directory of cyclotrons used for radionuclide production in member

IAEA-DCRP/2006

Directory of Cyclotrons used for Radionuclide Production in

Member States 2006 Update

October 2006

The originating Section of this publication in the IAEA was:

Industrial Applications and Chemistry Section International Atomic Energy Agency

Wagramer Strasse 5 P.O. Box 100

A-1400 Vienna, Austria

DIRECTORY OF CYCLOTRONS USED FOR RADIONUCLIDE PRODUCTION IN MEMBER STATES:

2006 UPDATE IAEA, VIENNA, 2006

IAEA-DCRP/2006 ISBN 92-0-111506-7

IAEA, 2006

Printed by the IAEA in Austria October 2006

FOREWORD

The present directory of cyclotron facilities used for the production of radionuclides in Member

States is an update of the one compiled by the International Atomic Energy Agency (IAEA) in late 2001 and published in 2002. This directory was prepared through information collected by questionnaires that the IAEA sent to known institutions operating cyclotrons for radionuclide production. Technical as well as administrative data supplied to the IAEA as of November 2005 were taken into account.

The directory is considered to include most of the cyclotrons of the world that are used at least

partially for radionuclide production. There are 262 entries for cyclotrons operating in 39 Member States of the IAEA. This is an increase of 7% over the 246 reported in the 2002 cyclotron directory. This can be compared to the 350 or so cyclotrons believed to be presently operating in the world, which are involved in some aspects of radionuclide production. The increase has been in the number of cyclotrons in developed countries, but even more so in the developing countries. The increase in number during the last four years was driven by several factors, i.e. advent of advances in medical imaging, introduction of compact, user friendly medical cyclotron, and a recent decision that costs for 15O-oxygen position emission tomography (PET) studies in Japan and 18F-FDG PET studies in Germany and the United States of America are eligible for reimbursement by government or health insurance companies. There is no doubt that the fastest growing segment of the market is in the commercial distribution of FDG to local hospitals.

The IAEA is promoting cyclotron technology as applied to nuclear medicine. Requests for

cyclotron technology is steadily increasing; many developing Member States are interested in this technology. There is need to stimulate, build and maintain consulting capability in interested developing Member States. There are good reasons to believe that the number of cyclotron facilities dedicated to the production of PET tracers will continue to grow in the near future, so the need to further update the directory will be assessed in due course, depending on comments and suggestions receiving from users of the directory. This directory will help decision makers and specialists in Member States to draft mid and long term strategies regarding the implementation of cyclotron technology for radioisotope production and their medical applications, as well as for selection of the most suitable alternative.

The IAEA wishes to thank D.J. Schlyer of the Brookhaven National Laboratories, USA, for his

analysis of the data. The IAEA officer responsible for the compilation of the directory was M. Haji-Saeid of the Division of Physical and Chemical Sciences.

EDITORIAL NOTE

This CD-ROM has been prepared from the original material as submitted by contributors. Neither the IAEA nor its Member States assume any responsibility for the information contained on this CD-ROM. The use of particular designations of countries or territories does not imply any judgement by the publisher, the IAEA, as to the legal status of such countries or territories, of their authorities and institutions or of the delimitation of their boundaries. The mention of names of specific companies or products (whether or not indicated as registered) does not imply any intention to infringe proprietary rights, nor should it be construed as an endorsement or recommendation on the part of the IAEA.

CONTENTS

SUMMARY ............................................................................................................................................ 1 1. Argentina......................................................................................................................................... 7 2. Australia........................................................................................................................................ 11 3. Austria........................................................................................................................................... 17 4. Belgium......................................................................................................................................... 21 5. Brazil............................................................................................................................................. 37 6. Canada........................................................................................................................................... 41 7. China............................................................................................................................................. 59 8. Czech Republic ............................................................................................................................. 77 9. Denmark........................................................................................................................................ 81 10. Egypt ........................................................................................................................................... 85 11. Finland ........................................................................................................................................ 87 12. France.......................................................................................................................................... 95 13. Germany.................................................................................................................................... 107 14. Hungary..................................................................................................................................... 153 15. India .......................................................................................................................................... 155 16. Indonesia ................................................................................................................................... 159 17. Iran, Islamic Republic of........................................................................................................... 161 18. Israel.......................................................................................................................................... 163 19. Italy ........................................................................................................................................... 167 20. Japan ......................................................................................................................................... 193 21. Kazakhstan................................................................................................................................ 265 22. Korea, Republic of .................................................................................................................... 267 23. Mexico ...................................................................................................................................... 297 24. Netherlands ............................................................................................................................... 299 25. Norway...................................................................................................................................... 319 26. Philippines................................................................................................................................. 321 27. Poland ....................................................................................................................................... 323 28. Romania .................................................................................................................................... 327 29. Russian Federation.................................................................................................................... 329 30. Saudi Arabia.............................................................................................................................. 347 31. Slovakia..................................................................................................................................... 349 32. South Africa .............................................................................................................................. 351 33. Spain ......................................................................................................................................... 353 34. Sweden...................................................................................................................................... 363 35. Switzerland ............................................................................................................................... 365 36. Syrian Arab Republic................................................................................................................ 371 37. Turkey ....................................................................................................................................... 373 38. United Kingdom........................................................................................................................ 377 39. United States of America .......................................................................................................... 391

SUMMARY

The directory of cyclotrons used for radionuclide production in Member States contains

technical, utilization and administrative information supplied to the IAEA as of November 2005. It was prepared through information collected by questionnaires sent to institutions that either have a cyclotron or were identified to be in the process of installing a cyclotron.

Included in the directory are a significant fraction of the cyclotrons of the world that are used at

least in part for radionuclide production. If replies were not received from institutions, it was assumed that the cyclotron is still being used for similar tasks as it was at the time of the last survey. Some institutions reported that older cyclotrons had been shut down and replaced with newer cyclotrons. The questionnaire was, in general, not completed by institutions that have cyclotrons dedicated to physics and/or material science activities. Certain of the institutions constructing superconducting cyclotrons for medical and nuclear physics applications responded even though they are not yet involved in radionuclide production initiatives.

The directory is organized alphabetically by Member States and by institutes. There are

individual entries for each cyclotron even for institutions having more than one cyclotron. The names, title/position of the persons listed in position in the entries for individual countries were taken directly from the answers in the questionnaires.

There are 262 entries for cyclotrons operating in 39 Member States of the IAEA. This is an

increase of 7% over the 246 reported in the 2002 cyclotron directory. This can be compared to the 350 or so cyclotrons believed to be presently operating in the world, which are involved in some aspects of radionuclide production. The increase has been in the number of cyclotrons in developed countries, but even more so in the developing countries. Large concentrations of cyclotrons for radionuclide production are located in the United States of America, Japan and Germany. The largest number of cyclotrons for a single country is in the United States of America. However, taken collectively there are more cyclotrons located in the European Union countries that are used for medical radionuclide production.

The number of institutions which distribute radiopharmaceuticals and 18F-FDG, in particular, is

significant and growing. In this sample, 75% of the cyclotrons are being used to produce FDG, either for internal use or for distribution. This is certainly an underestimate as the commercial suppliers are under represented in this survey.

The expansion in the number of cyclotrons during the last 10 years has been driven by the

advent of advances in medical imaging instrumentation (PET, SPECT and more recently PET/CT); introduction of user friendly compact medical cyclotrons from several companies that manufacture cyclotrons; and recent decisions that some PET radiopharmaceuticals are eligible for reimbursement by government or insurance companies. There is no doubt that the fastest growing segment of the market is in the commercial distribution of 18F-FDG to local hospitals. Many centers have begun distributing FDG and at present at least 36% of the centers producing FDG are distributing it. Again this is a lower limit rather than an accurate assessment. The satellite approach is cost-effective because it is not necessary for every medical imaging centre to own a cyclotron as a source of short-lived radiopharmaceuticals. 18F-FDG is gaining widespread clinical acceptance for a variety of disease states.

The number of types of cyclotrons available commercially is quite large and growing. The energies range from a few MeV for only PET isotope production to a few hundreds MeV for proton therapy or production of radioisotopes requiring these high energies. The beam currents range upwards from 40 to over 1 mA. The characteristics of the machines available for commercial acquisition are shown in Table I.

1

TABLE I. CHARACTERISTICS OF COMMERCIAL CYCLOTRONS

Company Model Description Oper. Plan CTI, Inc. RDS 111 11 MeV H-, 60A 44 10 RDS 112 11 MeV H-, 60A 30 Ebco Technologies TR 14 11-14 MeV H-, 100A 2 TR 19 14-19 MeV H-, 160A 2 TR 19/9 19 MeV H-, 9 MeV D-, 160A 1 3 TR30 30 MeV H-, 100A 2 TR30/15 30 MeV H-, 15 MeV D-, 160A 1 D.V. Efremov Institute MGC-20 18 MeV H-, 10 MeV D-, 160A 4 2 General Electric MiniTrace 9.6 MeV H-, 50A 2 PETrace 16.5 MeV H-, 8.6 MeV D-, 80A 16 Ion Beam Applications Cyclone 3 3.8 MeV D-, 60A 2 Cyclone 10/5 10 MeV H-, 5 MeV D-, 60A 3 Cyclone 18/9 18 MeV H-, 9 MeV D-, 80A 15 5 Cyclone 18+ 18 MeV H-, 80A 1 Cyclone 30 30 MeV H-, 15 MeV D-, 400A 16 2 Cyclone 235 240 MeV H- 1 Japan Steel Works BC168 16 MeV H+, 8 MeV D+, 50A 2 BC1710 17 MeV H+, 10 MeV D+, 60A 7 BC2010N 20 MeV H-, 10 MeV D-, 60A 2 BC2211 22 MeV H+, 11 MeV D+, 60A 1 BC3015 30 MeV H+, 15 MeV D+, 60A 1 Oxford Instrument Co. OSCAR 12 12 MeV H-, 60A 5 Scanditronix Medical AB MC17 17.2 MeV H+, 8.3 MeV D+, 60A 13 12 MeV 3He++, 16.5 4He++, 60A MC30 30 MeV H+, 15 MeV D+, 60A MC32NI 15-32 MeV H-, 8-16 MeV D-, 60A 3 11-23 MeV 3He++, 15-31 4He++, 60A MC40 10-40 MeV H+, 5-20 MeV D+, 60A 6 13-53 MeV 3He++, 10-40 4He++, 60A MC50 18-52 MeV H+, 9-25 MeV D+, 60A 1 24-67 MeV 3He++, 18-50 4He++, 60A MC60 50 MeV H+, 60A 1 K130 6-90 MeV H-, 10-65 MeV D-, 60A 16-173 MeV 3He++, 20-130 4He++ Sumitomo Heavy Industries CYPRIS 325 16 MeV H+, 8 MeV D+, 60A 1 CYPRIS 370 16 MeV H+, 10 MeV D+, 60A 4 HM 18 18 MeV H-, 10 MeV D-, 60A 7 HM 12 12 MeV H-, 6 MeV D-, 60A 1 480 AVF 30 MeV H+, 60A 1 AVF 680 40 MeV H+, 60A 1 AVF 715 50 MeV H+, 60A AVF 750 70 MeV H+, 60A 1 AVF 930 90 MeV H+, 60A 2 AVF 1000 80 MeV H+, 60A Ring Cyclotron 400 400 MeV H+ (K=400), 60A 1 Ring Cyclotron 540 240 MeV H+ (K=540), 60A 1 C235 240 MeV H-, 60A 1 KIRAMS Kirams-13 13 MeV H+, 100 A 3

2

Of the respondents to the survey, the number of existing cyclotrons broken down by energy

level is given in Fig. 1.

0

20

40

60

80

100

120

140

160

180

100 MeV

Energy Distribution

Number of Cyclotrons

FIG. 1. Distribution of proton energies as reported by respondents to the IAEA survey.

The preponderance of low energy cyclotrons can be clearly seen from the distribution which is very similar to the distribution from the 2002 edition of the directory. Another interesting aspect is the distribution of time being devoted to radioisotope production. This distribution is shown in Figure 2.

0

10

20

30

40

50

60

70

80

100 hrs

Radioisotope Production Hours per week

Number of Instutions

FIG. 2. Distribution of hours of radioisotope production from the respondents to the IAEA survey.

3

One interesting aspect of this distribution is that many institutions are spending a very small

fraction of the available time in radioisotope production. The cyclotron is idle for a significant fraction of the week. This implies that the cyclotron is not the slow step in clinical applications and that a single cyclotron can support several PET or PET/CT cameras.

The other interesting trend is in the compounds that are being synthesized with these

radioisotopes. A graph of the number of centres that responded synthesizing these compounds is given in Fig. 3.

0

50

100

150

200

250

FDG FLT FDOPA Methonine Ammonia Water

Compound

Number of Instutions

FIG. 3. Number of reporting institutions that use a particular compound.

This figure clearly shows that 18F-FDG is the most widely produced compound at cyclotron facilities world wide. It is now used in many applications in diagnostic nuclear medicine.

TABLE II. EXPECTED PRODUCTION YIELDS (MCI) OF SYNTHETIC PRECURSORS OF PET RADIOPHARMACEUTICALS WITH SELECTED PROTON AND DEUTERON ENERGIES AND IRRADIATION AT 20 TO 35 A AS RECOMMENDED BY THE MANUFACTURER OF VARIOUS CYCLOTRONS.

Precursor 12 MeV p only 10 MeV p + 5 MeV d 18 MeV p + 9 MeV d 11CO2 1500 1000 2800 11CO 1000 350 1400 11CO 1250 350 700 11CO 750 250 1200 13NH3 200 100 450 15O2 1000 >150/min. 1200 15OC 500 >75/min. 700 15OCO 500 >150/min. 700 15OH2 750 200 1000 18F- 700 >500 800 18FF 300

4

One of the areas of current research is on the development of very high current targets that can

produce several curies of fluorine-18 for synthesis of 18F-FDG. This type of target is advantageous for production facilities where distribution of 18F-FDG is being carried out on a routine basis.

5

1

1. ARGENTINA

2005 COUNTRY: ARGENTINA ARG-1 [1] INSTITUTE: Comisin Nacional de Energia Atmica (CNEA)

Avenida del Libertador 8250 1429 Buenos Aires

TELEPHONE NO.: E-MAIL ADDRESS: FAX NO.:

+54 11 4379 8250 [email protected] +54 11 4480 0615

[2] PERSON IN CHARGE: POSITION:

Mr. Carmelo Rocco Head of the Facility

OTHER SENIOR STAFF: NAME/POSITION

Mr. Ortega Daniel, in charge of Operation and Maintenance Mr. Guevara Ernesto, in charge of Radiochemistry

[3] TYPE OF CYCLOTRON:

Isochronous, negative ion

YEAR OF: (I) INSTALLATION:

1994

MANUFACTURER: The Cyclotron Corporation

(II) UPGRADE: Beam current increase

MODEL: CP - 42 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 25/42 Yes No Maximum beam available (A) 150 Typical beam employed (A) 100 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

29 22 - 7 - [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mssbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): 123I, 123I iodide and other compounds, 67Ga, 111In [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s and how often? Yes No

[10] Are clinical studies and/or medical research using cyclotron radiopharmaceuticals carried out on-site?

Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) Clinical Small animal Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for

agricultural applications such as plant biochemistry/research? Yes No

[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No

7

2

18F RADIONUCLIDE PRODUCTION Production Typical

production

yield (GBq)

% Isotopic

enrichment 18

O used

Target Volume Usage/year Do you

recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 25 95 1.7 45 Yes No

20Ne (d, ) 18F 16O (, d) 18F 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production

Used on site Distribution/

Sales

Price/

GBq 18FDG 15 4 weekly Yes No Yes No U$S 392 Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


Sales

Price

/GBq

Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield

on batch, GBq

Frequency of

production

Nuclear reaction used Distribution/

Sales

Price/

GBq

Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on batch

(GBq)

Frequency of production Nuclear reaction

used

Price/

GBq

OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


Sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl 37 2 monthly Yes No Yes No US$ 324 211At Yes No Yes No COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced) The production of high purity 123I is a project that was carried out under the IAEAs Technical Co-operation Programme (ARG/4/085). The IAEA supported the CNEA efforts to set up required facilities including different system provision of expert and personnel training.

8

3

2005 COUNTRY: ARGENTINA ARG-2 [1] INSTITUTE: Fundacin Escuela de Medicina Nuclear

Garibaldi 405, CP 5500 Mendoza 1429


+54 261 4201 615 (1ext. 564; 2ext. 562; 3 ext. 508) [email protected] +54 261 4203 288


Ing. Enrique R. Noya Electronic Engineer Head of Operation and Maintenance


Dr. Fernando Spigatin2, Head of Radiochemical Laboratory Ing. Norma Acosta3, Head of Radiological Security


Negative ion hospital cyclotron

YEAR OF: (I) INSTALLATION

1997

MANUFACTURER: CTI, Inc. (II) UPGRADE: MODEL: RDS 112 [4] CYCLOTRON CHARACTERISTICS:

This cyclotron is not self-shielded. This is installed inside a bunker. All the support equipment is located in different rooms.

1H 2H 3He 4He Dual Beams Beam energies (MeV) 11 Yes No Maximum beam available (A) 50 Typical beam employed (A) 20-40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

10 8 2 3 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mssbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): 15O, 11C [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? Yes No


Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence 1 Gamma camera 1 Single photon tomography (SPET) 1 Positron emission tomography (PET) 1 Clinical 1 Small animal Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



9

4


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 20 >97 0.330 100 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production

Used on site Distribution/sales Price/

GBq 18FDG 10 5/week Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia 4 6/week p+ H20 Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on batch (GBq) Frequency of production Nuclear reaction

used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced)

10

5

2. AUSTRALIA

2005 COUNTRY: AUSTRALIA AUL-1 [1] INSTITUTE: Austin and Repatriation Medical Centre

Studley Road, Heidelberg, VIC 3084 TELEPHONE NO.:

E-MAIL ADDRESS: FAX NO.:

+61 3 9496 3995 [email protected] +61 3 9496 5892


Dr. Henri Tochon-Danguy Senior Radiochemist

OTHER SENIOR STAFF: NAME/POSITION NAME/POSITION

Dr. John Sachinidis, Radiochemist Dr. Uwe Ackermann, Radiochemist Mr. Stan Poniger, Cyclotron/Robotic Engineer


Negative ion accelerator


1992

MANUFACTURER: IBA, s.a. (II) UPGRADE: 1996 (new sources) MODEL: Cyclone 10/5 2001 (remote start-up &

control) [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 10 5 Yes No Maximum beam available (A) 50 20 Typical beam employed (A) 25 8 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

25 25 1 4 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mssbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): 124I, [9] Do you supply radionuclides to other institutions?



Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) 4 Positron emission tomography (PET) Clinical 2 Small animal Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



11

6


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 37 90 1 200 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


Sales

Price/

GBq 18FDG 24 7/week Yes No Yes No 18F MISO 2 1/week Yes No Yes No 18FLT 2 2/month Yes No Yes No

18FA85380 2 1/week Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


Sales

Price/

GBq

PIB 2 2/week Yes No Yes No SCH23390 2 1/month Yes No Yes No Ro151788 2 2/month Yes No Yes No Choline 2 2/month Yes No Yes No PK11195 2 2/month Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


Sales

Price/

GBq

Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price/

GBq

Water 1/min 1/week 14N[d, n] 15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


Sales

Price/


12

7

2005 COUNTRY: AUSTRALIA AUL-2 [1] INSTITUTE: Australian Nuclear Science & Technology Organization

(ANSTO) Radiopharmaceutical Division New Illawarra Road


+61 2 9717 9079 [email protected]


Dr. S. Carr Director, Radiopharmaceuticals


D. Arnott


Negative ion YEAR OF: (I) INSTALLATION

1991

MANUFACTURER: IBA, s.a. (II) UPGRADE: 1997 MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) Yes No Maximum beam available (A) Typical beam employed (A) [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

140 90 60 10 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mssbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?



Yes No




13

8


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F Y No


(list)

Yield on batch

(GBq)

Frequency of

production


Sales

Price/

GBq 18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


Sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


Sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


Sales

Price/


14

9

2005 COUNTRY: AUSTRALIA AUL-3 [1] INSTITUTE: Peter MacCallum Cancer Institute

12 Cathedral Place East Melbourne 3002, Victoria


+61 3 9656 1852 [email protected] +61 3 9656 1826


Dr. Rodney J. Hicks Associate Professor/Director, PET Centre


Mr. Peter Eu, Radiochemist


Superconducting YEAR OF: (I) INSTALLATION

1998

MANUFACTURER: Oxford (II) UPGRADE: MODEL: 12 MeV [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 12 Yes N Maximum beam available (A) 80 Typical beam employed (A) 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

13 12 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mssbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): 18F-AZA, 18F-LT [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? 18F, Wesley Private Hospital/ 2-3 times/week

Yes No


Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) 2 Positron emission tomography (PET) Clinical 2 Small animal 1 (Jan. 2002 delivery) Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



15

10


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 55 95 5 500 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 6.5 1-2/day Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


16

11

3. AUSTRIA

2005 COUNTRY: AUSTRIA AUS-1 [1] INSTITUTE: ARGOS Zyklotron

Betriebs-Ges.m.b.H. LKH Klagenfurt, PET-Zentrum NMSE St. Veiter Str. 47, A-9026 Klagenfurt


+43 (0) 463 500 705 +43 (0) 463 500 705 14


Dr. Dirk W. Becker


Dipl. Ing. Mustafa Skenderi, QC Stefan Weber, Leading Technician


PT YEAR OF: (I) INSTALLATION

1999

MANUFACTURER: GE Medical Systems (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16 8.5 Yes N Maximum beam available (A) 75 60 Typical beam employed (A) 50 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

32 30 1 1 0 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) Isotope

production

[7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mssbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): (18F) FLT, 124I, 86Y [9] Do you supply radionuclides to other institutions?



Yes No




17

12


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 120 95-96 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

FDG 65 Yes No Yes No DOPA 10 Yes No Yes No MISO 30 Yes No Yes No Fluoride 150 Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Methionin Yes No Yes No Cholin Yes No Yes No Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

Ammonia Yes No Yes No Yes No 15O RADIOPHARMACEUTICALS PRODUCED Name

(list)


used

Price

/GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


18

13

2005 COUNTRY: AUSTRIA AUS-2 [1] INSTITUTE: sterreichisches Forschungszentrum Seibersdorf

Department of Radiopharmaka A-2444 Seibersdorf


+43 0 50 550 3470 [email protected] +43 0 50 550 3473


Dr. Peter Angelberger Department Head


Dr. Herbert Kvaternik, Deputy


Negative ion YEAR OF: (I) INSTALLATION

1999

MANUFACTURER: GE Uppsala (II) UPGRADE: MODEL: PET Trace [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 16.5 8.4 Yes N Maximum beam available (A) 75 60 Typical beam employed (A) 40 40 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

15 10 4 1 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mssbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): Further 18F radiopharmaceuticals [9] Do you supply radionuclides to other institutions?



Yes No




19

14


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 130 95 250 Yes No

20Ne (d, ) 18F 20 16O (, d) 18F 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 65 5/week Yes No Yes No FDOPA 2 2/month Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


20

15

4. BELGIUM

2005 COUNTRY BELGIUM BEL 1 [1] INSTITUTE: ULB/Erasme hospital

808 Lennik street, B-1070 Brussel TELEPHONE NO.:

E-MAIL ADDRESS: FAX NO.:

00.32.2.555.47.10 [email protected] 00.32.2.555.47.01

[2] PERSON IN CHARGE: TITLE/POSITION:

Dr. S.Goldman Doctor in medicine


M.Monclus (PhD, radiochemist) M.Kadiata (PhD, radiochemist) J.Van Naemen (cyclotron engineer)

[3] TYPE OFCYCLOTRON: MANUFACTURER: MODEL:

Negative ion IBA Cyclone-30

YEAR OF: (I) INSTALLATION: (II) UPGRADE:

1990 1999-2006

[4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams

Beam energies (MeV) 30 Yes No Maximum beam available (A) 200 Typical beam employed (A) 30 [5] CYCLOTRON OPERATION: Total hours/ week Hours/week

for radio. product

Hours/week for research Hours/week for

maintenance

Hours/week for

applications

20 3 2.5 1 0 [6] CYCLOTRON APPLICATIONS: Hours/week Hours/week Radiobiology: 20 Radiography: 0 Materials science: 0 Proton therapy: 0 Physics: 0 Neutron therapy: 0 Activation analysis: 0 Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mssbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] Radionuclides and radiopharmaceuticals planned to be produced in the next 1-3 years (specify): 18F labeled amino acid and derivatives [9] Do you supply radionuclides to other institutions?



Yes No

[11] Type of imaging equipment available on-site Number of 511 KeV coincidence 0 Gamma camera 4 Single photon tomography (SPET) 4 Positron emission tomography (PET) 2 - Clinical 2 - Small animal 0 - Plant biochemistry 0 [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for

agricultural applications such as plant biochemistry/research?

Yes No

[13] Is the cyclotron used for nuclear reaction cross-section measurements? Yes No [14] Is the cyclotron used for targetry development? Yes No [15] Is the cyclotron used for education and training in nuclear sciences, health physics, etc.? Yes No [16] Does your institute accept IAEA research fellows for training/experience? Yes No [17] COMMENTS: (e.g., you may add names of additional labelled compounds/radiopharmaceuticals being produced)

21

16


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle 18

OH2?

18

OH2 18

O2 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 111 95 1.5 ml 600 Yes No

Ne (d, ) 18F 16O (, x) 18F 18F RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 67 254/year Yes No Yes No 18F MPPF 2 10/year Yes No Yes No 18F F- 2 5/year Yes No Yes No 18F phenylalanine

2 5/year Yes No Yes No

18F FET 2 10/year Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 11C methionine 8 154 Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 13N radiopharmaceuticals produced Name (list)

Typical yield on batch (GBq)

Frequency of production

Nuclear reaction used Distribution/ sales

Price/ GBq

13N NH3 3 10 16O(p,)13N Yes No


(list)


used

Price/

GBq 15O H2O 3 10/year

16O(p,pn)15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu 0 Yes No Yes No 67Ga 0 Yes No Yes No 86Y 0 Yes No Yes No 94mTc 0 Yes No Yes No 103Pd 0 Yes No Yes No 111In 0 Yes No Yes No 123I 0 Yes No Yes No 124I 0 Yes No Yes No 201Tl 0 Yes No Yes No 211At 0 Yes No Yes No

22

17

2005 Country: BELGIUM BEL-2 [1] Institute: Institute of Nuclear Sciences

University of Ghent Proeftuinstraat 86, B-9000 Gent

Telephone no.: E-mail address: Fax No.:

+32 9 264 6616 [email protected] +32 9 264 6699

[2] Person in charge: Position:

Professor Dr. Karel Strijckmans Professor

Other senior staff: Name/Position

[3] Type of cyclotron: Isochronous Year of: (i) installation 1977 Manufacturer: CGR-MeV (France) (ii) upgrade: 1982 Model: 520 [4] Cyclotron characteristics: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 2.5 24 3 14.5 6 32 10 29 Yes No Maximum beam available (A) 100 100 60 60 Typical beam employed (A) 20 5 - - [5] Cyclotron operation: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

20-30 10 10-20

18

18F Radionuclide production Production Typical

production

yield (GBq)

% Isotopic

enrichment

18O used

Target Volume Usage/year Do you recycle 18OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 15 97 0.8 50 Yes No

20Ne (d, ) 18F 16O (, d) 18F 18F radiopharmaceuticals produced Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 4 3-4/week Yes No Yes No seronotin receptor antagonist

Yes No Yes No

Yes No Yes No Yes No Yes No 11C radiopharmaceuticals produced Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

PK 11195 4

19

2005 COUNTRY: BELGIUM BEL-3 [1] INSTITUTE: MDS Nordion S.A.

Zone Industrielle B-6220 Fleurus


+32 10 829 211 +32 10 829 696


Dr. Claude Pirarat Manager, Radiochemical Production



Isochronous Cyclotron H-


1992

MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 30 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 15 - 30 Yes No Maximum beam available (A) 400 Typical beam employed (A) 400 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

160 160 8 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mssbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions? If yes and available, name of

institution/s & how often? Bulk 201Tl Europe, North and South America, 123I, 201Tl Europe (OEM manufacturing)

Yes No


Yes No




25

20


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG Yes No Yes No 123I 100 250 4/week Yes No Yes No 201Tl 150 - 300 5/week Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


26

21

- 2005 COUNTRY: BELGIUM BEL-4 [1] INSTITUTE: Universite catholique de Louvain

Centre de Recherches du Cyclotron 2, Chemin du Cyclotron, B-1348 Louvain-la-Neuve


+32 10 472 998 [email protected] +32 10 452 183


Mr. Guido Ryckewaert Director


Mr. Daniel Labar Head of Radiochemistry


Compact H- YEAR OF: (I) INSTALLATION

1987

MANUFACTURER: UCL/IBA, s.a. (II) UPGRADE: MODEL: Prototype

Cyclone 30

[4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 15 30 Yes No Maximum beam available (A) 350 Typical beam employed (A) 50/300 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

30 - 4 15 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: 15 Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mssbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?



Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 2 Clinical Small animal Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



27

22


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 80 95 2 200 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/G

Bq 18FDG 40 daily Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq

Acetate 5 monthly Yes No Yes No Methionine 5 weekly Yes No Yes No Flumazenil 5 monthly Yes No Yes No Yes No Yes No 13N RADIOPHARMACEUTICALS PRODUCED Name

(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq

NH4OH 5 weekly 16O(p, )13N Yes No


(list)


used

Price/

GBq

Water 10 2/week 16O (p, pn)15O OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 64Cu Yes No Yes No 67Ga Yes No Yes No 86Y 1 weekly Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced)

28

23

2005 COUNTRY: BELGIUM BEL-5 [1] INSTITUTE: Universite catholique de Louvain

Centre de Recherches du Cyclotron 2, Chemin du Cyclotron, B-1348 Louvain-la-Neuve


+32 10 472 998 [email protected] +32 10 452 183


Mr. Guido Ryckewaert Director


Mr. Daniel Labar Head of Radiochemistry


Isochronous multiparticle variable energy


1969-1972

MANUFACTURER: Thomson CSF. (II) UPGRADE: MODEL: Cyclone [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 20 85 10 55 15 145 20 - 110 Yes No

Maximum beam available (A) 30 20 5 20 Typical beam employed (A) 20 10 5 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

150 8 - 4 - [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mssbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): [9] Do you supply radionuclides to other institutions?

If yes and available, name of institution/s & how often? To two centres, sporadically. Yes No


Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 Clinical Small animal Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



29

24


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F Ye No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG Yes No Yes No Yes No Yes No Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq


Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 28Mg 20 MBq Al (100%) Yes No Yes No 52Fe 0,2 2 MBq Mn (100%) Yes No Yes No 94,95,96Tc 0,1 0,01 MBq Mo (nat) Yes No Yes No 94mTc Yes No Yes No 103Pd Yes No Yes No 111In Yes No Yes No 123I Yes No Yes No 124I Yes No Yes No 201Tl Yes No Yes No 211At Yes No Yes No COMMENTS: (e.g. you may include names of additional labelled compounds/radiopharmaceuticals being produced)

30

25

2005 COUNTRY: BELGIUM BEL-6 [1] INSTITUTE: Universite de Liege

Centre de Recherches du Cyclotron Sart Tilman, B-4000 Liege


+32 4 366 2360 [email protected] +32 4 366 2946


Dr. A. Luxen Director


C. Brihaye, Senior Radiochemist G. Del Fiore, Senor Radiochemist C. Lemaire, Senior Radiochemist A. Plenevaux, Senior Radiochemist, Aerts/Pharmacist


H-/D- YEAR OF: (I) INSTALLATION

1999

MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: 18/9 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 18 9 Yes No Maximum beam available (A) 50 35 Typical beam employed (A) 50 35 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

30 10 20 8 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials science: Proton therapy: Physics: Neutron therapy: Activation analysis: Other (specify) PET/30 [7] IS THE CYCLOTRON USED TO PRODUCE: Calibration sources? (specify which & quantity) Yes No Mssbauer sources? (specify which & quantity) Yes No X ray sources? (specify which & quantity) Yes No Intense neutron beam? (specify average En = ?) Yes No [8] RADIONUCLIDES AND RADIOPHARMACEUTICALS PLANNED TO BE PRODUCED IN THE NEXT 1-3 YEARS (specify): Several radiopharmaceuticals specific for receptoe and gene expression imaging. [9] Do you supply radionuclides to other institutions?



Yes No

[11] TYPE OF IMAGING EQUIPMENT AVAILABLE ON-SITE Number 511 KeV coincidence Gamma camera Single photon tomography (SPET) Positron emission tomography (PET) 1 Clinical 2 Small animal Plant biochemistry [12] Are cyclotron radionuclides/labelled compounds used or planned to be used for



31

26


production

yield (GBq)

% Isotopic

enrichment

18O used


recycle18

OH2?

18

OH2 (ml) 18

O2 (ml) 18

OH2 (g) 18

O2 (l)

18O (p, n) 18F 4 Ci 95 2 Yes No


(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq 18FDG 75 250/year Yes No Yes No FTyrosine 11 12/year Yes No Yes No FDopa 11 12/year Yes No Yes No Yes No Yes No 11C RADIOPHARMACEUTICALS PRODUCED Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/

GBq


(list)

Typical yield on

batch (GBq)

Frequency of

production


sales

Price/

GBq


(list)


used

Price/

GBq

Water 0.37 4000/year OTHER ISOTOPES PRODUCED

Name

(list)

Yield on batch

(GBq)

Frequency of

production


sales

Price/


32

27

2005 COUNTRY: BELGIUM BEL-7 [1] INSTITUTE: University of Leuven (KUL)

Department of Nuclear Medicine, U.Z. Gasthuisberg Herestraat 49 B-3000 Leuven


+32 16 34 3715 [email protected] +32 16 34 3759


Luc Mortelmans, MD, PhD. Head of Nuclear Medicine



Negative ion YEAR OF: (I) INSTALLATION 1990

MANUFACTURER: IBA, s.a. (II) UPGRADE: MODEL: Cyclone 10/5 [4] CYCLOTRON CHARACTERISTICS: 1H 2H 3He 4He Dual Beams Beam energies (MeV) 10 5 Yes No Maximum beam available (A) 70 50 Typical beam employed (A) 45 10 [5] CYCLOTRON OPERATION: Total hours (h)/ week h/week for radionuclide

production

h/week for

research

h/week for

maintenance

h/week for

applications

5 4 0 1 0 [6] CYCLOTRON APPLICATIONS: h/week h/week Radiobiology: Radiography: Materials

directory of cyclotrons used for radionuclide production in member

Documents