defining total fitness for the 21 st century: getting to total fitness wayne b. jonas, md ltc (ret)...

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Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

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Page 1: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

Defining Total Fitness for the 21st Century: Getting to Total Fitness

Wayne B. Jonas, MDLTC (RET) USA

Samueli InstituteDecember 6-9, 2009

Page 2: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009
Page 3: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009
Page 4: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

Capability Gaps(COL O’Connor/RDML Miller)

• Alertness and sleep/rest management• Stress/mental management – schedule pressure• Endurance and Rapid recovery - short and long-term

• Fatigue and sustainment – “add in the heat, cold, altitude”• Knee, leg, ankle and spine – premature OA, “broken”

• Fitness – “quick ramp-up”• Not sustained during deployment • Not mission specific to prevent injury

• Psychological trauma – 12% to 40% - even the “tough” are affected• Rapid learning requirements and mental hardiness• Drug and supplement side effects and interactions• Pain, pain and pain – conscious and physiological

NO PLACE TO GO AND NO PROCESS TO GET CREDIBLE, RELEVANT, TIMELY INFORMATION AND KNOWLEDGE ON TF

Page 5: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

What’s a Warrior and Commander To Do?

Demand analysis

Lean 6Team training

Reset retreats

Getting toTotal Fitness

???

Adaptive leader courses COTS

SMART Clinics

Combines

Load assist

Psychological hardening

E-stim

Water

CaffeineTyrosine

Biomonitoring

PDAs and GPSThe -omics

Ambien

Amphetamines

EEGBiofeedback

Cultural conditioning

Hypnosis

Omega-3s

Antioxidants

Accelerated learning

EM Machines

Meditation Brain StimulationPPE

PTSD Tapes

EKG Biofeedback

Anabolic Steroids

Acupuncture

Carbs

Quercitine

FMS

Yoga

Finance$$$

Page 6: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

Foundations of Total Fitness

Readiness and Prevention

HPO

Resilience

Health and Wellness

Functional Excellence

Stress Resistance

System Balance

Risk Reduction

T o

t a l

F

i t n

e s

s

Page 7: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

Nothing works without it!• money• work and play• science, art, culture, thought, action• wars are won and lost on health

Health arises from our inherent capacity to resist breakdown and rapidly heal/recover.

Why is Health Important?

Page 8: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

What is Health?

• Definition: the general condition of a person in all aspects. It is also a level of functional and/or metabolic efficiency of an organism, often implicitly human.

• WHO Definition: “A state of complete physical, mental and social well-being, and not merely the absence of disease”

• Military: • Prevention– risk factor reduction• Health - Well-being vs dis-ease• Resilience – resistance and rebound from stress/injury• Optimal Functioning – human performance

• Sustainability• Throughout the deployment and military lifecycle

• Total – Mind, Body, Spirit and Social • Holistic, Biopsychosocial

Page 9: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

What Contributesto Human Health?

PhysicalActivity

Rest

DietDrugs

Supplements

MindSpirit

LeadershipFriendsFamily

Environment

Page 10: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

What Contributes Most toHuman Health and Performance?

Conditioning

Regression

Bias

Other

Optimal Health and

PerformanceEnvironment

Treatment

Page 12: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

Total Fitness RequestFrom Joint Chiefs

Page 13: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

Total Fitness: The New Paradigm

MIND BODY

SpiritualPsychologicalBehavioralSocial

PhysicalNutritionalMedicalEnvironmental

Page 14: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

Slide 14

Integrated Whole: Dynamic Systems Theory

• Systems (persons) cannot be understood by studying fundamental constituents, the properties of the parts are not intrinsic but can be understood within the context of the whole

• Nature of life > interconnection, interdependent, multileveled

• Living systems are dynamic and highly nonlinear

• Patterns of self-organization are the key

• Patterns of organized complexity have emergent properties at various levels of organization

The key to Total Fitness is to provide warriors, families and commanders with knowledge, skills and tools from which health, resistance and optimal performance can emerge.

Page 15: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

Slide 15

Entire Correlation Network : Organized complexity

~3400 nodes

~17000 edges

abs R > 0.8

Correlation Network in a Whole Organism

- Courtesy of Jan van der Greef, TNO, Netherlands

Page 16: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

Slide 16

Healthyand Fit

Example – Effect of Reductionist ApproachCorrelation Network in a Whole Organism

Network in Fat from Animal Model of T2DM

Page 17: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

Slide 17

Disease Animal+DrugUnhealthy

andUnfit

Example – Effect of Reductionist ApproachCorrelation Network in a Whole Organism

Page 18: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

Slide 18

Unhealthy+

Single Treatment

Example – Effect of Reductionist ApproachCorrelation Network in a Whole Organism

Page 19: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

Slide 19

Unhealthy

+

Single Treatment

Example – Effect of Reductionist ApproachCorrelation Network in a Whole Organism

unmet biochemical need

Page 20: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

Slide 20

Unhealthy+

Single Treatment

Example – Effect of Reductionist ApproachCorrelation Network in a Whole Organism

unmet biochemical needbiochemicalside effect

Page 21: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

Slide 21

How to design an intervention for a whole system?

Current paradigm: Monotherapy1 function– 1 target – 1 treatment fits all

Reductionistic approach

New paradigm : Integrated InterventionMedicine, nutrition, exercise, environmentBehavior, Psychology, social, spiritual

Systems Theory :

“The scale and complexity ofthe problem and solution should match”

- Yaneer Bar-Yam

Page 22: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

Disease

Healthy

Stress Injury Aging

Health Reversible Irreversible

“Total Fitness”Maintain Health

Reduce Risk

Improve resilience

Enhance performance

“Disease management”

Symptom and treatment focus

Changes in behavioursto maintain performance

Optimal

- Adapted from Jan van der Greef, TNO, Netherlands

Page 23: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

Slide 23

What Cannot Be Learnt from a Genome

Creating a Total Fitness Environment

One Animal

One Genome

Two States

The Performance of a Person and Unit is

Optimized with a

Total Fitness Environment

Understandingfrom

a Systems Perspective?

Page 24: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

Total Fitness

Medical & Behavioral

Fitness

Physical

Environmental Fitness

Nutritional Fitness

Psychological

Fitness

Spiritual Fitness

Social Fitness

DefinitionsDescriptions

OutcomesEvidenceMetrics

IntegrationApplication

Delivery

The Domains of Total Fitness

Page 25: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

Slide 25

Physical Fitness

Page 26: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

Physical Fitness

Strength

Endurance

Flexibility

Mobility

Injury Prevention

Rest & Recovery

Outcomes/Metrics

Page 27: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

Average Lap Time for Each 200 m of the 5 km Runs for Each Trial

Ace Sponsored Study. Mind Over Body. May/June 2006. ACE FitnessMatters. 12-13

Page 28: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

People frequently use mushrooms as tonics, such as the Chinese caterpillar fungus (Cordyceps sinensis) for improving athletic performance and increasing energy, and species like reishi (Ganoderma lucidum), shitake (Lentinella edodes), and maitake (Grifola frondosa) to boost immunity. Research on medicinal mushrooms suggests that taking more than one at the same time gives better results.

2nd Wind™, a unique, all-natural formulation of standardized herbal extracts, has been clinically proven to accelerate clearance of lactic acid from the bloodstream following exercise by over 100%. Faster utilization of lactate by the muscle after exercise indicates enhanced energy production, enabling speedier recovery of muscle strength and reaction time. Improved lactate clearance can also lead to a reduction in post-workout muscle soreness and fatigue.*

There is a combination mushroom extract called ESP, which is essentially the “second generation” of Second Wind product. All ingredients have a long history of safe use. Research involving ESP is currently ongoing and so far is showing a significant increase in physical stamina as indicated by a more than 800% increase in the maximum swim time of mice.

Mushroom Supplements to Improve Physical Performance

http://www.personalbestnutrition.com/cgi-bin/pbn/415.html

Page 29: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

Slide 29

Psychological

Fitness

Page 30: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

Psychological Fitness

Attitudes, Beliefs, Expectations

Mindfulness, Awareness,

Intention, Insights

Emotional Flexibility, Emotional Choice

Self:

Other Focus: 1:1

Outcomes/Metrics

Positivity 3:1

Page 31: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

Meta-analysis of omega-3’s on depressive symptoms, randomized placebo controlled trials, effect size = 0.54, p<0.008

Study name Statistics for each study Hedges's g and 95% CI

Hedges's Standard Lower Upper g error Variance limit limit Z-Value p-Value

Marangell 0.096 0.346 0.120 -0.582 0.774 0.277 0.782Peet 0.496 0.362 0.131 -0.214 1.205 1.370 0.171stoll 0.974 0.386 0.149 0.217 1.730 2.523 0.012Keck 0.030 0.187 0.035 -0.337 0.396 0.159 0.873Su 1.887 0.542 0.293 0.826 2.949 3.485 0.000Nemets 0.892 0.512 0.263 -0.113 1.896 1.740 0.082Silvers -0.342 0.234 0.055 -0.799 0.116 -1.462 0.144Frangou 0.645 0.245 0.060 0.165 1.126 2.630 0.009Hallahan 1.020 0.327 0.107 0.379 1.660 3.120 0.002

0.538 0.203 0.041 0.140 0.936 2.648 0.008

-1.00 -0.50 0.00 0.50 1.00

Favours Placebo Favours Omega-3

Omega-3 EFA in Affective Disorders

Eff ect Size g, SE, Variance 95% CI Z and P (Best Case)

Freeman M, Hibbeln JR, Davis JM et al. American Psychiatric Associations treatment recommendations for omega-3 fatty acids in psychiatric disorders. J Clin Psychiatry 2006; 67 12: 1954-1967 .

Page 32: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

0

Time to First Suicide Attempt (days)

0

200 400 600 800

Sur

viva

l Pro

babi

lity

0.2

0.4

0.6

0.8

1.0

High DHA (n=16)

Low DHA (n=17)

(median split of plasma phospholipid % fatty acids)

Low Plasma DHA at Baseline Predicts Greater Risk of Future Suicide AttemptsCox proportional hazard ratio=0.29, p<0.002

Sublette, Hibbeln et al Am J Psychiatry 2006;163: 1100-1102

InpatientDischarge

Page 33: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

Slide 33

Medical & Behavioral

Fitness

Page 34: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

Medical & Behavioral

Fitness

Immunizations

Disease Screening

Drug ProphylaxisRisk Factors

Environmental(see environmental figure)

Behavioral/ Occupational

(see behavioral figure)

Outcomes/Metrics

Page 35: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

Example of Extra-ordinary Pain and Healing Control

Page 36: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

Integrative Neural Immune Programhttp://neuralimmune.nih.gov/index.html

Brain~Mind Body Connections

Page 37: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

Train the BrainMind-body approaches can reduce pain, improve immune function and wound healing

Page 38: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

Family Conflict and Wound Healing:Time to healing was 1 day later following the conflict visit than after the social support visit (day 6 vs. day 5)

1

1

77

0.00

0.25

0.50

0.75

1.00

Sur

viva

l fun

ctio

n

0 5 10 15Days after wounding

Social support, visit 1 Conflict, visit 2

Time to Healing Across Visits

Kiecolt-Glaser JK, Loving TJ, Stowell JR, Malarkey WB, Lemeshow S, Dickinson SL & Glaser R (2005). Hostile marital interactions, proinflammatory cytokine production, and wound healing. Archives of General Psychiatry.

Page 39: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

Slide 39

Social Fitness

Page 40: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

Stressful events and depression slow local cytokine production at the wound site which is important for wound healing while promoting maladaptive systemic proinflammatory cytokine production

Kiecolt-Glaser JK, Loving TJ, Stowell JR, Malarkey WB, Lemeshow S, Dickinson SL & Glaser R (2005). Hostile marital interactions, proinflammatory cytokine production, and wound healing. Archives of General Psychiatry.

Page 41: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

Social Fitness

Peer Support/ Relationships

Family Support/ Relationships

Economic Relationships

Quality of Unit Leadership

Outcomes/Metrics

Unit Cohesion

Page 42: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

High Performance Teams vs. Low Performance Teams

Losada M. Mathematical and Computer Modeling 30 (1999): 179-192.

The personal connectivity of a team is highly correlated with its performance.

Page 43: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

Slide 43

Total Fitness

Medical & Behavioral

Fitness

Physical Fitness

Nutritional Fitness

Psychological

Fitness

Spiritual Fitness

Social Fitness

Page 44: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

The Challenge forThe Total Fitness Group

Science and Evidence

Utility and ApplicationIsolated Domains Whole Systems

Translation to Military Mission

Page 45: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

A Total Fitness UPSfor the Warrior and Commander

Nutritional

Physical

Social

SpiritualPsychological

Behavioral

Medical

0.00%

50.00%

100.00%

15.00%45.00%

87.00%

47.00%

67.00%

55.00%

56.00%

Total Fitness Domains

Percentage Value

Page 46: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009

Fitness Facilitators

An Integrated Total Fitness System

Fitness Metricsand

Monitoring

Evidence BasedTraining

Nutritional

Physical

Social

SpiritualPsychological

Behavioral

Medical

0.00%

50.00%

100.00%

15.00%45.00%

87.00%

47.00%

67.00%

55.00%

56.00%

Page 48: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009
Page 49: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009
Page 50: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009
Page 51: Defining Total Fitness for the 21 st Century: Getting to Total Fitness Wayne B. Jonas, MD LTC (RET) USA Samueli Institute December 6-9, 2009