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International Journal of Case Reports and Images, Vol. 11, 2020. ISSN: 0976-3198 Int J Case Rep Images 2020;11:101099Z01FV2020. www.ijcasereportsandimages.com Vieira et al. 1 CASE REPORT PEER REVIEWED | OPEN ACCESS Differential diagnosis, three-dimensional imaging aspects and interceptive orthodontic management of molar–incisor malformation Fernanda Gabriela de Fátima Vieira, Andréa Vaz Braga Pintor, Aline Corrêa Abrahão, Antônio Carlos de Oliveira Ruellas, Maria Augusta Visconti, Laura Guimarães Primo ABSTRACT Introduction: Molar–incisor malformation is a condition described in 2014, with few reports in the literature and characterized by atypical root formation in incisors and first permanent molars. Case Report: We report a case of an 8-year-old patient with central incisors and upper and lower first permanent molars with short roots and open apexes, situation not compatible with the chronological age. The patient was evaluated clinically, radiographically, and by blood tests. Anatomopathological analyses of a primary tooth were performed. Computed tomography (CT) was used to evaluate root development of first permanent molars and incisors and compare, by superimposition, the radicular aspect of affected with unaffected teeth of a control patient of the same sex and age. Fernanda Gabriela de Fátima Vieira 1 , Andréa Vaz Braga Pintor 1 , Aline Corrêa Abrahão 2 , Antônio Carlos de Olivei- ra Ruellas 1,3 , Maria Augusta Visconti 2 , Laura Guimarães Primo 1 Affiliations: 1 Department of Pediatric Dentistry and Ortho- dontics, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; 2 Department of Pathol- ogy and Oral Diagnosis, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; 3 Depart- ment of Orthodontics, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA. Corresponding Author: Laura Guimarães Primo, Faculdade de Odontologia da UFRJ, Departamento de Odontopediatria, Rua Professor Rodolpho Paulo Rocco, 325, Cidade Univer- sitária, Rio de Janeiro, RJ, CEP: 21941-617, Brazil; Email: [email protected] Received: 24 October 2019 Accepted: 08 January 2020 Published: 18 February 2020 Clinically, the patient presented tongue-thrust habit, central incisors with premature contact and abnormal mobility, and enamel hypoplasia at teeth #8 and #24. Imaging exams showed teeth #3, #8, #9, #14, #19, #24, #25, and #30 with short roots and open apexes. One year follow-up CT images evidenced absence of root development of these teeth and thin roots walls, especially at the incisors. Interceptive orthodontic treatment with fixed palatal crib was performed. Conclusion: This report showed the importance of early diagnosis and treatment of molar–incisor malformation patients. Keywords: Dentition, Molar, Oral, Pathology, Permanent, Tooth abnormalities, Tooth dis- eases How to cite this article Vieira FGF, Pintor AVB, Abrahão AC, Ruellas ACO, Visconti MA, Primo LG. Differential diagnosis, three-dimensional imaging aspects and interceptive orthodontic management of molar– incisor malformation. Int J Case Rep Images 2020;11:101099Z01FV2020. Article ID: 101099Z01FV2020 ********* doi: 10.5348/101099Z01FV2020CR INTRODUCTION Dental anomalies are caused by complex interactions between genetics, epigenetics, and environmental

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Page 1: Differential diagnosis, three-dimensional imaging aspects ......lingual surfaces of the #8 and #9 teeth, in order to remove the premature contact with antagonists, which could

International Journal of Case Reports and Images, Vol. 11, 2020. ISSN: 0976-3198

Int J Case Rep Images 2020;11:101099Z01FV2020. www.ijcasereportsandimages.com

Vieira et al. 1

CASE REPORT PEER REVIEWED | OPEN ACCESS

Differential diagnosis, three-dimensional imaging aspects and interceptive orthodontic management of molar–incisor

malformation

Fernanda Gabriela de Fátima Vieira, Andréa Vaz Braga Pintor, Aline Corrêa Abrahão, Antônio Carlos de Oliveira Ruellas,

Maria Augusta Visconti, Laura Guimarães Primo

ABSTRACT

Introduction: Molar–incisor malformation is a condition described in 2014, with few reports in the literature and characterized by atypical root formation in incisors and first permanent molars. Case Report: We report a case of an 8-year-old patient with central incisors and upper and lower first permanent molars with short roots and open apexes, situation not compatible with the chronological age. The patient was evaluated clinically, radiographically, and by blood tests. Anatomopathological analyses of a primary tooth were performed. Computed tomography (CT) was used to evaluate root development of first permanent molars and incisors and compare, by superimposition, the radicular aspect of affected with unaffected teeth of a control patient of the same sex and age.

Fernanda Gabriela de Fátima Vieira1, Andréa Vaz Braga Pintor1, Aline Corrêa Abrahão2, Antônio Carlos de Olivei-ra Ruellas1,3, Maria Augusta Visconti2, Laura Guimarães Primo1

Affiliations: 1Department of Pediatric Dentistry and Ortho-dontics, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; 2Department of Pathol-ogy and Oral Diagnosis, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; 3Depart-ment of Orthodontics, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA.Corresponding Author: Laura Guimarães Primo, Faculdade de Odontologia da UFRJ, Departamento de Odontopediatria, Rua Professor Rodolpho Paulo Rocco, 325, Cidade Univer-sitária, Rio de Janeiro, RJ, CEP: 21941-617, Brazil; Email: [email protected]

Received: 24 October 2019Accepted: 08 January 2020Published: 18 February 2020

Clinically, the patient presented tongue-thrust habit, central incisors with premature contact and abnormal mobility, and enamel hypoplasia at teeth #8 and #24. Imaging exams showed teeth #3, #8, #9, #14, #19, #24, #25, and #30 with short roots and open apexes. One year follow-up CT images evidenced absence of root development of these teeth and thin roots walls, especially at the incisors. Interceptive orthodontic treatment with fixed palatal crib was performed. Conclusion: This report showed the importance of early diagnosis and treatment of molar–incisor malformation patients.

Keywords: Dentition, Molar, Oral, Pathology, Permanent, Tooth abnormalities, Tooth dis-eases

How to cite this article

Vieira FGF, Pintor AVB, Abrahão AC, Ruellas ACO, Visconti MA, Primo LG. Differential diagnosis, three-dimensional imaging aspects and interceptive orthodontic management of molar–incisor malformation. Int J Case Rep Images 2020;11:101099Z01FV2020.

Article ID: 101099Z01FV2020

*********

doi: 10.5348/101099Z01FV2020CR

INTRODUCTION

Dental anomalies are caused by complex interactions between genetics, epigenetics, and environmental

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factors during the long period of dental development, and may manifest individually, as a group or as a whole [1]. Morphologically, tooth development begins with thickening of the dental epithelium to form a structure known as dental lamina. Within this band of thickened epithelium, the cells begin to proliferate and invaginate in certain positions to form the placodes, leading to the odontogenesis stages of bud, cap, and bell [2]. The epithelial–mesenchymal interaction is a normal and necessary event during odontogenesis [3], being susceptible to errors due to the complexity of the molecular processes involved.

Molar–incisor malformation (MIM) or molar root–incisor malformation (MRIM) is a condition described in 2014 [4] and characterized by atypical root formation in incisors and first permanent molars. Few reports are found in the literature [4–12]. Its etiology remains unknown and the phenotype varies according to its severity [7]. As clinical and imaging aspects are observed first permanent molars and, in some cases, primary second molars with normal crowns and thin, narrow, short, or even absent roots. Meanwhile, upper central incisors may exhibit, in addition to the abnormal root formation, hypoplastic enamel areas near the cervical third of the clinical crowns [4]. The dental team should be aware of this condition, aiming to perform the correct diagnosis, treatment plan, and control in order to prevent infections, painful conditions, and early loss of affected teeth [7].

The objective of this study was to present the clinical, radiographic and tomographic aspects, and the unprecedented three-dimensional (3D) superimposition images of first permanent molars and incisors affected by MIM, comparing them to those of an unaffected patient, highlighting the differential diagnosis, clinical and orthodontic interceptive management.

CASE REPORT

This report was approved by Ethical Committee of Hospital Universitário Clementino Fraga Filho—Universidade Federal do Rio de Janeiro (Opinion Number 3.451.539) and prepared according to the CARE Statement (CARE-Statement.org). Teeth are designated with the Universal Numbering System.

An 8-year-old black male patient was referred to Pediatric Dental Clinic of the Department of Pediatric Dentistry and Orthodontics of the Universidade Federal do Rio de Janeiro (UFRJ), by the Unified Health System (SUS), due to “a possible dentin alteration characterized by differentiated root formation in permanent teeth.”

Medical historyMedical history during pregnancy could not

be confirmed, although the adoptive parents have reported abortion attempts. General health, after birth,

was considered to be good by clinical and laboratory routine tests (Hemogram, Iron, Vitamin B12, T3, FT4, TSH, Vitamin D, and Folic Acid), assessments by the pediatrician. The parents presented the exam results within the normal standards and medical report at the initial dental appointment.

Dental historyParents reported object-biting habit and no previous

history of dental trauma.

Clinical examinationOn general physical examination we observed that the

patient had the weight and height relationship compatible with age, according to the growth curves proposed by the World Health Organization and confirmed at the medical report.

At intraoral clinical examination it was observed that the patient was in the first transitional period of mixed dentition, with overbite decreased due to tongue-thrust habit and short overjet, causing premature contact between the upper and lower permanent central incisors, which also presented with a slight degree of mobility. Caries lesions were not observed. Both permanent central incisors presented white lesions compatible with fluorosis. Enamel hypoplasia was observed on teeth #8 and #24 on their mesial and buccal surfaces, respectively (Figure 1). Periodontal examination showed no changes in probing depth.

Radiographic findingsThe panoramic radiograph showed central incisors

and upper and lower first permanent molars with short roots and open apexes (Figure 2), evidencing that the dental development was not compatible with the chronological age.

Differential diagnosisThe diagnostic hypotheses for the altered pattern of

root formation were Hypophosphatasia, Dentin Dysplasia Type I, MIM and Papillon–Lefréve syndrome. The latter was discarded since there were no episodes of fever, spots

Figure 1: (A) Initial clinical aspect: decreased overbite. (B) Enamel hypoplasia presents on teeth #8 and #24, on the mesial and buccal surfaces, respectively.

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on the skin, and the neutrophils count was within normal limits (2.580/mm³). Hypophosphatasia hypothesis was ruled out since a new blood test showed normal levels of alkaline phosphatase (573 U/L). The involvement of only one group of teeth and the presence of enamel hypoplasias in upper and lower permanent incisors associated with the root malformation process led to the diagnostic of molar–incisor malformation.

Dental managementThe patient was submitted to dental prophylaxis and

topical application of fluoride. Oral hygiene instructions and dietary advice were given by dental team. Occlusal adjustment was performed with a diamond bur on the lingual surfaces of the #8 and #9 teeth, in order to remove the premature contact with antagonists, which could be influencing in the tooth mobility observed. Then, interceptive orthodontic treatment was started with a fixed palatal crib and the patient was referred for speech therapy, aiming to prevent and correct the tongue-thrust and object-biting habits. After six months, it was possible to observe a significant improvement in the overbite and overjet (Figure 3); however, mobility in the upper and lower permanent central incisors remained, probably due to the low root formation associated with these teeth.

Anatomopathological findingsBoth primary mandibular lateral incisors were

surgically removed since the physiological rhizolysis did not occur, even after the eruption of the successor

permanent teeth. Although unaffected by MIM, the extracted primary teeth were submitted to anatomopathologic analysis. The gross specimen evaluation of teeth did not show any surface or shape alterations. One tooth was decalcified in 4.13% ethylenediaminetetraacetic acid (EDTA), hematoxylin-eosin stained, and microscopically evaluated in a light microscope (Olympus BX41, Tokyo, Japan). Normal tubular dentin was observed, underlined by a columnar odontoblastic layer. Inside the pulp chamber a loose connective tissue was present with blood vessels and nerves. The lack of dentin alterations suggested that, in this patient, MIM was only associated to the permanent dentition.

Tomographic findingsCone-beam computed tomography (CBCT) was

performed one year after the last panoramic radiograph, with the purpose of monitoring and accurate volumetric evaluation of the affected teeth and adjacent structures. The images obtained showed no evolution in the root formation process of the permanent teeth in question, first molars and incisors. It was possible to observe that the affected teeth presented thinned dentinal faces at the root portion, being this aspect still more accentuated in the incisors. Teeth #8 and #9 presented large pulp chambers, with a hypodense image associated with the mesial root surfaces in cervical and middle thirds (Figure 4), suggesting an incomplete formation/resorptive process. In the sagittal reconstructions it was possible to detect the maintenance of the spaces corresponding to the periodontal ligaments, incomplete radicular apexes formation in all the involved teeth and alteration of the root morphology in the incisors, characterized by enlarged pulp chambers and root canals.

Figure 2: Initial panoramic radiograph, evidencing the incomplete root formation of the central incisors and upper and lower first permanent molars.

Figure 3: (A) Immediate clinical appearance after installation of the fixed palatal crib. (B) Clinical aspect after six months of interceptive orthodontics, evidencing a considerable improvement in the overbite.

Figure 4: Tomographic reconstructions evidencing altered conditions of the molars and incisors one year after the initial panoramic radiograph. (A) Panoramic reconstruction. (B)–(K) Oblique reconstructions of teeth #3, #8, #9, #14, #19, #23, #24, #25, #26, #30, respectively.

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Tomographic images superimpositionIn order to evidence the magnitude of the present root

malformation, the CBCT images were superposed using the ITK-Snap v. 2.2 (Penn Image Computing and Science Laboratory, Philadelphia, PA; http://www.itksnap.org/) and 3-D Slicer (http://www.slicer.org/). Segmentations and 3D surface models were created for upper incisors and first permanent molars. Best-fit overlay of the images was performed comparing the images obtained in the present case with those already existing, acquired in an image bank, of a patient of the same sex and age (control). The images were leveled at the cementum enamel junction. It was observed that permanent first molars and incisors presented incomplete root formation, with open and wide root apexes. For the incisors, it was also observed an altered proportion between crown and root size (Figure 5).

DISCUSSION

The process of permanent tooth formation begins in intrauterine life and any serious systemic alterations occurring between pregnancy and the first two to three years of life may affect the formation of first molars and incisors [7], as observed by Lee et al. (2014) [4], who described the process of atypical root formation in these teeth and called it as MIM. In this same year, Witt et al. [6]

reported two cases of patients with poor root formation in the first permanent molars, who had a medical history marked by hospitalization due to premature birth and severe infection at nine months old. Alterations, such as meningitis, myelomeningocele, chronic renal failure [10],

and severe health problems in the head and neck regions at the onset of life, were also observed in patients with MIM [7].

In the present case, even in the absence of systemic factors associated with the general health of the patient during his first three years of life, there were reports of a troubled gestation. This fact suggests that may exist an association between the environmental stressors experienced in his early life and the root molar malformations and incisor constrictions [7]. It is known that genetic and epigenetic factors can also influence the process of root development [3, 7, 11], but one limitation

of the present report was the impossibility of carrying out genetic tests.

The worldwide prevalence of this newly described condition is still unknown [7]. Based on all the studies published to date [4–12] this seems to be the first report of MIM in a child in South America. Bilateral symmetry [8] and variable phenotype according to its severity are characteristics of MIM. The present patient showed bilateral symmetry involvement in addition to the poor root formation of the permanent first molars and incisors. Furthermore, an aspect of taurodontism at the lower first permanent molars, as described by Brusevold et al. (2017) [7], was observed. However, the second primary molars were unaffected, although these teeth may, eventually, be affected by this condition [4, 7, 8, 10], since their formation process occurs at a period similar to that of incisors and first permanent molars.

The altered characteristics evidenced in two-dimensional (2D) radiographic examinations are sufficient to detect this condition [8]. However, CBCT which provides more accurate root measurements and greater sensitivity and specificity than panoramic or 2D radiographs in detecting root resorption [13] is an important tool for the diagnosis and strategic planning of affected teeth by this condition [5, 6, 8, 11]. The overlapping and segmentation of the tomographic images allowed comparing the radicular portions of affected teeth by MIM with one from a control patient without the alteration. Even though, due to ethics limitation, it was not possible to match the case with a patient with similar crown proportions, the superimposed images enabled the visualization, in detail, of the irregularities present on the root surfaces, in a way not yet described in the literature. Although alterations in the pulp chamber have already been observed in some studies [5, 8, 11], it is important to emphasize the presence of other alterations, such as exacerbated thinning of the dentinal faces of the root portion, enlargement of the root canal, alteration in the root morphology (rounded aspect), and resorptive aspect of the root dentin.

Interceptive orthodontic management, performed during the establishment of the permanent denture in a patient with different types of root malformation, was shown to be relevant [14], by allowing the interception of deleterious habits and promoting improvement in overbite and overjet. We believe, without the orthodontic and speech intervention, that the maintenance of the permanent incisors with MIM in their respective arches would be compromised, due to the overload produced by the tongue-thrust habit.

CONCLUSION

Molar–incisor malformation is an unusual condition and reports using new methodologies, such as the overlapping of tomographic images, are important to elucidate the knowledge of other professionals, allowing

Figure 5: Segmented and overlapping volumetric images where the red portions refer to the control patient. (A) and (B) Front view. (C) Oblique view. (D) Superior view.

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a better understanding of this alteration, early diagnosis, correct treatment approach, and preservation of such teeth, as well as for the establishment of the prevalence.

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2. Bei M. Molecular genetics of tooth development. Curr Opin Genet Dev 2009;19(5):504–10.

3. Cobourne MT, Sharpe PT. Diseases of the tooth: The genetic and molecular basis of inherited anomalies affecting the dentition. Wiley Interdiscip Rev Dev Biol 2013;2(2):183–212.

4. Lee HS, Kim SH, Kim SO, et al. A new type of dental anomaly: Molar-incisor malformation (MIM). Oral Surg Oral Med Oral Pathol Oral Radiol 2014;118(1):101–9.e3.

5. Yue W, Kim E. Nonsurgical endodontic management of a molar-incisor malformation-affected mandibular first molar: A case report. J Endod 2016;42(4):664–8.

6. Witt CV, Hirt T, Rutz G, Luder HU. Root malformation associated with a cervical mineralized diaphragm – a distinct form of tooth abnormality? Oral Surg Oral Med Oral Pathol Oral Radiol 2014;117(4):e311–9.

7. Brusevold IJ, Bie TMG, Baumgartner CS, Das R, Espelid I. Molar incisor malformation in six cases: Description and diagnostic protocol. Oral Surg Oral Med Oral Pathol Oral Radiol 2017;124(1):52–61.

8. McCreedy C, Robbins H, Newell A, Mallya SM. Molar-incisor malformation: Two cases of a newly described dental anomaly. J Dent Child (Chic) 2016;83(1):33–7.

9. Lee HS, Kim SH, Kim SO, et al. Microscopic analysis of molar – incisor malformation. Oral Surg Oral Med Oral Pathol Oral Radiol 2015;119(5):544–52.

10. Wright JT, Curran A, Kim KJ, et al. Molar root-incisor malformation: Considerations of diverse developmental and etiologic factors. Oral Surg Oral Med Oral Pathol Oral Radiol 2016;121(2):164–72.

11. Choi S, Lee J, Song J. Molar-incisor malformation: Three cases of a newly identified dental anomaly. J Korean Acad Pediatr Dent 2017;44(3):370–7.

12. Pavlić A, VreclM, Jan J, BizjakM,Nemec A. Casereport of a molar-root incisor malformation in a patient with an autoimmune lymphoproliferative syndrome. BMC Oral Health 2019;19(1):49.

13. Kapila SD, Nervina JM. CBCT in orthodontics: Assessment of treatment outcomes and indications for its use. Dentomaxillofac Radiol 2015;44(1):20140282.

14. Pintor A, Alexandria A, Marques A, Abrahao A, Guedes F, Primo L. Histological and ultrastructure analysis of dentin dysplasia type I in primary teeth: A case report. Ultrastruct Pathol 2015;39(4):281–5.

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AcknowledgmentsThis work was supported in part by scholarships from Coordenação de Aperfeiçoamento de Pessoal de

Nível Superior—Brasil (CAPES), Finance Code 001—and Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro—Brasil (FAPERJ) process number E-26/202.399/2017.

Author ContributionsFernanda Gabriela de Fátima Vieira – Conception of the work, Design of the work, Acquisition of data, Analysis of data, Interpretation of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved

Andréa Vaz Braga Pintor – Conception of the work, Design of the work, Acquisition of data, Analysis of data, Interpretation of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved

Aline Corrêa Abrahão – Conception of the work, Design of the work, Acquisition of data, Analysis of data, Interpretation of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved

Antônio Carlos de Oliveira Ruellas – Conception of the work, Design of the work, Acquisition of data, Analysis of data, Interpretation of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved

Maria Augusta Visconti – Conception of the work, Design of the work, Acquisition of data, Analysis of data, Interpretation of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved

Laura Guimarães Primo – Conception of the work, Design of the work, Acquisition of data, Analysis of data, Interpretation of data, Drafting the work, Revising the work critically for important intellectual content, Final approval of the version to be published, Agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved

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Guarantor of SubmissionThe corresponding author is the guarantor of submission.

Source of SupportCoordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES), Finance Code 001— and Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro—Brasil (FAPERJ) process number E-26/202.399/2017.

Consent StatementWritten informed consent was obtained from the patient for publication of this article.

Conflict of InterestAuthors declare no conflict of interest.

Data AvailabilityAll relevant data are within the paper and its Supporting Information files.

Copyright© 2020 Fernanda Gabriela de Fátima Vieira et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.

ABOUT THE AUTHORS

Article citation: Vieira FGF, Pintor AVB, Abrahão AC, Ruellas ACO, Visconti MA, Primo LG. Differential diagnosis, three-dimensional imaging aspects and interceptive orthodontic management of molar–incisor malformation. Int J Case Rep Images 2020;11:101099Z01FV2020.

Fernanda Gabriela de Fátima Vieira is a Master Degree Student at Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. She earned the undergraduate degree (Doctor in Dental Science, DDS) from Universidade de Itaúna, Itaúna, Minas Gerais, Brazil and postgraduate degree (Specialist in Orthodontics and Pediatric Dentistry) from Instituto de Estudos da Saúde Sérgio Feitosa and Faculdade São Leopoldo Mandic, respectively, both in Belo Horizonte, Minas Gerais, Brazil. Her research interests include Pediatric Dentistry, Dental Enamel Defects, and Dental Caries. She intends to pursue PhD in future.Email: [email protected]

Dr. Aline Corrêa Abrahão is Adjunct Professor of Oral Pathology at Department of Pathology and Oral Diagnosis, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. She earned the undergraduate degree (Doctor in Dental Science, DDS) from School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil and postgraduate degree (PhD in Oral Pathology) from University of São Paulo, São Paulo, Brazil. She has published research papers in national and internationalacademicjournalsinthefieldofOralPathology,OralMedicine,andPediatricDentistry.Her research interests include Oral Pathology. She intends to pursue Postdocs in future.Email: [email protected]

Dr. Andréa Vaz Braga Pintor is a Post-doctoral fellow at the Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. She earned the postgraduate degree (PhD in Dental Sciences) from Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. She is a member of the Brazilian Committee for the Study of Restorative, Filling and Prosthetic Dental Materials – CE-026:050.004. She has published research papers in national and international academic journals and contributed todental books in thefieldofPediatricDentistry.Her researchinterests include Materials Sciences, Dental Materials Development and testing, Pediatric Dentistry andEndodontics.Sheintendstopursuetheacademicresearchfieldinfuture.Email: [email protected]

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Dr. Maria Augusta Visconti is Adjunct Professor of Oral Radiology at Department of Pathology and Oral Diagnosis, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. She earned the undergraduate degree (Doctor in Dental Science, DDS) from School of Dentistry, Federal University of Juiz de Fora, Juiz de Fora, Minas Gerais, Brazil and postgraduate degree (PhD in Oral Radiology) from Piracicaba Dental School, Piracicaba, São Paulo, Brazil. ShehaspublishedresearchpapersinnationalandinternationalacademicjournalsinthefieldofOralRadiology, Oral Medicine, Orthodontics, and Pediatric Dentistry. Her research interests include Oral Radiology. She intends to pursue Postdocs in future.Email: [email protected]

Dr. Antônio Carlos de Oliveira Ruellas is a Professor at the Orthodontics and Pediatric Dentistry Department, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. He earned the undergraduate degree (DDS) from the Federal University of Alfenas, Alfenas, Brazil and postgraduate degree (MS and PhD) from the Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. He had his postdoctoral training at the University of Michigan, Ann Arbor, United States. He has published many papers in national and international academic journals and authored and co-authored books. His research interests include 3D image analysis for diagnosis, treatment plan, and treatment outcomes.

Dr. Laura Guimarães Primo is Associate Professor at Department of Pediatric Dentistry and Orthodontics, School of Dentistry at Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. She earned the undergraduate degree (Dentistry) from School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil and postgraduate degree (PhD in Dentistry) from Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Universidade de São Paulo, São Paulo, Brazil. She has published 130 research papers in national and international academic journals and authored 13 book chapters. Her research interests include Endodontics, Pediatric Dentistry, and Child Behavior.Sheintendstocontinueintheacademicfield,conductingresearchintheareasofinterest,and guiding students in the Graduate Program in Dentistry at the Universidade Federal do Rio de Janeiro in the future.Email: [email protected]

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