1. Disclaimer: Due to issues with PowerPoint not complying, the replication fork at the end of the original strand has been left out.------------------------------------------------When you see a red box like so, stop proceeding into the stop motion so you can acquire valuable information for the presentation. Thank you in advance. -------------------------------------------------DNA Replication -This partBy Jake The Fresh Prince Dinger Himself. Ph.D

2. Lagging StrandLeading Strand------------------------------------------------First, the DNA helicase unwinds the DNA strand, separating it into the Leading, and the lagging strand.------------------------------------------------- Adenine - Phosphate - Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 3. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 4. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 5. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 6. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 7. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 8. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 9. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 10. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 11. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 12. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 13. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 14. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 15. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 16. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 17. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 18. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 19. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 20. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 21. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 22. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 23. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 24. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 25. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 26. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 27. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 28. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 29. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 30. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 31. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 32. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 33. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 34. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 35. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 36. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 37. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 38. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 39. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 40. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 41. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 42. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 43. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 44. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 45. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 46. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 47. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 48. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 49. Lagging StrandLeading StrandBomb- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 50. Lagging StrandLeading StrandBomb- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 51. Lagging StrandLeading StrandBomb- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 52. Lagging StrandLeading StrandBomb- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 53. Lagging StrandLeading StrandBomb- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 54. Lagging StrandLeading StrandBomb- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 55. Lagging StrandLeading StrandBomb- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 56. Lagging StrandLeading StrandBomb- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 57. Lagging StrandLeading StrandBomb- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 58. Lagging StrandLeading StrandBomb- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 59. Lagging StrandLeading StrandBomb- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 60. Lagging StrandLeading StrandBomb- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 61. Lagging StrandLeading Strand- Adenine Bomb- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 62. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- HelicaseBomb 63. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- HelicaseBomb 64. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- HelicaseBomb 65. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 66. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 67. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 68. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 69. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 70. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 71. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 72. Lagging StrandLeading Strand- Adenine- Phosphate- Cytosine- Sugar- Thymine- Backbone- Guanine- Helicase 73. Lagging StrandLeading Strand 74. Lagging StrandLeading Strand 75. Lagging StrandLeading Strand 76. Lagging StrandLeading Strand 77. Lagging StrandLeading Strand 78. Lagging StrandLeading Strand 79. Lagging StrandLeading Strand 80. Lagging StrandLeading Strand-----------------------------------------------Woah! That was a large explosion! Good thing the DNA wasnt affected. We know that could cause harmful mutations! ----------------------------------------------- 81. Lagging StrandLeading Strand-----------------------------------------------Woah! That was a large explosion! Good thing the DNA wasnt affected. We know that could cause harmful mutations! ----------------------------------------------- 82. Lagging StrandLeading Strand-----------------------------------------------Woah! That was a large explosion! Good thing the DNA wasnt affected. We know that could cause harmful mutations! ----------------------------------------------- 83. Lagging StrandLeading Strand-----------------------------------------------Woah! That was a large explosion! Good thing the DNA wasnt affected. We know that could cause harmful mutations! ----------------------------------------------- 84. Lagging StrandLeading Strand-----------------------------------------------Woah! That was a large explosion! Good thing the DNA wasnt affected. We know that could cause harmful mutations! ----------------------------------------------- 85. -------------------------------------------------We will start the pairing process with the leading strand. Fitting, huh?-------------------------------------------------- 86. -------------------------------------------------We will start the pairing process with the leading strand. Fitting, huh?-------------------------------------------------- 87. -------------------------------------------------We will start the pairing process with the leading strand. Fitting, huh?-------------------------------------------------- 88. -------------------------------------------------We will start the pairing process with the leading strand. Fitting, huh?-------------------------------------------------- 89. -------------------------------------------------We will start the pairing process with the leading strand. Fitting, huh?-------------------------------------------------- 90. -------------------------------------------------We will start the pairing process with the leading strand. Fitting, huh?-------------------------------------------------- 91. -------------------------------------------------We will start the pairing process with the leading strand. Fitting, huh?-------------------------------------------------- 92. -------------------------------------------------We will start the pairing process with the leading strand. Fitting, huh?-------------------------------------------------- 93. -------------------------------------------------We will start the pairing process with the leading strand. Fitting, huh?-------------------------------------------------- 94. -------------------------------------------------We will start the pairing process with the leading strand. Fitting, huh?-------------------------------------------------- 95. -------------------------------------------------We will start the pairing process with the leading strand. Fitting, huh?-------------------------------------------------- 96. -------------------------------------------------We will start the pairing process with the leading strand. Fitting, huh?-------------------------------------------------- 97. The enzyme Polymerase, reads each half-pair to find out which compliment is necessary. 98. The enzyme Polymerase, reads each half-pair to find out which compliment is necessary. 99. The enzyme Polymerase, reads each half-pair to find out which compliment is necessary. 100. The enzyme Polymerase, reads each half-pair to find out which compliment is necessary. 101. The enzyme Polymerase, reads each half-pair to find out which compliment is necessary. 102. The enzyme Polymerase, reads each half-pair to find out which compliment is necessary. 103. The enzyme Polymerase, reads each half-pair to find out which compliment is necessary. 104. The enzyme Polymerase, reads each half-pair to find out which compliment is necessary. 105. The enzyme Polymerase, reads each half-pair to find out which compliment is necessary. 106. The enzyme Polymerase, reads each half-pair to find out which compliment is necessary. 107. The enzyme Polymerase, reads each half-pair to find out which compliment is necessary. 108. The enzyme Polymerase, reads each half-pair to find out which compliment is necessary. 109. The enzyme Polymerase, reads each half-pair to find out which compliment is necessary. 110. The enzyme Polymerase, reads each half-pair to find out which compliment is necessary. 111. The enzyme Polymerase, reads each half-pair to find out which compliment is necessary. 112. The enzyme Polymerase, reads each half-pair to find out which compliment is necessary. 113. The enzyme Polymerase, reads each half-pair to find out which compliment is necessary. 114. The enzyme Polymerase, reads each half-pair to find out which compliment is necessary. 115. The enzyme Polymerase, reads each half-pair to find out which compliment is necessary. 116. The enzyme Polymerase, reads each half-pair to find out which compliment is necessary. 117. The enzyme Polymerase, reads each half-pair to find out which compliment is necessary. 118. The enzyme Polymerase, reads each half-pair to find out which compliment is necessary. 119. The enzyme Polymerase, reads each half-pair to find out which compliment is necessary. 120. The enzyme Polymerase, reads each half-pair to find out which compliment is necessary. 121. ------------------------------The compliment is then made and put into place. ------------------------------- 122. ------------------------------The compliment is then made and put into place. ------------------------------- 123. ------------------------------The compliment is then made and put into place. ------------------------------- 124. ------------------------------The compliment is then made and put into place. ------------------------------- 125. ------------------------------The compliment is then made and put into place. ------------------------------- 126. ------------------------------The compliment is then made and put into place. ------------------------------- 127. ------------------------------The compliment is then made and put into place. ------------------------------- 128. ------------------------------The compliment is then made and put into place. ------------------------------- 129. ------------------------------The compliment is then made and put into place. ------------------------------- 130. ------------------------------The compliment is then made and put into place. ------------------------------- 131. ------------------------------The compliment is then made and put into place. ------------------------------- 132. ------------------------------We have now successfully Created a new DNA Molecule! ------------------------------- 133. ------------------------------We have now successfully Created a new DNA Molecule! ------------------------------- 134. ------------------------------We will now move on to The lagging strand ------------------------------- 135. ------------------------------We will now move on to The lagging strand ------------------------------- 136. ------------------------------We will now move on to The lagging strand ------------------------------- 137. ------------------------------We will now move on to The lagging strand ------------------------------- 138. ------------------------------The lagging strand is now In small sections known As Okazaki Fragments. ------------------------------- 139. ------------------------------The lagging strand is now In small sections known As Okazaki Fragments. ------------------------------- 140. ------------------------------The lagging strand is now In small sections known As Okazaki Fragments. ------------------------------- 141. ------------------------------The lagging strand is now In small sections known As Okazaki Fragments. ------------------------------- 142. ------------------------------The lagging strand is now In small sections known As Okazaki Fragments. ------------------------------- 143. ------------------------------The lagging strand is read And complimented just as The Leading strand was Moments ago.------------------------------- 144. ------------------------------The lagging strand is read And complimented just as The Leading strand was Moments ago.------------------------------- 145. ------------------------------The lagging strand is read And complimented just as The Leading strand was Moments ago.------------------------------- 146. ------------------------------The lagging strand is read And complimented just as The Leading strand was Moments ago.------------------------------- 147. ------------------------------The lagging strand is read And complimented just as The Leading strand was Moments ago.------------------------------- 148. ------------------------------The lagging strand is read And complimented just as The Leading strand was Moments ago.------------------------------- 149. ------------------------------The lagging strand is read And complimented just as The Leading strand was Moments ago.------------------------------- 150. -------------------------------Then, after the lagging strand is complimented the enzyme Ligase, seals off the spaces between the fragments------------------------------- 151. -------------------------------Then, after the lagging strand is complimented the enzyme Ligase, seals off the spaces between the fragments------------------------------- 152. -------------------------------Then, after the lagging strand is complimented the enzyme Ligase, seals off the spaces between the fragments------------------------------- 153. -------------------------------Then, after the lagging strand is complimented the enzyme Ligase, seals off the spaces between the fragments------------------------------- 154. -------------------------------Then, after the lagging strand is complimented, the enzyme Ligase, seals off the spaces between the fragments------------------------------- 155. And so it was, first there was one strand of DNA, then there were two, identical strands of DNA. 156. However, we cant forget that the DNA is supposed to be in a helix, twisted ladder, form. Due to the difficulty of doing such a thing, it has been left out, but not forgotten. 157. On a side note, it is nowrealized that there is a mistake in my work. I have accidently paired the orange Adenine, with the blue Cytosine. As well as Guanine with Thymine. After 163 slides, I hope you can omit this error after I have shown that I realize this is incorrect. Thank you for Viewing. 158. Brief Summary of DNA Replication DNA replication occurs in the step just before Mitosis, known as Interphase. DNA Replication is the process by which Cells divide, and make exact copies of themselves in order to heal, grow or other utilities. 159. Telomere This is a unit that lies at the end of a chromosome to prevent the disaster of two chromosomes from becoming stuck together by their ends. Okazaki Fragment This is a section of the lagging strand that is synthesized (put together) by the enzyme Ligase to create one strand of DNA 160. DNA Ligase This is an enzyme that puts together the Okazaki fragments to form a single strand of DNA. Telomerase This is an enzyme that allows certain organisms to maintain their telomeres at the same length. Cancer Cancer is a devastating disease in which a persons cells of a certain area are produced incorrectly, then these cells are dividing rapidly causing large amounts of cell death. 161. Cell Transplant This is the process by which the diseased, or damaged cells of the body are replaced by healthy, functioning cells. Cloning This is when the nucleus of an egg cell from a female animal of the same species is stripped of its nucleus, then supplemented with the nucleus of the soon to be cloned animal. 162. Aging This is when cells slow down their rate of Mitosis and begin to die off.