Dengue feverDengue fever

Dengue feverDengue fever

Pengertian dengue feverPengertian dengue fever

Dengue (DF) and dengue hemorrhagic fever Dengue (DF) and dengue hemorrhagic fever (DHF) are caused by one of four closely related, (DHF) are caused by one of four closely related, but antigenically distinct, virus serotypes (DEN-but antigenically distinct, virus serotypes (DEN-1, DEN-2, DEN-3, and DEN-4), of the genus 1, DEN-2, DEN-3, and DEN-4), of the genus FlavivirusFlavivirus. .

Infection with one of these serotypes provides Infection with one of these serotypes provides immunity to only that serotype for life, so immunity to only that serotype for life, so persons living in a dengue-endemic area can persons living in a dengue-endemic area can have more than one dengue infection during have more than one dengue infection during their lifetime. their lifetime.

DF and DHF are primarily diseases of DF and DHF are primarily diseases of tropical and sub tropical areas, and the tropical and sub tropical areas, and the four different dengue serotypes are four different dengue serotypes are maintained in a cycle that involves maintained in a cycle that involves humans and the humans and the AedesAedes mosquito. mosquito.

However, However, Aedes aegyptiAedes aegypti, a domestic, day-biting , a domestic, day-biting mosquito that prefers to feed on humans, is the mosquito that prefers to feed on humans, is the most common most common AedesAedes species. species.

Infections produce a spectrum of clinical illness Infections produce a spectrum of clinical illness ranging from a nonspecific viral syndrome to ranging from a nonspecific viral syndrome to severe and fatal hemorrhagic disease. severe and fatal hemorrhagic disease.

Important risk factors for DHF include the strain Important risk factors for DHF include the strain of the infecting virus, as well as the age, and of the infecting virus, as well as the age, and especially the prior dengue infection history of especially the prior dengue infection history of the patient.the patient.

No dengue vaccine is available. No dengue vaccine is available.

Beberapa pengertianBeberapa pengertian

Endemic Endemic - means a disease occurs continuously - means a disease occurs continuously and with predictable regularity in a specific area and with predictable regularity in a specific area or population . or population .

EpidemicEpidemic - a widespread outbreak of an - a widespread outbreak of an infectious disease where many people are infectious disease where many people are infected at the same time. infected at the same time.

OutbreakOutbreak - an epidemic limited to localized - an epidemic limited to localized increase in the incidence of a disease, e.g., in a increase in the incidence of a disease, e.g., in a village, town, or closed institution village, town, or closed institution

Pandemic Pandemic - an epidemic occurring worldwide, or - an epidemic occurring worldwide, or over a very wide area, crossing international over a very wide area, crossing international boundaries, and usually affecting a large number boundaries, and usually affecting a large number of people. of people.

Recombinant vaccine - using the technique of Recombinant vaccine - using the technique of recombination to create an attenuated virus recombination to create an attenuated virus which elicits an immune response against the which elicits an immune response against the viral strain of interest in order to use as a viral strain of interest in order to use as a vaccine in humans. vaccine in humans.

Seroytpe - a closely related set of viruses that Seroytpe - a closely related set of viruses that can be differiented by the immune response they can be differiented by the immune response they produce.  produce. 

Viral envelope gene sequence - the nucleic acid Viral envelope gene sequence - the nucleic acid composition in the envelope gene composition in the envelope gene