department of physiology, 2 nd faculty of medicine, charles university copyright © 2011 luděk...
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![Page 1: Department of Physiology, 2 nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad Sensory transduction Neurophysiology page 1](https://reader036.vdocuments.us/reader036/viewer/2022062407/56649c875503460f9493f19f/html5/thumbnails/1.jpg)
Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
![Page 2: Department of Physiology, 2 nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad Sensory transduction Neurophysiology page 1](https://reader036.vdocuments.us/reader036/viewer/2022062407/56649c875503460f9493f19f/html5/thumbnails/2.jpg)
Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Reception, perception, and transmission of information
Our actions arebased on whatwe perceive, i.e. the brain can ”read” it.
The brain createssubj. experience
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
How neurones communicate
Action potentialAction potential
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Action potential
Voltage-gatedNa+ and K+
ion channels
Na+ Na+
K+ K+
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Postsynapticpotentials
Neurotransmissionat a chemicalsynapse
Source ofexcitation isanother neurone
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Reception
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Stimulus processing and information coding
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Sensory receptors
Anatomical classification
Nerve endings
Sensory neurones
Classification based on physical stimulus
Mechanoreceptors
Thermoreceptors
Photoreceptors
Chemoreceptors
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
.. Common to all types of sensory receptors
Change of membrane potential-> Generation of receptor (“generator”) potential
Similar to postsynaptic potentials-> Threshold for action potential must be crossed
Receptor potentialis graded, i.e., itis proportional tostimulus strength
Receptor potentialsdecrease with distance
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
.. Common to all types of sensory receptors
The number of action potentials per time unitis linearly proportional to the receptor potential
Receptor potential [mV]
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
.. Common to all types of sensory receptors
The number of action potentials per time unitis linearly proportional to the receptor potential
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
.. Common to all types of sensory receptors
Receptor membrane becomes permeablefor all small ions (however Na+ prevail)
Receptor membrane is not electrically excitable
Action potentials are generated down the line(even in different neurones, such as in vision)
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
.. Common to all types of sensory receptors
Summation ofreceptor potentialsin time
Summation ofreceptor potentialsin space
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Adaptation
Decrease in amplitude of the generator potentialduring a prolonged sustained stimulation
Stimulation Stimulation
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Coding
All-or-none (binary)
Frequency vs. interval coding
Ensemble coding (a combination of morereceptors codes for a single feature)
Non-spiking coding (cells in the retina)
There are 10 kinds of people: Those whoUnderstand binary and those who don’t.
10 means 1x21 + 0x20 = 2
There are 10 kinds of people: Those whoUnderstand binary and those who don’t.
10 means 1x21 + 0x20 = 2
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Sensory systems
Visual system
Auditory system
Vestibular system
Olfactory system
Gustatory system
Somatosensory s.
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Olfactory system
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Olfactory system
Lamprey Shark Frog
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Olfactory system
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Olfactory system
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Olfactory system
Receptor cells
Mitral cells
Periglomerularcells
Granule cells
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Olfactory receptor
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Olfactory receptorOdorant binding proteinOdorant binding protein
Odorant receptor (onetype for each cell)Odorant receptor (onetype for each cell)
Olfactory G-proteinOlfactory G-protein
Increase of cAMPIncrease of cAMP
Opens Na+, K+, Ca2+ ch.Opens Na+, K+, Ca2+ ch.
Cell depolarisationCell depolarisation
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Olfactory pathway
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Gustatory system
SweetSaltySourBitterUmami
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Tongue
TongueTongue PapillaPapilla
Taste budsTaste buds
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Taste buds
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Taste receptor
G-protein coupled receptor
Ion channels
Sweet
Bitter
Umami
Salty
Sour
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Taste receptor
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Taste receptor
Receptor binding
G-protein
Second messengers
Opening of TRPM5
Depolarisation
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Taste receptor
Na+ enter cell
Depolarisation
Low pH opens H+ ch.
H+ enter cell
Depolarisation
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Taste receptor
Depolarisation
Ca2+ channels open
Ca2+ causesneurotransmitterrelease
ATPATP
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Gustatory pathway
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Visual system
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Retina
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Rods and cones - photoreceptors
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Retinal cells
Rods
Cones
Bipolar cells
Ganglion cells
Horizontal cells
Amacrine cells
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Photo-transduction in rods
rhodopsinrhodopsin
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Rhodopsin cycle
rhodopsinrhodopsin
scotopsinscotopsin
all-trans retinalall-trans retinal
Metarhodopsin IItriggers cellhyperpolarisation
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Rod receptor potential
Metarhodopsin II reducesinward flow of Na+ in outersegment
In the dark, the outer segmentsuffers from the leakage of Na+
This reduces resting potentialto -40mV
Light produces metarhodopsin II
Resting potential drops to as lowas -70mV
glutamateglutamateGlutamate release is reduced
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Action potentials in the retina
The only type of retinal cell thatgenerates action potentials areganglion cells
Other cells conduct signals bysimple electric conduction
Retinal ganglion cells produceaction potentials repeatedly(40 Hz), even if not stimulated.
Visual signal is formed by ‘extra’action potentials.
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Auditory and vestibular system
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Auditory and vestibular system
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Organ of Corti
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Organ of Corti
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Stereocilia
glutamateglutamate
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Vestibular system
Semicircular canals
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Somatosensory system
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Somatosensory system
Mechanoreceptors
Thermoreceptors
Nociceptors
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Somatosensory receptors
Ruffini’s corpuscle – pressure sensor
Merkel’s cells – pressure receptor
Meissner’s corpuscle – light touch
Hair follicle receptor – analog. to Meissner’s c.
Pacinian corpuscle – fast-adapting pressure sensor
Cold and warmth sensors
Pain sensor – free nerve ending
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
Sensory Sensory transductiontransduction
NeurophysiologyNeurophysiologypage 1page 1
Pain receptors
Nerve endingsNon-adapting
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Department of Physiology, 2nd Faculty of Medicine, Charles University Copyright © 2011 Luděk Nerad
SummarySummaryNeurophysiologyNeurophysiologypage 1page 1
Sensory transduction in general
Specific sensory systems
Receptor neurones
Receptor potential
Olfactory
Gustatory
Visual
Auditory