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R Superior Handling Exceptional Handling and stability at the surgical site Natural Carrier Uses patented and proprietary natural human tissue carrier Biocompatible and resorbable Guaranteed Safety Allowash XG® proprietary steriliza- tion technology yields final product with the same Sterility Assurance Level (SAL) as medical devices, without damaging inherent osteoin- ductive potential NOT FOR DISTRIBUTION IN THE UNITED STATES Predictable Regeneration Each lot of final product is im- planted in a scientifically-proven in vivo rodent intramuscular model to confirm osteoinductivity (Urist standard model). Only final product exceeding LifeNet Health standards for osteoinductivity is released* PAD™ patented demineralization technology un-shields growth fac- tors trapped within cortical bone to scientifically proven optimal levels** ADVANCING DBM TECHNOLOGY DBM PUTTY *Findings from an animal model are not necessarily predictive of human clinical results **Optimal residual calcium levels are only one of several variables which can contribute to optimal osteoinductivity

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Superior HandlingExceptional Handling and stability at •

the surgical site

Natural CarrierUses patented and proprietary •

natural human tissue carrier

Biocompatible and resorbable•

Guaranteed SafetyAllowash XG® proprietary steriliza-•

tion technology yields final product

with the same Sterility Assurance

Level (SAL) as medical devices,

without damaging inherent osteoin-

ductive potential

NOT FOR DISTRIBUTION IN THE UNITED STATES

Predictable RegenerationEach lot of final product is im-•

planted in a scientifically-proven in

vivo rodent intramuscular model

to confirm osteoinductivity (Urist

standard model). Only final product

exceeding LifeNet Health standards

for osteoinductivity is released*

PAD™ patented demineralization •

technology un-shields growth fac-

tors trapped within cortical bone

to scientifically proven optimal

levels**

advancing dbm technology

dbm putt y*Findings from an animal model are not necessarily predictive of human clinical results

**Optimal residual calcium levels are only one of several variables which can contribute to optimal osteoinductivity

R

1864 concert drive | virginia beach, va 23453 +1 (757) 464-4761 ext. 2000

LifeNet Health helps to save lives and restore health for thousands of

patients each year. We are the world’s most trusted provider of transplant

solutions, from organ procurement to new innovations in bio-implant

technologies and cellular therapies—a leader in the field of regenerative

medicine, while always honoring the donors and healthcare professionals

that allow the healing process.

The LifeNet Health logo, Allowash XG and ReadiGraft are registered trademarks of LifeNet Health. ©2011 LifeNet Health, Virginia Beach, VA. All rights reserved.

www.AccessLifeNetHealth.orgwww.LifeNetHealth.org

LifeNet Health: A Global Leader in Regenerative Medicine

65-0164 REV.01 NOT FOR DISTRIBUTION IN THE UNITED STATES

ReadiGraft® bLx DbM PuttyOptimal exposure of growth factors• 1, 2, 3, 4, 5

Natural human tissue carrier •moldable with excellent handling properties•Resists migration•Ready-to-use•Sterile: 10• -6 Sterility Assurance Level (SAL)

Effect(s) of the demineralization process on the 1. osteoinductivity of demineralized bone matrix. Zhang M, Powers R M, and Wolfinbarger L. J Periodontol 1997; 68:1085-1092

The affects of residual calcium in decalcified 2. freeze-dried bone allograft in a critical-sized defect in the Rattus norvegicus calvarium . Turonis JW, McPherson JC 3rd, Cuening MF:. J Oral Implantol. 2006;32(2):55-62

Effects of Varying degrees of Allograft 3. Decalcification on the Cultured Porcine Osteoclast cells . Herold RW, Pashley DH, Cuening MF J Periodontol. 2002 Feb; 73(2):213-9

BMP depletion occurs during prolonged acid 4. demineralization of bone: characterization and implications for graft preparation. Pietrzak WS, Ali SN, Chitturi D, Jacob M, Woodell-May JE. Cell Tiss. Bank 2007 (Published on line)

Enhancement of osteoblast proliferation in vitro 5. by selective enrichment of demineralized freeze-dried bone allograft with specific growth factors. Mott DA., Mailhot J, Cuenin MF, Sharawy M, Borke J; J Oral Implantol 2002;28(2):57-66

DbM PuttyoRdeR code volUme

BF-1000-001 .5 cc

BF-1000-002 1 cc

BF-1000-003 2.5 cc

BF-1000-004 5 cc

BF-1000-005 10 cc

Cleaned & Sterilized withDemineralized with

R

The new ReadiGraft® BLX Cancellous Sponge from LifeNet Health is an ideal natural

scaffold for cellular ingrowth in spine bone void applications. Its flexible cancellous

structure provides optimal flexibility and absorption that conforms to and fills most

bone void defects and resists migration from the surgical site. A proprietary deminer-

alization process used for ReadiGraft BLX Cancellous Sponge exposes natural growth

factors present in allograft tissue. You can have confidence in the all-allograft solution

for your spine applications with ReadiGraft BLX Cancellous Sponge.

Confidence in the Natural Choice.

Natural Scaffold for Healing and Cellular Ingrowth*:

Compresses to fit inside •bone voidsAbsorbent (blood, bone marrow •aspirate or platelet rich plasma)Resists migration from surgical site •Contains exposed growth factors •with osteoinductive potential

CaNCellouS SpoNge

VG1® Cervical featuring ReadiGraft® BLX Cancellous Sponge.

*Data on file at LifeNet Health.

AvAilAble 2011

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1864 Concert Drive | Virginia Beach, Va 23453 1 (888) 847-7831

LifeNet Health helps to save lives and restore health for thousands of

patients each year. We are the world’s most trusted provider of transplant

solutions, from organ procurement to new innovations in bio-implant

technologies and cellular therapies—a leader in the field of regenerative

medicine, while always honoring the donors and healthcare professionals that allow the

healing process.

The LifeNet Health logo, Allowash XG and ReadiGraft are regis-tered trademarks of LifeNet Health. VG1 Cervical is a registered trademark of DePuy Spine. ©2011 LifeNet Health, Virginia Beach, VA. All rights reserved.

65-0159 REV.02

www.AccesslifeNetHealth.org

Cube Filler Strip

Ordering information

lifeNet Health: A Global leader in Regenerative Medicine

CuBeoRDeR CoDe SIZe

OSC1003 8 x 8 x 8 mm

OSC1000 10 x 10 x 10 mm

OSC1001 12 x 12 x 12 mm

OSC1002 14 x 14 x 14 mm

FIlleRoRDeR CoDe SIZe

OSF2000 2.5 cc

OSF2001 5 cc

OSF2002 10 cc

STRIpoRDeR CoDe SIZe

OSS3004 20 x 25 x 6 mm

OSS3005 15 x 20 x 6 mm

OSS3006 10 x 20 x 8 mm

ReadiGraft® blx Cancellous SpongeProvides natural scaffold for healing and •cellular ingrowth*

Compresses to fit irregular voids•Absorbs fluid (blood, bone marrow aspirate or •platelet rich plasma)Resists migration from surgical site•Contains exposed natural growth factors with •osteoinductive potential

Processed with Allowash XG,® shown to sterilize• to a Sterility As-surance Level of 10-6—the same sterility level of medical devicesAvailable in Cube, Strip and Filler configurations•

R

*Data on file at LifeNet Health.