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Vitamin C

Vitamin E

-Carotin

Zinkoxid

Kupferoxid

500 mg

400 mg

15 mg

80 mg

2 mg

Erkrankungsreduktion in 5 Jahren um 25%

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Drug class potential mechanism

Cholesterol Anti- Anti- Aß

homoeostasis inflammatory angiogenetic effects

ACE inhibitors - + - ?

All blockers - + - ?

PPARG agonists - + - ?

ACAT inhibitors + ? - ?

Statins + + + +

Aspirin - + + -

NSAIDs - + + +

COX2 inhibitors - + + ?

Thienopyridines- ? ? ?

+ indicates positive; - indicates negative

0,01 0,1 1 10

Risk of Incident AD: The Effect of HT

Men

Women: No HT Use

Past HT Use <3 Years

Past HT Use 3-10 Years

Past HT Use >10 Years

Current HT Use <3 years

Current HT Use 3-10 Years

Current HT Use >10 Years

Relative Hazard (95% CI)

Mean Age, 74 Years

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Hyperurikämie

Renale Vasokonstriktion

Reduktion des Stickmonoxyds

Erhöhung des RAS

Endotheliale Stickstoff Synthase (NOS3)

5'

+1

T>C pos-786

ATG

Translation

Promoter 3'

Glu>Asp Codon 298

Exon 7Promoter Intron 4

Ins>Del

polymorphic 287 bp insertion/deletion sequence

5‘ 3‘

INTRON 16 of the ACE gene

Angiotensin I-Converting Enzym (ACE)

Polymorphism: Ins/Del (287bp) in Intron 16

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Serum immunoreactive ACE concentrations (ag/liter) forindividual with the II, ID, and DD genotypes, respectively,

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Reduktion der Harnsäure

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Harnsäure wirkt angiostatisch

Harnsäure reduziert fetale Nephrone

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WARFARIN BENÖTIGTE INDIVIDUALDOSIS

KALIBIRIERT AN CYP 2C9 *1• CYP 2 C 9

• 1*/2* 80 %• 2*/2* 20 %• 1*/3* 56 %• 2*/2* 23 %• 3*/3* 9%

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Breast-Cancer Susceptibility Loci and Genes

Mammakarzinom

RR > 5,0 Breast-cancer gene 1, Breast-cancer gene 2 Tumor protein p53Phosphatase and tensin homologueSerine-threonine protein kinase 11E-cadherin

(<0.5)(<0,5)(<0,1)(<0,1)

RR 1,5 – 5,0 Cell-cycle–checkpoint kinaseAtaxia–telangiectasia mutatedPartner and localizer of BRCA2BRCA1-interacting protein C-terminal helicase 1

RR 1,01 – 1,5 Caspase 8Fibroblast growth factor receptor 2 (ER pos)Mitogen-activated protein kinase kinase kinase 1Tox high-mobility group box family member 3 (ER pos)Lymphocyte-specific protein 1

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Established Common Breast-Cancer Susceptibility Alleles

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Schematic illustration of 2-ME synthesis by COMT

Präeklampsie

Plazentare Östrogene ↓

2-Methroxyöstradiol ↓

Hypoxie inducible Factor 1

Trophoblastinvasion in Spiralarterien

supprimiert

Hypoxia inducible Factor 1 (HIF12)

suluble Fms like Tyrosin Kinase 1(= löslicher VEGF Receptor)

2 Methoxyöstradiol

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A hypothetical working model of preeclampsia derived from our studies with COMT/2-ME

Supplementary Figure 15