detect new infections of hiv, hepatitis c, syphilis and hepatitis b feasibility of conduct
DESCRIPTION
TUPDD0101:Will a multiplex assay detect new infections of HIV, Syp , Hep C and B in Urban India?. Objective. Detect New infections of HIV, Hepatitis C, syphilis and Hepatitis B Feasibility of conduct Diagnostic accuracy Client preference. Intervention. Setting. Population. - PowerPoint PPT PresentationTRANSCRIPT
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TUPDD0101:WILL A MULTIPLEX ASSAY DETECT NEW INFECTIONS OF HIV, SYP, HEP C AND B IN URBAN INDIA?
1. Detect New infections of HIV, Hepatitis C, syphilis and Hepatitis B
2. Feasibility of conduct3. Diagnostic accuracy4. Client preference
POPULATION
INTERVENTION SETTING
Hinduja National Hospital and Medical Research Center, and Sion Hospitals Mumbai, India
Point of care + combined counselling+
confirmatory testing STD Clinic attendees
Sion Hospital, Mumbai
OBJECTIVE
Mumbai Urban Poor
MiriadTM test on fingerstick blood
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FLOW OF PARTICIPANTS
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CATEGORY
SENSITIVITY
SPECIFICITY
REFERENCE STANDARDIndex test statusPRELIMINARY
POSITIVE
Index test statusPRELIMINARY
NEGATIVE
HIV 100% [95%, CI: 94.8,
100]
99.7% [95%, CI: 98.3,
99.9]
ELISA (antigen+antibody) +
Western BlotELISA
HBV 13.3% [95%, CI: 6.6, 23.2]
99.3% [95%, CI: 97.6,
99.9]
HBsAg + Total anti HBc + HBV DNA HBsAg + anti-HBc
HCV 50% [95%, CI: 1.26,
98.74]
99.7% [95%, CI: 98.5,
99.9]
HCV antibody + HCV RNA
Anti HCV screening test (EIA based)
Syphilis 86.1% [95%, CI: 70.5,
95.3]
85.2% [95%, CI: 80.9,
88.8]TRUST + TPHA TPHA
RESULTSDemographics
Gender 83% males
Age (mean) 31.2 years
Sample size375 STD Clinic
attendees
NITIKA PANT PAI, MD, MPH, PhDAssistant professor
McGill University, MontrealEmail: [email protected];
Co-investigators: Dr Anjali Shetty Hinduja Dr Rachita Dhurat, Sion