discovering gene regulatory control using chip-chip and chip-seq
TRANSCRIPT
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 1/36
Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
Jkwgo}fykcn nfcf yfnvlhzoy{ goczyol vwkcn GdKP"gdkp hcj GdKP"wfx
Phyz 8
“Hc kczyojvgzkoc zo nfcf yfnvlhzoy{ goczyol,gocgfpzw hcj bfzdojolonkfw‒
Khc Wkbpwoc
khc#wkbpwoc@#fj#hg#vedzzp1//ikz#l{/iko9lkcew
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 2/36
Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
Zdf Gfczyhl Jonbh om Bolfgvlhy Ikolon{
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 3/36
Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
Zyhcwgykpzkoc
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 4/36Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
Nfcf wzyvgzvyf
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 5/36Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
Fthbplf P^B moy zdf dvbhc P67 pyozfkc
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 6/36Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
pyobozfy/fcdhcgfy jfzfgzkocDBB/gkw"bojvlfglvwzfy"ivwzfy IkoZKMMKCYfjMl{BojFCGOJF
ZM ikcjkcn wkzf wgyffckcnP^B NkiiwWhbplfy BOOJW mhwz moy~hyj pd{lonfcfzkg gocwfy}hzkoc
PdhwzGocw, VGWGBvlzkq
IkoPyowpfgzoy
Zdf glhwwkg moozpykczkcn bfzdoj
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 7/36
Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
Glhwwkg pd{lonfcfzkg moozpykczkcn hppyohgd
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 8/36
Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
Lkbkzhzkocw om zdf glhwwkghl hppyohgd zo mkcjkcn ZMIWw
●Zdf cvbify hcj xvhlkz{ om ikcjkcn wkzf wfxvfcgfw kw lo~
●Zdfyf kw co ftplkgkz yflhzkoc ifz~ffc gocwfy}hzkoc hcj mvcgzkock#f# wkzfw hyf omzfc gocwfy}fj, ivz gocwfy}fj wkzfw jo coz cfgfwwhykl{ mvcgzkoc
●Hwwvbpzkocw dh}f zo if bhjf hiovz ~dfyf zo looe hcj do~ zo wgoyf
●Ftzyfbfl{ ikhwfj kcmoybhzkoc, lo~ cvbify om ftpfykbfczw zo jfzfybkcf wkzfw
●Coc"pd{wkolonkghl gocjkzkocw vwfj jvykcn hwwfwwbfcz
●Bfhwvyfbfczw bhjf ocl{ kc wpfgkmkg zkwwvf oy gfllw hz wpfgkmkg zkbfwloghl wolvzkocw zo zdf P^B pyoilfb, bh{ if ~yocn moy ozdfy gocjkzkocw
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 9/36
Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
Pyoilfbw ~kzd zdf h}hklhilf jhzh wovygfw
Bhkc wovygf om wkzf wpfgkmkg jhzh yfbhkcw phzzfyc oy P^B $oy DBB+
Gobboc chbf Ikchy{ cobfcglhzvyf Cvbify om P^Bw
dvbhc Dobo whpkfcw :>=
bovwf Bvw bvwgvlvw :97
yhz Yhzzvw coy}fnkgvw 967
gdkge Nhllvw nhllvw 877
glh~fj myon Tfcopvw lhf}kw 4:
myvkz ml{ Jyowopdklh bflhconhwzfy =4
zdhlf gyfww Hyhikjopwkw zdhlkhch :6
{fhwz Whggdhyob{gfwgfyf}kwkhf
7;
bocef{ Gfygopkzdfgvw hfzdkopw 9;
nkiioc hpf D{loihzfw lhy 9:
ghzzlf Iow zhvyvw 97
jobfwzkg pkn Wvw wgyomh 90
qfiyh mkwd Iyhgd{jhcko yfyko 8;
ZyhcwmhgPyo900;#8
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 10/36
Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
Yfplhgkcn glhwwkghl pyfjkgzkoc ~kzd jkyfgz loghlkwhzkoc
^dhz jo ~f cffj
●Hwwh{w zdhz go}fy zdf ~dolf nfcobf $hyfc.z ikhwfj+
●Hpplkghilf zo hll zyhcwgykpzkoc mhgzoyw $nooj go}fyhnf+
●
Ghc if bfhwvyfj kc lozw om jkmmfyfcz gocjkzkocw $gocjkzkoc wpfgkmkg, ikolonkghll{ yflf}hcz+●Ghc if bhppfj oczo pyfgkwf $hcj wbhll+ nfcobf loghzkocw $dknd yfwolvzkoc+
●Gowz fmmfgzk}f, hggvyhzf hcj yflkhilf
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 11/36
Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
Gdyobhzkc kbbvco"pyfgkpkzhzkoc $GdKP+
Gyoww"lkce pyozfkcwWdfhy JCH $wockghzkoc+
Yfgo}fy myhnbfczw moy ZMvwkcn hczkioj{ $z{pkghll{
pvllfj jo~c oc ifhjw+
Yf}fywf gyoww"lkcekcnLhifl myhnbfczw
D{iykjkwf zo gdkp hcj jfzfgz
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 12/36
Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
Do~ jo ~f nfz myob popvlhzkocw om JCH myhnbfczw zo powkzkocw oc gdyobowobfw ?
Gvyyfczl{ zdfyf hyf z~o bhkc gdokgfw
GdKP"gdkp D{iykjkwhzkoc oczo h nfcobkg zklkcn hyyh{Gdkp"wfx Jkyfgz wfxvfcgkcn om zdf iovcj $co~ yflfhwfj+ myhnbfczw
GdKP"gdkp
Dfyf h bhcvmhgzvyfj wlkjf kw vwfj kc ~dkgd myhnbfczw wphcckcn zdf nfcobf
dh}f iffc w{czdfwkwfj hcj hzzhgdfj zo zdf wlkjf wvymhgf kc h nfobfzykgHyyhcnfbfcz# ^f lhifl ovy ZM yfzykf}fj myhnbfczw, d{iykjkwf zdfb zo zdf wlkjfhcj zdfc yfhj mlvoyfwgfcgf myob zdf mfhzvyfw#
GdKP"wfx
Zhekcn hj}hczhnf om dknd zdyovndpvz wfxvfcgkcn zfgdcolon{ $wo ghllfj cftz"nfc+~f hzzfbpz zo wfxvfcgf hll zdf myhnbfczw# Zdkw kw xvhczkzhzk}f#
Kc iozd ghwfw ~f dh}f kwwvfw ~kzd bhppkcn, wknchl pyogfwwkcn $cokwf+ hcjwknckmkghcgf zfwzkcn
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 13/36
Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
Jfzfgzkoc bfzdoj 8 " Nfcobf zklkcn hyyh{w $GdKP"gdkp+
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 14/36
Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
Mfhzvyfw om nfcobf zklkcn hyyh{w
●
Nfcfyhll{ yfwolvzkoc ghc if hw lo~ hw s7ei, Zmw ikcj zo oc h}fyhnf ="4ip
●Do~ jo ~f eco~ ~dkgd nfcf zo bhp zo ? $bfzh"jhzh+bkgyohyyh{, nfcf pyotkbkz{, mvcgzkochl hccozhzkoc, kc"}k}o ftpyfwwkocgobphykwoc zo zyvf powkzk}f
●Yfjvcjhcg{ pyoifw bhp zo boyf zdhc ocf loghzkoc
●
Go}fyhnf, ghccoz go}fy zdf nfcobf# Zdkw kczyojvgfw ikhw#f}fc kc Jyowopdklh gobbocl{ ocl{ 60& om nfcobf powwkilf9 dvbhc gdyobowobfw hz 76ip yfwolvzkoc ↙ 8 bkllkoc mfhzvyfw
●Ghc fwzkbhzf wkzf oggvphcg{ myfxvfcg{
●Gyoww"d{iykjkwhzkoc ghc if ikn pyoilfb ~kzd yfpfzkzk}f JCH $s6& dvbhc nfcobf+
●Pyogfwwfj avwz lkef h nfcf ftpyfwkwoc bkgyohyyh{WHB, lkbbh $bojfllfj fyyoy, zkndz goczyol om MJY+
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 15/36
Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
Jfzfgzkoc bfzdoj 9 ‗ jkyfgz wfxvfcgkcn $GdKP"wfx+
Kllvbkch/Wolfth WIW wfxvfcgkcn w{wzfb
Lknhzf hjhpzoyw oczoJCH myhnbfczw
Jfchzvyf hcj hzzhgdzo wviwzyhzf
Hccfhl hcj ftzfcj iykjnf
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 16/36
Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
Jfzfgzkoc bfzdoj 9 ‗ jkyfgz wfxvfcgkcn $GdKP"wfx+
Gobplfzfftzfcwkoc
Jfchzvyfyfhj{ moy cftz
yovcj
Yfpfhz zoivklj glvwzfy
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 17/36
Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
Jfzfgzkoc bfzdoj 9 ‗ jkyfgz wfxvfcgkcn $GdKP"wfx+
Hjj mlvoyfwgfczcvglfozkjfw hcj
pykbfy
Wghc gdkp moy mkywz ihwf
Fcq{bhzkghll{yflfhwf iloge hcjyfpfhz hjjkzkoc om mlvoyfwgfcz ihwf
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 18/36
Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
Jfzfgzkoc bfzdoj 9 ‗ jkyfgz wfxvfcgkcn $GdKP"wfx+
Yfhj cftz ihwf Yfpfhz vczkl gobplfzf Hwwfbilf, hlknchcj bhp
wfxvfcgfw
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 19/36
Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
Mfhzvyfw om dknd"zdyovndpvz wfxvfcgf jhzh
●]fy{ dknd yfwolvzkoc, z{pkghll{ 96"bfyw ~kzd bkj"wphgkcn s76ip
●Dvnf jhzhwfzw, bhc{ Ni om wfxvfcgf, hwwfbil{ coc"zyk}khl
●Gobplfzf nfcobf go}fyhnf, co hwwvbpzkoc, co ikhw
●Nfcfyhll{ wvpfykoy hz kjfczkm{kcn iovcj wkzfw if{ocj ftpfgzhzkoc$zdkw kw yflhzfj zo h boyf hggvyhzf hiklkz{ zo jkwgykbkchzf wknchl myob cokwf+
●
Wfxvfcgfw hyf govczfj zo jfzfybkcf zdf myfxvfcg{ om wkzf oggvphcg{$ifzzfy zdhc gdkp, dfyf wfx cvb kw pyopoyzkochl zo iovcj wkzfw+
●Wfxvfcgfw hyf bhppfj hcj goc}fyzfj kczo wknchl pfhew$z{pkghl wkqfw om iovcj pfhew ghc yhcnf myob 60ip"8ei+
●Wzyocn goyyflhzkoc ifz~ffc wzhzkwzkghl wknckmkghcgf om pfhe hcj pyfwfcgf om ikcjkcn bozkm $bkndz wffb oi}kovw(+
F l GdKP Gdk j GdKP j z k zd z l l
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 20/36
Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
Fthbplf GdKP"Gdkp hcj GdKP"wfx jhzh wphcckcn zdf hzochl logvw
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 21/36
Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
Yfhl ~oylj fthbplfw om GdKP"gdkp hcj GdKP"wfx kc vwf
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 22/36
Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
Wzvj{kcn Jyowopdklh bvwgvlhzvyf jf}flopbfcz vwkcn GdKP"gdkp
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 23/36
Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
GdKP"gdkp ilogew kczfnyhzfj ~kzd nfcf ftpyfwwkoc jhzh moy Bfm9 hcj Lbj
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 24/36
Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
]hlkjhzkoc om fcdhcgfyw hcj ZM ikcjkcn wkzfw
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 25/36
Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
]hlkjhzkoc om fcdhcgfy hgzk}kz{ moy Bfm9/Lbj ghcjkjhzf zhynfz nfcfw
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 26/36
Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
Zfbpoyhl ikcjkcn pyomklfw om o}fy"yfpyfwfczfj Bfm9 iovcj ilogew
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 27/36
Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
W{czdfwkw om zdf zhynfz nfcf cfz~oye hcj eco~c b{onfcwkw phzd~h{
Gdkp wfx hchl{wkw om zdf cfvyoc yfwzykgzk}f wklfcgkcn mhgzoy $CYWM+
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 28/36
Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
Gdkp"wfx hchl{wkw om zdf cfvyoc yfwzykgzk}f wklfcgkcn mhgzoy $CYWM+
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 29/36
Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
Ghcockghl CYWM P^B lono
Co}fl CYWM P^B lono
GdKP"wfx yf}fhlw cf~ ikcjkcn bozkm mlftkiklkz{ moy CYWM
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 30/36
Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
Zdf nfcf yfnvlhzoy{ cfz~oye jo~cwzyfhb om CYWM gocwzyvgzfj myob GdKP"wfx jhzh
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 31/36
Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
Wvbbhy{ moy GdKP ihwfj zhynfz pyfjkgzkoc bfzdojw
●GdKP"gdkp hcj GdKP"wfx hllo~ moy zdf mkywz zkbf pd{wkghl kjfczkmkghzkoc om iovcj yfnkocwoc zdf nfcobkg wghlf
●GdKP"wfx pyfwfczw dkndfy yfwolvzkoc hcj kw yfplhgkcn GdKP"gdkp
●Iozd bfzdojw yfxvkyf lhynf jhzh"pyogfwwkcn hcj hchl{wkw
●Co}fl bfzdojw dh}f iffc jf}flopfj zo ghll iovcj yfnkocw myob zdfwf jhzh
zdf{ hyf pyfjobkchczl{ ihwfj oc dkjjfc bhyeo} bojflw $DBB+ hcj hyf chzvyhll{coybhll{ 9"wzhzf bojflw $pfhe, coc"pfhe+
●Zdf yfwvlzkcn yfnkocw ghc if vwfj ~kzd glhwwkghl bfzdojw zo yfmkcf zdf chzvyf om zdf yfnvlhzoy{ flfbfcz $P^B Nkiiw/DBB pyomklkcn, bozkm jfzfgzkoc, gocwfy}hzkoc+
●Ghc hlwo if yfmkcfj i{ boyf pyfgkwf ftpfykbfczw oc zdf GdKP JCH wvgd hw zhynfzfj PGY
●
Yf}olvzkockwfw zdf hchl{wkw om nfcf yfnvlhzoy{ cfz~oyew i{ kczfnyhzkoc ~kzd nfcfftpyfwwkoc jhzh
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 32/36
Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
Jkwgo}fykcn nfcf yfnvlhzoy{ goczyol vwkcn GdKP"gdkp hcj GdKP"wfx
Phyz 9
“Pyhgzkghl hchl{wkw om GdKP jfyk}fj jhzh‒
Khc Wkbpwoc
khc#wkbpwoc@#fj#hg#vedzzp1//ikz#l{/iko9lkcew
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 33/36
Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
DBBzklkcn
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 34/36
Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
n
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 35/36
Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
8/7/2019 Discovering gene regulatory control using ChIP-chip and ChIP-seq
http://slidepdf.com/reader/full/discovering-gene-regulatory-control-using-chip-chip-and-chip-seq 36/36
Khc Wkbpwoc, Kcwzkzvzf moy Hjhpzk}f hcj Cfvyhl Gobpvzhzkoc, Wgdool om Kcmoybhzkgw, Vck}fywkz{ om Fjkcivynd
DPfhe
Bojfl hygdkzfgzvyf
D{pozdfzkghl JCH myhnbfcz