development and evaluation of xyloglucan matrix release tabs contaning glipizide
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8/7/2019 Development and Evaluation of Xyloglucan Matrix release tabs contaning Glipizide
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\_IJGNV
^VE_V
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FGSGHI\BGMV EMF
GSEHWEVKIM IC
P[HIDHWNEM BEV_KP
_GHGE^GVEOHGV^
NIMVEKMKMD DHK\KZKFG
\rijgnv ~wobkvvgf viEn`er{e Mederjwme Wmksgr~kv{( Dwmvwr-
FG\E_VBGMV IC \@E_BENGWVKN^ SKNVI_KE NIHHGDG IC
\@E_BEN[
Wmfgr v`g dwkfemng ic
Br- \- Erwm Awber ( B-\`erb-(
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Iojgnvksg \rg|erg emf gsehwevg bevrkp veohgv~ ic dhk|kzkfg w~kmd P[HIDHWNEM e~ e
|ih{bgr-
\hem ic tira
Gpvrenvkim ic p{hidhwnem
\rg|erevkim ic bevrkp rghge~g veohgv~
Gsehwevkim ic |rg|ergf bevrkp veo~
_g~whv~ emf fk~nw~~kim
FG\E_VBGMV IC \@E_BENGWVKN^ SKNVI_KE NIHHGDG IC
\@E_BEN[
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Dhk|kzkfg
Ireh emvk fkeogvkn edgmv oghimdkmd vi ~wh|`im{h wrge~ nhe~~-
Kv k~ km~ihwohg km tevgr emf ehni`ih~( ~ihwohgkm
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8/7/2019 Development and Evaluation of Xyloglucan Matrix release tabs contaning Glipizide
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Kmvrifwnvkim ^w~vekmgf rghge~g v`gir{ : Bifkckgf rghge~g) mim"kbbgfkevg"rghge~g fghksgr{ ~{~vgb~ tgrg fgsghi|gf emf be{ og
fkskfgf kmvi ciwr nevgdirkg~:
5-Fghe{gf rghge~g
?-^w~vekmgf rghge~g
E+Nimvrihhgf rghge~g
O+\rihimdgf rghge~g >-^kvg"~|gnkckn rghge~g
6-_gng|vir rghge~g
Cir mim kbbgfkevg rghge~g fi~edg cirb( Ar888Ae( v`ev k~( rghge~g ic frwd crib v`g fi~edg
cirb k~ v`g revg " hkbkvkmd ~vg|- V`k~ new~g~ v`g eoisg akmgvkn vi rgfwng v`g cihhitkmd:
BEV_KP
_GHGE^G
VEOHGV^
Fi~edg cirb Ar Verdgv erge Ag
Frwd rghge~g Ghkbkmevkim
FG\E_VBGMV IC \@E_BENGWVKN^ SKNVI_KE NIHHGDG IC
\@E_BEN[
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Bgn`emk~b ic frwd rghge~g E ~grkg~ ic vrem~|irv |`gmibgme erg kmsihsgf km v`g rghge~g ic e frwd crib e
~tghheohg( fkccw~kim)grifeohg bevrkp:
Kmkvkehh{( v`grg erg ~vgg| tevgr nimngmvrevkim drefkgmv~ ev v`g |ih{bgr)tevgr kmvgrceng(
rg~whvkmd km eo~ir|vkim ic tevgr kmvi v`g bevrkp
Fwg vi v`g eo~ir|vkim ic tevgr( v`g |ih{bgr ~tghh~( rg~whvkmd km frebevkn n`emdg~ ic
frwd emf |ih{bgr nimngmvrevkim( kmnrge~kmd v`g fkbgm~kim~ ic v`g ~{~vgb emf
kmnrge~kmd benribihgnwher biokhkv{
W|im nimvenv tkv` tevgr v`g frwd fk~~ihsg~ emf fkccw~g~ iwv ic v`g fgskng-
Tkv` kmnrge~kmd tevgr nimvgmv( v`g fkccw~kim nigccknkgmv ic v`g frwd kmnrge~g
~wo~vemvkehh{
Km v`g ne~g ic e |iirh{ tevgr"~ihwohg frwd( fk~~ihsgf emf wmfk~~ihsgf frwd nigpk~v
tkv`km v`g |ih{bgr"bevrkp
Ckmehh{( v`g |ih{bgr kv~ghc fk~~ihsg~
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Gccgnv ic revg hkbkvkmd |erebgvgr~ \ih{bgr `{frevkim
Frwd ~ihwokhkv{
^ihwvkim ~ihwokhkv{
\ih{bgr fkccw~kskv{
e+ \ih{bgr |ervknhg ~kzgo+ \ih{bgr sk~ni~kv{
n+ \ih{bgr nimngmvrevkim
V`knamg~~ ic |ih{bgr fkccw~kimeh |ev`
V`knamg~~ ic `{frif{mebkn fkccw~kim he{gr
Frwd hiefkmd fi~g
^wrceng erge emf sihwbg
Fkhwgmv~ gccgnv
Effkvksg~
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Gpvrenvkim ic P{hidhwnem
?< db ic veberkmf agrmgh |itfgr
Effgf vi ?
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\rg|erevkim ic bevrkp veo~
PDH 5 PDH? PDH> PDH6 PDH7
Dhk|kzkfg 5
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\ringfwrg Veohgv~ tgrg |rg|ergf o{ tgv dremwhevkim vgn`mkuwg-
^vern` bwnkhedg e~ okmfgr( henvi~g e~ fkhwgmv emf bkpvwrg ic vehn emf bedmg~kwb
~vgrevg e~ hworknemv-
P{hidhwnem( @\BN( NE\( GN tgrg kmnhwfgf km v`g cirbwhevkim~ nimvekmkmd 5
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\rgcirbwhevkim ~vwfkg~
CVK_ IC DHK\KZKFG
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CVK_ IC DHK\KZKFG ! P[HIDHWNEM
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G~vkbevkim Nim~vrwnvkim ic ^vemferf nwrsg ic Dhk|kzkfg
E
o
~
i
r
o
e
m
ng
Nimngmvrevkim d)bh+
^h-
Mi
Nimngmvrevkim ( d)bh+ Eo~iroemng km
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8/7/2019 Development and Evaluation of Xyloglucan Matrix release tabs contaning Glipizide
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Fk~~ihwvkim ^vwfkg~
VKBG Km @iwr~+
'
F
r
w
d
r
g
h
g
e~
g
C5 cibwhevkim
gp`kokv~ ;; ' frwd
rghge~g cir |rihimdgffwrevkim-
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8/7/2019 Development and Evaluation of Xyloglucan Matrix release tabs contaning Glipizide
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VKBG `r+ C5 C? C> C6 C7
< < < < < ?5 3-735 ;-356 3-756 0-?63
? 5;-73> 5>-6?0 54->?0 57->?5 57-?75
> >->?6 ?3-65? ?>-653 ?7-56>
6 6?-656 >5-373 >6-737 >?-53? >>->7;
7 70-75? >;-77? 6-077 63-5?6 6;-73 7?-;53 6;-?>44 06-335 3>-430 77-5?0 35-5?> 74-7;5
0 ;7-3?? 4;-05? 36->?7 46-47? 33-503
NIB\E_K^IM IC FK^^IHWVKIM _EVG^
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\`{~kneh |erebgvgr~
FG\E_VBGMV IC \@E_BENGWVKN^ SKNVI_KE NIHHGDG IC
\@E_BEN[
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Fk~nw~~kim Km v`k~ ~vwf{( dhk|kzkfg bevrkp veohgv~ bgv v`g |`erbeni|igkeh rguwkrgbgmv ic wmkcirbkv{
ic tgkd`v-
Ehh v`g veohgv~ nimcirbgf vi v`g rguwkrgbgmv ic e~~e{( e~ |gr K-\- `erfmg~~( ' crkeokhkv{(
emf v`knamg~~ tgrg tghh tkv`km enng|veohg hkbkv~-
Kv `e~ oggm io~grsgf v`ev v`g nwbwhevksg |grngmv frwd rghge~g fgnrge~g~ tkv` kmnrge~kmd
nimngmvrevkim ic dwb emf ~tghhkmd kmfgp-
Kmnrge~kmd v`g ebiwmv ic dwb km v`g cirbwhevkim( rg~whvgf km ~hitgr revg( emf fgnrge~gf
ebiwmv ic frwd rghge~g crib v`g veohgv-
^veokhkv{ ~vwfkg~ rgsgehgf v`ev v`grg te~ mi ~kdmkcknemv n`emdg km `erfmg~~( crkeokhkv{(
frwd nimvgmv emf fk~~ihwvkim |rickhg~ ic C5-
^i( C5 cirbwhevkim niwhf og w~gf e~ em gccgnvksg bevrkp cirbgr( vi rgverf v`g rghge~g ic
dhk|kzkfg cir gpvgmfgf |grkif ic vkbg-
FG\E_VBGMV IC \@E_BENGWVKN^ SKNVI_KE NIHHGDG IC
\@E_BEN[
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Nimnhw~kim Km v`g |rg~gmv tira gccirv~ `esg oggm befg vi cirbwhevg emf n`gnakmd ic frwd rghge~g
og`eskir ic p{hidhwnem bevrkp veohgv~
Ehh v`g cirbwhevkim~ tgrg gp`kokvgf emibehiw~ fkccw~kim bgn`emk~b emf C5 cirbwhevkim
te~ ciwmf vi og v`g og~v cirbwhevkim im v`g vrekh emf grrir bgv`if emf kv te~ ~ghgnvgf
cir w~g e~ ~w~vekmgf bevrkp rghge~g veohgv~
Ckmehh{( v`g og~v cirbwhevkim C5 frwd rghge~g km serkiw~ enkfkn emf oe~kn owccgr~( v`g
frwd rghge~g te~ fg|gmfgmv im imh{ |ih{bgr nimngmvrevkim~-
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Okohkidre|`{ Mkn`ihe~ D-hirfk(~w~vekmgf rghge~g fi~edg cirb km v`g v`gir{ emf |renvkng ic kmfw~vrkeh
|`erben{h- Hen`bem(`- E- Hkogrbem( emf j- H- Aemkd( gf~( hge # cgokdgr+( |`khefgh|`ke(|e(
5;03+( kkkrf gfkvkim-(6>
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J- Nrema( v`g bev`gbevkn~ ic fkccw~kim( ipcirf wmksgr~kv{ |rg~~( ipcirf 5;73+-
Edk~ a{fimkgw~( vrgevk~g im nimvrihhgf frwd fghksgr{ berngh fgaagr( kmn: ?73"?;