MONTHLY INTELLIGENCE | UPCOMING EVENTS | MEDIA DIRECTORY | CONFERENCES

MONTHLY HEALTHCARE NEWSLETTER - JUNE 2020A GLOBAL LEADER IN STRATEGIC HEALTHCARE COMMUNICATIONSLondon | New York | Boston | San Francisco

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DIGITAL THERAPEUTICS A NEW FRONTIER IN PATIENT CARE

Working within the space of substance use disorder and mental health we have long realised that access to both medical treatment and psychological support is critical for patients The COVID-19 pandemic has added further urgency to this need Though recent years have seen some improvements in terms of access to care in the US largely as a response to the ongoing opioid crisis there is still a high unmet need due to the lack of specialist services such as qualified counselling in the first few crucial months of treatment which is exactly where digital therapeutics fit in

Digital therapeutics are evidence-based therapeutic interventions driven by high quality software programs to prevent manage or treat patients with a broad spectrum of physical mental and behavioural conditions These new and innovative treatment options offer obvious benefits in terms of convenience and ease of access for patients but most importantly have the potential to be a game-changing development especially within mental health to extend access to treatment to a much wider patient population Digital therapies give developers operating in the space such as Orexo the ability to push beyond existing treatment regimens to deliver innovative solutions to provide much needed psychological care with highly sophisticated and individualised support 247

As the impact of COVID-19 continues to affect us all globally the digital therapeutics space is advancing rapidly as the need for digital solutions becomes more acute It has also presented the opportunity to accelerate

the adoption of new technologies including video conferencing and digital health leading to improved patient outcomes In April the FDA took the encouraging step of proactively introducing an emergency policy for digital therapeutics The policy aims to expand the availability of digital health therapeutic devices for psychiatric disorders to facilitate consumer use while reducing contact and potential exposure to COVID-19

The potential breadth of the digital therapeutics space is enormous Over the last ten months Orexo has acquired exclusive US rights to products offering treatments in what we see as three key areas that have great potential to digital therapies opioid use disorder (OXD01) alcohol misuse (vorvidareg) and most recently depression (deprexisreg) All three therapies are backed by our partner GAIA AG using their proprietary artificial intelligence expert system brocareg The technology will enable the provision of tailored therapeutic support by stimulating effective up-to-date and personalised cognitive behavioural therapy interventions

Digital therapeutics are already set to become one of the most exciting and rapidly growing areas of the life sciences industry this decade and we are excited to play a part in shaping the future of this industry

Orexo develops improved pharmaceuticals and digital therapies mainly within the growing space of substance use disorder and mental health The Companyrsquos lead product Zubsolvreg is commercialised by its sales force in the US for the treatment of opioid use disorder

EUROPEAN MEDISCIENCE AWARDS SHORTLIST ANNOUNCED

Congratulations to all nominees shortlisted for the 2020 European Mediscience Awards who have been recognised for their achievements over the past year

We are particularly pleased for our clientshellip

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THIS MONTHrsquoS MOVERS AND SHAKERS

CONNAUGHT ROOMS WC2B19 NOVEMBER

If you would like to receive our Monday Healthcare Bulletin which summarises all healthcare business news from the weekend please contact

admincscconsilium-commscom

ndash Oxford Biomedica announced that Dr Roch Doliveux will join as Chairman from 24 June 2020

ndash Vectura appointed Trevor Archbold Robert Gurley and Chris Vernall as Business Development Directors

ndash Radius Health appointed Kelly Martin as CEO

ndash Targovax appointed Victor Levitsky as CSO ndash Rome Therapeutics appointed Rosana Kapelier as CEO

ndash Anika Therapeutics appointed Cheryl Blanchard as president and CEO

ndash Xilio Therapeutics appointed Martin Huber as CMO

ndash Saniona appointed Rudolf Baumgartner as CMO

ndash Mirum Pharmaceuticals appointed Peter Radovich as COO

ndash Galecto appointed Jonathan Freve as CFO

ndash Aurinia Pharmaceuticals appointed Joe Miller as CFO

ndash ProBioGen AG appointed Lutz Hilbrich as CEO

ndash Semma Therapeutics appointed David Lebwohl as CMO

ndash Johnson amp Johnson appointed Najat Khan as Chief Data Officer

ndash Icon appointed Kristen Buck as CMO ndash Enteris Biopharma appointed Rajiv Khosla as CEO

ndash Cardiff Oncology appointed Mark Erlander as CEO

ndash Deinove appointed Alexis Rideau as CEO ndash FogPharma appointed Tony Gibney as CFO and CBO

ndash Immunocore appointed Brian Di Donato as CFO

ndash Horama appointed Ian Catchpole as CSO ndash HealthReveal appointed Julie Stern as CTO

ndash VuMedi appointed Dan Mosher as its COO

ndash Aruvant Sciences appointed Joseph McIntosh as CMO

ndash Bolt Biotherapeutics appointed William Quinn as CFO

ndash Celsius Therapeutics appointed Jeanne Magram as CSO

ndash Lodo Therapeutics appointed Donald Marvin as executive VP and CFO

ndash Antibe Therapeutics appointed Joseph Stauffer as CMO

ndash Phoenix Tissue Repair appointed Hal Landy and Deborah Ramsdell as CMO and COO respectively

ndash Wellcome Leap appointed Regina Dugan as CEO

ndash Aktana appointed Pini Ben-Or as CSO Colm Callan as CFO and Kate Terrell as chief people officer

ndash Pandion Therapeutics appointed John Sundy as CMO

ndash Merck appointed Matthew Walsh as CFO and Rachel Stahler as Chief Information Officer

ndash Evox Therapeutics appointed Sonya Montgomery as CMO

ndash Mirati Therapeutics appointed Joseph Leveque as CMO

ndash AgeX Therapeutics appointed Andrea Park as CFO

ndash Flagship Biosciences appointed Aymii Couzelis as Chief Information Officer

ndash Ipsen appointed David Loew as CEO

MONTHLY INTELLIGENCE

MEDIA MOVES ndash Harriet Clarfelt is now covering the healthcare sector at Investors Chronicle

CONSILIUM STAFFS CHARITY INITIATIVES

At Consilium we are profoundly committed to diversity inclusiveness amp equal treatment of all people We will continue to listen and work to foster change towards an equitable world

You can join us and donate to the George Floyd Memorial Fund here

HIGHLIGHTED FUNDRAISING ACTIVITY FROM MAY TO JUNE 2020

COMPANY NAME AMOUNT RAISED

TYPE OF FUNDRAISE COUNTRY DATE

PUBLIC COMPANY FINANCINGS

Insmed $2255 million Follow-on US 7-May-20

TG Therapeutics $60 million Private Placement US 7-May-20

BerGenBio $487M Private Placement Norway 7-May-20

Ayala Pharmaceuticals $55 million Postmoney Valuation US 9-May-20

MyoKardia $5513 million Follow-on US 14-May-20

ADC Therapeutics $2327 million IPO US 14-May-20

Bellerophon Therapeutics $40 million Follow-on US 18-May-20

bluebird bio $500 million Follow-on US 18-May-20

Clovis Oncology $893 million Follow-on US 18-May-20

Gamida Cell $60 million Follow-on US 18-May-20

Gossamer Bio $125 million Follow-on US 18-May-20

Krystal Biotech $1251 million Follow-on US 18-May-20

Moderna $13 billion Follow-on US 18-May-20

Turning Point Therapeutics $325 million Follow-on US 18-May-20

Applied Molecular Transport $100 million IPO US 20-May-20

Atara Biotherapeutics $1755 million Follow-on US 28-May-20

Geron $150 million Follow-on US 28-May-20

Poxel SA $193 million Private Placement France 28-May-20

argenx $750 million Follow-on Belgium 28-May-20

Arena Pharmaceuticals $275 million Follow-on US 29-May-20

Viela Bio $169 million Follow-on US 29-May-20

BioCryst Pharmaceuticals $100 million Follow-on US 29-May-20

Mersana Therapeutics $152 million Follow-on US 30-May-20

PRIVATE COMPANY FINANCINGS

Dascena $50 million Series B US 2-May-20

Medable $25 million Private Offering US 5-May-20

Grail $390 million Series D US 7-May-20

Limbix $9 million Series A US 7-May-20

Kineta $5 million Private Round US 7-May-20

Travecta Therapeutics $15 million Series A US 14-May-20

SQZ Biotechnologies $65 million Series D US 19-May-20

Cowen Healthcare Investments $493 million Fund Close US 20-May-20

Guangzhou BeBetter Medicine Technology Undisclosed Series A China 20-May-20

Fountain Therapeutics $6 million Series A-1 US 20-May-20

Amplyx Pharmaceuticals $53 million Series C US 20-May-20

ChromaCode $10 million Series C US 20-May-20

Rallybio $145 million Series B US 20-May-20

Rapid Micro $120 million Debt and Equity US 20-May-20

Atea Pharmaceuticals $215 million Series D US 21-May-20

HotSpot Therapeutics $65 million Series B US 21-May-20

Nautilus Biotechnology $76 million Series B US 22-May-20

insitro $143 million Series B US 26-May-20

Exscientia $60 million Series C UK 28-May-20

Arvelle Therapeutics $427 million Final Tranche Switzerland 28-May-20

ViaCyte $27 million Series D US 28-May-20

Accure Therapeutics $83 million Series A Spain 28-May-20

Tollys $25 million Series A France 28-May-20

AbCellera Biologics $105 million Series B Canada 28-May-20

Ginkgo Bioworks $70 million Private Round US 28-May-20

Source BioCentury

INVESTOR CONFERENCE EVENT CALENDAR

2020

JUNE Next Generation CAR amp T Cell Therapies San Francisco (Rescheduled to November) Piper Jaffray Heartland Summit Minneapolis (Cancelled) Biotech CEO Summit Europe (Cancelled)

JULYBiotech CEO Summit Napa Napa (Cancelled) BIO Asia Taiwan (22-26 July) - NOW A DIGITAL EVENT

AUGUSTCanaccord Genuity Annual Growth Conference Boston (11-13 August) - NOW A DIGITAL EVENT

SEPTEMBERRW Baird Healthcare Conference New York (4-5 September)Citi 15th Annual BioPharma Conference Boston (9-10 September)Goldman Sachs Annual Biotech Symposium London (11 September)Morgan Stanley Global Healthcare Conference New York (14-16 September) CAR-TCR Summit Boston 2020 Boston (14-17 September) Cantor Global Healthcare Conference New York (15-17 September)BAML Global Healthcare Conference London (16-17 September) Cell amp Gene Therapy Manufacturing and Commercialization Boston (21-24 September)Boston Biotech Week Boston (21-24 September)Boston BioTech BD Conference Boston (21-24 September) Annual HealthTech Investment Forum Basel (22 September)Sachs 20th Annual Biotech in Europe Forum Basel (23-24 September) Ladenburg Thalman Healthcare Conference New York (26 September)Rodman amp Renshaw Annual Global Investment Conference New York (TBD)BioCentury Annual Newsmakers in the Biotech Industry New York (TBD)

OCTOBERLSX World Congress USA Boston (7 October)BIO Investor Forum 2020 San Francisco (13-14 October)ARM Cell amp Gene meeting on the Mesa Carlsbad (14-16 October)BIO-Europe 2020 Hamburg (26-28 October)BIA UK Bioscience Forum London (TBD)Cowen amp Co Annual Therapeutics Conference New York (TBD)

NOVEMBERBIO Latin America Brazil (Cancelled)FT Global Pharmaceutical and Biotechnology Conference London (9-10 November) European Mediscience Awards London (10 November)Credit Suisse Annual Healthcare Conference Scottsdale (9-11 November)Consilium Strategic Communications Annual Healthcare Conference London (16 November)Inveuro$tival Showcase London (16 November)Bryan Garnier amp Co 2020 Healthcare Conference Paris (16-17 November) Stifel Nicolaus Weisel Healthcare Conference 2020 New York (17-18 November)Jefferies Annual Healthcare Conference London (17-19 November)

DECEMBERBerenberg Bank Annual European Conference Surrey (30 November-3 December)Piper Jaffray Annual Healthcare Conference New York (1-3 December)Forbes Healthcare Summit New York (TBD)Citibank Global Healthcare Conference New York (TBD)

INVESTOR CONFERENCE EVENT CALENDAR

2020

JUNE Next Generation CAR amp T Cell Therapies San Francisco (Rescheduled to November) Piper Jaffray Heartland Summit Minneapolis (Cancelled) Biotech CEO Summit Europe (Cancelled)

JULYBiotech CEO Summit Napa Napa (Cancelled) BIO Asia Taiwan (22-26 July) - NOW A DIGITAL EVENT

AUGUSTCanaccord Genuity Annual Growth Conference Boston (11-13 August) - NOW A DIGITAL EVENT

SEPTEMBERRW Baird Healthcare Conference New York (4-5 September)Citi 15th Annual BioPharma Conference Boston (9-10 September)Goldman Sachs Annual Biotech Symposium London (11 September)Morgan Stanley Global Healthcare Conference New York (14-16 September) CAR-TCR Summit Boston 2020 Boston (14-17 September) Cantor Global Healthcare Conference New York (15-17 September)BAML Global Healthcare Conference London (16-17 September) Cell amp Gene Therapy Manufacturing and Commercialization Boston (21-24 September)Boston Biotech Week Boston (21-24 September)Boston BioTech BD Conference Boston (21-24 September) Annual HealthTech Investment Forum Basel (22 September)Sachs 20th Annual Biotech in Europe Forum Basel (23-24 September) Ladenburg Thalman Healthcare Conference New York (26 September)Rodman amp Renshaw Annual Global Investment Conference New York (TBD)BioCentury Annual Newsmakers in the Biotech Industry New York (TBD)

OCTOBERLSX World Congress USA Boston (7 October)BIO Investor Forum 2020 San Francisco (13-14 October)ARM Cell amp Gene meeting on the Mesa Carlsbad (14-16 October)BIO-Europe 2020 Hamburg (26-28 October)BIA UK Bioscience Forum London (TBD)Cowen amp Co Annual Therapeutics Conference New York (TBD)

NOVEMBERBIO Latin America Brazil (Cancelled)FT Global Pharmaceutical and Biotechnology Conference London (9-10 November) European Mediscience Awards London (10 November)Credit Suisse Annual Healthcare Conference Scottsdale (9-11 November)Consilium Strategic Communications Annual Healthcare Conference London (16 November)Inveuro$tival Showcase London (16 November)Bryan Garnier amp Co 2020 Healthcare Conference Paris (16-17 November) Stifel Nicolaus Weisel Healthcare Conference 2020 New York (17-18 November)Jefferies Annual Healthcare Conference London (17-19 November)

DECEMBERBerenberg Bank Annual European Conference Surrey (30 November-3 December)Piper Jaffray Annual Healthcare Conference New York (1-3 December)Forbes Healthcare Summit New York (TBD)Citibank Global Healthcare Conference New York (TBD)

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Trusted long-term relationships with clients

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19 November Connaught Rooms WC2B