diabetic retinopathy
DESCRIPTION
DIABETIC RETINOPATHY. DIABETIC RETINOPATHY. 1. Epidemiology and risk factors 2. Classification and features of Diabetic retinopathy (DR) 3. Complications of DR and their prevention 4. Screening protocol for DR and referral to Ophthalmologist - PowerPoint PPT PresentationTRANSCRIPT
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DIABETIC RETINOPATHY
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DIABETIC RETINOPATHY
1. Epidemiology and risk factors
2. Classification and features of Diabetic
retinopathy (DR)
3. Complications of DR and their prevention
4. Screening protocol for DR and referral to Ophthalmologist
5. Direct ophthalmoscopy and identification of fundus findings
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Epidemiology of DR
RISK of developing DR:
• Type I or IDDM – 70%
• Type II or NIDDM - 39%
• Type II on insulin – 70%
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Prevalence of the type of Diabetes
Type 2 – in 90% of diabetic patients
Diabetic retinopathy - most common cause of legal blindness between ages 20 and 70 years.
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RISK FACTORS:
1. Duration of diabetes
2. Poor control of Diabetes
3. Hypertension
4. Nephropathy
6. Obesity and hyperlipidemia
7. Smoking
8. Pregnancy
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Pathogenesis
Microangiopathy which has features of both microvascular leakage and occlusion
Larger vessels may also be involved
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Microvascular leakage
Loss of pericytes results in distention of weak capillary wall producing microaneurysms which leak.
Blood-retinal barrier breaks down causing plasma constituents to leak into the retina – retinal oedema, hard exudates
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Microvascular occlusion
Basement membrane thickening, endothelial cell damage, deformed RBCs, platelet stickiness and aggregation
Vascular Endothelial Growth Factor (VEGF) is produced by hypoxic retina
VEGF stimulates the growth of shunt and new vessels
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Classification of DR
I. Non-proliferative DR (NPDR)• Mild • Moderate• Severe• Very severe
II. Proliferative DR (PDR)
III. Clinically significant macular oedema (CSME)
- May exist by itself or along with NPDR and PDR
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• At least one microaneurysm - earliest clinically detectable lesion
Retinal hemorrhages Hard or soft exudates
Mild NPDR
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Moderate NPDR
• Microaneurysms and/or dot and blot hemorrhages in at least 1 quadrant
• Soft exudates (Cotton wool spots)
• Venous beading or
IRMA (intraretinal microvascular abnormalities)
IRMA
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Mild and Moderate Non- proliferative DR was previously known as Background DR
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Severe NPDR
Any one of the following 3 features is present
• Microaneurysms and intraretinal hemorrhages in all 4 quadrants
• Venous beading in 2 or more quadrants
• Moderate IRMA in at least 1 quadrant
Known as the 4-2-1 rule
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Very severe NPDR
Any two of the features of the 4-2-1 rule is present
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Severe and Very severe Non-proliferative DR was known as the Pre-proliferative DR
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Clinically significant Macular Oedema
• Retinal oedema close to fovea
• Hard exudates close to fovea
• Presents with dimness of vision
• By itself or along with NPDR or PDR
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CSME – Hard exudates close to fovea and associated retinal thickening
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Proliferative DR (PDR)
Characterized by Proliferation of new vessels from retinal veins
• New vessels on the optic disc
• New vessels elsewhere on the retina
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Proliferative DR
NVD
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COMPLICATIONS OF DIABETIC RETINOPATHY
• Vitreous hemorrhage
• Tractional retinal detachment
• Rubeosis Iridis
• Glaucoma
• Blindness
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Vitreous Hemorrhage
SUBHYALOID HEMORRHAGE
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Tractional retinal detachment
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Rubeosis Iridis
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Neovascular Glaucoma• Complication of rubeosis iridis
• New vessels cause angle closure
• Mechanical obstruction to aqueous outflow
• Intra ocular pressure rises
• Pupil gets distorted as iris gets pulled
• Eye becomes painful and red
• Loss of vision
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Blindness
• Non-clearing vitreous hemorrhage
• Neovascular glaucoma
• Tractional retinal detachment
• Macular ischemia
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PREVENTION OF COMPLICATIONS
• By early institution of appropriate treatment
• This requires early detection of DR in its asymptomatic treatable condition
• By routine fundus examination of all Diabetics (cost effective screening)
• And appropriate referral to ophthalmologist
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Mild and Moderate NPDR
- No specific treatment for retinopathy
- Good metabolic control to delay progression
- Control of associated Hypertension, Anemia and Renal failure
Severe and very severe NPDR
– Close follow up by Ophthalmologist
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Clinically significant macular oedema - Laser photocoagulation to minimise risk of
visual loss
─ Retinal laser photocoagulation as per the judgment of ophthalmologist (in high risk eyes)
─ It converts hypoxic retina (which produces ANGIOGENIC factors) into anoxic retina (which can’t)
Proliferative DR
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Screening protocol for Diabetic retinopathy
1. Screening once in a 1 year
• Diabetics with normal fundus• Mild NPDR
2. Screening once in 6 months
• Moderate NPDR
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Referral to Ophthalmologist • Visual Symptoms
– Diminished visual acuity
– Seeing floaters– Painful eye
• Fundus findings
- Macular oedema/hard exudates close to fovea
- Proliferative DR
- Vitreous hemorrhage
- Moderate to severe and very severe NPDR- Retinal detachment- Cataract obscuring fundus view
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Referral to Ophthalmologist
• Presence of Risk Factors
- Pregnancy
- Nephropathy
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Simulation of defective vision as experienced by a Diabetic whose vision has been affected by Diabetic retinopathy
Normal Defective
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DIRECT OPHTHALMOSCOPY
• Examination of the fundus of the eye
• To screen for Diabetic Retinopathy
• After dilatation of both eyes with 0.5% tropicamide
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View of the retina through an ophthalmoscope
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Normal fundus views of Right and left eye
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Mild NPDR – Microaneurysms, Dot and Blot hemorrhages
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Moderate NPDR
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Moderate NPDR with CSME
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Circinate retinopathy – Hard exudates in a ring around leaking aneurysms
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DRUSEN
Age related Macular degeneration: Note the drusen. Not to be confused with Hard exudates. There are no microaneurysms or dot/blot hemorrhages.
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Severe NPDR• Cotton wool patches
• Hemorrhages - 4 quadrants
With CSME
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Very severe NPDR
-Venous beading
- scars of laser spots
- Absorbing hemorrhages
Cotton-wool patches, venous segmentation
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CSME – in
Different
Stages of
NPDR
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Proliferative DR – New vessels elsewhere on the retina along the supero-temporal vessels
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PDR – New vessels on disc
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PDR – New vessels on disc and new vessels elsewhere on retina
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PDR – with vitreous hemorrhage
Vitreous bleed
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Vitreous Hemorrhage
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Tractional retinal detachment
Fibro-vascular proliferation
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