delivering a new generation of enzyme solutions. michael... · delivering a new generation of...
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| © 2015 Agrivida, Inc. |
GraINzyme®: Novel animal nutrition
feed additives
World Congress on Industrial Biotechnology
Montreal, Canada, July 20, 2015
Delivering a new generation of enzyme solutions
| © 2015 Agrivida, Inc. |
Agrivida Crop Production Platform
Agrivida engineers plants to add value to grain and biomass
GraINzyme®
“The plant is the factory”
INzyme®
Forage
GreenstarchTM
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| © 2015 Agrivida, Inc. |
Proprietary Technology Platforms Drive Innovation in Target Markets
Enables multiple large-scale product offerings across a broad range of industries
Improve production economics
Superior functional product solutions
Enhance existing industrial processes and infrastructure
Plant Expression Platform
GraINzyme®
Feed Additive
Program
INzyme®
Forage
Program
INergyTM
(Greenstarch)
Silage/ Forage
Program
High-Value Animal Nutrition Products
Regulated Enzyme Platform
INzyme® Regulated Agricultural &
Industrial Enzymes
High-Performance
Industrial EnzymesBiomass for Fuel &
Chemical Feedstocks
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| © 2015 Agrivida, Inc. |
Enzyme Innovation Driving a Proprietary Animal Nutrition Portfolio
Enables multiple large-scale product offerings across a broad species segments
GraINzyme®
Feed Additive
Program
INzyme®
Forage
Program
Greenstarch™
Program
Agrivida plants commercial GraINnzyme acres Spring 2016; Revenue starts Fall 2016
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Approval in poultry in 2016
Approval in Swine in 2017
Aquaculture + New enzymes – 2017+
GraINzyme enters ruminant market 2018
Greenstarch silage enters dairy market 2017
80 % lower cost-of-goods-sold versus existing enzymes – enables high-performance dosing
$150 added value per acre on ~ 7 million acres
$350 added value per acre on ~ 30 million acres
| © 2015 Agrivida, Inc. | 5
GraINzyme® Product Line
| © 2015 Agrivida, Inc. |
GraINzyme®: Delivering Enzymes in Grain
Enzyme expression in grain enables low cost enzyme dosing for animals
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Enzyme is expressed in grain and is milled for use as a feed additive
Feed Enzyme
GraINzyme®
| © 2015 Agrivida, Inc. |
GraINzyme® Production
Enzyme Expression:• 6,000 – 10,000 Units/ g corn grain
Corn production:• Identity preserved,
closed loop system• Grain milling,
formulation, and packaging
Animal feed:• Low COGS enables dosing at very
high doses, improving animal performance
• Grain value - $0.05 / ton feed
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| © 2015 Agrivida, Inc. |
GraINzyme®: Delivering Enzymes in Grain
Enzyme expression in grain enables low cost enzyme dosing for animals
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Enzyme is expressed in grain and is milled for use as a feed additive
Feed Enzyme
GraINzyme®
Critical Considerations:• Enzyme properties
• Specific activity• Specificity• Product distribution• Thermal stability• Shelf life• Animal efficacy• Regulatory considerations
• Plant expression properties• Accumulation levels• Stability• Crop yield & agronomics
| © 2015 Agrivida, Inc. |
Improved Activity Relative to Leading Commercial Enzyme
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| © 2015 Agrivida, Inc. |
Competitive Rate of Inositol Production
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| © 2015 Agrivida, Inc. |
Enzyme Thermal Stability in Pelleting Trials
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Agrivida Phy02 Enzyme
| © 2015 Agrivida, Inc. |
Performance of GraINzyme® Phytase in Poultry
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| © 2015 Agrivida, Inc. |
Performance of GraINzyme® Phytase in Poultry
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| © 2015 Agrivida, Inc. |
Super-dosing Performance of Phytase GraINzyme®
Relative efficacy of grain-expressed phytase in corn-soy diet
Dietary TreatmentDose
(U/Kg)
BodyWT
FCR
ControlLow-Phosphate
- 621 1.42
ControlHi-Phosphate
- 660 1.42
GraINzyme® Phytase 5200 706 1.38
Microbial CommercialCompetitor
4800 680 1.38
Trial Results (21 day)
• Loading ~200g/ ton feed• Performance parity with
microbial enzyme• Excellent thermal stability
in pelleting• Up to 12% improvement
over PC weight gain across trials
• Up to 10 Pts improved FCR in repeated trials
Corn phytase No phytase
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| © 2015 Agrivida, Inc. | 15
Next Steps and Opportunities
| © 2015 Agrivida, Inc. |
Focus on Output Traits Meets Industry’s Needs
• Product lines address end user needs
• Increases production efficiencies and capacity
• Significantly decreases costs
• High value products produced on low acreages (1,000’s –
10,000’s acres)
• Can access competitive germplasm
• Identity preservation manageable at smaller scales
• Some products may have more regulatory certainty
• Enzymes have a long history of safe use in animal nutrition
• Potential for products made using genome editing
technologies to be unregulated in the US
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| © 2015 Agrivida, Inc. |
Capital is critical to building any company, especially a start-up…
Venture capital financing to achieve critical mass…
• Equity financing from
Grant support from
Excellent Products Require Significant Resources
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| © 2015 Agrivida, Inc. |
Michael Raab, CTO
Agrivida is composed of a diverse team of scientists and business
professionals in biotechnology, agriculture, and industrial processing.