development of nano-scale technologies for food safety protection
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Improving Life through Science and Technology.
Development of nano-scale technologies for food safety protection
Matthew Taylor, Ph.D.
Department of Animal Science, Texas AgriLife ResearchSeptember 14, 2011
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Nanotechnology Significance
“Nanotechnology holds great promise for the development of new treatments and diagnostics.”
Andrew Von Eschenbach, MDFDA Commissioner, 2007
FDA Nanotechnology Task Force Report, 2007
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Global Nanotechnology Research Funding
Adapted from Bugusu (2010). Food Technology (www.ift.org)
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Nano-materials in Foods
• Naturally occurring– Food macro-, micro-components &
nutrients– DNA, RNA– Casein micelles
• Synthetic systems– Encapsulates– Nano-wires– Biosensors
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Nano-materials entry into foods
Magnuson et al. 2011. J. Food Sci. 76:R126.
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Food Safety Applications of Nanotechnology
• Antimicrobial encapsulation/delivery strategies– Encapsulates– Nano-wires
• Active packaging/antimicrobial-bearing films
• Pathogen detection/diagnostics– Biosensors
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Nanotechnologies: Regulatory Concerns
• Definition of nano and engineered versus naturally occurring
• Purpose(s) of engineered nanotechnology use in foods
• Detection of nanomaterial presence in foods
• Characterization of interactions with food components
• Safety and toxicity of nanomaterials
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Antimicrobial Encapsulations
Liposomes, Micelles– Self-directed
formation– Entrapment rate
can be high– Formed from
lipids dispersed in aqueous systems
– Not long-term stable without post-formation modifications
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Liposomal Formulations
Taylor et al. 2006. Crit. Rev. Food Sci. Nutr. 45:587.
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L. monocytogenes Inhibition in Milk with Liposomal Nisin (50 IU/ml) at 20°C
Schmidt et al. 2009. Probiotics Antimicrob. Prot. 1:152-8.
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E. coli O157:H7 Inhibition in 2% Milk with 0.5% Eugenol Microemulsions
Gaysinsky et al. 2007. J. Food Protect. 70: 2631-7.
Assay Detection Limit
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Polymeric Encapsulate Research
• Β-Cyclodextrins
• Antimicrobials (Essential Oils)– Carvacrol– Thymol
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Texas A&M Nanotechnology Research in Food Safety• Dairy (Fluid Milk): Liposomes with
entrapped nisin inhibit Listeria monocytogenes (Schmidt et al. 2009)
• Fresh Produce (Pre-, Post-Harvest)–Micellar organic acids, essential oils–Field application, packing house–Pathogen inhibition–USDA Funding: NIFSI, AFRI
• Processed/RTE poultry: Incorporated pre-lethality for L. monocytogenes control post-processing–Corporately sponsored–Validation of antimicrobial activity
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Forced nano-particle/pathogen interaction on produce surfaces
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Collaborators (TAMU)
• Investigators:– Elsa Murano– Alex Castillo– Luis Cisneros-
Zevallos– Carmen Gomes– Christine Alvarado
• Graduates:– Laura Hill (PhD)– Keila Perez (PhD)– Songsirin
Ruengvisesh (PhD)– Shannon Schmidt
(MS)
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T. Matthew Taylor, PhD
• 310 Kleberg Animal and Food Sciences Center, College Station, TX, 77843-2471
• P: 979.862.7678; F: 979.862.3475• Email: [email protected]
• http://animalscience.tamu.edu/facultystaff/faculty/taylor.htm
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Thank you!