DENGUE FEVER

Amber BegApril 6, 2010Biology 402

http://www.mosquitoage.org/Portals/12/Images/dengue%20virus_em.jpg

Dengue is a tropical febrile disease

http://gamapserver.who.int/mapLibrary/Files/Maps/World_DengueTransmission_Extension_2008.png

992- Chinese Encyclopedia

1780- Philadelphia “break-bone fever”

Benjamin Rush

Dengue Fever has a long history…

www.philadelphia-reflections.com/topic/17.htm

Isolated by Albert Sabin in 1944

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…and become a MAJOR pandemic in the last 50 years

Endemic in more

than 1oo countries

2.5 billion people at risk

www.tatterhood.com/category/gameart/tastyplanet

How is it spread??

THE VECTOR: Aedes aegyptihttp://www.metapathogen.com/IMG/Aedes-aegypti.jpg

Ae. aegypti likes humans and our products

http://www.bviplatinum.com/images/articleimg/6442b.jpg

Spread of the vector and the disease go hand in hand

Transatlantic Slave Trade

World War IIhttp://neatorama.cachefly.net/images/2007-09/world-war-2.jpg

www.latinamericanstudies.org/Transatlantic.htm

Why such a problem??

Ineffective mosquito

control

Rapid population growth

Non-biodegradable

packaging

Rapid increase in air travel

http://farm1.static.flickr.com/81/285601911_f859e04e39.jpg

So how do I know if I have it?

Fever

Rash

Severe

headache

Musculoskelet

al painshttp://www.microbiologybytes.com/blog/2008/05/

Sounds a lot like the flu…

The Real Problem: Dengue Hemorrhagic Fever

Symptoms:

Plasma leakage

Hepatomegaly

Low blood pressure

Hypovolemic shock

Death

There is no specific treatment for DHF

Can only treat the symptoms

http://www.health-res.com/EX/08-01-15/82560-main_Full.jpg

There are 4 viral serotypes

Family Flaviviridae

Same family as

Yellow Fever

http://www.microbiologybytes.com/virology/3035pics/dengue.jpg

Dengue is an RNA Virus

Single strand

positive RNA

Genome

Envelope Virus too!

http://www.microbiologybytes.com/blog/2007/10/23/dengue-virus-infection-activates-the-unfolded-protein-response/

Secondary infections tend to produce DHF….

Antibodies enhance viral replication!

How can we stop it?

Mosquito control:Improved water storage

InsecticidesIntroduction of mosquito-eating fish

and copepods

Even Better: A Vaccine

Tetravalent live

attenuated

Intertypic

chimaeric

vaccine

Chimaeric

vaccine

http://thefreemarketeers.files.wordpress.com/2009/07/syringe2.jpg

Nothing yet but progress is being made

Works Cited

"Dengue." Centers for Disease Control and Prevention. Centers for Disease Control and Prevention, 16 Mar. 2010. Web. 30 Mar. 2010. <http://www.cdc.gov/Dengue/>.

Dengue Haemorrhagic Fever: Diagnosis, Treatment, Prevention, and Control. 2nd ed. Geneva: World Health Organization, 1997. Print.

"Dengue." World Health Organization. World Health Organization. Web. 30 Mar. 2010. <http://www.who.int/topics/dengue/en/>.

Gubler, D. J., and Goro Kuno, eds. Dengue and Dengue Hemorrhagic Fever. Wallingford, Oxon, UK: CAB International, 1997. Print.

Mandell, Gerald L., John E. Bennett, and Raphael Dolin. Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. 7th ed. New York: Elsevier/Churchill Livingstone, 2010. Print.

Mustafa, Maj, and V. K. Agrawal. "Dengue Vaccine: The Current Status." Medical Journal Armed Forces India 64.2 (2008): 161-64. Web.

Rothman, Alan L. "Dengue: Defining Protective versus Pathologic Immunity." The Journal of Clinical Investigation 113.7 (2004): 946-51. Web.