dental implant therapy - trends & literature critical ... lecture implant... · 2/23/2007 ·...
TRANSCRIPT
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D t l I l t ThDental Implant Therapy -Trends & LiteratureTrends & Literature Critical AppraisalCritical Appraisal
American Academy Of Fixed ProsthodonticsA l M ti F b 23 24 2007
Asbjørn Jokstad DDS PhD
Annual Meeting February 23-24, 2007
Asbjørn Jokstad, DDS, PhDProfessor and Head, Prosthodontics
Faculty of Dentistry, University of Toronto
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Adolescent patient with a crown–root fracture of central: options? p
Fracture line palatinallypalatinally
1. Extraction orthodontics veneer or crown2. Extraction etch-bridge or FPD3. Extraction implant abutment crown4. Extraction & replantation 180° endo crown5 Endo orthodontic extrusion crown
Faculty of Dentistry, University of Oslo, Depts. of Pedodontics, Orthodontics & Prosthodontics. Stenvik & Birkeland, 2007.
5. Endo orthodontic extrusion crown6. Decoronation+etch-bridge/flipper implant
abutment crown
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Adolescent patient with missing laterals: options? p
A. Orthodontic TreatmentB. Etch-bridgesC. (Provisional) Removable Partial
CD. Conventional Fixed PartialE. Implant-supported crowns
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More treatment considerations:
Adolescent patient with missing laterals: options?
considerations:A. Orthodontic Treatment
What if buccal bone augmentation is required?A. Single implants + crowns in the lateral
regionsB. Mesial movement of canines composites
+ single implants in canine region g p gC. Mesial movement of canines & bicuspids
composites + single implants in bicuspidcomposites + single implants in bicuspid region
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Useful, or just kb k?cookbook?
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“Medicine is a science of uncertainty and an art of probability”art of probability
Sir William Osler Canadian Physician (1849-1919)
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What has been shown to influence our treatment decisions in practice?our treatment decisions in practice?
Evidence
The last patient Education
Dental PracticeThe last patient
Litigation
Education and training
A ditLitigation society
Audit
Payment systems
Resources & staff y
Past experience
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"A science of uncertainty and an art of probability"
Adopting an p gevidence-based li i l ti illclinical practice will
facilitate arriving atfacilitate arriving at appropriate treatmentappropriate treatment
decisionsdecisions
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Decision making in prosthodontics"A science of uncertainty and an art of probability"
Historically, prosthodontic decision making has always been i fl d b
Fixed or
influenced by:
1. a narrow range removable denture ?
$$?
of technical solutions (limited by biology) and$$? by biology) and
2. the patient finances.
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Decision making in prosthodontics"A science of uncertainty and an art of probability"
Traditional prosthodontic pdecision making is equivalent to
how evidence
…Fixed or how evidence-
based medicine is meant to be
removable denture ?
$$?practiced From: Haynes et al. Br
$$?
Med J 1998; 317:273-6
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"A science of uncertainty and an art of probability"
Scientific studies are graded according to theaccording to the
theoretical possibilityp yof a
false conclusionfalse conclusion
This is reflected by theThis is reflected by the design of the study.g y
...the correct conclusions will remain uncertain forever….
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“A science of uncertainty and an art of probability”
“Doubt is not a pleasant conditionpleasant condition, but certainty is an absurd one”
VoltaireVoltaire French Philosopher (1694-1778)
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Clinical trial terminology - tower of Bable?analytical studycase control study (89)case serie
ecological studyetiological studyexperimental study
prospective cohort studyprospective follow-up study,observational or experimental
case study, case reportcause-effect studyclinical trial (79)
p yexplorative studyfeasibility study (79)follow up study (67)
pprospective study (67)quasi-experimental studyrandomized clinical trial RTCclinical trial (79)
cohort study (89)cohort study with historical
follow-up study (67)historical cohort studyincidence study
randomized clinical trial, RTCrandomized controlled trial, RCT (89)retrospective cohort study
controlscontrolled clinical trial (95)cross-sectional study (89)
intervention studylongitudinal study (79)N=1 trial
retrospective follow-up studyretrospective study (67)surveillance study
descriptive studydiagnostic meta-analysisdiagnostic study
non-randomized trial withcontemporaneous controlsnon randomized trial with
survey, descriptive surveytherapeutic meta-analysistrohoc studydiagnostic study
double blind randomizedtherapeutical trial with cross-over design
non-randomized trial withhistorical controlsobservational study
trohoc study
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Clinical trial terminology - Medical Subject Headings (MESH) terms 1967
analytical studycase control study (89)case serie
ecological studyetiological studyexperimental study
prospective cohort studyprospective follow-up study,observational or experimental
case study, case reportcause-effect studyclinical trial (79)
p yexplorative studyfeasibility study (79)follow up study (67)
pprospective study (67)quasi-experimental studyrandomized clinical trial RTCclinical trial (79)
cohort study (89)cohort study with historical
follow-up study (67)historical cohort studyincidence study
randomized clinical trial, RTCrandomized controlled trial, RCT (89)retrospective cohort study
controlscontrolled clinical trial (95)cross-sectional study (89)
intervention studylongitudinal study (79)N=1 trial
retrospective follow-up studyretrospective study (67)surveillance study
descriptive studydiagnostic meta-analysisdiagnostic study
non-randomized trial withcontemporaneous controlsnon randomized trial with
survey, descriptive surveytherapeutic meta-analysistrohoc studydiagnostic study
double blind randomizedtherapeutical trial with cross-over design
non-randomized trial withhistorical controlsobservational study
trohoc study
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Clinical trial terminology - MESH terms 1979analytical studycase control study (89)case serie
ecological studyetiological studyexperimental study
prospective cohort studyprospective follow-up study,observational or experimental
case study, case reportcause-effect studyclinical trial (79)
p yexplorative studyfeasibility study (79)follow up study (67)
pprospective study (67)quasi-experimental studyrandomized clinical trial RTCclinical trial (79)
cohort study (89)cohort study with historical
follow-up study (67)historical cohort studyincidence study
randomized clinical trial, RTCrandomized controlled trial, RCT (89)retrospective cohort study
controlscontrolled clinical trial (95)cross-sectional study (89)
intervention studylongitudinal study (79)N=1 trial
retrospective follow-up studyretrospective study (67)surveillance study
descriptive studydiagnostic meta-analysisdiagnostic study
non-randomized trial withcontemporaneous controlsnon randomized trial with
survey, descriptive surveytherapeutic meta-analysistrohoc studydiagnostic study
double blind randomizedtherapeutical trial with cross-over design
non-randomized trial withhistorical controlsobservational study
trohoc study
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Clinical trial terminology - MESH terms 1989analytical studycase control study (89)case serie
ecological studyetiological studyexperimental study
prospective cohort studyprospective follow-up study,observational or experimental
case study, case reportcause-effect studyclinical trial (79)
p yexplorative studyfeasibility study (79)follow up study (67)
pprospective study (67)quasi-experimental studyrandomized clinical trial RTCclinical trial (79)
cohort study (89)cohort study with historical
follow-up study (67)historical cohort studyincidence study
randomized clinical trial, RTCrandomized controlled trial, RCT (89)retrospective cohort study
controlscontrolled clinical trial (95)cross-sectional study (89)
intervention studylongitudinal study (79)N=1 trial
retrospective follow-up studyretrospective study (67)surveillance study
descriptive studydiagnostic meta-analysisdiagnostic study
non-randomized trial withcontemporaneous controlsnon randomized trial with
survey, descriptive surveytherapeutic meta-analysistrohoc studydiagnostic study
double blind randomizedtherapeutical trial with cross-over design
non-randomized trial withhistorical controlsobservational study
trohoc study
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Clinical trial terminology - MESH terms 1995analytical studycase control study (89)case serie
ecological studyetiological studyexperimental study
prospective cohort studyprospective follow-up study,observational or experimental
case study, case reportcause-effect studyclinical trial (79)
p yexplorative studyfeasibility study (79)follow up study (67)
pprospective study (67)quasi-experimental studyrandomized clinical trial RTCclinical trial (79)
cohort study (89)cohort study with historical
follow-up study (67)historical cohort studyincidence study
randomized clinical trial, RTCrandomized controlled trial, RCT (89)retrospective cohort study
controlscontrolled clinical trial (95)cross-sectional study (89)
intervention studylongitudinal study (79)N=1 trial
retrospective follow-up studyretrospective study (67)surveillance study
descriptive studydiagnostic meta-analysisdiagnostic study
non-randomized trial withcontemporaneous controlsnon randomized trial with
survey, descriptive surveytherapeutic meta-analysistrohoc studydiagnostic study
double blind randomizedtherapeutical trial with cross-over design
non-randomized trial withhistorical controlsobservational study
trohoc study
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Clinical trial terminology - tower of Bable stick to the Medical Subject Headings terms
analytical studycase control study (89)case serie
ecological studyetiological studyexperimental study
prospective cohort studyprospective follow-up study,observational or experimental
case study, case reportcause-effect studyclinical trial (79)
p yexplorative studyfeasibility study (79)follow up study (67)
pprospective study (67)quasi-experimental studyrandomized clinical trial RTCclinical trial (79)
cohort study (89)cohort study with historical
follow-up study (67)historical cohort studyincidence study
randomized clinical trial, RTCrandomized controlled trial, RCT (89)retrospective cohort study
controlscontrolled clinical trial (95)cross-sectional study (89)
intervention studylongitudinal study (79)N=1 trial
retrospective follow-up studyretrospective study (67)surveillance study
descriptive studydiagnostic meta-analysisdiagnostic study
non-randomized trial withcontemporaneous controlsnon randomized trial with
survey, descriptive surveytherapeutic meta-analysistrohoc studydiagnostic study
double blind randomizedtherapeutical trial with cross-over design
non-randomized trial withhistorical controlsobservational study
trohoc study
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Clinical study designs (U.S. NLM Medical Subject Headings terms):Medical Subject Headings terms):
1. Randomised Controlled Trial2. Controlled Clinical Trial3. Cohort Study 4. Case-Control Study 5 Cross Sectional Survey5. Cross-Sectional Survey 6 Case study/ case series6. Case study/ case series
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Study Designs and strengths“A science of uncertainty and an art of probability”
Study Designs and strengthsRCT CCT Cohort Case Cross Case RCT CCT Cohort Case
ControlCross-
sectionalCase series
Therapy / P ti /
Prevention / Education Prognosis
Diagnosis
ScreeningScreening test Prevalence/ h th i
hypothesis generation
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Therapy / Prevention / “A science of uncertainty and an art of probability”
pyEducation
• Which implant design / surgical• Which implant design / surgical technique /maintenance regime / education strategy provides the best result*?best result ?
* Clinical, patient-centred, surrogate ior economic outcomes
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Therapy / Prevention /“A science of uncertainty and an art of probability”
1 Random allocation of the participants
Therapy / Prevention / Education
1. Random allocation of the participants to the different interventions
2. Outcome measures of importance for at least 80 per cent of participantsat least 80 per cent of participants who entered the investigation
3 A t ti ti l l i i t t ith3. A statistical analysis consistent with the study design
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Prognosis“A science of uncertainty and an art of probability”
Prognosis• How predictable is the performance• How predictable is the performance
of the implant “Speedy Fantastico” i th t i j ?in the upper posterior jaw?
• What is the risk that patients willWhat is the risk that patients will experience a fractured screw /
b t t i l t?abutment or implant?
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Prognosis“A science of uncertainty and an art of probability”
g1. A cohort of persons, all initially free p y
of the outcome of interest 2 Follow up of at least 80 per cent of2. Follow-up of at least 80 per cent of
patients until the occurrence of ith j t d it i theither a major study criteria or the
end of the study3. A statistical analysis consistent
with the study designwith the study design.
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Diagnostic tests“A science of uncertainty and an art of probability”
Diagnostic tests• Does the use of RFA or the• Does the use of RFA or the
Periotest to predict loading strategy have any merits?have any merits?
• What is the validity of the Zarb and Lekholm bone quality classification?
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Diagnostic tests“A science of uncertainty and an art of probability”
Diagnostic tests1. Clearly identified comparison groups, at least
one of which is free of the target disorderone of which is free of the target disorder 2. Either an objective diagnostic standard or a
contemporary clinical diagnostic standardcontemporary clinical diagnostic standard with reproducible criteria
3 Interpretation of the test without knowledge of3. Interpretation of the test without knowledge of the diagnostic standard result
4 Interpretation of the diagnostic standard4. Interpretation of the diagnostic standard without knowledge of the test result
5 A statistical analysis consistent with study5. A statistical analysis consistent with study design
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Etiology – Harm “A science of uncertainty and an art of probability”
gy• Does trace elements from implants p
cause adverse general effects?H t i b t h f i l t• Has a certain batch of implants been contaminated during the gproduction process?
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Etiology Harm Causality“A science of uncertainty and an art of probability”
Etiology – Harm - CausalityRandomised controlled trial >Randomised controlled trial > clinical controlled trial > cohort > case -control > cross-sectional > single casecross sectional single case A statistical analysis
i i h h dconsistent with the study design.design.
Thus: Purely probabilistic considerations
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“A science of uncertainty and an art of probability”
“ Doctors prescribe pmedicine of which they know little to cure diseasesknow little, to cure diseases of which they know less, in human beings of which they know nothing”know nothing
Voltaire French Philosopher (1694-1778)
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Views /beliefs /perceptions“A science of uncertainty and an art of probability”
Views /beliefs /perceptions •How does implant•How does implant
prostheses impact on the patient’s daily life?Wh ll h it t•Why are colleagues hesitant to implement implantto implement implant prosthetics in their practices?
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“A science of uncertainty and an art of probability”
Study Designs and strengths Qualit-
ative researc
h
Cross-section
al Survey
Case
Control
Cohort CCT RCT Systematic
review
Study Designs and strengths
h Survey trolEffectiveness: Does it work? Process of intervention/ delivery: How does it work?
delivery: How does it work?Salience: Does it matter? Safety: Will it do more good than harm?
Acceptability: Will the patient accept the intervention?
Cost effectiveness: Is it worth i f h i i ?
paying for the intervention?Appropriateness: Is this the right intervention for this patient?
Satisfaction with theSatisfaction with the intervention: Are users, providers and other stakeholders satisfied?
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EBM can beEBM can be implemented in dailyimplemented in daily practice in various p
ways
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Modified from Haynes et al. BMJ 1998;317:273-6
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Modified from Haynes et al. BMJ 1998;317:273-6
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Modified from Haynes et al. BMJ 1998;317:273-6
Pub~'" "..,""":w:,:-:: =,
; ,
A'''''' EviDents Seal"Ch Engine
0 1: Fran,als
(under revision)
Generating evjdence from research
Synthesising the evidence
The patient's
circumstances
The evidence
The patient's wishes
Making clinical decisions
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80
90
100
%
Independentvariables
Bi-variateoddsratios
Bivariatesignificance
95%Confidenceintervalsbivariateodds ratios
Multi-variateodds ratios
Multivariatesignificance
95%Confidenceintervals formultivariateodds ratios
Age group20-3030-40+40
-2.322 63
-*****
-1.15 - 3.131 43 - 3 08
-2.522 63
-*****
-1.35 - 3.331 83 - 3 8
Risk factors – odds ratios
50
60
70
0 5 10 15 20 years
+40 2.63 1.43 - 3.08 2.63 1.83 - 3.8GenderMaleFemale
-2.42
-**
-1.61 - 2.79
-2.12
-**
-1.91 - 2.9
MaterialAmalgamCompositesGlass ionom.
-1.123.12
-NS***
-0.13 - 1.562.52 - 4.34
-1.425.65
-NS**
-1.13 - 1.964.67 - 7.23
Dentists#1#2
-1.34
-NS
-0.35 - 1.61
-1.04
-NS
-1.35 - 2.01
Location
Correcttreatmentdecision S i l ti t Mandible
Maxilla-1.55
-*
-1.17 - 2.04
-1.15
-*
-1.57 - 2.14decision
København Aarskursus Mars 2000
gingivitt
%?%?
%?%?Survival estimates
Dentist:patient relationshipTwo-way communication
Outcome probabilities
communication
København Aarskursus Mars 2000
15
20.
% worst case scenarios
København Aarskursus Mars 2000
0
5
10
0 5 10 15 20 25År
1000
KR
.
Patient values & preferences
Cost increments
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“Guerir quelquefois, soulager souventsoulager souvent, consoler toujours”
“C i ll“Cure occasionally, relieve often, Ambroise Paré,console always “
Ambroise Paré French Physician(1510 –1590)
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Overall strengthOverall strength of current oralof current oral implant researchimplant research
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Review of existing literatureEckert S et al. Validation of dental implant
systems through a review of literature
g
systems through a review of literature supplied by system manufacturers. J Prosthet Dent 1997;77: 271-9Prosthet Dent 1997;77: 271 9.
Conclusion:O th b i f th lit t li d bOn the basis of the literature supplied by the manufacturers, only one implant
t d t t d i tifi ll lidsystem demonstrated scientifically valid long-term success.
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Situation, 19991 The number of implants and implant systems1. The number of implants and implant systems
increase continuously worldwide2 The FDI World Dental Federation is concerned2. The FDI World Dental Federation is concerned
about the quality of all the new implants being marketedmarketed
3. The FDI Science Committee is asked to investigate the issueinvestigate the issue
4. The work is commissioned to prof. A Jokstad
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Implant brands/ systems available i N A i i 1999 ( 98)in N. America in 1999 (n=98)
Binon, IJOMI, 2000, 15(1): 76-95
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Jokstad, Brägger, Brunski, Carr, Naert, Wennerberg. Int Dent J , g2003; 53 Sup 2: 409-33
A bj J k t d O l NAsbjørn Jokstad, Oslo, NorwayUrs Braegger, Bern, SwitzerlandJohn B. Brunski, Troy, USA, y,Alan B. Carr, Rochester, USAIgnace Naert, Leuven, BelgiumAnn Wennerberg Gothenburg SwedenAnn Wennerberg, Gothenburg, Sweden
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Commercially available implant and implant y p psystems in October 2003:
225 implant brands78 manufacturers from all continents78 manufacturers – from all continents~70 implant brands no longer marketed
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Straight, Tapered, Conical, Ovoid, Trapezoidal, Stepped & combinations …
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Flange designg
Flange vs. no flangeStraight vs. flared vs. wideningHeightPolished vs threadsPolished vs. threadsAdded featuresS fSurface topography
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Threads vs. non-threadsShape: V- vs. square- vs. reverse buttress- vs. combinationsNumber and size of “lead threads”Number and location of grooves, groove forms and groove sizesSurface micro-topography Thread angle
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ApexTh d dThreaded vs non-threadedV h fl tV-shape vs flat vscurved apexH l dHoles, round, oblongA i l h bApical chamberGrooves and
igroove sizeFlared apexSurface topography
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Interface geometryExternal vs InternalHexagonal vs. Octagonal vs coneM tMorse taper Rotational vs non-rotationalrotationalAdded non-rotational featuresHeights & widthsButt vs bevel jointsjSlip-fit vs friction-fit jointsResilience vs nonresilience ….
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High (top) and low (bottom) magnification of cpTi surfaces as used for surface characterizationsurfaces as used for surface characterization.
Plasma– Grit-blasted Grit-blasted Dual acid- Machined sprayed (TPS);
and dual acid-etched
etched (turned)
Davies, 2003
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Surface topography Machining process Example
Anisotropic with Turned Brånemark System® MKIII oriented cutting marks (Nobel Biocare)
Isotropic Blasted TiO2 particles (Tioblast®, A t T h)AstraTech)
Isotropic Blasted + acid etched 1. Large size Al2O3 particles & HCl & H2SO4 (SLA®, St ) 2 T i l iStraumann) - 2. Tricalcium phosphate & HF & NO3 (MTX®, Centerpulse)
Isotropic with high frequency irregularities
Acid etched HCl / H2SO4 (Osseotite®, 3i)
Isotropic and rough Hydroxyapatite coated Sustain® (Lifecore)
Isotropic and rough Titanium Plasma ITI® TPS (Straumann)p gSprayed
( )
Isotropic with craterous structure
Oxidized TiUnite® (Nobel Biocare)
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Clinical documentationA. Implant or implant system with
extensive clinical documentation: >4 10clinical trials
B. Implant or implant system with limited 11B. Implant or implant system with limited clinical documentation, i.e. <4 trials, but of good methodological quality
11but of good methodological quality
C. Implant or implant system with limited published clinical documentation
29published clinical documentation
D. Implant or implant system with no bli h d li i l d t ti
28published clinical documentation.
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The quality of RCTs of oral implants is generally poor and needs to be improved
Esposito et al., IJOMI 2001; 16: 783-92
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Clinical documentation of
i l tnew implant systemssystems
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Clinical trials – Dental implantsClinical trials Dental implants
350
250
300
350
3091 0
200
250
142175
233263 282
309
100
150
1 2 1 0 0 4 4 4 7 14 16 2857
85
0
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967 69 71 73 74 76 78 80 82 84 86 88 90 92 94 96 98 00 02 04
196
1968
-619
70-7
1972
-719
73-7
1975
-719
77-7
1979
-819
81-8
1983
-819
85-8
1987
-819
89-9
1991
-919
93-9
1995
-919
97-9
1999
-020
01-0
2003
-0
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Clinical trials – Dental implants
168180
122 123
140 138 144
168
141134140
160
180
76 72
102
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123
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37 34 3946
6676 72
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6 6 7 8 9 0 1 2 3 4 5 6 7 8 9 0 1 2 3 4 5 6
<198
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Implant ManufacturersImplant ManufacturersUSA: 28Germany: 25Italy: 14Korea: 8Korea: 8Spain: 8Brazil: 5Switzerland : 5Canada: 4France: 4France: 4Sweden: 4Israel: 3
per 2.2007 (n=120!)
United Kingdom: 3Other countries: 9
( )
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Implant systems introducedImplant systems introduced since October 2003 ?
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Binon PP Implants and components: entering the new
Jokstad A, et al. Quality of dental implants. Int Dent J. 2003;53(6 Suppl
2):409-43
Binon PP.Implants and components: entering the new millennium. Int J Oral Maxillofac Implants. 2000;15:76-94.
English CE. Implants. Part three. An TODAY
357350
400
goverview.CDA J. 1988;16: 34-8.
220250
300
220
150
200
45
98
50
100
0
1980
1982
1984
1986
1988
1990
1992
1994
1996
1998
2000
2002
2004
2006
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Clinical trials – Dental implants
Clinical trials since 2003 = 362Clinical trials since 2003 = 362Brånemark / Replace 122ITI /Straumann 79ITI /Straumann 793i/Osseotite 34
2 23Frialit2/Frialit+/Frialoc/Frios 23Astra 18
267 (73%)( )
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New Implant materials
Tilllelol achallue? Me"'l Ilee "elKilI de51heli<s wilh I_Sysl"""S
I-Lock dental implants ~re r"""llltianising Europe, and are the on~ ,.rtified ceramic implants ""ailabl. in New Iealand
Cel1ifielllJiQ_jllel1
I-LoCk dental implants ha", passed all re~Ulled biocOf/lpatibllily tests and certified and approved
In contrast to titanium, lul~ ceramic materials My. a
- ""","-01-
e~isli1IU10(1Is
UO l00'·, lIleli1I.llee
can place I-Lvck ceramIC dental implants usin~ most standard Implant surQical instruments sa set up costs are minimal AlternatM! ~ )'Ou
can ChOose tQ prcMde a t 00% metal Iree s"mce uSing ISystems latest technoloQY cerarnto tools
CO~lIlelicilll)' SlIpellQI
Can )\)I.J see lVl1ite through wMe?
I-lock ceram]c dental Implants nave o"tinct ,olour ad'.'antaQe DYertitan,urn dental implants Which tend to shOW through the thin bucc.'
,
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New Implant surface treatmentMagnesium ion incorporated, oxidized implants ? Dr Young-Taeg Sul - Korea
Sul YT, et al. Biomaterials. 2005Biomaterials. 2005 Nov;26(33):6720-30
Sul YT, et al. Int J Prosthodont. 2006;19:319-28
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Implant surface treatmentMagnesium ion incorporated, oxidized implants ? Dr Young-Taeg Sul - Korea
Sul YT, et al. Biomaterials. 2005
Sul YT, et al. Int J Prosthodont.
Biomaterials. 2005 Nov;26(33):6720-30
2006;19:319-28
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www.torontoimplantconference.ca
~~ 1I~"n; since the 1982 7bronto Conference on Osseointegration in Clinical
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Cli i l l fClinical relevance of i l d l fanimal models for
predicting implantpredicting implant therapy outcomes?therapy outcomes?
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The relevance of data from animal models to predict plongitudinal trial results?
is high?
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The relevance of data from animal models to predictanimal models to predict longitudinal trial results?
is high?is of little or no value?is of little or no value?
London et al. 2002; Novaes et al. 2002; Carlsson et al 1988; Gotfredsen et al 1992;Carlsson et al. 1988; Gotfredsen et al. 1992; Vercaigne et al. 1998, 2000.
Offers some indications within a midrangeOffers some indications within a midrange of roughness?
Wennerberg & Albrektsson 2000Wennerberg & Albrektsson, 2000
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Relevance animal models vz.l it di l t i l lt ?longitudinal trial results?
Surface topography description?Model used?Model used?Roughness characterization?Measuring device?Consistency of results?Consistency of results?Surgical technique for placement?
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Variables affecting histologic/biomechanical data
Sykaras et al., 2000
Implant length
Surface topography
Biomecha ica I load ing speed
Implant diameter
Animal model
Fu nctiona I loading
conditions
Implant design
I m pia ntation t ime
Analyzed lerlgth
Im plant material
I mpla ntation site
Orientation of histologic section
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www.torontoimplantconference.ca
~~ 1I~"n; since the 1982 7bronto Conference on Osseointegration in Clinical
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THE EFFICACY OF DENTAL IMPLANTS: EVIDENCE-BASED OVERVIEWS
From 11 Cochrane reviews onFrom 11 Cochrane reviews on osseointegrated dental implants
Last update, Jan 2007Esposito, Coulthard, Worthington;
Thomson, (Wennerberg, Jokstad et al.)
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Cochrane systematic reviews1. Fresh extraction sockets 20062. Perimplantitis 2006 ver.22. Perimplantitis 2006 ver.23. Bone augmentation techniques 2006 ver.24. Zygomatic implants 2005 ver.25. Various implant systems 2003 ver.36. Immediate/early or delayed loading 2004 ver.27. Maintenance 2004 ver.28. Hyperbaric oxygen therapy 20039 Use of prophylactic antibiotics 20039. Use of prophylactic antibiotics 2003 10. Surgical techniques 2003 11 Preprosthetic surgery vs implants 200211. Preprosthetic surgery vs implants 2002
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1. Fresh extraction sockets1. Fresh extraction socketsLast literature search: Aug 20062 RCTs 96 patients2 RCTs – 96 patientsConclusion:M ff d t i tMay offer some advantages in terms of patient satisfaction and aesthetics possibly by preserving alveolar bonepossibly by preserving alveolar bone. Properly designed RCTs are still needed to fully evaluate the potentialneeded to fully evaluate the potential advantages and risks of this treatment modality since more complicationsmodality since more complications and failures may occur
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2. Perimplantitis - ver 2 20062. Perimplantitis ver 2. 2006
Last literature search: March 20065 RCTs – 134 patients
Conclusion:There is no reliable evidence suggesting which could be the mostsuggesting which could be the most effective interventions for treating
i l titiperimplantitis.
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3. Bone augmentation techniques – ver 2 2006techniques ver. 2 2006Last literature search: October 200513 RCT 330 ti t13 RCTs – 330 patientsConclusion:M j b fti d f t lMajor bone grafting procedures of extremely resorbed mandibles may not be justified. Bone substitutes may replace autogenousBone substitutes may replace autogenous bone for sinus lift procedures of extremely atrophic sinuses. pBoth guided bone regeneration (GBR) procedures and distraction osteogenesis can
t b ti ll b t it i l hi haugment bone vertically, but it is unclear which is the most efficient technique.
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4. Zygomatic implants –ver 2. 2005
Last literature search: May 2005Last literature search: May 2005 0 RCTs
Conclusion:Cannot answer whether Zygomatic implants without bone grafting
i l i l iversus conventional implants in grafted or regenerated bone is superiorsuperior
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5. Various implant characteristics & systemscharacteristics & systems ver.3 -2005
Last literature search: June 200412 RCTs with 512 participants and 12 different implant systems (19 RCTs were p y (excluded). 4 RCTs with a 5-year follow-upConclusion:Conclusion:Minor differences in marginal bone loss and i th f i l titi Nin the occurrence of perimplantitis. No statistically significant difference in failure
t W d t k h th i l trates. We do not know whether any implant system is superior to the others.
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6. Immediate, early or conventional loading -conventional loading ver.2-2004Last literature search: February 2004Last literature search: February 20045 RCTs with 124 participants (2 RCTs
l d d)excluded)Conclusion:While it is possible to successfully load oral implants immediately after their p yplacement in mandibles of adequate bone density and height of carefully selected y g ypatients, it is yet unknown how predictable this approach is.
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Thank you for your ki d tt tikind attention