dietary intake and ibd
DESCRIPTION
This meta-analysis provides data on dietary intake of main macronutrients/foods and their role in the development of infammatory bowel diseases (Hou et al. 2011)TRANSCRIPT
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Dietary intake and risk of developing inflammatory bowel disease: a systematic review of
the literature
Hou JK et al.
Am J Gastroenterol 2011;106:563-573
Page 1 Hou JK et al. Am J Gastroenterol 2011;106:563-573.
Page 2
Background
• The incidence of inflammatory bowel disease (IBD) is increasing• Etiology of IBD is not fully understood, but many factors may
influence such as genetics and environmental factors• The association between diet and IBD
risk has not been clearly demonstrated
Hou JK et al. Am J Gastroenterol 2011;106:563-573. www.pronutritionist.net
Methods
• A systematic review of– fully published case-control and cohort studies of the
association between pre-illness diet and IBD risk
• 19 studies were included– 18 case-control studies, 1 cohort study– 2 609 IBD patients
• 1 269 Crohn’s disease (CD)• 1 340 ulcerative colitis (UC)• > 4 000 controls
Page 3 Hou JK et al. Am J Gastroenterol 2011;106:563-573. www.pronutritionist.net
Results (1/3): dietary intake and Crohn’s Disease risk
Page 4 Hou JK et al. Am J Gastroenterol 2011;106:563-573. www.pronutritionist.net
Results (2/3): dietary intake and Colitis Ulcerosa risk
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Results (3/3)
• No consistent associations between total carbohydrate intake and IBD were observed
www.pronutritionist.netHou JK et al. Am J Gastroenterol 2011;106:563-573.Page 6
Discussion
• This was the first systematic review on diet and incidence of IBD
• Currently recommended high intake of PUFA, especially omega-6 fatty acids, may increase the risk of IBD disease
• High intake of fiber, vegetables and fruit seems to be protective against IBD
• Meat consistently increased the risk of IBD, whereas other protein sources (fish, eggs, dairy) had no effect
• Biggest shortfall of this meta-analysis is its retrospective nature
• More randomized studies are urgently needed as the prevalence of IBD increases worldwide
Page 7 Hou JK et al. Am J Gastroenterol 2011;106:563-573. www.pronutritionist.net