyngitisand rhinitis.Fever (99.5101.5), slightcough.Nasaldischarge(bilateral)Catarrhalconjunctivitis.Lymph nodesabscessrupture on tothe skin withyellow- whitepus

*In nasalform, deepulcers in thenasal cavity.Healedulcersbecome star–shaped.

*In thepulmonaryform,nodules andabscesses inthe lungs.

*In thecutaneousform, theskin containsnodules thatulcerate,dischargingyellowexudate.

*Glanderousorchitis iscommon inmales.

*Mucopurulentnasal discharge,conjunctivitis,salivation, fever,in-appetanceand depression.

*Semen maycontain BHV1

*Mouthbreathing

GrossExamination

*Tubercles b/w1-2 mmdiameter ondifferentorgans,specially onlungs.

*Tubercle cutsection -caseousnecrotic centredry, calcified,gritty sensation.

*Nodules onpleura &peritonium.

Petechial andecchymotichaemorrhageson the heart.Pericarditis,pleuritis andperitonitis.

*Abundantfluid in thethoracic cavity(upto 30liters)

*Markedlywidenedinterlobularsepta, resultingin marbledappearance.*Lung will befound asequestrum

*In lungsGranularappearance,Fibrinouspneumonia,Straw-colored fluidin thorax,

*Pea-sizedyellownodules,Congestionaround thenodules.

*Retropharyngeal and sub-mandibularlymph nodesmostcommonlydevelopabscesses.

*If theinfectionspreads tointernalorgans suchas spleen andliver referredto as bastardstrangles

PM isprohibted

*Tiny necroticfoci in liver,pharynx, larynx,and trachea.

*Petechial toecchymotichemorrhages inthe nasal cavity.

*Sinuses areoften filled witha serous/serofibrinousexudate.