designed and produced by the - events at the institute for ... · designed and produced by the ....

Designed and produced by the Communications Office of the Institute for Bioengineering of Catalonia

Printed by GAM

www.ibecbarcelona.eu

10th IBEC Symposium · BIOENGINEERING for FUTURE MEDICINE 3

Welcome to IBEC’s 10th anniversary symposiumThe Institute of Bioengineering of Catalonia is a leading-edge multidisciplinary research centre based in Barcelona that conducts interdisciplinary research at the frontiers of engineering and life sciences in order to generate new knowledge by putting together fields like nanomedicine, biophysics, biotechnology, tissue engineering and the applications of health information technology.

IBEC was formally set up in December 2005 by the Departments of Innovation, Universities and Enterprise and Health of the Government of Catalonia, the University of Barcelona and the Technical University of Catalonia, but it was in 2007, with the first IBEC Bioengineering and Nanomedicine Symposium, when IBEC started to disseminate its research results.

In just ten years IBEC has positioned itself among the best research centres in bioengineering at an international level. The major results obtained by IBEC’s research groups, which can be summarized in the quality of scientific publications, the 11 prestigious ERC Grants developed at the institute, the coordination of many international consortia, the development of a high number of cooperative agreements with hospitals and biotechnological and medical technology companies, and the generation of spin-offs. Today IBEC is recognized as a leader in mechanobiology, nano-characterization at molecular and cellular levels, nanomedicine for diagnostics, biomaterials for regenerative medicine, and biomedical signals.

IBEC’s excellence has been acknowledged by the Spanish Ministry of Economy and Competitiveness through its Severo Ochoa Excellence Programme, which recognises IBEC as one of Spain’s top research centres at the highest international level in terms of cutting-edge research, training, human resources management, outreach and technology transfer.

This year we commemorate our 10th anniversary with a special symposium where we want to celebrate our success story and our contribution to the advancement of science for the improvement of health and quality of life. For the first time, we're also inviting IBEC's alumni to contribute to the programme within the framework of our newly launched Alumni Network.

Join us in this celebration! IBEC’s 10th Anniversary – 10 years of impact… But the best is yet to come!

4 10th IBEC Symposium · BIOENGINEERING for FUTURE MEDICINE

Information for participants

Information Desk

The conference registration and information desk will be located in the main reception hall of the AXA Auditorium building. It will be staffed from 14:00 to 19:30 on Tuesday 6th June, and from 8:30 to 17:00 on Wednesday 7th June.

Badges

Each registered participant will receive a name badge. For security reasons, the badge must be clearly exhibited in order to access the congress area during all scientific and social events. Replacements for lost badges will be available from the registration desk.

Speakers/Flash presentations

All presentations should be upload during registration time (from 14:00 to 15:00 on Tuesday and from 8:30 to 9:00 on Wednesday) or during the coffee breaks.

Poster sessions

Posters should be hung during registration between 8:30 and 9:00 on Wednesday 7th June. Please refer to the information board in the registration area or this book to check which board number has been allocated to you.

Posters can remain on display throughout the conference and should be removed between 17:00 and 18:00 on Wednesday. Any posters remaining after the indicated time will be removed by the organizers, who accept no responsibility for loss or damage.

Poster sessions will take place during the coffee and lunch breaks on Wednesday 7th June.

Certificate of attendance

If you wish to have a Certificate of Attendance, you can request one from the Secretariat at [email protected].


ProgrammeTuesday 6th June · 10th Anniversary Commemoration

14:00 – 15:00 Registration

15:00 – 16:00 Opening ceremony

16:00 – 16:40Keynote speaker (Chair: Núria Montserrat) "Future Shock Again – The Promise of Bioengineering Innovation" Thomas C. Skalak, The Paul G. Allen Frontiers Group

16:40 – 17:00 Keynote speaker (Chair: Josep Samitier) "Regenerative algorithms?" Josep A. Planell, Universitat Oberta de Catalunya (UOC)

17:00 – 17:30 Coffee break

17:30 – 18:30

Round Table (Chair: Cristina Sáez, Science journalist) "The role of bioengineering in the advancement of healthcare, and the contribution of IBEC"

Jean-Louis Coatrieux, INSERM, Université de Rennes Josep A. Planell, Universitat Oberta de Catalunya (UOC) Emilià Pola, Catalan Institution for Research and Advanced Studies (ICREA) Josep Samitier, Institute for Bioengineering of Catalonia (IBEC) Sam Stupp, Simpson Querrey Institute for BioNanotechnology

18:30 – 19:10

Keynote speaker (Chair: Samuel Sánchez) "A brighter future? The social implications of biomedical discoveries" Salvador Macip, University of Leicester President of the Catalan Association for the dissemination of science

19:10 – 19:20 Closing Remarks

19:20 Cocktail to commemorate IBEC’s 10th anniversary


Wednesday 7th June · 10th IBEC Symposium: Bioengineering for Future Medicine

09:00 – 09:35

Keynote speaker "IBEC’s Evolution and Scientific highlights" Josep Samitier, Institute for Bioengineering of Catalonia (IBEC), Spain

09:35 – 10:25

Alumni Session (Chair: Teresa Sanchis) "Biofabrication strategies to recapitulate articulating joint complexity" Riccardo Levato, University Medical Center Utrecht, The Netherlands

"Epigenomic mechanisms controlling β cell development, regeneration and survival" Santiago A. Rodríguez-Seguí, Universidad de Buenos Aires, Argentina

10:25 – 11:20Flash poster presentations I (Chairs: Javier Ramón and Raimon Jané) Nanomedicine and ICT for Health

11:20 – 11:50 Coffee break and poster session

11:50 – 12:25

Technology Transfer session (Chair: Xavier Rubies) "Inhibiting mechanostransduction as a novel therapy in the treatment of solid tumors" Pere Roca-Cusachs, Institute for Bioengineering of Catalonia (IBEC), Spain

12:25 – 13:00Flash poster presentations II (Chair: Eduard Torrents) Cell Engineering

13:00 – 13:15 Time for sponsors

13:15 – 13:35

Keynote speaker (Chair: José A. del Río) "How the brain decides to wake us up: optogenetic control of arousal circuits" Luis de Lecea, Stanford University, USA


13:35 – 14:45 Lunch and poster session

14:45 – 15:20

Keynote speaker (Chair: Elena Martínez) "Bio-responsive hybrid materials for regenerative medicine and biosensing" Molly Stevens, Imperial College, UK

15:20 – 15:55

Keynote speaker (Chair: Elisabeth Engel) "Dynamic Hydrogel Matrices: Cell Biology in the Fourth Dimension" Kristi S. Anseth, University of Colorado Boulder, USA

15:55 – 16:10 Time for sponsors

16:10 – 16:25 Time for PhD Committee (Chair: Sergio González)

16:25 – 16:50 Awards and closing ceremony

16:50 End of Symposium

Keynote Lectures


Tuesday, 6th June 16:00

Future Shock Again – The Promise of Bioengineering Innovation

Tom SkalakExecutive DirectorThe Paul G. Allen Frontiers Group

The 21st century promises to be a time of exponential growth in our collective knowlege of living systems. In the last few years alone, major paradigms in biology and medicine have been completely overturned by radical new discoveries about molecular, cellular, organism, and ecosystem structure and behavior. This rapid growth in basic knowledge, within the still young field of bioscience, opens the door widely for new bioengineering innovations. Examples include major diseases ranging from Alzheimer’s disease to cancer and cardiovascular disease, use of biophysical, electrical, and optical methods in diagnostics or therapy, nanomedicine, healthy aging, biomanufacturing, and plant science for agriculture or ecosystems retoration. Such innovations will create vast improvements in human health, lift national or regional economies that can take advantage of fast-moving bio-innovation ecosytems, sustain the natural environment, and help preserve human dignity, peace, and freedom.


Tom Skalak

Tom Skalak is the founding Executive Director of The Paul G. Allen Frontiers Group, launched in 2016. The Frontiers Group, based in Seattle, seeks to explore new frontiers, re-invent fields in ways that reflect major societal challenges and fundamental scientific curiosity, and bring new knowledge to light with a broad array of global partners, making a positive impact on the world. A major interest of the Frontiers Group is the growing landscape of quantitative bioscience. Pioneering research is supported through the Allen Distinguished Investigators and the Allen Discovery Centers. Previously, Tom was Vice President for Research at the University of Virginia, where he led research and innovation programs spanning biosciences, environmental sustainability, physical sciences, engineering and technology, arts, design, and humanities. Tom led the launch of the OpenGrounds collaboration initiative, bringing people together across fields for ideation; the statewide i6 Virginia Innovation Partnership with the U.S. Department of Commerce; and the Global Water Games, a participatory computer game that improves the health of watersheds worldwide. As a Professor of Biomedical Engineering, Tom’s personal research included biomechanics of the cardiovascular system, angiogenesis, computational modeling, systems biology, wound repair, and regenerative medicine. He is a past President of both the American Institute of Medical and Biological Engineering (AIMBE) and the Biomedical Engineering Society (BMES), representing over 60,000 professionals. Tom is a frequent speaker on innovation and creativity with Fortune 500, venture capital, major art museum, foundation, and government partners, including The White House, NIH, and NSF. He is a Council Member of the GUIRR Research Roundtable, a convening body of the National Academies of Sciences, Engineering, and Medicine in the U.S. Tom was the founder of the UVA-Coulter Foundation Translational Research Partnership and other proof-of-concept funds with corporate partners such as Johnson & Johnson and AstraZeneca, which produced an international innovation industry-leading 22-1 return-on-investment. One outcome was that the National Venture Capital Association ranked the Charlottesville region the #1 fastest-growing venture capital ecosystem in the United States between 2010-2015. Tom was educated as a bioengineer at The Johns Hopkins University (B.E.S. 1979) and at the University of California, San Diego (Ph.D. 1984), is a Fellow of the National Academy of Inventors, and enjoys exploring the waters of the Pacific Northwest.



Regenerative algorithms?

Josep A. PlanellPresident, Universitat Oberta de Catalunya / Institute for Bioengineering of Catalonia (IBEC), Barcelona, Spain

In the same way that industry lead to the industrial society, information is leading us towards the informational society. Universities providing education on arts, humanities and sciences before the industrial revolution, incorporated education on the different engineering branches, economy or psychology among others, in order to provide high with level professionals the industrial society. Research boosted then, because the successive industrial revolutions required not only increasing knowledge, but also know-how to sustain their progress. The advent of the informational society opens new questions both on education and research. In recent years in this 21st century we have been seeing that systems biology and the application of the theory of complexity is moving science from an eminently reductionist approach to a more holistic one. This statement is especially valid in the biological field. The complexity concept of emergence (the whole is more than the sum of its parts) allows to understand that complex regulatory networks can be revealed. On the other hand, the idea that biology is governed by algorithms brings new insights on regeneration. In 2015, a planarian regeneration model is discovered by means of an artificial intelligence algorithm. From there, machine learning provides reverse-engineer cellular control networks, as well as to predict stem cell knee arthritis outcomes, or to predict the look of stem cells in 3D. Artificial intelligence and machine learning seem to become an integrated part of life science research. These tools should allow regenerative medicine researchers to develop their work faster, more informed and more accurate. Such an integrative and more holistic approach should open a whole new perspective in biomaterials design.


Josep Anton Planell Estany graduated in Physics from the University of Barcelona in 1975 and earned his doctorate in Materials Science from Queen Mary, University of London in 1983. Since 1992 he has been full professor in the Materials Science and Metallurgy department of the Barcelona School of Industrial Engineering (UPC). He was Director of the Institute of Bioengineering of Catalonia (IBEC) from its establishment in December 2005 until April 2013, when he took office as President of the Universitat Oberta de Catalunya (Open University of Catalonia, UOC). He is a member of the Royal Academy of Sciences and Arts and of the Royal Academy of Doctors, both in Barcelona.

Josep A. Planell



A brighter future? The social implications of biomedical discoveries

Salvador MacipUniversity of LeicesterPresident of the Catalan Association for the dissemination of science

There has never been a more exciting time to be involved in science. The tools we currently have at our disposal allow us to ask questions that not so long ago were thought to belong in science fiction. Bioengineering and biomedicine are leading the way in a revolution that will reshape our society. As science changes the way we live and treat disease, as well as our understanding of what it means to be human, a series of concerns are arising faster than our ability to process them. Because of this, scientists cannot only focus on generating knowledge anymore: we also need to be involved in discussing the social implications of our discoveries. Biomedicine will indeed bring a brighter future to humanity but only if we are able to understand and control its darker side.


Prof. Salvador Macip

Salvador Macip, MD, PhD, graduated in Medicine from the University of Barcelona (1994), where he also obtained a PhD in Molecular Genetics and Human Physiology (1998). He then moved to the Mount Sinai Hospital in New York to study the molecular basis of cancer and cellular ageing. From 2008, he has continued this research at the Mechanisms of Ageing and Cancer Group he leads at the University of Leicester (UK). His work has contributed to the description of the mechanisms involved in human ageing as well as new treatments for leukaemia, among other things. He is the author of over thirty books, translated into seven languages, and provides popular science content to several media outlets.


Wednesday 7th June 9:00

IBEC's Evolution and Scientific highlights

Josep SamitierInstitute for Bioengineering of Catalonia (IBEC), Barcelona, SpainUniversity of Barcelona (UB), Spain

In calendar terms, last year was the end of an era, being the ninth year of activity for IBEC as a research institution and a year spent full of excited anticipation for the current tenth anniversary celebration

But in other ways, it also felt like a new beginning. With the generous buffer of 2015’s Severo Ochoa award we were able to feel that we were finally able to put the country’s financial crisis behind us. We boosted our global links by entering the EBICS International exchange program and attending their 1st International Workshop on Engineering Living Systems in Chicago, as well as with our continued involvement in EIT Health and the European Technological Platform on Nanomedicine. On a national level, we continued our management of the Spanish Nanomedicine Platform and became part of the new NEXTHEALTH RIS3CAT community of research innovation strategies for smart specialisation in Health.

The junior group leader who started in January 2017, Javier Ramon, boosted our ERC count with a Starting Grant for his project ‘Diabetes Approach by Multi-Organ-on-a-Chip’, being one of only six researchers in Catalonia to receive the Starting Grant in 2016.

Other awards since our last symposium included two for junior group leader Pere Roca-Cusachs, who received the American Society for Cell Biology’s Gibco Emerging Leader Prize as well as being accepted into the EMBO Young Investigator Programme. Samuel Sánchez received Catalonia’s National Research Award for Young Talent – one more accolade to add to his growing collection.

During 2016 we celebrated six Nature group papers and a Science paper; 108 indexed journal papers in total, 86% of them in the first quartile; four new patents; and 17 PhD theses.

Research highlights during the year included the resolution of a long-standing chemistry enigma when researchers at IBEC, the UB and two universities in Australia introduced in Nature a new way of catalysing chemical reactions. IBEC researchers also revealed how tissue rigidity activates cancer in a Nature Cell Biology study, and in Science they showed that several types of cells are attracted to the most rigid areas of tissues.

In regards to our relationships with industry, in the last year we signed one collaboration agreement with the pharmaceutical company Ferrer and bioinformatics company Mind the Byte. At MEDICA in Germany, GENOMICA presented a new in vitro diagnostics device for HPV testing developed by the IBEC-GENOMICA Joint Unit, a


tangible success story in the institute’s active pursuit of the establishment of research projects with industry partners who share its commitment to bringing high-quality health research and technologies to market and the patient. We also introduced our 3D bioprinting capabilities at the first IN(3D)USTRY event, reinforcing our role as the organisation that has made this technology available to researchers, clinicians and companies in Barcelona, Spain and the south of Europe.

We also saw with pride the PIONER award obtained by Santiago Marco’s PhD Student Ariadna Bartra. The award recognises those researchers who have presented a doctoral thesis with results that are clearly aimed at commercial exploitation.

Regarding projects, we are very excited about MECHANOCONTROL, the 7M€ project awarded to IBEC and coordinated by Pere Roca-Cusachs to develop therapeutic approaches for cancer and other diseases in the framework of the FET proactive programme of H2020, and the generous support provided by Fundació La Caixa to Eduard Torrents to fight Cystic fibrosis.

Already in 2017, March saw the first applicants to the second call of IBEC’s International PhD Programme compete for the programme’s positions. For more established researchers, the first Bioengineering Excellence Scientific Training (BEST) call for postdocs, co-funded by H2020 and our Severo Ochoa grant, took place in September. We are also proud of IBEC’s new Master Programme, what will allow 10 talented Master students to join IBEC in January 2018.

With all this going on, since last symposium we’ve enjoyed another great and memorable year in the consolidation of IBEC as a global reference in bioengineering – as well as a pioneer in work-life balance for its staff, winning an Alares Foundation prize for “Reconciliation of Working Life, Family and Personal and Social Responsibility” in the Universities, Business Schools and Research Organisations category.

All these achievements and more give us every reason to feel hugely proud on our 10th birthday. Let's enjoy our anniversary celebrations, and look forward together to many more successful years to come!

Josep Samitier


Prof. Josep Samitier

Professor Josep Samitier is Director of the Institute for Bioengineering of Catalonia (IBEC), group leader of the Nanobioengineering Group at IBEC and Full Professor of Electronics and Biomedical Engineering in the Physics Faculty (Electronic Department) University of Barcelona.

Prof. Samitier is President of the Catalan Association of Research Centres (Associació Catalana d'Entitats de Recerca - ACER) and EIT Health Supervisory Board member.

He is founder and coordinator of the Spanish Platform on Nanomedicine, member of the international committee of the International Society for BioMEMS and Nanotechnology, on the editorial board of the Journal of Nanoscience and Nanotechnology, and member of the international scientific committee of ITAV (Toulouse) and Canceropole CLARA (Lyon). He has also been scientific advisor for a programme of the government of Argentina to foster nanotechnologies among SMEs and promoted and coordinated the Catalan Nanobiomedicine Alliance, involving 20 institutions in the Barcelona region.

Since 2013 he has served as Spanish Delegate of the working group on Biotechnology and Nanotechnology of the Organization for Economic Cooperation and Development.

He was a member of the Science to Business Committee for ESOF 2016.

From March 2001 to June 2005 Prof. Samitier was Deputy Head of the Barcelona Science Park (PCB). From 2009 to 2013 he was one of the 20 Spanish researchers in biomedicine and biotechnology supported by the TechTransfer Programme of the Botin Foundation.

He has more than 225 ISI publications, with over 3500 citations and an H-index of 28. He received the Barcelona City Prize of Technology in 2003 and is inventor of 4 licensed patents.

His research focuses on the design and development of miniaturized devices containing micro- and nanoscale features for biomedical applications. His group develops microfluidics and lab-on-a-chip devices with integrated multiplexed electrochemical biosensors.


Notes


Wednesday, 7th June 11:50

Inhibiting mechanostransduction as a novel therapy in the treatment of solid tumors

Pere Roca-CusachsInstitute for Bioengineering of Catalonia (IBEC), Barcelona, SpainUniversity of Barcelona, Spain

Most solid tumours are associated with increased tissue stiffness, and this stiffening can per se promote tumour progression. This mechanical aspect of cancer has been the subject of intense research in the last decade, but its potential as a therapeutic approach remains untested. In recent work, we have identified that cell response to increased stiffness is triggered by the interaction between talin and vinculin molecules, leading to the activation of the well-known oncogene YAP. Thus, inhibiting the talin-vinculin interaction may inhibit tumor progression. In this talk, I will explain our work towards the development of a drug inhibiting this interaction for the treatment of solid tumors, and our preliminary results. I will also take the opportunity to discuss my personal experience as a fundamental biophysics researcher approaching the world of technology transfer and the pharma industry for the first time.


Pere Roca-Cusachs

Pere Roca-Cusachs obtained his PhD in cellular biophysics in 2007 from the Medical School of the University of Barcelona. He then worked in the lab of Prof. Michael Sheetz (Department of Biological Sciences, Columbia University) as a post-doctoral researcher until 2011. In 2011, He joined the University of Barcelona as a tenure-track lecturer. In 2012, he obtained a position as group leader at the Institute for bioengineering of Catalonia (IBEC). He is also an EMBO young investigator. His research focuses on unraveling the physical and molecular mechanisms by which cells detect and respond to mechanical force.



How the brain decides to wake us up: optogenetic control of arousal circuits

Luis de LeceaStanford University, USA

The arousal construct underlies a spectrum of behaviors that include sleep, exploration, feeding, sexual activity and adaptive stress. Pathological arousal conditions include stress, anxiety disorders, and addiction. In the past few years we have used optogenetics to interrogate neuronal circuits underlying transitions between arousal states. In particular, I will talk about how the hypocretin system, makes the decisions about when to mark the transition between sleep and wakefulness. The dynamics between arousal state transitions are also modulated by norepinephrine neurons in the locus coeruleus, histaminergic neurons in the hypothalamus, dopaminergic neurons in the mesencephalon and cholinergic neurons in the basal forebrain. I will present data deconstructing some of the circuits associated with hypervigilance. I will also talk about experiments uncovering a new paradigm to study social arousal and intersubjectivity, and how optogenetics can assist to map the underpinnings of complex social behavior.


Prof. Luis de Lecea

Professor Luis de Lecea is Director of Major Research Laboratory and Incubator and Professor in the Department of Psychiatry and Behavioral Sciences at Stanford University School of Medicine.

Dr. de Lecea obtained his PhD the University of Barcelona and conducted postdoctoral studies at The Scripps Research Institute in La Jolla, California. He was promoted to Assistant and Associate Professor at Scripps, and in 2006 he moved to Stanford University. Dr. de Lecea’s research is based on his discovery of three neurotransmitters that affect cortical activity and arousal. Dr de Lecea’s work has led to the development of multiple drugs for the treatment of sleep disorders; one of which was recently approved by the FDA and several in Phase III trials. His laboratory also pioneered the implementation of optogenetic methods in vivo to manipulate neuronal activity in genetically defined neuronal circuits and alter behavior.

Prof. de Lecea is one of the most highly cited sleep researchers, with over 19,000 citations (h-index: 60) and has received numerous awards, including Brain Research Foundation Distinguished Scientist Award, American College of Neuropsychopharmacology Innovation Award, and the Sleep Research Society Outstanding Research Achievement award. He has served on multiple national and international committees and on the National Institute of Drug Abuse Board of Scientific Counselors.



Bio-responsive hybrid materials for regenerative medicine and biosensing

Prof. Molly StevensDepartment of Materials and Department of Bioengineering, Imperial College London, UK

Bio-responsive hybrid materials are of growing importance with potential applications including drug delivery, diagnostics and tissue engineering. A disagreeable side effect of longer life-spans is the failure of one part of the body – the knees, for example – before the body as a whole is ready to surrender. The search for replacement body parts has fuelled the highly interdisciplinary field of tissue engineering and regenerative medicine. This talk will describe our research on the design of new hybrid (nano)materials and nanomaterials to direct stem cell differentiation for regenerative medicine. We have also designed and developed porous silicon “nanoneedles” capable of efficiently, rapidly and safely delivering sensitive biocargoes to cells and tissues in vivo as well as interfacing with cells to inform intracellular pH and high resolution demarcation of tumorous region boundaries. This talk will also provide an overview of our recent developments in the design of materials for ultrasensitive biosensing. We are applying these nanomaterial-based approaches both in high throughput drug screening and to diagnose diseases ranging from cancer to global health applications.


Prof. Molly Stevens

Professor Molly Stevens is Professor of Biomedical Materials and Regenerative Medicine & Research Director for Biomedical Material Sciences in the Department of Materials, Department of Bioengineering and the Institute of Biomedical Engineering at Imperial College London. She was born in Nottingham, UK and received her PhD from The University of Nottingham in 2000, working within the School of Pharmaceutical Sciences. She conducted her postdoctoral research within the Department of Chemical Engineering at MIT in the labs of Prof Robert Langer, where she co-developed innovative techniques for the regenerative of bone and other tissues. She joined Imperial College in 2004 and was promoted as Professor in 2008. Research in the Stevens Programme focuses on designing and developing innovative bio-inspired materials for applications in regenerative medicine, tissue engineering and biosensing.

Molly Stevens’ research has been recognised by over 20 major awards, such as the 2016 Clemson Award for Basic Research from the Society for Biomaterials, the EU40 Prize for best material scientist under 40, a listing in The Times as one of the top 10 scientists under 40 and the European Life Sciences 2014 Research Group of the Year Award, amongst many others. She was recently elected to the Fellowship of the Royal Academy for Engineering and delivered the Clifford Paterson Lecture for the Royal Society in 2012. She has previously served on the Board of Reviewing Editors for Science and is Associate Editor of ACS Nano. More information on the Stevens Group can be found at http://www.stevensgroup.org.



Dynamic Hydrogel Matrices: Cell Biology in the Fourth Dimension

Kristi S. Anseth Department of Chemical and Biological Engineering and the BioFrontiers Institute, University of Colorado at Boulder, USA

Methods for culturing mammalian cells in a biologically relevant context are increasingly needed to study cell and tissue physiology, expand and differentiate progenitor cells, and to grow replacement tissues for regenerative medicine. Two-dimensional culture has been the paradigm for in vitro cell culture; however, evidence and intuition suggest that cells behave differently when they are isolated from the complex architecture of their native tissues and constrained to petri dishes or material surfaces with unnaturally high stiffness, polarity, and surface to volume ratio. As a result, biologists are often faced with the need for a more physiologically relevant 3D culture environment, and many researchers are realizing the advantages of hydrogels as a means of creating custom 3D microenvironments with highly controlled chemical, biological and physical cues. Further, the native ECM is far from static, so ECM mimics must also be dynamic to direct complex cellular behavior, the so called fourth-dimension. In general, there is an un-met need for materials that allow user-defined control over the spatio-temporal presentation of important signals, such as integrin-binding ligands, growth factor release, and biomechanical signals. Developing such hydrogel mimics of the ECM for 4D cell culture is an archetypal engineering problem, requiring control of numerous properties on multiple time and length scales important for cellular functions. New materials systems have the potential to significantly improve our understanding of how cells receive information from their microenvironment and the role that these dynamic processes may play in controlling the stem cell niche to cancer metastasis. This talk will illustrate our recent efforts to advance hydrogel chemistries for 4D cell culture and regenerative biology, and how we dynamically control biochemical and biophysical properties through orthogonal, photochemical click reaction mechanisms.


Prof. Kristi S. Anseth

Professor Kristi S. Anseth is presently a Distinguished Professor of Chemical and Biological Engineering and Associate Faculty Director of the BioFrontiers Institute at the University of Colorado at Boulder. Her research interests lie at the interface between biology and engineering where she designs new biomaterials for applications in drug delivery and regenerative medicine. Dr. Anseth is an elected member of the National Academy of Engineering (2009), the National Academy of Medicine (2009), the National Academy of Sciences (2013), and the National Academy of Inventors (2016). She is also a dedicated teacher, who has received four University Awards related to her teaching, as well as the American Society for Engineering Education’s Curtis W. McGraw Award. Dr. Anseth is a Fellow of the American Association for the Advancement of Science, the American Institute for Medical and Biological Engineering, American Institute of Chemical Engineers, and the Materials Research Society. She serves on the editorial boards or as associate editor of Biomacromolecules, Journal of Biomedical Materials Research - Part A, Acta Biomaterialia, Progress in Materials Science, and Biotechnology & Bioengineering.

Round Table



The role of bioengineering in the advancement of healthcare, and the contribution of IBEC

Sam StuppSimpson Querrey Institute for BioNanotechnology, Northwestern University

Samuel Stupp is Board of Trustees Professor of Materials Science and Engineering, Chemistry, Medicine, and Biomedical Engineering at Northwestern University. He directs at Northwestern the Simpson Querrey Institute for BioNanotechnology and the Energy Frontiers Research Center for Bio-Inspired Energy Science funded by the Department of Energy. Professor Stupp is a member of the National Academy of Engineering, the American Academy of Arts and Sciences, and the Spanish Royal Academy. He is a fellow of the American Physical Society, the Materials Research Society, and the Royal Society of Chemistry. His awards include the Department of Energy Prize for Outstanding Achievement in Materials Chemistry, the Materials Research Society Medal Award, the American Chemical Society Award in Polymer Chemistry, the American Chemical Society Ronald Breslow Award for Achievement in Biomimetic Chemistry, the International Award from The Society of Polymer Science in Japan, and the Royal Society Award in Soft Matter and Biophysical Chemistry. He has received honoris causa doctorates from Eindhoven Technical University in the Netherlands, the University of Gothenburg in Sweden, and the National University of Costa Rica.


Jean-Louis Coatrieux INSERM, Université de Rennes

Jean-Louis Coatrieux graduated in Electrical Engineering at the Polytechnic Institute, Grenoble, France in 1970 and received the PhD and State Doctorate in Sciences in 1973 and 1983 respectively from the University of Rennes 1, France. He was Assistant Professor from 1970 to 1975 and Associate Professor from 1976 to 1986 at the Institute of Technology of Rennes. Since 1986, he has been Director of Research at the National Institute for Health and Medical Research (INSERM), France, and since 1993 has been Professor at the New Jersey Institute of Technology, Newark, USA. He has been the Head of the “Laboratoire Traitement du Signal et de l’Image”, INSERM, up to 2003 and in charge of the National Research Program in Health Technology at the Ministry of Research (1998-2001), France. He was President of the International Scientific Committee of IBEC (2008-2013), Spain, and member of the CIBER-BBN Advisory Board, Spain. He served as expert for the European Commission on FP6 and 7 assessment committees and also as independent observer. He is regularly solicited by universities, research institutes and agencies over the world (USA, Canada, Sweden, Australia, etc).

His experience is related to statistical analysis, 3D images, signal processing, pattern recognition, computational modeling and complex systems with applications in ICT and Health. He founded the IEEE EMBS International Summer School on Biomedical Imaging in 1994. He published more than 300 papers in journals and conferences and edited many books in these areas. He has served as the Editor-in-Chief of the IEEE Transactions on Biomedical Engineering (1996-2000) and on the Boards of several major journals: Proceedings of IEEE, Critical Review on Biomedical Engineering, Medical and Biological Engineering and Computing, Medical Image Analysis, etc. He has received several awards from IEEE (among which the EMBS Service Award, 1999, the Third Millennium Award, 2000, EMBS Career Achievement Award, 2006). He is Doctor Honoris Causa from the South East University of Nanjing, China, and Foreign Excellence Professor (2011-2015). He is the recipient of the Brittany Regional Council Medal (2006), the Claude Fourcade Award (2011) and the China Friendship Award (2014). He is currently Emeritus Research Director of INSERM.


Emilià PolaCatalan Institution for Research and Advanced Studies (ICREA)

Emilià Pola is a research manager with a long experience in managing research institutions, technology transfer and innovation. He has a Biology degree (UB), a Master in Sciences (UB) and an MBA (ESADE).

Currently he is the Executive Director of ICREA, the Catalan Institution for Research and Advanced Studies.

He was the first director of the CERCA programme, and before that he was advisor to the Ministry of Universities and Research. He was also the managing director of ACER, the Catalan Association of Research Entities, of which he later on became Secretary of the Board. For five years he was the General Director of IDIBELL, a large hospital research centre.

He has been member of the board of several research centres of the CERCA network (CRG, ICFO, CRESIB, among others) and also member of the investment board of INVERTEC, a venture capital agency. His entrepreneurial activities include the participation in several spin-off companies, and he was the CEO of the first spin-off company of the University of Barcelona (OED). As an independent consultant, he has worked for universities, regional governments, research institutions and investors.

He has been associate professor at ESADE, and has extensive teaching experience in several universities (UB, UPF). He regularly collaborates with mainstream newspapers and media, generally in research and innovation support and advocacy.


Josep SamitierInstitute for Bioengineering of Catalonia (IBEC), Barcelona, SpainUniversity of Barcelona (UB), Spain

(See biography on page 18)

Josep A. PlanellPresident, Universitat Oberta de Catalunya / Institute for Bioengineering of Catalonia (IBEC), Barcelona, Spain

(See biography on page 13)

Alumni Session



Biofabrication strategies to recapitulate articulating joint complexityRiccardo Levato1, Jos Malda1,3

1 Department of Orthopaedics, University Medical Center Utrecht, Utrecht, The Netherlands2 Department of Equine Sciences, Utrecht University Utrecht, The Netherlands

Biofabrication enables building patient-specific, complex tissue constructs in which the three-dimensional spatial distribution of cells and materials is precisely controlled. By applying the principles of layer-by-layer additive manufacturing technologies to biological entities, it is possible to generate 3D structures that accurately recapitulate key features of the native architecture of living tissues, and thus to produce functional engineered grafts for regenerative medicine or as in vitro models. We investigated the potential of biofabrication to produce complex grafts for articular cartilage regeneration, that i) take into account the zonal, depth-dependent composition of cartilage and its integration with the subchondral bone, and ii) provide adequate mechanical properties to withstand the loads in the articulating joint. Cell-laden gelatin- and PEG-based hydrogel bioinks were designed to allow bioprinting with high shape fidelity, and to allow cartilage and bone matrix deposition by accurately selected populations of articular cartilage-derived progenitor cells (ACPCs) and mesenchymal stromal cells (MSCs). The effect of printing on long-term cell performance was evaluated during 56 days of culture, and a differential expression of zonal markers was detected between MSCs and ACPCs, the latter significantly upregulating the superficial zone marker PRG4. Conversely, MSCs had higher expression of collagen type X, a marker for the calcified zone. Constructs exibithing a biomimicry of salient features of the zonal composition of cartilage were obtained printing a superficial zone-competent bioink, laden with ACPCs and an MSC-laden middle/deep zone bioink. Bioinks were also co-printed with filaments acting as mechanical reinforcement, using either stiff biodegradable hydrogels or thermoplastic polyester frames, produced either by fused deposition modelling or melt electrospinning writing. Remarkably, biofabricated composites formed by cell-laden hydrogels and organized meshes of microfibers produced by melt electrospinning showed a range of compressive properties analogous to that of native articular cartilage.The combination of hydrogel bioprinting and printing of submillimiter to micrometer scale reinforcing fibers allows the production of multiscale, cellularized constructs, that can be used as partial joint replacement in animal models, in the perspecive of future clinical translation. Finally, the current rapid advances in biofabrication hold significant potential for developing larger grafts to address the treatment of the articulating joint, as well as in vitro model to understand joint physiology and pathology.


Dr. Riccardo Levato is a senior postdoctoral researcher in Biofabrication and Regenerative Medicine at the Department of Orthopaedics, University Medical Center Utrecht (UMCU) and at the Regenerative Medicine Center Utrecht.

His main research focus is on the development of Biofabrication strategies to create bioprinted and lab-made tissue models, including cartilage, vascular structures and liver. At UMCU, he focuses particularly on novel treatments for cartilage and osteochondral defects and their application in translational regenerative medicine. For his work on biofabrication, he was conferred the 2016 Wake Forest Institute for Regenerative Medicine Young Investigator Award.

From January 2010 to May 2015 he worked at the Institute for Bioengineering of Catalonia at the Biomaterials for Regenerative Therapies group, first as a predoctoral researcher, and as a postdoc after the completion of the PhD programme (January 2010).

Dr. Levato worked in several research groups across Europe: 3Bs, University of Minho, (Portugal, in 2008); BioMatLab, Technical University of Milan (Italy, in 2009) in the field of Biomaterials and Regenerative Medicine. Dr. Levato holds a cum laude PhD in Biomedical Engineering (awarded by the Technical University of Catalonia, Spain), and for his doctoral research performed at IBEC, he was conferred the 2015 Julia Polak award by the European Society for Biomaterials.

He is member of the International Society for Biofabrication, European Society for Biomaterials, Tissue Engineering and Regenerative Medicine Internatonal Society, and the International Cartilage Repair Society.

Dr. Riccardo Levato



Epigenomic mechanisms controlling β cell development, regeneration and survivalSilvio A. Traba1, Inês Cebola2, Candy H.-H. Cho3,10, José Bessa4,11, Meritxell Rovira5,6, Mario Luengo4, Mariya Chhatriwala7, Andrew Berry8, Joan Ponsa-Cobas2, Miguel Angel Maestro5,6, Rachel E. Jennings8, Lorenzo Pasquali5,6, Ignasi Morán2, Natalia Castro5,6, Neil A. Hanley8,9, Jose Luis Gomez-Skarmeta4, Ludovic Vallier3,7, Jorge Ferrer2,5,6, Adali Pecci1 and Santiago A. Rodríguez-Seguí1,12

1 Laboratorio de Fisiología y Biología Molecular, Departamento de Fisiología, Biología Molecular y Celular, IFIBYNE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina.

2 Department of Medicine, Imperial College London, United Kingdom.3 Anne McLaren Laboratory for Regenerative Medicine, Department of Surgery and Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, United Kingdom.

4 Centro Andaluz de Biología del Desarrollo, Consejo Superior de Investigaciones Científicas/Universidad Pablo de Olavide, Carretera de Utrera Km1, 41013 Sevilla, Spain.

5 Genomic Programming of Beta-cells Laboratory, Institut d'Investigacions August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain.

6 CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), 08036 Barcelona, Spain.7 Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, United Kingdom.

8 Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical & Human Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Oxford Rd, Manchester M13 9PT, United Kingdom.

9 Endocrinology Department, Central Manchester University Hospitals NHS Foundation Trust, Grafton St, Manchester, United Kingdom.

10 Present address: Genomics Research Center, Academia Sinica 128 Academia Road, Section 2, Nankang, Taipei, 115, Taiwan.

11 Present address: Instituto de Biologia Molecular e Celular (IBMC), 4150-180 Porto, Portugal.

The genomic regulatory programs that underlie human organogenesis are poorly understood. Human pancreas development, in particular, has pivotal implications for pancreatic regeneration, cancer, and diabetes. We have now created maps of transcripts, active enhancers, and transcription factor networks in pancreatic multipotent progenitors obtained from human embryos, or derived in vitro from human embryonic stem cells. This revealed that artificial progenitors recapitulate salient transcriptional and epigenomic features of their natural counterparts. Using this resource, we show that TEAD1, a transcription factor associated with Hippo signaling, is a core component of the active cis-regulatory modules in pancreatic progenitors. TEAD1-bound enhancers thus provide a selective genomic regulatory network for activation of genes encoding regulators of signaling pathways and stage-specific transcription factors that are essential for normal pancreas development. Accordingly, chemical and genetic perturbations of TEAD and its co-activator YAP inhibited expression of known regulators such as FGFR2 and SOX9, and suppressed the proliferation and expansion of mouse and zebrafish pancreatic progenitors. These


findings provide a resource of active enhancers and transcripts in human pancreatic multipotent progenitors, and uncover a central role of TEAD and YAP as signal-responsive regulators of the transcriptional program of early pancreas development.

In this talk I will make an overview of epigenetic research and how this might help to understand the developmental programs in human organogenesis, with special emphasis on our lastest results showing how other signaling pathways might interfere with the gene expression regulation controlled by TEAD and YAP during pancreas development. As well, from a nanobioengineering point of view, I will discuss how microfluidic devices might improve pancreatic epigenetic research by accurately sorting pancreatic cell populations and pancreatic islets.


Dr. Santiago A. Rodríguez Seguí is a Bioengineer graduated from the University of Entre Ríos, Argentina (2004). He did his MSc in Biomedical Engineering and PhD in Biomedicine at the Institute for Bioengineering of Catalonia (IBEC), and the Electronics Department of the University of Barcelona, in Spain. His MSc studies were supervised by Prof. Abdelhamid Errachid and involved the design of biosensors to study protein and carbohydrate interactions (2005-2006). His PhD thesis, supervised by Prof. Josep Samitier and Prof. Elena Martínez (2006-2010), involved the use of nanotechnology tools, focusing on cell microarrays, to study stem cell differentiation.

Afterwards, he moved on to study the epigenomic regulation of pancreatic beta cells, as a postdoc at the Laboratory of Prof. Jorge Ferrer, in the Institut d’investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), in Barcelona, Spain (2010-2012).This training allowed him to learn and master the coupling of molecular biology experiments with the use of next generation sequencing tools.

Next, he got a repatriation grant from the National Research and Technical Council of Argentina (CONICET), and obtained a postdoctoral position at the Laboratory of Prof. Adali Pecci (2012). In 2013 he was accepted into the CONICET, joining the Institute for Physiology, Molecular Biology and Neurosciences (IFIBYNE-UBA-CONICET) and obtaining funding from the National Agency for Promotion of Science in Argentina to start his own research line. Since 2013 he has held a Laboratory Professor position in Genetics at the Faculty of Exact and Natural Sciences at the University of Buenos Aires, Argentina. Currently, Dr. Rodríguez Seguí is a research fellow of the CONICET and he has 4 funded research projects as a PI. He has ongoing collaborations with well known local and external researchers, including collaborations with Prof. Ludovic Vallier (Wellcome Trust Sanger Institute, Cambridge, UK), Prof. Silvio Gutkind (UCSD, California, USA), Prof. Alberto Kornblihtt (IFIBYNE-UBA-CONICET, Buenos Aires Argentina) and Prof. Gabriel Rabinovich (IBYME-CONICET, Buenos Aires, Argentina).

Dr. Rodríguez Seguí has published 14 scientific papers (7 of them as principal author) in recognized peer reviewed journals, including works published in Nature Cell Biology and Nature Genetics. He has also published 2 commentaries, and a book chapter in Methods in Molecular Biology: Epigenetics Protocols. He directed a graduate student thesis (2014-2016) and is currently directing a PhD student.

His current research is focused on the study of cell signaling pathways underlying the processes of pancreas development and beta cell regeneration, subjects of

Dr. Santiago A. Rodríguez Seguí


relevance in the field of diabetes research. For this purpose he uses mouse and rat as model organisms, as well as human pancreatic samples, and combines the use of molecular biology, next generation sequencing and bioinformatic tools to study the epigenome changes involved in these processes. His current interest is to apply novel nanotechnology tools for the study of beta cell differentiation and regeneration that help to bypass some of the limitations of this field of research.


Posters and flash presentations


NANOMEDICINE - Posters with flash presentation

NANOMEDICINE - Posters

Poster Name Title

1Livia Neves Borgheti Cardoso

Extracellular Vesicles as Drug Delivery System for the Treatment of Malaria

2Tania Patiño Padial

Effect of enzyme quantity and distribution on the self-propulsion of urease-powered micromotors

3 Lucas PedrazA bioreactor to evaluate the effect of oxygen gradients in bacterial infections: deepening in oxygen-controlled gene expression

4Sílvia Pujals Riatós

Studying structure and dynamics of self-assembled peptide nanostructures using fluorescence and super resolution microscopy

5Romén Rodríguez Trujiilo

Microfluidic Platform for Circulating Tumor Cells Isolation

6Dobryna Zalvidea

3D forces measurement during in vivo remodelling capillary network in the chorioallantoic membrane of the chicken embryo

Poster Name Title

7Francesc Xavier Arqué Roca

Acetylcholinesterase-Powered Microswimmers and their Biomedical Applications

8 Aida Baelo Hydroxylamines as a new family of antibacterial agents

9 Aida BaeloAdvanced therapies for the treatment of biofilm wound infections

10Arnau Biosca Romanillos

Immunoliposome-based Drug Delivery to Plasmodium falciparum Gametocytes

11Nuria Blanco Cabra

Aerobic vitamin B12 biosynthesis is essential for Pseudomonas aeruginosa class II ribonucleotide reductase activity during planktonic and biofilm growth


12Laura Carol Perdiguer

Magnetic Hyperthermia: Potential Therapeutic Tool for Malaria

13 Martí ChecaElectric forces in electrolyte solutions under non-static conditions measured with the Atomic Force Microscope

14Joan Espelt Ballarà

The stringent response is essential for maintaining virulence in the enteroaggregative E. coli strain 042

15Natalia Feiner-Gracia

Super-resolution microscopy unveils dynamic nanoparticle protein corona formation

16Edgar Fuentes Fuentes

Stability in Biological Media of Molecularly-Precise Micelles Dictates Internalization in Living Cells

17Andrea García Lizarribar

Microfluidic system for liposome formation

18 Tânia GonçalvesEngineering of Si-Au Janus Motors for Biomedical Applications

19Víctor González-Tarragó

Binding of ZO-1 to a5β1 integrins regulates the mechanical properties of a5β1-fibronectin links

20Berta Gumí Audenis

Structure and nanomechanics of quatsomes membranes

21 Ricardo Hidalgo Electrochemical studies of Shewanella oneidensis MR-1

22 Ana HortelãoEnhancement of Drug Release through Enzyme-Powered nanomotors based on Tunable Mesoporous Silica Nanoparticles

23 Mario HüttenerCrosstalk between IncHI1 plasmids and their hosts: tetracycline-dependent induction of the heat shock regulon

24 Ignasi JorbaNanomechanics of the Drosophila Embryonic Central Nervous System

25 Jaideep KaturiCross-streamline migration of chemically active Janus particles in flow

26Elena Lantero Escolar

Developing Aptamers against Plasmodium falciparum: Different Approaches to Overcome the Challenge

27 Helena LozanoElectrical and morphological characterization of bacterial polar flagella


28Albert Martí i Simó

Implementation of a Patient-Specific Workflow for Assessing Endothelialization of Elastin-like Recombinamers for Cardiovascular Applications: from Computational Fluid Dynamics to Microfluidics.

29Rafael Mestre Castillo

Electrical control of 3D bio-printed muscle cells towards biomedical applications

30 Ruben Millan Electrostatic Force Microscopy in liquid media

31 Monica MirEarly Diagnosis of Alzheimer in a Multiplexed approach based on New blood biomarkers

32Nerea Murillo-Cremaes

Construction of highly Ciprofloxacin-loaded mesoporous silica nanoparticles for drug delivery applications in bacteria-protected biofilms

33Lucas Santiago Palacios Ruiz

Active colloids at a liquid-liquid interface

34 Jemish ParmarCobalt Iron Oxide based micromotors for degradation of antibiotic

35 Lucas PedrazPseudomonas aeruginosa AlgR regulates ribonucleotide reduction and links it to oxidative stress signals

36Santiago Raymond

Development of patient-specific biomimetic bone grafts

37 Sergi Rey ViñolasDevelopment of the fabrication process of a scaffold for rotator cuff augmentation and its biological characterization

38 Roger RieraA study of polyplexes as gene delivery vectors using super-resolution microscopy

39 Agostino RomeoFlexible and Conformable Biosensors for Personalized Medicine

40 Gerard Rubí SansMacromolecular Crowders for Cell-Derived Matrix deposition enhancement

41 Eduard Torrents

Pseudomonas aeruginosa PAO1 is impaired in anaerobic growth and infectivity compared to clinical isolates due to a single point mutation in the class III ribonucleotide reductase promoter region

42Diana Vilela Garcia

Microbots decorated with silver nanoparticles kill bacteria in aqueous media


ICT FOR HEALTH - Posters with flash presentation

Poster Name Title

43 Noelia CampilloFrequency and Magnitude of Intermittent Hypoxia Modulate Endothelial Wound Healing in a Cell Culture Model of Sleep Apnea

44 Jordi FonollosaChemical gas sensor array for non-invasive home activity monitoring

45Manuel Lozano García

Continuous Adventitious Respiratory Sound Analysis for the Assessment of Bronchodilator Response in Asthma Patients

ICT FOR HEALTH - Posters

Poster Name Title

46Luis Carlos Estrada Petrocelli

Neural inspiratory time detection from surface diaphragm electromyography

47 Rene FabregasMapping of electric permittivity with high pixel resolution: steps toward SPM-Nanotomography

48 Bryan FalconesA Novel Cell Culture Device to Study the Cross-talk Between Cells Simultaneously Exposed to Different Oxygenation Mimicking Hypoxic Gradients in Tumors

49Luis Fernández Romero

Signal preprocessing stages for evaluating ham quality through GC-IMS

50R. Nuemi Hernandiz Solares

Feasibility study of a low-cost miniature device for the analysis of ammonia in breath

51 Ignasi JorbaMultiscale Nonlinear Mechanics of Lung Extracellular Matrix

52 Ignasi JorbaAn Acellular Myocardial Scaffold Optimal for Cardiac Recovery: Proteomic, Structural and Mechanical Characterization

53Albert Miguel López

Tracking Software for Active Micro and Nanomotors


CELL ENGINEERING - Posters with flash presentation

Poster Name Title

56Alberto Elosegui Artola

Force triggers YAP nuclear entry by mechanically regulating transport across nucleopores

57Andrea Malandrino

Analysis of Extracellular Deformations During Vasculogenesis

58Andreu Matamoros Angles

Understanding functions of the Cellular Prion Protein in synapse formation and neurotransmission: From lab-on-a-chip devices to neuronal network analysis

59Jesús Ordoño Fernández

Lactate based scaffolds as modulators of cardiac tissue remodeling

60Patricia Prado Peralta

Biofabrication of 3D self-assembling nephron structures from human pluripotent stem cells

61Maria Valls Margarit

Generation of human cardiac patches with tissue-like functionality

62 Elia Vidal GironaDirect ink printed titanium scaffolds functionalized with an antibacterial calcium phosphate coating obtained by one-step pulsed electrodeposition

54Leonardo Sarlabous

Non-invasive technique for estimating the inspiratory mechanical muscle activation during breathing in healthy subjects and COPD patients

55 Jia YanNumber of discriminable odor features for the optimization of MOX gas sensor operating temperatures

84 Sílvia MasA method for the analysis of flatus: Perspectives for non-invasive assessment of gastrointestinal diseases


Poster Name Title

63 Gizem AltayEpithelial monolayers obtained from intestinal epithelial stem cells

64Ignasi Casanellas Mercado

Uneven nanopatterns promote the formation of a connectivity network among human stem cells undergoing chondrogenesis

65 Laura Clua FerreA tissue-specific decellularized extracellular matrix platform for the generation of human pluripotent stem cell derived tissue constructs by 3D bioprinting

66Jordi Comelles Pujadas

Hydrogels with independently controlled topography and stiffness reveal contact guidance as stiffness independent

67 María García-DíazTowards biomimetic 3D multicellular models of the intestinal mucosa

68Elena Garreta Bahima

Generation of kidney organoids by differentiation of human pluripotent stem cells to intermediate mesoderm progenitors using culture substrates of controlled stiffness

69 Dencho GugutkovHybrid nanofibers' orientation and dimensionality govern the behavior and osteogenic differentiation of ADMSCs

70Kevin Ibeas Martinez

Development the pETS-IBECGLOW vectors: a useful tool to study bacterial gene expression during biofilm formation and infection

71Enara Larrañaga Carricajo

Effects of ephrin micro and nanopatterns on Eph receptor oligomerization and cell positioning

72Ernest Latorre Ibars

Tensional homeostasis in three-dimensional epithelia of controlled size and shape

73 Laia Lidón GilTranscriptional control of PrPc by Tau in Alzheimer's disease

74Andrés Marco Giménez

An upgraded iCRISPR2 Platform for Human Functional Genetics in a Dish

75 Joan Martí MuñozInducing bone formation through vascularization. A novel process to modulate Ca2+ release in physiological conditions

CELL ENGINEERING - Posters


76Agata Mata Rodríguez

Aberrant integration of adult-generated granule cells and mossy fiber formation in absence of Sema3E/PlexinD1 signalling in the adult hippocampus

77Francina Mesquida Veny

Modulation of axonal growth through optogenetic control of neuronal activity

78 Salima NedjariThree Dimensional Honeycomb Patterned Fibrinogen Based Nanofibers Induce Substantial Osteogenic Response Of Mesenchymal Stem Cells

79 Roger OriaMolecular force loading explains cell sensing of extracellular ligand density and distribution

80Tania Patiño Padial

3D Bioprinting for the engineering of bio-hybrid actuators based on skeletal muscle

81Alejandro Prieto Durán

Role of Hha-like proteins in conjugation of the virulence plasmid pAA2 in the enteroaggregative E. coli strain 042

82 Laura UrreaThe Cellular Prion Protein as Neuronal Receptor for a-Synuclein Spreading in Parkinson's Disease

83 Irene CanoEvaluation of angiogenic potential of cell-derived ECM scaffolds on chick embryo chorioallantoic membrane (CAM) animal model

Baldiri Reixac, 10-12 08028 Barcelona, Spain Tel. +34 934 039 706

www.ibecbarcelona.eu

With the generous support of:

designed and produced by the - events at the institute for ... · designed and produced by the ....

Documents