david a. sullivan, ph.d. 1 curriculum vitae part i: general … · 2015-11-30 · 1 curriculum...

David A. Sullivan, Ph.D. 1

CURRICULUM VITAE

Part I: General Information

November 2015

David A. Sullivan

Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114

FAX: 617-912-0101 [email protected]

Medford, MA

Date Prepared:

Name:

Office Address:

E-Mail:

Place of Birth:

Education:

1972 A.B., Biology Boston University, Boston, MA 1976 M.S., Physiology University of Minnesota Medical School, Minneapolis, MN 1980 Ph.D., Physiology Dartmouth Medical School, Hanover, NH

Postdoctoral Training:

Research Fellowships:

1980-1982 Research Fellow, Department of Physiology, Dartmouth Medical School, Hanover, NH

1982-1983 Research Fellow, Schepens Eye Research Institute 1982-1983 Research Fellow, Department of Ophthalmology, Harvard Medical School

Professional Appointments:

Academic Appointments:

1983-1986 Instructor in Ophthalmology, Harvard Medical School 1986-1995 Assistant Professor in Ophthalmology, Harvard Medical School 1995- Associate Professor in Ophthalmology, Harvard Medical School

Institute Appointments:

1983-1986 Assistant Scientist, Schepens Eye Research Institute 1986-1991 Associate Scientist, Schepens Eye Research Institute 1991- Senior Scientist, Schepens Eye Research Institute 2007- Margaret S. Sinon Scholar in Ocular Surface Research, Schepens Eye Research

Institute


National and International:

1984-1986 Member, International Advisory Committee, First International Conference on Hormones and Immunity, Toronto, Ontario, Canada

1987-1991 Chairman, Graduate Education Committee, Dartmouth Medical School Alumni Council

1988-1996 Founding Member, Lacrimal Gland Study Group (Sarasota, FL) 1990-1992 Organizer/Director, 1st International Conference on the Lacrimal Gland, Tear Film

and Dry Eye Syndromes: Basic Science and Clinical Relevance (Bermuda, 1992) 1994 Participant, National Eye Institute/Industry Workshop on Clinical Trials in Dry

Eyes 1994-1996 Organizer/Director, 2nd International Conference on the Lacrimal Gland, Tear

Film and Dry Eye Syndromes: Basic Science and Clinical Relevance (Bermuda, 1996)

1996-2001 Medical and Scientific Advisory Board, Sjögren’s Syndrome Foundation; 2000-2001, Chair

1998-2000 Organizer/Director, 3rd International Conference on the Lacrimal Gland, Tear Film and Dry Eye Syndromes: Basic Science and Clinical Relevance (Maui, 2000)

2000-2001 Chair, Medical and Scientific Advisory Board, Sjögren’s Syndrome Foundation 2000-2001 Board of Directors, Sjögren’s Syndrome Foundation 2001-2013 President, Tear Film & Ocular Surface Society (TFOS) 2002-2004 Organizer/Director, 4th International Conference on the Tear Film & Ocular

Surface: Basic Science & Clinical Relevance (Puerto Rico, 2004) 2003 Co-Organizer, Immunology of the Ocular Surface and Tear Film WorkShop,

Bavaria, Germany 2003-2004 Organizer, Symposium on Sex Differences in Ocular Surface Biology, International

Congress of Eye Research, Sydney, Australia 2003-2004 Consultant and Fundraiser, International WorkShop for the Definition, Diagnosis

and Classification of Dry Eye Syndromes (DEWS) 2005-2007 Organizer/Director, 5th International Conference on the Tear Film & Ocular

Surface: Basic Science & Clinical Relevance (Taormina, 2007) 2005-2007 Co-Organizer and Steering Committee member, TFOS International Dry Eye

WorkShop (DEWS) 2005-2007 Chair, Industry Liaison Subcommittee, TFOS DEWS 2005-2007 Co-Organizer, 2007 TFOS Report of the International Dry Eye WorkShop

(DEWS), published in The Ocular Surface, Volume 5, Number 2, pp. 65-204, 2007; additional material placed online at www.TearFilm.org

2005-2006 Organizer, Symposium on Immunology of Dry Eye, International Congress of Eye Research, Buenos Aires, Argentina

2007 Organizer, Special Interest Group Meetings, Conclusions and Recommendations of the TFOS International Dry Eye Workshop (DEWS), Association for Research in Vision and Ophthalmology Annual Meeting (ARVO), Fort Lauderdale, FL, and European Association for Vision and Eye Research Annual Meeting (EVER), Portoroz, Slovenia

2008-2010 Organizer/Director, 6th International Conference on the Tear Film & Ocular Surface: Basic Science & Clinical Relevance (Florence, 2010)

Major Administrative Responsibilities:


2008 Organizer, TFOS Corporate Advisory Board and Associate Corporate Sponsor Meeting, Rome, Italy

2008-2011 Organizer and Steering Committee Member, TFOS International Workshop on Meibomian Gland Dysfunction

2008-2011 Chair, Industry Liaison Subcommittee, TFOS International Workshop on Meibomian Gland Dysfunction

2009-2010 Co-Programmer and Co-Chair, Ocular Surface Disease session, World Cornea Congress, Boston

2009-2010 Organizer, International Regulatory Officials and Experts Meeting, “Global Treatments for Dry Eye Syndrome: An Unmet Need,” Florence, Italy

2009-2010 Organizer, Special Interest Group Meetings, Conclusions and Recommendations of the TFOS International Workshop on Meibomian Gland Dysfunction, ARVO (Fort Lauderdale, FL), British Contact Lens Association Clinical Conference and Exhibition (Birmingham, UK), World Ophthalmology Congress (Berlin, Germany), EVER (Hersonissos, Crete) and the International Symposium on Ocular Pharmacology and Therapeutics (Macau, China)

2011-2013 Organizer/Director, 7th International Conference on the Tear Film & Ocular Surface: Basic Science & Clinical Relevance (Taormina, 2013)

2011-2014 Member, ARVO Program Committee (Cornea Section) 2011 Co-Organizer, ARVO 2012 Minisymposium on Surgical Innovations for the

Treatment of Eye Disease 2011- Chair, TFOS Young Investigator Committee 2011-2012 Organizer, Session on Surgery-Induced Dry Eye, World Ophthalmology Congress

2012, Abu Dhabi 2011-2013 Organizer and Steering Committee member, TFOS International Workshop on

Contact Lens Discomfort 2012-2013 Chair, Industry Liaison Subcommittee, TFOS International Workshop on Contact

Lens Discomfort 2013-2014 Co-Chair, ARVO Program Committee (Cornea Section) 2013- Member, TFOS Board of Directors 2013- Chairman, TFOS Board of Directors 2014- Organizer and Steering Committee member, TFOS International Dry Eye

WorkShop II (DEWS II) 2014 Chair, Sex, Hormones & Gender Subcommittee, TFOS DEWS II 2014 Chair, Industry Liaison Subcommittee, TFOS DEWS II 2014 Member, Harmonization Subcommittee, TFOS DEWS II 2014 Organizer, TFOS meeting on “Initiating Innovation: Targeting the Unmet Need

for Dry Eye Treatment” (London, UK) 2015- Organizer/Director, 8th International Conference on the Tear Film & Ocular

Surface: Basic Science & Clinical Relevance (Montpellier, France, 2016)

Harvard Medical School: 1982-1984 Co-Organizer, Mucosal Immunology Seminar Series, involving Schepens Eye

Research Institute, Massachusetts General Hospital, Shriners Burns Institute, Children’s Hospital and Tufts Medical Center (Boston)

1997-1998 Founding Member, Joint Clinical Research Center of the Schepens Eye Research Institute and the Massachusetts Eye & Ear Infirmary


1998- 2001 Founding Member, Joint Governance Committee, Joint Clinical Research Center of the Schepens Eye Research Institute and the Massachusetts Eye & Ear Infirmary

Schepens Eye Research Institute:

1990-1994 Head, Immunology Unit

1990-1994 Research Council (Faculty Senate); 1993-1994, Head 1995-2006 Chair, Technology Transfer Committee 2003-2004 Founding Member, Corporate Alliance Program 2007-2012 Chair, Distinguished Alumni Committee 2008-2010 Director, Center for Corneal and External Eye Disease Research

Major Committee Assignments: National and International:

1989-1991 Reviewer of research grant proposals, Veteran's Administration and the North Carolina Biotechnology Center

1990 Member, Ad hoc NIH Study Section 1992-1995 Member, Fellowship Review Panel for the Fight for Sight Research Division of the

National Society to Prevent Blindness 1995 Consultant, National Eye Institute/Industry Dry Eye Epidemiology Project,

Washington, DC 1996 Consultant, CIBA Vision Ophthalmic’s 1st International Advisory Board Meeting

on Dry Eye, Bermuda 1997 Reviewer of research grant proposal, The Wellcome Trust, England 1998-2001 Member, Fund Raising Committee, Sjogren's Syndrome Foundation 1998-2001 Member, Research Grant Program Committee, Sjogren's Syndrome Foundation 1999 Adjunct Faculty Appointment, Promotion and Tenure Committee of the State

University of New York at Stony Brook 2000 Consultant, Novartis’ International Advisory Board Meeting on Dry Eye, Maui 2001 Participant, 1st National Eye Institute Initiative Workshop, Florida 2001 Reviewer of research grant proposal, Concerted Action Program of the Ministry of

Education of Flanders 2002- Member, Advisory Board of the Women's Eye Health Task Force

2003 Consultant, Dry Eye / Contact Lens Blue Ribbon Panel of the Vistakon Division of Johnson & Johnson Vision Care

2003-2008 Member, Scientific Advisory Board, OcuSense 2004 Consultant, Novartis’ Advisory Board Meeting, Florida 2005-2006 Member, Organizing Committee, 9th International Symposium on Sjögren's

Syndrome, Washington, DC 2005, 2006 Ad hoc member, NIH Anterior Eye Disease Study Section 2007-2008 Member, International Advisory Committee, 9th Congress of International Society

of Dacryology and Dry Eye, Istanbul, Turkey 2008- Scientific Advisor, TearLab 2008 Consultant, Pfizer Advisory Board Meeting, New York City, NY 2009 Consultant, Pfizer Advisory Board Meeting, Fort Lauderdale, FL 2010 Consultant, Pfizer Advisory Board Meeting, Florence, Italy


2011-2012 Consultant, Forest Pharmaceutical Advisory Group, Jersey City, NJ 2012 - Member, Organizing Committee, 12th International Symposium of Sjögren’s

Syndrome, Kyoto, Japan 2015 Consultant, Ophthakem, Diepenbeek, Belgium 2015 Consultant, MG Therapeutics, Tel Aviv, Israel

Department of Ophthalmology, Harvard Medical School:

1989-1997 Member, Organizing Committee, 16th, 18th, 19th and 20th Biennial Cornea Research Conference

1992 Member, Research Retreat Steering Committee 1997-1998 Member, Schepens Eye Research Institute / Massachusetts Eye & Ear

Infirmary/Harvard Medical School Human Studies Center Committee 2002 Member, Massachusetts Eye & Ear Infirmary Cornea Fellowship Review

Committee 2004- Participant, NIH grant for Harvard Vision Clinical Scientist Development Program 2006 Judge, Basic Science Poster Contest, HMS Department of Ophthalmology Annual

Meeting 2008-2009 Co-Chair, 26th Biennial Cornea Research Conference, Boston, MA 2010-2011 Member, Organizing Committee, 27th Biennial Cornea Research Conference,

Boston, MA 2014-2015 Member, Organizing Committee, 29th Biennial Cornea Research Conference,

Boston, MA 2012- Member, Distinguished Achievements Department Awards Committee

Schepens Eye Research Institute: 1984-1990 Radioisotope Safety Committee; 1988-1990, Chair 1985-1994 Member, Broadhurst Lecture Committee 1986 Member, Search Committee for an Institute Molecular Biologist 1987-1990 Member, NIH Shared Instrument Grants Committee 1988 Member, Search Committee for a Mast Cell Biologist 1990-1999 Member, Postdoctoral Fellow Training Committee 1991-1996 Member, Appointments and Promotions Committee 1993 Member, Technology Transfer Committee 1994-1995 Member, Ad Hoc Committee on Indirect Costs 1994-1995 Member, Training Advisory Group to the Director of Research

1995 Member, Visiting Professor Committee 1995, 2002 Presenter, seminars for Development Department in Andover (MA) and Florida

1995-1997 Leader, Immunity, Inflammation and Transplantation Focus Group 1996-1997 Member, Research Advisory Group to the Director of Research

1996 Member, Public Relations and Development Advisory Group to the Director of Research

1996 Member, Public Relations and Development Committee 1998 Member, Ad Hoc Telescience Center Committee

1999-2000 Coordinator and Co-Program Chairperson, Schepens Eye Research 50th Anniversary Clinical Science Symposium

1998-2002 Member, Dry Eye Focus Group


1998-2004 Scientific Communications Center Committee; 1998, Chair 1999-2001 Member, Strategic Issue Subcommittee

2000 Member, Ad Hoc Committee on a Proposed Center for Development and Testing of Ophthalmic Therapeutics

2000-2001 Member, DNA Microarray Committee 2002-2003 Member, Seminars Committee

2003-2004 Member, Ad Hoc Committee on Corporate Sponsorship Program 2003-2006 Invited presenter, research overview to Trustees and Corporators 2004 Participant, Planning Grant for Exploratory Center for Interdisciplinary Research

on Blinding Diseases 2004-2005 Member, Governance Evaluation Committee

2005-2010 Member, Faculty Retreat Committee 2005-2006 Member, Committee to explore possible joint interests of the Schepens Eye

Research Institute and the Retina Associates 2006-2012 Member, Human Studies Committee 2006 Co-Organizer, Cornea & External Disease Focus Group 2007-2010 Member, Seminars Committee 2007- Presenter, dry eye treatment overview for Corporate Alliance Program visitors 2009 Member, Committee to address Director of Research position description 2009 Invited presenter, Center for Corneal and External Eye Disease Research seminar series 2010 Invited presenter, SERI Faculty Retreat 2010-2011 Member, Faculty Recruitment Committee 2013 Judge, SERI “Best Paper” contest 2013- Member, Training Committee 2014 Judge, SERI Lions’ grant applications 2014-2015 Chair, Distinguished Lecture Series Committee 2015 Judge, SERI Lions’ grant applications Massachusetts Eye and Ear: 2013 Invited presentation to the Leadership Group Harvard Medical School Department of Ophthalmology: 2013 Invited presentation for the November New Frontiers in Corneal Research meeting Memberships, Offices and Committee Assignments in Professional Societies: 1982- Association for Research in Vision and Ophthalmology 1984-2011 The American Association of Immunologists 1984-1993 The New York Academy of Sciences 1984-1995 The American Association for the Advancement of Science 1987-2001 Society for Mucosal Immunology 1990-1991 International Society for Neuroimmunomodulation 1996-2012 Endocrine Society


2000- Founding Member, Tear Film & Ocular Surface Society (TFOS); 2001-2013, President. The purpose of this Society is to [a] advance the research, literacy, and educational aspects of the scientific field of the tear film and ocular surface; [b] organize and coordinate international conferences, meetings, seminars, events and workshops to promote better understanding of the tear film and ocular surface; and [c] stimulate interactions among members, and attract new members with diverse disciplinary interests and expertise throughout the world. Since the Society’s incorporation, and during the course of my Presidency, I organized 6 International Conferences, organized 4 International Workshops on Dry Eye Disease, Meibomian Gland Dysfunction and Contact Lens Discomfort, oversaw the awarding of more than 225 Young Investigator Travel Awards and helped raise over 5.0 million dollars from industry to fund the Society. The Society has also sponsored, and promoted the growth and recognition of, the peer-reviewed journal, The Ocular Surface. This Society has a distribution to ~ 5,000 basic scientists, clinical researchers and industry representatives from over 90 countries. I receive no compensation for my TFOS service.

2013- Chair, TFOS Board of Directors

Community Service: 1983- Speaker and Participant, Lion's Club meetings and events in Acton (MA),

Springfield (MA), Boston, and the Schepens Eye Research Institute 2000 Invited speaker; Eastern Massachusetts Sjögren’s Syndrome Chapter; Brookline,

MA 2004 Invited speaker & Moderator; Sjogren's Syndrome Foundation Regional Seminar,

Braintree, MA 2006 Invited speaker; Fall meeting of the Greater Boston Chapter of the Sjogren’s

Syndrome Foundation, Boston

Editorial Boards:

1983- Ad Hoc Reviewer and/or Guest Editor: Acta Ophthalmologica Scandinavia, Archives of Ophthalmology, Arthritis Journal, Arthritis Research & Therapy, Biochimie, Biology of Reproduction, Breast Cancer Research and Treatment, British Journal of Ophthalmology, Clinical Ophthalmology, Cornea, Current Eye Research, Drugs, Evidence-Based Complementary and Alternative Medicine, Experimental Eye Research, Human Reproduction, International Archives Allergy & Immunology, Investigative Ophthalmology & Visual Science, JAMA Ophthalmology, Journal of Anatomy, Journal of Clinical Investigation, Journal of Immunology, Journal of Nutrition, Journal of Rheumatology, Journal of Steroid Biochemistry & Molecular Biology, Life Sciences, Lupus, Maturitas, Menopause, Molecular Vision, Ocular Immunology & Inflammation, Ophthalmic Research, Ophthalmology, Optometry & Vision Science, Oral Diseases, Physiological Genomics, PLoS ONE, Psychiatry Research, Regional Immunology, Survey of Ophthalmology, The Ocular Surface, Translational Vision Science & Technology

2001-2004 Editorial Board Member, Cornea 2002-2013 Editorial Board Member, The Ocular Surface 2003 Editorial Board Member, Middle East Journal of Ophthalmology


2006-2008 Editorial Board Member, Eye & Contact Lens 2011- Editorial Board Member, Archivos de la Sociedad Española de Oftalmologia

Awards and Honors:

1974 University of Minnesota Graduate School Academic Scholarship 1974-1977 Dartmouth College Graduate School Academic Scholarships 1997 Inductee, Matignon High School Achievement Hall of Fame, Cambridge, MA 1997 Invited participant, Research to Prevent Blindness National Science Writers

Seminar 2007- Margaret S. Sinon Scholar in Ocular Surface Research, Schepens Eye Research Institute 2009 Best Paper of Ocular Surface Disease Session, Middle East and African Congress

of Ophthalmology, Manama, Kingdom of Bahrain 2010 Lifetime Achievement Award, Tear Film & Ocular Surface Society 2011 Carel C. Koch Memorial Medal Award, American Academy of Optometry 2013 Silver Fellow Honor, ARVO Class of 2013 2013 Honorary Member, French Society of Ophthalmology


Part II: Research and Teaching Contributions A. Narrative Report of Research and Teaching Contributions I am a medical research scientist with training in physiology, endocrinology and immunology. I was recruited into ophthalmology in 1982. To summarize my laboratory’s research accomplishments, I would like to place them in the context of our overall hypotheses and discoveries. Thus, we have discovered that sex and sex steroid hormones are critical factors in the regulation of ocular surface tissues, as well as in the pathogenesis of dry eye disease. We have also discovered that androgens may suppress, and that estrogens may promote, aqueous-deficient and/or evaporative dry eye. More specifically: • we have shown that sex and sex steroids, as well as neuropeptides and cytokines, regulate the secretory

immune system of the eye. This system is designed to protect the ocular surface against bacterial colonization, viral adhesion, parasitic infestation and toxin-induced damage, thereby preserving corneal integrity and preventing severe visual impairment. Our results support our hypothesis that the endocrine, neural and immune systems govern ocular mucosal immunity. To help conduct these experiments we developed a defined culture system for the long term maintenance of responsive acinar epithelial cells from the lacrimal gland. This accomplishment was commended as one of the foremost achievements in ocular surface research by an NEI National Plan for Vision Research.

• we have shown that androgens reduce the inflammation in, and enhance the functional activity of,

lacrimal glands in mouse models of Sjögren’s syndrome. These findings are extremely significant, given that no clinical therapy currently exists for this debilitating autoimmune disease, which occurs almost exclusively in women and is one of the leading causes of aqueous-deficient dry eye disease in the world. The mechanism(s) involved in this androgen-induced immunosuppression is unknown. However, our evidence indicates that this hormone action is a unique, tissue-specific effect, that is initiated through androgen binding to receptors in lacrimal gland epithelial cells. In addition, we hypothesize that this androgen interaction then causes the altered expression and/or activity of specific genes and proteins in lacrimal tissue, resulting in the reduction of immunopathological lesions and an improvement in glandular function. Our research has supported this hypothesis, which, if true, may lead to the development of unique, therapeutic strategies to safely and effectively treat this chronic and vision-threatening disease;

• we have shown that androgens regulate the meibomian gland, which is the primary tissue involved in

maintaining tear film stability and preventing tear film evaporation. This finding is also very significant, given that almost no other information exists concerning the physiological control of this tissue, and that meibomian gland dysfunction is the major cause of evaporative dry eye disease throughout the world. Based upon our research, we hypothesize that: [a] androgens regulate meibomian gland function, improve the quality and/or quantity of lipids produced by this tissue and promote the formation of the tear film’s lipid layer; and [b] androgen deficiency, such as occurs during menopause, aging, Sjögren's syndrome, complete androgen insensitivity syndrome and the use of anti-androgen medications, leads to meibomian gland dysfunction, altered lipid profiles in meibomian gland secretions, decreased tear film stability and evaporative dry eye. Our data support these hypotheses, and have significantly increased our understanding of the physiological mechanisms controlling the meibomian gland in both health and disease;

• we have shown, in collaboration with others, that dry eye disease occurs predominantly in women and

that estrogen replacement therapy increases the prevalence of dry eye signs and symptoms in


postmenopausal women. This latter finding is extraordinary, given that many millions of women worldwide are prescribed estrogen to alleviate menopausal symptoms and are therefore at heightened risk of developing dry eye. The precise mechanism(s) underlying the sex-related difference in, and the estrogen effect on, dry eye prevalence is unclear. However, we hypothesize that: [a] androgen deficiency and estrogen use are key factors in the predominance of dry eye disease in women; and [b] sex, androgen and estrogen effects are mediated through the regulation of gene expression in the cornea and the lacrimal and meibomian glands. Our research supports these hypotheses, which, if correct, may be translated into new insights into how estrogens influence ocular tissues, and how these hormones may contribute to the etiology of dry eye disease.

• in addition to these findings, we have discovered that: [a] lubricin, a boundary lubricant, is transcribed,

translated, and expressed by human ocular surface epithelia; [b] lubricin presence significantly reduces friction between the human cornea and conjunctiva; and [c] lubricin deficiency may play a role in promoting corneal damage. Overall, we believe that lubricin may be an important barrier to the development of corneal and conjunctival epitheliopathies that may occur in dry eye disease and contact lens wear.

In summary, our research has addressed the sex steroid regulation of the ocular surface and adnexa, the interrelationships between sex, sex steroids and dry eye disease, as well as the role of a boundary lubricant on the ocular surface. Our studies have involved basic, clinical and epidemiological aspects, and have required the establishment of new and unique experimental approaches (e.g. lipid analytical, proteomic and molecular biological methods). Of particular interest, our research findings have led to the development of topical treatments (i.e. androgen, lubricin) that may serve as a potential therapy for both aqueous-deficient and evaporative dry eye disease. In terms of teaching, I have served as a preceptor for 29 postdoctoral fellows and 4 students, been invited to present numerous research seminars, organized 8 International Conferences and 4 multi-year Workshops on the tear film and ocular surface, and acted as a Chairman of the Graduate Education Committee of the Dartmouth Medical School Alumni Council. I am also a Founding Member and President of the Tear Film & Ocular Surface Society, which we created to advance the research, literacy, and educational aspects of the scientific field of the tear film and ocular surface throughout the world. B. Research Funding Information: Past: 1983-1988 NIH/R01EY02882 Associate Investigator The secretory IgA system of the eye 1985-1988 NIH/R01EY05612 PI Endocrine control of the ocular secretory immune system 1988-1994 NIH/R01EY05612 PI Endocrine control of the ocular secretory immune system 1988-1991 NIH/R01EY02882 Co-PI The secretory IgA system of the eye 1991-1993 NIH/R01EY02882 PI The secretory IgA system of the eye


1991-1993 MA Lion's Fund PI Ocular immunology and immunopathology 1992-1994 Allergan Inc. PI Ocular androgen therapy for dry eye in Sjögren's syndrome 1994-1996 Allergan Inc. PI Ocular androgen therapy for dry eye in Sjögren's syndrome 1994-1998 NIH/R01EY05612 PI Neuroendocrinimmune control of lacrimal gland immunity 1996-1997 MA Lion’s Fund Co-PI New strategies for controlling ocular inflammation 1996-1999 Allergan Inc. PI Ocular androgen therapy for dry eye syndromes 1998-2001 NIH/R01EY05612 PI Gender, sex steroids and dry eye syndromes 1999-2000 Allergan Co-PI Prevalence of dry eye syndromes 1999-2000 SERI/MEEI Co-PI Gender and dry eye syndromes 1999-2005 Allergan Inc. PI Ocular androgen therapy for dry eye syndromes 2000-2001 NIH/SERI PI Influence of estrogen and progesterone on gene expression in the lacrimal and meibomian glands 2001-2005 NIH/R01EY05612 PI Gender, sex steroids and dry eye syndromes 2005 NIH/R01EY05612 (Supplement) PI Gender, sex steroids and dry eye syndromes 2005-2010 NIH/R01EY05612 PI Sex, sex steroids and dry eye syndromes 2007-2010 Alcon Laboratories PI Regulation of the meibomian gland in health & disease 2014-2015 GlaxoSmithKline PI


Modulation of human meibomian gland epithelial cells 2010-2015 NIH/R01EY05612 PI Sex, sex steroids and dry eye syndromes Current:

2007- Margaret S. Sinon Scholar in Ocular Surface Research Fund,

Schepens Eye Research Institute 2015- MEE Development Office Co-PI Estrogens & glaucoma 2015- TearLab Donation PI Physiology and pathophysiology of human corneal epithelial cells 2015- Cempra PI Solithromycin and human meibomian gland epithelial cells C. Report of Current Research Activities: Project Role Sex, sex steroids and dry eye syndromes PI D. Report of Teaching: 1. Local Contributions

a. Local invited teaching presentations 1981-1982 Lectures on clinical endocrinology to critical care nurses of New Hampshire and

Vermont, Dartmouth Hitchcock Medical Center, Hanover, NH 1981-1982 Instructed in a laboratory course devoted to methodological techniques in physiology

and immunology, Dartmouth Medical School, Hanover, NH 1982- Schepens Eye Research Institute Seminar Series 1982-1984 Mucosal Immunology Seminar Series, Massachusetts General Hospital 1988 Combined Program in Pediatric Gastroenterology and Nutrition at Massachusetts

General and Children's Hospitals 1989 Immunology Department, Massachusetts Eye and Ear Infirmary 1989 Immunology Graduate Student Lecture Series, Harvard Medical School 1991 Forsyth Dental Center


1991 Department of Ophthalmology Retreat, Harvard Medical School 1993 Department of Pathology, Beth Israel Hospital 1995 19th Biennial Cornea Research Conference 1998 Clinical Research Jumpstart Program, New England College of Optometry 1999 Schepens Eye Research Institute Symposium on Sjögren’s Syndrome and Allied

Disorders 1999 21st Biennial Cornea Conference 1999 Research Lecture Series, New England College of Optometry 2000 1st International Congress For Research on the Aging Eye, Boston 2001 Second Symposium on Sjögren’s Syndrome, Boston 2003 Cornea Department, Massachusetts Eye & Ear Infirmary 2003 Invited discussant, Women's Eye Health Task Force meeting, Boston 2005 Harvard Department of Ophthalmology Annual Meeting 2006 1st Annual Ocular Immunology & Uveitis Foundation Physician Education

Conference, Boston 2012 Harvard Department of Ophthalmology Annual Meeting

b. Advisory and supervisory responsibilities 1987-1992 Preceptor for 3 NIH Training Grant Fellowship Awards 1988-1991 Preceptor for 3 Fight for Sight-Prevent Blindness Fellowship Awards 1992-1993 Preceptor for Sjögren's Syndrome Foundation Fellowship Award 1992-1993 Sponsor for Bausch & Lomb Postdoctoral Fellowship Award 1994-1995 Sponsor for Uehara Memorial Foundation Postdoctoral Fellowship Award

1995-1996 Preceptor for Sjögren's Syndrome Foundation Fellowship Award

1999 Invited jury member of a graduate student’s Ph.D. thesis (addressing androgen-responsive enhancers and gene regulation), Katholieke Universiteit Leuven, Leuven, Belgium


1999-2000 Preceptor for Sjögren's Syndrome Foundation Fellowship Award 1999-2001 Preceptor for Allergan Postdoctoral Fellowship Award 1999 -2001 Sponsor for Deutsche Forschungsgemeinschaft Postdoctoral Fellowship Award 2000-2003 Preceptor for Allergan (Japan) Postdoctoral Fellowship Award 2002-2003 Preceptor for Bausch & Lomb Postdoctoral Fellowship Award 2002-2003 Preceptor for Japanese Eye Bank Association Postdoctoral Fellowship Award 2008-2009 Preceptor for Fellowship Award from the Harvard Medical School Postdoctoral Training Program in the Molecular Bases of Eye Disease 2009-2011 Preceptor for Turkish Postdoctoral Fellowship Awards 2009-2010 Preceptor for ARVO/Pfizer Postdoctoral Fellowship Award 2012-2013 Preceptor for AFER/Vistakon Dry Eye Fellowship Award 2013-2014 Sponsor for ARVO/Merck Collaborative Research Fellowship Award to Geeta K.

Vemuganti, DNB, FAMS, MD (University of Hyderabad, India)

c. Professional leadership roles related to teaching

1975-1976 Organizer, graduate/medical student course on parturition, Dartmouth Medical School, Hanover, NH

1982-1984 Co-Organizer, Mucosal Immunology Seminar Series, involving Schepens Eye

Research Institute, Massachusetts General Hospital, Shriners Burns Institute, Children’s Hospital and Tufts Medical Center (Boston)

1989-1990 Director, Immunology Unit Research Series, Schepens Eye Research Institute 1991-1992 Organizer, Journal Club series on Ocular Inflammation, Schepens Eye Research

Institute

d. Names of advisees or trainees

Postdoctoral Fellows:

1987 Marie T. Girard, Ph.D. Project: Development of rat/mouse hybridomas and monoclonal antibodies Current Position: Associate Director, R&D Project Management, Boehringer

Ingelheim Pharmaceuticals, Inc. Ridgefield, CT


1988-1989 Hiroko Ariga, M.D. Project: Androgen influence on lacrimal gland autoimmune disease Current Position: Ophthalmologist, National Hospital, Sapporo, Japan 1988-1990 Robin S. Kelleher, Ph.D. Project: Neural, endocrine and immune regulation of the ocular secretory immune

system Current Position: Senior Scientific Associate, Schepens Eye Research Institute,

Boston 1988-1989 Ana Cristina Vendramini, M.D. Project: Androgen impact on lacrimal gland autoimmune disease Current Position: Ophthalmologist and Eye Bank Coordinator, Hospital Ofir

Loyola, Belem, Brazil 1989-1991 Elcio H. Sato, M.D. Project: Effects of immunosuppressive agents on lacrimal gland autoimmune

disease Current Position: Professor, São Paulo Federal University, São Paulo, Brazil;

Medical Director, São Paulo Hospital Eye Bank; President, Pan-American Association of Eye Banks

1990-1993 Ross William Lambert, Ph.D. Project: Neuroendocrinimmune control of secretory component production by

lacrimal gland epithelial cells Current Position: Associate Professor, Department of Kinesiology, Western Illinois

University, Macomb, IL 1991-1993 Zhiyan (James) Huang, M.D. Project: Impact of viral infection on the ocular secretory imune system Current Position: Associate Professor, Oakland University-William Beaumont

School of Medicine; Pathologist and Associate Medical Director, Flow Cytometry, William Beaumont Hospital, Royal Oak, MI

1991-1992 Flavio Jaime Rocha, M.D. Project: Endocrine influence on the normal and autoimmune lacrimal gland Current Position: Chairman & Associate Professor, Department of

Ophthalmology, University of Uberlandia Medical School, Uberlandia, Brazil; Director of the Eye Bank - University Federal of Uberlandia

1992-1994 Masafumi Ono, M.D. Project: Regulation of androgen receptors in the lacrimal gland Current Position: Assistant Professor, Department of Ophthalmology, Nippon

Medical School, Tokyo, Japan 1993-1994 Janethe D.O. Pena, M.D., Ph.D. Project: Hormonal control of the lacrimal gland


Current Position: Senior Medical Scientific Expert, Novartis Pharma, Florham Park, New Jersey

1994-1997 Ikuko Toda, M.D. Project: Sex and androgen influence on lacrimal gland autoimmune disease Current Position: Director, Minamiaoyama Eye Clinic, Tokyo, Japan 1995-1996 Kathleen L. Krenzer, O.D., Ph.D. Project: Effect of androgen deficiency on the human meibomian gland and ocular

surface Current Position: Principal Scientist, Bausch and Lomb, Rochester, NY 1995-1997 Eduardo M. Rocha, M.D., Ph.D. Projects: Androgen regulation of pro- and anti-inflammatory cytokines in the

lacrimal gland; Identification of androgen receptors in human ocular suface tissues Current Position: Associate Professor, Department of Ophthalmology, São Paulo

University, Ribeirao Preto, Brazil 1997-1999 Jennifer M. Cermak, Ph.D. Project: Influence of complete androgen insensitivity syndrome on the human

meibomian gland and ocular surface; Nutrient intake in women with Sjögren’s syndrome

Current Position: Senior Director, Portfolio Management at Sirtris, Director of Portfolio Management at Sirtris, GSK Company, Cambridge, MA

1998-2000 Hiroko Yamagami, M.D., Ph.D. Project: Sex and androgen influence on gene expression in the meibomian gland Current Position: Associate Professor, Department of Ophthalmology, Jichi

Medical School, Omiya Medical Center, Saitama, Japan 1999-2001 Meng Liu, M.D., Ph.D. Project: Androgen regulation of gene expression in the lacrimal gland Current Position: Director of Molecular Pathology, General Manager, OriGene

Beijing eTown Site, OriGene Technologies, Inc, Rockville, MD 1999-2002 Frank Schirra, M.D., Ph.D. Project: Androgen regulation of gene expression in the meibomian gland;

Identification of steroidogenic enzyme mRNAs in the lacrimal gland, meibomian gland, cornea and conjunctiva

Current Position: Attending in Ophthalmology and Director of Outpatient Division, Universitätsklinikum des Saarlandes, Homburg, Germany

2000-2003 Tomo Suzuki, M.D., Ph.D. Project: Estrogen and progesterone influence on gene expression in the meibomian

gland; Effect of estrogens on human corneal epithelial cells Current Position: Ophthalmologist, Kyoto Municipal Hospital, and Researcher,

Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan


2002-2005 Nathaniel S. Treister, D.M.D., D.MSc. Project: Sex and androgen influence on gene expression in the salivary glands Current Position: Assistant Professor, Division of Oral Medicine, Infection, and

Immunity at the Harvard School of Dental Medicine, Boston, MA; Associate Surgeon, Division of Oral Medicine and Dentistry, Brigham and Women's Hospital, Boston, MA

2004-2005 Patricia S. Tsai, M.D. Project: Proteomic analysis of human meibomian gland secretions Current Position: Ophthalmologist, Cornea and External Diseases, Kaiser

Permanente, Woodland Hills, CA 2006-2011 Shaohui Liu, M.D., Ph.D. Project: Regulation of the meibomian gland in health and disease Current Position: Ophthalmology Resident, Louisiana State University Health

Science Center, Shreveport, LA 2008-2010 Payal Khandelwal, Ph.D. Project: Endocrine regulation of the ocular surface and adnexa Current Position: Product Manager, BioVision, Milpitas, CA 2008-2009 Shaun Murphy, Ph.D. Project: Identification, function and regulation of surfactant-associated proteins on

the ocular surface and adnexa Current Position: Preclinical studies consultant, Abpro, Woburn, MA 2009-2011 Raheleh Rahimi Darabad, M.D. Project: Immortalization and physiological control of human corneal epithelial cells Current Position: Anesthesiology Resident, Advocate Illinois Masonic Medical

Center, Chicago, IL 2009-2011 Afsun Sahin, M.D. Project: Analysis of inflammatory pathways in human ocular surface epithelial cells Current Position: Assistant Professor of Ophthalmology, Eskisehir Osmangazi

University Medical School, Eskisehir, Turkey 2011-2013 Juan Ding, Ph.D. Project: Influence of retinoic acid on the meibomian gland Current Position: Investigator, Schepens Eye Research Institute, and Instructor,

Harvard Medical School 2012- Yang Liu, M.D. Project: Endocrine regulation of ocular surface and adnexal tissues 2015- Yi Zhang, MD Project: Impact of anti-glaucoma drugs on the ocular surface & adnexa


2015- Xiaomin Chen, M.D. Project: Hormonal control of the eye

Visiting Scientists: 2012 Hikmet Basmak, M.D. 2014-2015 Bing Niu, Ph.D. 2014-2015 Chi Zhang, M.D.

Medical Students:

1999 Ward R. Bijlsma, Dutch Medical Student Project: Androgen influence on lymphocyte gene expression Current Position: Assistant Professor, Department of Ophthalmology, University

Medical Center Utrecht, Utrecht, The Netherlands

1999 Bart A. R. Tonino, Dutch Medical Student Project: Androgen influence on lymphocyte gene expression Current Position: Radiologist, Nijmegen, Netherlands 2015 Beril Arica, Turkish Medical Student Project: Impact of Sjögren’s syndrome on the human meibomian gland

College Students:

1992-1994 Amy Gallant Sullivan, Acton, MA Project: Translation of French and Spanish medical literature (book, articles) into

English Current Position: Executive Director, Tear Film & Ocular Surface Society, Boston,

MA 2010 Kimberly Topilow, Barnard, NYC, NY Project: Leukotriene B4 in ocular surface epithelial cells

High School Students:

1986 Linda A. Block, Scarsdale Alternative School, NY Project: Hormonal influence on lacrimal gland morphology 1991-1993 Benjamin D. Sullivan, Acton-Boxboro High School, MA Project: Computer assistance, graphics and slide generation, image and statistical

analyses Current Position: Founder, Chief Scientific Officer, TearLab, Corp, San Diego;

Founder and Director, Singularis/Lµbris LLC; Founding Inventor, Biological Dynamics, Inc.; Founder and Director, Code Fluidics LLC; Earned MS and PhD degrees in Biomedical Engineering from the University of California San Diego


2. Regional, National and International Contributions

a. Invited presentations

1986 Invited speaker; First International Conference on Hormones and Immunity, Toronto, Canada

1987 Invited speaker; Department of Immunology and Microbiology, Wayne State

University Medical School 1988 Invited speaker; International Symposium on Interactions Between the

Neuroendocrine and Immune Systems, Montepaone Lido, Italy Invited speaker; Immunology Workshop, American Uveitis Society and the American

Society of Veterinary Ophthalmologists, Las Vegas, Nevada 1989 Invited speaker; Eighth International Symposium of the Journal of Steroid

Biochemistry, Las Palmas, Grand Canary Island Invited speaker; Lacrimal Gland Study Group Lecture Series, Association for

Research in Vision and Ophthalmology Meeting, Sarasota, Florida Invited speaker; Fifth International Congress of Mucosal Immunology, London,

England 1990 Selected presenter; 1st International Congress on Neuroimmunomodulation,

Florence, Italy Invited participant; Workshop on Research Perspectives in

Psychoneuroimmunology, Rochester, NY 1992 Invited speaker; Hans Selye Symposium on Neuroendocrinology and Stress,

Budapest, Hungary Invited speaker; Allergan, Los Angeles, CA Invited speaker; International Conference on the Lacrimal Gland, Tear Film and Dry

Eye Syndromes: Basic Science and Clinical Relevance, Southampton, Bermuda 1993 Selected presenter; 11th International Symposium of the Journal of Steroid

Biochemistry and Molecular Biology, Seefeld, Austria Invited speaker; Keio University School of Medicine, Tokyo, Japan Invited speaker; 4th International Symposium on Sjögren's Syndrome, Tokyo, Japan Invited speaker; Allergan, Los Angeles, CA


Invited speaker; American Academy of Optometry Meeting, Boston, MA 1994 Invited speaker; Special Minisymposium/Workshop, entitled "New Insights into the

Cause of Tear Deficiency," Association for Research in Vision and Ophthalmology Meeting, Sarasota, FL

1995 Invited speaker; International Conference on Ocular Infections, Jerusalem, Israel Invited keynote speaker; Ocular Cell & Molecular Biology Symposium II, San Diego,

CA Invited speaker; International Workshop on the Immunology of Oculo-Muco-

Cutaneous Disorders, Berlin, Germany Invited speaker; Allergan, Los Angeles, CA Invited speaker; American Academy of Optometry Meeting, New Orleans, LA 1996 Invited speaker; Department of Immunology and Microbiology, Wayne State

University School of Medicine, Detroit, MI Invited speaker; Special Minisymposium/Workshop, entitled "Ocular Changes

Associated with Normal Physiological Variation in Women," Association for Research in Vision and Ophthalmology Meeting, Fort Lauderdale, FL

Invited speaker; MGI PHARMA, Minnetonka, MN Invited keynote speaker; Second International Conference on the Lacrimal Gland,

Tear Film and Dry Eye Syndromes: Basic Science and Clinical Relevance, Southampton, Bermuda

Invited speaker; CIBA Vision Ophthalmic’s 1st International Advisory Board

Meeting on Dry Eye, Bermuda 1997 Invited keynote speaker; 9th International Congress of Mucosal Immunology,

Sydney, Australia Invited speaker; Cooperative Research Centre for Eye Research and Technology, The

University of New South Wales, Sydney, Australia Invited speaker; Special Minisymposium/Workshop, Association for Research in

Vision and Ophthalmology Meeting, Fort Lauderdale, FL Invited speaker; Allergan, Los Angeles, CA Invited speaker; Research to Prevent Blindness National Science Writers Seminar, Los Angeles, CA


Invited keynote speaker; International Symposium on Sjögren’s Syndrome, Avon,

Connecticut Invited speaker; Ocular Mucosal Immunology Meeting, Bavaria, Germany 1998 Invited speaker; OHSA/Casey Eye Institute, Portland, Oregon Selected presenter; The First International Conference on the Neuroendocrine

Immune Basis of Rheumatic Diseases, Genoa, Italy 1999 Invited participant; Roundtable discussion entitled “Classification, Diagnosis and

Treatment of Dry Eye,” sponsored by Ocular Surgery News and Allergan, Kona, HI

Invited keynote speaker; Association for Ocular Pharmacology and Therapeutics, Irvine, CA

Invited speaker; Katholieke Universiteit Leuven, Leuven, Belgium Invited speaker; Workshop on the Meibomian Gland and its Disease, Coral Gables,

FL Invited keynote speaker; Dry Eye Research Meeting, Japanese Academy of

Ophthalmology, Tokyo, Japan Invited keynote speaker; Symposium on the Mucosa Associated Lymphoid Tissue of

the Ocular Surface, Palma de Mallorca, Spain Selected presenter; 5th International Congress of The International Society of

Dacryology, Jerusalem, Israel Invited keynote speaker; VIIth International Symposium on Sjögren’s Syndrome,

Venice, Italy 2000 Invited speaker; Allergan, Los Angeles, CA Invited speaker; University of Florida School of Dentistry, Gainesville, FL Invited speaker; Meibomian Gland Conference, Boca Raton, FL Invited speaker; International Congress of Eye Research, Santa Fe, New Mexico 2001 Invited speaker; The Second International Conference on the Neuroendocrine

Immune Basis of Rheumatic Diseases, Santa Margherita, Italy 2002 Invited speaker; Imunology of the Ocular Surface and Tearfilm Workshop, Bavaria,

Germany


Invited speaker; Conference on Sex and Gene Expression, San Jose, CA Invited speaker; Kyoto Prefectural University of Medicine, Kyoto, Japan Invited keynote speaker; VIIIth International Symposium on Sjögren’s Syndrome,

Kanazawa, Japan Invited speaker; Novartis Ophthalmics, Basel, Switzerland Invited speaker; Societa Industria Farmaceutica Italiana SpA, Aci Sant’ Antonio,

Sicily, Italy Invited speaker; Symposium on Functional Anatomy of the Ocular Surface, Joint

European Research Meetings in Ophthalmology and Vision, Alicante, Spain Invited speaker; Symposium on Major Advances in Dry Eye Research, Joint

European Research Meetings in Ophthalmology and Vision, Alicante, Spain Invited speaker; The Third International Conference on Sex Hormones, Pregnancy and the Rheumatic Diseases, New Orleans, LA 2003 Invited speaker; Dry Eye / Contact Lens Blue Ribbon Panel of the Vistakon

Division of Johnson & Johnson Vision Care, Jacksonville, FL Invited speaker; First Singapore Eye Research Institute-Association for Research and

Vision and Ophthalmology Meeting, Singapore (note: given by fellow) Invited speaker; Allergan's American Androgen Tears Investigators Meeting, New

Orleans, LA Invited speaker; European Research Group of Oral Biology meeting, Fislisbach,

Switzerland Invited speaker; L'Oreal Recherche, Paris, France Invited speaker; Allergan's European Androgen Tears Investigators Meeting, Lisbon,

Portugal Invited speaker; American College of Rheumatology Sjögren's Syndrome Study

Group Meeting, Orlando, FL Invited speaker; ARVO/AAO Research Symposium of the American Academy of

Optometry, Dallas, TX 2004 Invited speaker; Vistakon Division of Johnson & Johnson Vision Care, Jacksonville,

Florida Invited speaker; Mexican Congress of Ophthalmology, Vera Cruz, Mexico


Invited speaker; International Congress for Eye Research, Sydney, Australia Invited speaker; 40th Annual Meeting of the Department of Ophthalomology,

Ribeirao Preto Medical, School, University of Sao Paulo, Ribeirao Preto, Brazil 2005 Invited speaker; Seminars in Basic Ocular Biology Series, Mount Sinai School of

Medicine, New York City Invited speaker; Societa Industria Farmaceutica Italiana SpA, Aci Sant’ Antonio,

Sicily, Italy

2006 Invited speaker; Alcon Laboratories, Fort Worth, TX Invited speaker; Symposium on Dry Eye, Fermo, Italy

Invited speaker; Symposium on Immunology of Dry Eye, International Congress of

Eye Research, Buenos Aires, Argentina 2007 Invited speaker; The 2nd World Congress on Gender-Specific Medicine and Aging:

The Endocrine Impact, Rome, Italy Invited speaker; Pfizer, La Jolla, CA Invited introductory speaker; International Dry Eye Workshop Symposium,

Association for Research in Vision and Ophthalmology Meeting, Fort Lauderdale, FL

Invited speaker; Resolvyx Pharmaceuticals, Bedford, MA Invited speaker; Pfizer, New York City, NY Invited speaker; International Dry Eye WorkShop Symposium, European

Association for Vision and Eye Research Meeting, Portoroz, Slovenia Invited speaker; American Academy of Optometry/Association for Research in

Vision and Ophthalmology Symposium on Advances in Dry Eye Disease: Women, Nutrition, and Impact on Vision and Quality of Life, Tampa, FL

2008 Invited speaker; Glasgow Caledonian University, Glasgow, Scotland Invited Conference speaker; 9th Congress of the International Society of Dacryology

and Dry Eye, Istanbul, Turkey Invited keynote speaker; Brazilian Research Association of Vision and

Ophthalmology Annual Meeting, Brazil Invited Speaker; Wyeth Pharmaceuticals, Cambridge, MA


Invited Speaker; Tear Film & Ocular Surface Society Corporate Advisory Board and

Associate Corporate Sponsor meeting, Rome, Italy Invited Speaker; Alcon Laboratories, Fort Worth, TX Invited Speaker; Inaugural Steering Committee Meeting of the International

Workshop on Meibomian Gland Dysfunction, Atlanta, GA Invited Speaker; Association for Research in Vision and Ophthalmology

Headquarters, Rockville, MD 2009 Selected speaker; Middle East and African Congress of Ophthalmology, Manama,

Kingdom of Bahrain Invited speaker; Meet the Experts Breakfast, sponsored by Pfizer Ophthalmics for

the Vision Care Media, Fort Lauderdale, FL

2010 Invited speaker; World Ophthalmology Congress, Berlin, Germany

Introductory speaker; International Regulatory Officials and Experts Meeting (“Global Treatments for Dry Eye Syndrome: An Unmet Need”), Florence, Italy

Invited speaker; European Association for Vision and Eye Research Meeting,

Hersonissos, Crete Invited speaker; American Academy of Optometry Meeting, San Francisco, CA Invited Keynote speaker; Japanese Dry Eye Society Meeting, Kobe, Japan Invited speaker; International Symposium on Ocular Pharmacology and

Therapeutics, Macau, China

2011 Invited Speaker; ARVO Foundation for Eye Research Investor Seminar, Fort Lauderdale, FL

Invited Speaker; Ocular Surface Society of Optometry Meeting, Salt Lake City, UT

Invited Speaker; American Optometric Association Meeting, Salt Lake City, UT Invited Speaker; Vistakon, Jacksonville, FL Invited Speaker; 16th Congress of Chinese Ophthalmological Society, Guangzhou, China Invited Speaker; Shandong Eye Institute, Qingdao, China Invited Speaker; Eye and ENT Hospital of Fudan University, Shanghai, China


Invited Speaker; Ocular surface disease: A problem seeking an innovative treatment, Vienna, Austria Invited Speaker; 11th International Symposium on Sjögren’s Syndrome, Athens, Greece Invited Speaker; Optometric Council on Refractive Technology Meeting, Boston Invited Speaker; European Regulatory Ophthalmology Meeting, sponsored by the European Medicines Agency and the Swedish Medicinal Agency, London, UK Invited Speaker; Global Contact Lens Summit: Past & Current Perspectives, New Research and Future Implications, Seattle Invited Speaker; Genzyme, Cambridge, MA

Invited Speaker; New England Ophthalmology Society Meeting, Boston

2012 Invited Speaker; Greater Boston Sjögren’s Syndrome Support Group Meeting,

Boston

Invited Speaker; Journées de Réflexions Ophtalmologiques (JRO) Congress, Paris, France Invited Speaker; Symposium on Dry eye: New scientific concepts and novel solutions, Paris, France Invited Speaker; TFOS Asia 2012 Meeting, Kamakura, Japan

Invited Speaker; Santen Symposium, Kamakura, Japan

Invited Speaker; Steering Committee meeting of the TFOS International Workshop on Contact Lens Discomfort, San Diego, CA Invited Speaker; Neurobiology of discomfort and pain Subcommittee meeting, TFOS Workshop on Contact Lens Discomfort, New York City Invited Speaker; Trial design and outcomes Subcommittee meeting, TFOS Workshop on Contact Lens Discomfort, Boston

Invited Speaker; Contact lens materials, design & care Subcommittee meeting, TFOS Workshop on Contact Lens Discomfort, Boston Invited Speaker; Management & therapy Subcommittee meeting, TFOS Workshop on Contact Lens Discomfort, Boston


Invited Speaker; Contact lens interactions with the ocular surface & adnexa Subcommittee meeting, TFOS Workshop on Contact Lens Discomfort, London, UK Invited Speaker; Contact Lens Interactions with the tear film Subcommittee meeting, TFOS Workshop on Contact Lens Discomfort, London, UK Invited Speaker; Epidemiology Subcommittee meeting, TFOS Workshop on Contact Lens Discomfort, New York City Invited Speaker; Definition & classification Subcommittee meeting, TFOS Workshop on Contact Lens Discomfort, Houston

Invited Speaker, European Association for Vision and Eye Research Congress, Nice, France

Invited Speaker; Farabi Eye Hospital, Tehran, Iran (date to be determined) Invited Speaker; The 3rd Biennial Scientific Meeting of the Asia Cornea Society, Manila, Philippines

2013 Invited Speaker; Industry Liaison Subcommittee meeting, TFOS Workshop on Contact Lens Discomfort, Houston Invited Speaker; Boynton Colloquium Series, Center for Visual Science, University of Rochester, NY Invited Speaker; Distinguished Lecture and Grand Rounds, Jules Stein Eye Institute, Los Angeles Invited Speaker; University of Southern California, Los Angeles

Invited Speaker; French Society of Ophthalmology Annual Meeting, Paris, France Invited Speaker; 7th International Conference on the Tear Film & Ocular Surface: Basic Science & Clinical Relevance, Taormina, Sicily Invited Speaker; Romanian National Congress of Ophthalmology, Sinaia, Romania

2014 Invited Speaker; 14th International Congress of Ophthalmology and Optometry China, Shanghai, China Invited Speaker; Optician’s Association of Massachusetts Education Meeting, Worcester, MA Invited Speaker; Dompé, Milan, Italy Invited Speaker; Conference on Ocular Surface Science and Dry Eye, Sydney, Australia


Invited Speaker; New Zealand National Eye Centre, Auckland, New Zealand Invited Speaker; Sanofi Fovea Pharmaceuticals, Paris, France Invited Speaker; The 19th Congress of the Chinese Ophthalmological Society, Xi’an, China Invited Speaker; The 17th Afro-Asian Congress of Ophthalmology, Xi’an, China Invited Keynote Speaker; European Association for Vision and Eye Research Congress, Nice, France Invited Speaker; Department of Ophthalmology, Dartmouth-Hitchcock Medical Center, Lebanon, NH

Invited Speaker; Henry Schroeder Visiting Scientist, Department of Physiology and Neurobiology, Dartmouth Medical School, Lebanon, NH

2015 Invited Speaker; Grand Rounds, Department of Ophthalmology, Tufts University School of Medicine, Boston (January) Invited Speaker; TFOS meeting on “Initiating Innovation: Targeting the Unmet Need for Dry Eye Treatment,” London, UK (March) Invited Speaker; Steering Committee meeting of the TFOS International Dry Eye Workshop II (DEWS II), San Francisco, CA (March) Invited Speaker; Brigham and Women’s Hospital, Boston (April) Invited Speaker; National Congress of the Argentine Council of Ophthalmology, Buenos Aires, Argentina (May) Invited Speaker; School of Optometry, University of Alabama, Birmingham, AL (May) Invited Speaker; Pathophysiology Subcommittee meeting, TFOS DEWS II, Paris, France (June) Invited Speaker; 2nd Meeting on Ocular Surface Disorders and Keratoprosthesis, Sankara Nethralaya, Chennai, India (6 different presentations) (July) Invited Speaker; L V Prasad Eye Institute, Hyderabad, India (3 different presentations)(July) Invited Speaker; Epidemiology Subcommittee meeting, TFOS DEWS II, Paris, France (July)


Invited Speaker; Sex, hormones & gender Subcommittee meeting, TFOS DEWS II, Washington DC (July) Invited Speaker; Diagnosis Subcommittee meeting, TFOS DEWS II, Paris, France (July) Invited Speaker; Novartis Biomedical Institute, Cambridge, MA (August) Invited Speaker; Iatrogenic dry eye disease Subcommittee meeting, TFOS DEWS II, Barcelona, Spain Invited Speaker; Definition & classification Subcommittee meeting, TFOS DEWS II, Paris, France (September) Invited Speaker; Pain & sensation Subcommittee meeting, TFOS DEWS II, Paris, France (September) Invited Speaker; Public Awareness & Education Subcommittee meeting, TFOS DEWS II, New York City (October) Invited Speaker; Subcommittee Chair meeting, TFOS DEWS II, London, UK (October) Invited Speaker; Industry liaison Subcommittee meeting, TFOS DEWS II, Las Vegas, NV (November)

b. Professional leadership roles related to teaching 1990-1992 Organizer, International Conference on the Lacrimal Gland, Tear Film and Dry

Eye Syndromes: Basic Science and Clinical Relevance (Bermuda, 1992) 1994-1996 Organizer, Second International Conference on the Lacrimal Gland, Tear Film and

Dry Eye Syndromes: Basic Science and Clinical Relevance (Bermuda, 1996) 1998-2000 Organizer, Third International Conference on the Lacrimal Gland, Tear Film and

Dry Eye Syndromes: Basic Science and Clinical Relevance (Maui, 2000) 2002-2004 Organizer, 4th International Conference on the Lacrimal Gland, Tear Film, Ocular

Surface and Dry Eye Syndromes: Basic Science and Clinical Relevance (Puerto Rico, 2004)

2003 Co-Organizer, Immunology of the Ocular Surface and Tear Film WorkShop,

Bavaria, Germany 2003-2004 Organizer, Symposium on Sex Differences in Ocular Surface Biology, International

Congress of Eye Research, Sydney, Australia


2005-2007 Organizer, 5th International Conference on the Tear Film & Ocular Surface: Basic Science and Clinical Relevance (Taormina, Sicily, 2007)

2005-2007 Organizer, Symposium on Immunology of Dry Eye, International Congress of Eye Research, Buenos Aires, Argentina

2007 Organizer, Special Interest Group Meeting, Conclusions and Recommendations of

the TFOS International Dry Eye Workshop (DEWS), ARVO, Fort Lauderdale, FL 2007- Co-Organizer, 2007 TFOS Report of the International Dry Eye WorkShop

(DEWS), published in The Ocular Surface, Volume 5, Number 2, pp. 65-204, 2007; additional material placed online at www.TearFilm.org

2007 Organizer, Special Interest Group Meeting, Conclusions and Recommendations of

the TFOS International Dry Eye WorkShop (DEWS), EVER, Portoroz, Slovenia 2008-2010 Director, 6th International Conference on the Tear Film & Ocular Surface: Basic

Science and Clinical Relevance (Florence, Italy, 2010) 2009-2010 Co-Programmer and Co-Chair, Ocular Surface Disease session, World Cornea

Congress, Boston 2009-2010 Organizer, Special Interest Group Meeting, Conclusions and Recommendations of

the TFOS International Workshop on Meibomian Gland Dysfunction, ARVO, Fort Lauderdale, FL

2009-2010 Organizer, Special Interest Group Meeting, Conclusions and Recommendations of

the TFOS International Workshop on Meibomian Gland Dysfunction, British Contact Lens Association Clinical Conference and Exhibition, Birmingham, UK


the TFOS International Workshop on Meibomian Gland Dysfunction, World Ophthalmology Congress, Berlin


the TFOS International Workshop on Meibomian Gland Dysfunction, European Association for Vision and Eye Research Annual Meeting, Hersonissos, Crete


the TFOS International Workshop on Meibomian Gland Dysfunction, ISOPT, Macau, China

2011 Co-Organizer, ARVO 2012 Minisymposium on Surgical Innovations for the

Treatment of Eye Disease 2011-2012 Organizer, Session on Surgery-Induced Dry Eye, World Ophthalmology Congress

2012, Abu Dhabi


2011-2013 Director, 7th International Conference on the Tear Film & Ocular Surface: Basic Science and Clinical Relevance (Taormina, Italy, 2013)

2015- Director, 8th International Conference on the Tear Film & Ocular Surface: Basic

Science and Clinical Relevance (Montpellier, France, September 2016) Note: These series of 8 “Tear Film” Conferences were designed to: [a] Assess the current knowledge and

'state of the art' research on the structure and function of tear film-producing tissues, tears and the ocular surface in both health and disease; and [b] Promote an international exchange of information that would be of value to basic scientists involved in eye research, to clinicians in the eye care community, and to pharmaceutical companies with an interest in the treatment of lacrimal gland, tear film or ocular surface disorders. The first 3 Conferences were also created to generate books, which would contain summaries of the Conference's presentations, and provide an educational foundation and scientific reference for research on the tear film, ocular surface and dry eye syndromes. These books were published, cited in Index Medicus, and contained 729 (1992), 1,051 (1996) and 1,385 (2004) pages. Participation in these Conferences grew from 1992 (n ~ 175 people), to 1996 (n ~ 235), to 2000 (n ~ 335), to 2004 (n ~ 380), to 2007 (n ~ 500) and to 2010 (n ~ 600). The number of participants in 2013 exceeded 500 people. Numerous travel awards have been given in these Conferences to students, fellows and young investigators. 2013-2014 Organizer, Special Interest Group Meeting, Conclusions and Recommendations of

the TFOS International Workshop on Contact Lens Discomfort, Orlando, FL


Part III: Bibliography Original Articles: 1. Sullivan DA, Wira CR. Sex hormone and glucocorticoid receptors in the bursa of Fabricius of

immature chicks. J Immunology 1979;122:2617-2623. 2. Wira CR, Hyde E, Sandoe CP, Sullivan DA, Spencer S. Cellular aspects of the rat uterine IgA

response to estradiol and progesterone. J Steroid Biochem 1980;12:451-459. 3. Sullivan DA, Wira CR. Estradiol regulation of secretory component in the female reproductive tract.

J Steroid Biochem 1981;15:439-444. 4. Sullivan DA, Wira CR. Hormonal regulation of immunoglobulins in the rat uterus: Uterine response

to a single estradiol treatment. Endocrinology 1983;112:260-268. 5. Sullivan DA, Wira CR. Variations in free secretory component levels in mucosal secretions of the rat.

J Immunology 1983;130:1330-1335. 6. Sullivan DA, Underdown BJ, Wira CR. Steroid hormone regulation of free secretory component in

the rat uterus. Immunology 1983;49:379-386. 7. Wira CR, Sullivan DA, Sandoe CP. Epithelial cell involvement in the estradiol-stimulated

accumulation of IgA in the rat uterus. J Steroid Biochem 1983;19:469-474. 8. Sullivan DA, Richardson GS, McLaughlin DT, Wira CR. Variations in the levels of secretory

component in human uterine secretions during the menstrual cycle. J Steroid Biochem 1984;20:509-513.

9. Sullivan DA, Wira CR. Hormonal regulation of immunoglobulins in the rat uterus: Uterine response

to multiple estradiol treatments. Endocrinology 1984;114:650-658. 10. Sullivan DA, Bloch KJ, Allansmith MR. Hormonal influence on the secretory immune system of the

eye: Androgen regulation of secretory component levels in rat tears. J Immunology 1984;132:1130-1135.

11. Sullivan DA, Bloch KJ, Allansmith MR. Hormonal Influence on the secretory immune system of the

eye: Androgen control of secretory component production by the rat exorbital gland. Immunology 1984;52:239-246.

12. Sullivan DA, Allansmith MR. Source of IgA in tears of rats. Immunology 1984;53:791-799. 13. Wira CR, Sullivan DA. Estradiol and progesterone regulation of IgA, IgG and secretory component

in vaginal secretions of the rat. Biol Reprod 1985;32:90-95. 14. Gudmundsson OG, Sullivan DA, Bloch KJ, Allansmith MR. The ocular secretory immune system of

the rat. Exp Eye Res 1985;40:231-238.


15. Sullivan DA, Allansmith MR. Hormonal influence on the secretory immune system of the eye: Androgen modulation of IgA levels in tears of rats. J Immunology 1985;134:2978-2982.

16. Cornell-Bell AH, Sullivan DA, Allansmith MR. Gender-related differences in the morphology of the

lacrimal gland. Invest Ophthalmol Vis Sci 1985;26:1170-1175. 17. Sullivan DA, Allansmith MR. Hormonal modulation of tear volume in the rat. Exp Eye Res

1986;42:131-139. 18. Sullivan DA, Colby E, Hann LE, Allansmith MR, Wira CR. Production and utilization of a mouse

monoclonal antibody to rat IgA: Identification of gender-related differences in the secretory immune system. Immunol Invest 1986;15:311-318.

19. Sullivan DA, Allansmith MR. Hormonal influence on the secretory immune system of the eye:

endocrine interactions in the control of IgA and secretory component levels in tears of rats. Immunology 1987;60:337-343.

20. Allansmith MR, Gudmundsson OG, Hann LE, Keys C, Bloch KJ, Sullivan DA. The immune

response of the lacrimal gland to antigenic exposure. Curr Eye Res 1987;6:921-928. 21. Sullivan DA. Influence of the hypothalamic-pituitary axis on the androgen regulation of the ocular

secretory immune system. J Steroid Biochem 1988;30:429-433. 22. Sullivan DA, Allansmith MR. The effect of aging on the secretory immune system of the eye.

Immunology 1988;63:403-410. 23. Sullivan, DA, Hann LE, Vaerman JP. Selectivity, specificity and kinetics of the androgen regulation of

the ocular secretory immune system. Immunol Invest 1988;17:183-194. 24. Hann LE, Allansmith MR, Sullivan DA. Impact of aging and gender on the Ig-containing cell profile

of the lacrimal gland. Acta Ophthalmologica 1988;66:87-92. 25. Gudmundsson OG, Bjornsson J, Olafsdottir K, Bloch KJ, Allansmith MR, Sullivan DA. T cell

populations in the lacrimal gland during aging. Acta Ophthalmologica 1988;66:490-497. 26. Hann LE, Tatro J, Sullivan DA. Morphology and function of lacrimal gland acinar cells in primary

culture. Invest Ophthalmol Vis Sci 1989;30:145-158. 27. Harmatz PR, Carter EA, Sullivan DA, Hatz RA, Baker R, Breazeale E, Grant K, Bloch KJ. Effect of

thermal injury in the rat on transfer of IgA protein into bile. Annals Surgery 1989;210:203-207. 28. Ariga H, Edwards J, Sullivan DA. Androgen control of autoimmune expression in lacrimal glands of

MRL/Mp-lpr/lpr mice. Clin Immunol Immunopathol 1989;53:499-508. 29. Sullivan DA, Hann LE. Hormonal influence on the secretory immune system of the eye: endocrine

impact on the lacrimal gland accumulation and secretion of IgA and IgG.J Steroid Biochem 1989; 34:253-262.


30. Sullivan DA, Hann LE, Yee L, Allansmith MR. Age- and gender-related influence on the lacrimal gland and tears. Acta Ophthalmologica 1990;68:188-194.

31. Entwistle ML, Hann LE, Sullivan DA, Tatro JB. Characterization of functional melanotropin

receptors in lacrimal glands of the rat. Peptides 1990;11:477-483. 32. Taubman MA, Halazonetis TD, Stack SE, Smith DJ, Sullivan DA. Thyroid influence on the salivary

secretory immune system. In: Advances in Mucosal Immunology. London: Kluwer Academic Publishers; 1990. p.497-499.

33. Sullivan DA, Yee L, Conner AS, Hann LE, Olivier M, Allansmith MR. Influence of ocular surface

antigen on the postnatal accumulation of immunoglobulin-containing cells in the rat lacrimal gland. Immunology 1990;71:573-580.

34. Sullivan DA, Kelleher RS, Vaerman JP, Hann LE. Androgen regulation of secretory component

synthesis by lacrimal gland acinar cells in vitro. J Immunology 1990;145:4238-4244. 35. Kelleher RS, Hann LE, Edwards JA, Sullivan DA. Endocrine, neural and immune control of secretory

component output by lacrimal gland acinar cells. J Immunology 1991;146:3405-3412. 36. Hann LE, Kelleher RS, Sullivan DA. Influence of culture conditions on the androgen control of

secretory component production by acinar cells from the lacrimal gland. Invest Ophthalmol Vis Sci 1991;32:2610-2621.

37. Sullivan DA, Hann LE, Soo CH, Yee L, Edwards JA, Allansmith MR. Neural-immune

interrelationship: effect of optic, sympathetic, temporofacial or sensory denervation on the secretory immune system of the lacrimal gland. Regional Immunology 199l;3:204-212.

38. Vendramini AC, Soo C, Sullivan DA. Testosterone-induced suppression of autoimmune disease in

lacrimal tissue of a mouse model (NZB/NZW F1) of Sjogren's Syndrome. Invest Ophthalmol Vis Sci 1991;32:3002-3006.

39. Cappeller WA, Bloch KJ, Hatz RA, Carter EA, Fagundes J, Sullivan DA, Harmatz PR. Reduction in

biliary IgA after burn injury: Role of diminished delivery via the thoracic duct and of enhanced loss from the systemic circulation. Annals Surgery 1992;215:338-343.

40. Sato EH, Ariga H, Sullivan, DA. Impact of androgen therapy in Sjögren's syndrome: Hormonal

influence on lymphocyte populations and Ia expression in lacrimal glands of MRL/Mp-lpr/lpr mice. Invest Ophthalmol Vis Sci 1992;33:2537-2545.

41. Cappeller WA, Bloch KJ, Fagundes J, Carter EA, Sullivan DA, Harmatz PR. Effect of thermal injury

on transfer of IR22 IgA myeloma protein into bile in the rat. Liver 1992;12:124-131. 42. Sullivan DA, Vaerman JP and Soo C. Influence of severe protein malnutrition on rat lacrimal, salivary

and gastrointestinal immune expression during development, adulthood and aging. Immunology 1993;78:308-317.


43. Rocha FJ, Wickham LA, Pena JDO, Gao J, Ono M, Lambert RW, Kelleher RS, Sullivan DA. Influence of gender and the endocrine environment on the distribution of androgen receptors in the lacrimal gland. J Steroid Biochem Mol Biol 1993;46:737-749.

44. Lambert RW, Kelleher RS, Wickham LA, Vaerman JP, Sullivan DA. Neuroendocrinimmune

modulation of secretory component production by rat lacrimal, salivary and intestinal epithelial cells. Invest Ophthalmol Vis Sci 1994;35:1192-1201.

45. Sato EH, Sullivan DA. Comparative influence of steroid hormones and immunosuppressive agents

on autoimmune expression in lacrimal glands of a female mouse model of Sjögren’s syndrome. Invest Ophthalmol Vis Sci 1994;35:2632-2642.

46. Rocha FJ, Sato EH, Sullivan BD, Sullivan DA. Effect of androgen analogue treatment and androgen

withdrawal on lacrimal gland inflammation in a mouse model (MRL/Mp-lpr/lpr) of Sjögren’s syndrome. Reg Immunol 1994;6:270-277.

47. Gao J, Lambert RW, Wickham LA, Banting G, Sullivan DA. Androgen control of secretory

component mRNA levels in the rat lacrimal gland. J Steroid Biochem Mol Biol 1995;52:239-249. 48. Ono M, Rocha FJ, Sullivan DA. Immunocytochemical location and hormonal control of androgen

receptors in lacrimal tissues of the female MRL/Mp-lpr/lpr mouse model of Sjögren’s syndrome. Exp Eye Res 1995;61:659-666.

49. Sullivan DA, Edwards JA, Wickham LA, Pena JDO, Gao J, Ono M, Kelleher RS. Identification and

endocrine control of sex steroid binding sites in the lacrimal gland. Curr Eye Res 1996;15:279-291. 50. Huang Z, Lambert RW, Wickham A, Sullivan DA. Analysis of cytomegalovirus infection and

replication in acinar epithelial cells of the rat lacrimal gland. Invest Ophthalmol Vis Sci 1996;37:1174-1186.

51. Sullivan DA, Block L, Pena JDO. Influence of androgens and pituitary hormones on the structural

profile and secretory activity of the lacrimal gland. Acta Ophthalmol Scand 1996;74:421-435. 52. Sullivan DA, Edwards J. Androgen stimulation of lacrimal gland function in mouse models of

Sjögren's syndrome. J Ster Biochem Mol Biol 1997;60:237-245. 53. Wickham A, Huang Z, Lambert RW, Sullivan DA. Effect of sialodacryoadenitis virus exposure on

acinar epithelial cells from the rat lacrimal gland. Ocular Immunol Immunopathol 1997;5:181-195. 54. Toda I, Wickham LA, Sullivan DA. Gender and androgen treatment influences the expression of

proto-oncogenes and apoptotic factors in lacrimal and salivary tissues of MRL/lpr mice. Clin Immunol Immunopath 1998;86:59-71.

55. Haendler B, Toda I, Sullivan DA, Schleuning W-D. Expression of cysteine-rich proteins (CRISPs) in

the murine lacrimal gland. J Cell Physiol 1999;178:371-378.


56. Sullivan DA, Krenzer KL, Sullivan BD, Tolls BD, Toda I, Dana MR. Does androgen insufficiency cause lacrimal gland inflammation and aqueous tear deficiency? Invest Ophthalmol Vis Sci 1999;40:1261-1265.

57. Toda I, Sullivan BD, Rocha EM, Silveira LA, Wickham LA, Sullivan DA. Impact of gender on

exocrine gland inflammation in mouse models of Sjögren’s syndrome. Exp Eye Res 1999;69:355-366. 58. Toda I, Sullivan BD, Wickham LA, Sullivan DA. Gender and androgen-related influence on the

expression of proto-oncogene and apoptotic factor mRNAs in lacrimal glands of autoimmune and non-autoimmune mice. J Steroid Biochem Mol Biol 1999;71:49-61.

59. Rocha EM, Wickham LA, Silveira LA, Krenzer KL, Yu FS, Toda I, Sullivan BD, Sullivan DA.

Identification of androgen receptor protein and 5a-reductase mRNA in human ocular tissues. Brit J Ophthalmol 2000;84:76-84.

60. Wickham LA, Gao J, Toda I, Rocha EM, Ono M, Sullivan DA. Identification of androgen, estrogen

and progesterone receptor mRNAs in the eye. Acta Ophthalmologica 2000;78:146-153. 61. Sullivan DA, Sullivan BD, Ullman MD, Rocha EM, Krenzer KL, Cermak JM, Toda I, Doane M,

Evans JE, Wickham LA. Androgen influence on the meibomian gland. Invest Ophthalmol Vis Sci 2000;41:3732-3742.

62. Krenzer KL, Dana MR, Ullman MD, Cermak JM, Tolls BD, Evans JE, Sullivan DA. Effect of

androgen deficiency on the human meibomian gland and ocular surface. J Clin Endocr Metab 2000;85:4874-4882.

63. Sullivan BD, Evans JE, Krenzer KL, Dana MR, Sullivan DA. Impact of antiandrogen treatment on

the fatty acid profile of neutral lipids in human meibomian gland secretions. J Clin Endocr Metab 2000;85:4866-4873.

64. Schaumberg DA, Buring JE, Sullivan DA, Dana MR. Hormone replacement therapy and dry eye

syndrome. JAMA 2001;286:2114-2119. 65. Sullivan BD, Evans JE, Cermak JM, Krenzer KL, Dana MR, Sullivan DA. Complete androgen

insensitivity syndrome: Effect on human meibomian gland secretions. Arch Ophthalmol 2002;120:1689-1699.

66. Cermak JM, Papas AS, Sullivan RM, Dana MR, Sullivan DA. Nutrient intake in women with primary

and secondary Sjögren’s syndrome. Eur J Clin Nutr 2003;57:328-334. 67. Schaumberg DA, Sullivan DA, Buring JE, Dana MR. Prevalence of dry eye syndrome among US

women. Am J Ophthalmol 2003;136:318-326. 68. Cermak JM, Krenzer KL, Sullivan RM, Dana MR, Sullivan DA. Is complete androgen insensitivity

syndrome associated with alterations in the meibomian gland and ocular surface? Cornea 2003;22:516-521.


69. Sullivan DA, Bélanger A, Cermak JM, Bérubé R, Papas AS, Sullivan RM, Yamagami H, Dana MR, Labrie F. Are women with Sjögren’s syndrome androgen deficient? J Rheumatology 2003;30:2413-2419.

70. Treister NS, Richards SM, Lombardi MJ, Rowley P, Jensen RV, Sullivan DA. Sex-related differences

in gene expression in salivary glands of BALB/c mice. J Dental Res 2005;84:160-165. 71. Suzuki T, Sullivan DA. Estrogen stimulation of proinflammatory cytokine and matrix

metalloproteinase gene expression in human corneal epithelial cells. Cornea 2005;24:1004-1009. 72. Richards SM, Jensen RV, Liu M, Sullivan BD, Lombardi MJ, Rowley P, Schirra F, Treister NS, Suzuki

T, Steagall RJ, Yamagami H, Sullivan DA. Influence of sex on gene expression in the mouse lacrimal gland. Exp Eye Res 2006;82:13-23; 2005, Jun 24 [Epub ahead of print].

73. Richards SM, Liu M, Jensen RV, Schirra F, Yamagami H, Lombardi MJ, Rowley P, Treister NS,

Suzuki T, Sullivan BD, Sullivan DA. Androgen regulation of gene expression in the mouse lacrimal gland. J Steroid Biochem Mol Biol 2005;96:401-413.

74. Schirra F, Suzuki T, Richards SM, Jensen RV, Liu M, Lombardi MJ, Rowley P, Treister NS, Sullivan

DA. Androgen control of gene expression in the mouse meibomian gland. Invest Ophthalmol Vis Sci 2005;46:3666-3675.

75. Treister NS, Richards SM, Jensen RV, Sullivan DA. Influence of androgens on gene expression in the

BALB/c mouse submandibular gland. J Dental Res 2005;84:1187-1192. 76. Suzuki T, Schirra F, Richards SM, Treister NS, Lombardi MJ, Rowley P, Jensen RV, Sullivan DA.

Estrogen and progesterone impact on gene expression in the mouse lacrimal gland. Invest Ophthalmol Vis Sci 2006;47:158-168.

77. Schirra F, Suzuki T, Dickinson DP, Townsend DJ, Gipson IK, Sullivan DA. Identification of

steroidogenic enzyme mRNAs in the human lacrimal gland, meibomian gland, cornea and conjunctiva. Cornea 2006;25:438-42.

78. Richards SM, Yamagami H, Schirra F, Suzuki T, Jensen RV, Sullivan DA. Sex-related effect on gene

expression in the mouse meibomian gland. Curr Eye Res 2006;31:119-128. 79. Suzuki T, Sullivan DA. Comparative effects of estrogen on matrix metalloproteinases and cytokines

in immortalized and primary human corneal epithelial cell cultures. Cornea 2006;25:454-459. 80. Tsai P, JE Evans, Green KM, Sullivan RM, Schaumberg DA, Richards SM, Dana MR, Sullivan DA.

Proteomic analysis of human meibomian gland secretions. Br J Ophthalmol 2006;90:372-377. 81. Schirra F, Richards SM, Liu M, Suzuki T, Yamagami H, Sullivan DA. Androgen regulation of

lipogenic pathways in the mouse meibomian gland. Exp Eye Res 2006;83:291-296. 82. Gulati A, Sullivan R, Buring JE, Sullivan DA, Dana R, Schaumberg DA. Validation and repeatability

of a short questionnaire for dry eye syndrome. Am J Ophthalmol 2006;142:125-131.


83. Treister NS, Richards SM, Rowley P, Jensen RV, Sullivan DA. Influence of testosterone on gene expression in the ovariectomized mouse submandibular gland. Eur J Oral Sci 2006;114:328-336.

84. Sullivan BD, Evans JE, Dana MR, Sullivan DA. Influence of aging on the polar and neutral lipid

profiles in human meibomian gland secretions. Arch Ophthalmol 2006; 124:1286-1292. 85. Miljanovic B, Dana R, Sullivan DA, Schaumberg DA. Impact of dry eye syndrome on vision-related

quality of life. Am J Ophthalmol 2007;143:409-415. 86. Schirra F, Richards SM, Sullivan DA. Androgen influence on cholesterogenic enzyme mRNA levels in

the mouse meibomian gland. Curr Eye Res 2007;32:393-398. 87. Suzuki T, Schirra F, Richards SM, Jensen RV, Sullivan DA. Estrogen and progesterone control of

gene expression in the mouse meibomian gland. Invest Ophthalmol Vis Sci 2008;49:1797-1808. 88. Schaumberg DA, Dana R, Buring JE, Sullivan DA. Prevalence and risk factors for dry eye disease

among US men. Arch Ophthalmol 2009;127:763-768. 89. Richards SM, Sullivan DA. Do genetic alterations in sex steroid receptors contribute to lacrimal gland

disease in Sjögren’s syndrome? Open Endocrinol J 2009;3:5-11. 90. Sullivan DA, Jensen RV, Suzuki T, Richards SM. Do sex steroids exert sex-specific and/or opposite

effects on gene expression in lacrimal and meibomian glands? Mol Vis 2009;10:15:1553-1572. 91. Suzuki T, Richards SM, Liu S, Jensen RV, Sullivan DA. Impact of sex on gene expression in human

corneal epithelial cells. Mol Vision 2009;15:2554-2569. 92. Liu S, Khandelwal P, Hatton M, Sullivan DA. Culture, immortalization and characterization of human

meibomian gland epithelial cells. Invest Ophthalmol Vis Sci 2010;51:3993-4005. 93. Liu S, Richards SM, Lo K, Hatton M, Fay AM, Sullivan DA. Changes in gene expression in

meibomian gland dysfunction. Invest Ophthalmol Vis Sci 2011;52:2727-2740. 94. Nichols KK, Foulks GN, Bron AJ, Glasgow BJ, Dogru M, Tsubota K, Lemp MA, Sullivan DA. The

International Workshop on Meibomian Gland Dysfunction: Executive Summary. Invest Ophthalmol Vis Sci 2011;52:1922-1929.

95. Knop E, Knop N, Millar T, Obata H, Sullivan DA. The International Workshop on Meibomian

Gland Dysfunction: Report of the Subcommittee on Anatomy, Physiology, and Pathophysiology of the Meibomian Gland. Invest Ophthalmol Vis Sci 2011;52:1938-1978.

96. Kam WR, Sullivan DA. Neurotransmitter activation of signaling pathways in human meibomian

gland epithelial cells. Invest Ophthalmol Vis Sci 2011;52:854-8548. 97. Morrison S, Sullivan DA, Sullivan BD, Sheardown H, Schmidt TA. Dose-dependent & synergistic

effects on proteoglycan 4 (PRG4) on boundary lubrication at a human cornea – polydimethylsiloxane (PDMS) biointerface. Eye and Contact Lens 2012;38:27-35.


98. Sullivan DA, Hammitt KM, Schaumberg DA, Sullivan BD, Begley CG, Gjorstrup P, Garrigue J-S, Nakamura M, Quentric Y, Barabino S, Dalton M, Novack GD. Report of the TFOS/ARVO Symposium on global treatments for dry eye disease: An unmet need. Ocul Surf 2012;10:108-116.

99. Khandelwal P, Liu S, Sullivan DA. Dihydrotestosterone regulation of gene expression in human

meibomian gland and conjunctival epithelial cells. Mol Vis 2012;18:1055-1067. 100. Ding J, Sullivan DA. Aging and dry eye disease. Exp Gerontol 2012; 47:483-490. 101. Sahin A, Kam WR, Rahimi Darabad R, Topilow K, Sullivan DA. Regulation of leukotriene B4

secretion by human corneal, conjunctival and meibomian gland epithelial cells. Arch Ophthalmol 2012;130:1013-1018.

102. Davis RK, Doane MG, Knop E, Knop N, Dubielzig RR, Colitz CMH, Argüeso P, Sullivan DA.

Characterization of ocular gland morphology and tear composition of pinnipeds. Veterinary Ophthalmology 2013;16:269-275.

103. Schmidt TA (co-first), Sullivan DA (co-first), Knop E, Richards SM, Knop N, Liu S, Sahin A,

Darabad RR, Morrison S, Kam WR, Sullivan BD. Transcription, translation and function of lubricin at the ocular surface. JAMA Ophthalmol 2013;18:1-11.

104. Rahimi Darabad R, Suzuki T, Richards SM, Jensen R, Jakobiec FA, Zakka FR, Liu S, Sullivan DA.

Impact of estrogen absence on gene expression in the meibomian gland. Invest Ophthalmol Vis Sci 2013;54:987-998.

105. Liu S, Kam W, Ding J, Hatton MP, Sullivan DA. Effect of growth factors on the proliferation and

gene expression of human meibomian gland epithelial cells. Invest Ophthalmol Vis Sci 2013; 54:2541-2550.

106. Ding J, Kam WR, Dieckow J, Sullivan DA. The influence of 13-cis retinoic acid on human

meibomian gland epithelial cells. Invest Ophthalmol Vis Sci 2013;54:4341-4350. 107. Nichols JJ, Jones L, Nelson JD, Stapleton F, Sullivan DA, Willcox MDP, and the members of the

TFOS International Workshop on Contact Lens Discomfort. The TFOS International Workshop on Contact Lens Discomfort: Introduction. Invest Ophthalmol Vis Sci 2013;54:TFOS1-6.

108. Nichols JJ, Willcox MDP, Bron AJ, Belmonte C, Ciolino CB, Craig JP, Dogru M, Foulks GN, Jones

L, Nelson JD, Nichols KK, Purslow C, Schaumberg DA, Stapleton F, Sullivan DA, and the members of the TFOS International Workshop on Contact Lens Discomfort. The TFOS International Workshop on Contact Lens Discomfort: Executive Summary. Invest Ophthalmol Vis Sci 2013;54:TFOS7-13.

109. Liu Y, Kam WR, Ding J, Sullivan DA. Effect of azithromycin on lipid accumulation in immortalized

human meibomian gland epithelial cells. JAMA Ophthalmology 2014; 132:226-228. 110. Liu Y, Kam WR, Ding J, Sullivan DA. One man's poison is another man's meat: Using azithromycin-

induced phospholipidosis to promote ocular surface health. Toxicology 2014;320C:1-5.


111. Ding J, Sullivan DA. The effects of insulin-like growth factor-1 and growth hormone on human meibomian gland epithelial cells. JAMA Ophthalmology 2014;132:593-599.

112. Sullivan DA, Liu Y, Kam WR, Ding J, Green KM, Shaffer SA, Hatton MP, Liu S. Serum-induced

differentiation of human meibomian gland epithelial cells. Invest Ophthalmol Vis Sci 2014; 55:3866-3877.

113. Samsom ML, Morrison S, Masala N, Sullivan BD, Sullivan DA, Sheardown H, Schmidt TA.

Characterization of full-length recombinant human Proteoglycan 4 as an ocular surface boundary lubricant. Exp Eye Res 2014;127:14-19.

114. Rahimi Darabad R, Suzuki T, Richards SM, Barabino S, Jensen R, Jakobiec FA, Zakka FR, Sullivan

DA. Influence of estrogen deficiency on lacrimal gland gene expression. Exp Eye Res 2014;127:153-160.

115. Liu Y, Kam WR, Ding J, Sullivan DA. Can tetracycline antibiotics duplicate the ability of

azithromycin to stimulate meibomian gland epithelial cell differentiation? Cornea 2015;34:342-346. 116. Ding J, Wirostko B, Sullivan DA. Human growth hormone promotes corneal epithelial cell

migration in vitro. Cornea 2015;34:686-692. 117. Wirostko B, Rafii MJ, Sullivan DA, Morelli J, Ding J. Novel therapy to treat corneal epithelial

defects: a hypothesis with growth hormone. Ocul Surf 2015; 13:204-212. 118. Ding J, Liu Y, Sullivan DA. Effects of insulin and high glucose on human meibomian gland

epithelial cells. Invest Ophthalmol Vis Sci 2015; in press. 119. Chao W, Belmonte C, Benitez del Castillo J, Bron A, Dua H, Nichols K, Novack G, Schrader W,

Willcox M, Wolffsohn J, Sullivan DA. Report of the Inaugural Meeting of the TFOS i2 = initiating innovation Series: Targeting the Unmet Need for Dry Eye Treatment. Ocul Surf 2015; in press.

Proceedings of Meetings: 120. Wira CR, Sullivan DA, Sandoe CP. Estrogen-mediated control of the secretory immune system in

the uterus of the rat. Ann NY Acad Sci 1983;409:534-551. 121. Sullivan DA, Wira CR. Estradiol regulation of secretory component in the rat uterus. Ann NY Acad

Sci 1983;409:882-884. 122. Sullivan DA, Allansmith MR. Androgen regulation of IgA levels in tears of rats. Protides Biol Fluids

1985;32:93-94. 123. Sullivan DA, Allansmith MR. Origin of IgA in tears of rats. Protides Biol Fluids 1985;32:89-91. 124. Stern JE, Sullivan DA, Wira CR. Secretory component in breast cancer: Correlations with patient age

and hormone receptor levels in primary breast tumors. Protides Biol Fluids 1985;32:579-581.


125. Gudmundsson OG, Sullivan DA, Bloch KJ, Allansmith MR. Immunoglobulins and secretory component in rat tears and ocular adnexa. In: III International Symposium on Immunology and Immunopathology of the Eye. New York, NY: Masson Publishing, Inc.; 1985. p. 287-290.

126. Sullivan DA, Hann LE. Endocrine regulation of the ocular secretory immune system. Adv Exp Med

Biol 1987;216:765-774. 127. Sullivan DA, Hann LE, Allansmith MR. The influence of age on the ocular secretory immune system

of the rat. Adv Exp Med Biol 1987;216:1395-1407. 128. Seo JK, Grant KE, Sullivan DA, Hanson DB, Bloch, KJ, Harmatz PR, Walker WA. Fluctuation in

biliary IgA content following cannulation of the common bile duct. Adv Exp Med Biol 1987;216:1133-1138.

129. Sullivan DA, Allansmith MR. Involvement of the hypothalamic-pituitary axis in the androgen

regulation of the ocular secretory immune system. In: Secchi AG, Fregona, IA, editors. Modern Trends in Immunology and Immunopathology of the Eye. S.p.A.-Milano; 1989. p. 363-366.

130. Sullivan DA, Hann LE, Allansmith MR. The effect of aging on the ocular secretory immune system

of the rat. In: Secchi AG, Fregona, IA, editors. Modern Trends in Immunology and Immunopathology of the Eye. S.p.A.-Milano; 1989. p. 367-370.

131. Ariga H, Vendramini AC, Soo C, Edwards J, Sullivan DA. Hormonal influence on autoimmune

expression in lacrimal tissue of MRL/Mp-lpr/lpr and NZB/NZW F1 mice. In: Advances in Mucosal Immunology. London: Kluwer Academic Publishers; 1990. p. 520-521.

132. Sullivan DA, Yee L, Conner AS, Olivier, M, Hann, LE, Allansmith MR. Impact of antigenic

exposure on the developmental appearance of IgA-, IgG- and IgM-containing cells in the lacrimal gland. In: Advances in Mucosal Immunology. London: Kluwer Academic Publishers; 1990. p. 518-519.

133. Kelleher, RS, Hann LE, Edwards, JA, Sullivan, DA. Endocrine and neuropeptide control of

secretory component synthesis by acinar cells from the lacrimal gland. In: Advances in Mucosal Immunology. London: Kluwer Academic Publishers; 1990. p. 522-523.

134. Sullivan, DA, Hann, LE. Androgen regulation of the ocular secretory immune system. In: Advances

in Mucosal Immunology. London: Kluwer Academic Publishers; 1990. p. 250-254. 135. Sullivan DA, Hann LE, Yee L, Edwards JA, Soo C, Allansmith MR. Neural-immune interactions:

role of ocular innervation in the secretory immune system of the lacrimal gland. In: Advances in Mucosal Immunology. London: Kluwer Academic Publishers; 1990. p. 524-525.

136. Cappeller WA, Bloch KJ, Sullivan DA, Carter EA, Harmatz PR. Dissociation of IR22 IgA myeloma

protein during hepatobiliary transfer after thermal injury in the rat. In: Advances in Mucosal Immunology. London: Kluwer Academic Publishers; 1990. p. 586-587.


137. Kelleher RS, Hann LE, Edwards JA, Sullivan DA. Hormonal and neural modulation of secretory component production by lacrimal gland acinar cells. In: Ocular Immunology Today. New York: Elsevier Science Publishers; 1990. p. 289-292.

138. Sullivan DA, Hann LE, Soo C, Edwards JA, Allansmith. Influence of neural innervation on the

expression of the secretory immune system of the lacrimal gland. In: Ocular Immunology Today. New York: Elsevier Science Publishers; 1990. p. 321-324.

139. Ariga H, Vendramini ACLM, Soo C, Edwards JA, Sullivan DA. Androgen treatment of autoimmune

disease in lacrimal glands of MRL/Mp-lpr/lpr and NZB/NZW F1 mice. In: Ocular Immunology Today. New York: Elsevier Science Publishers; 1990. p. 95-98.

140. Sullivan DA, Soo C, Allansmith MR. Severe protein malnutrition: impact on tear IgA levels during

development and aging. In: Ocular Immunology Today. New York: Elsevier Science Publishers; 1990. p. 325-328.

141. Sullivan DA. Preface. Lacrimal Gland, Tear Film and Dry Eye Syndromes: Basic Science and Clinical

Relevance. Sullivan DA, Bromberg BB, Cripps MM, Dartt DA, MacKeen DL, Mircheff AK, Montgomery PC, Tsubota K, Walcott B, editors. New York: Plenum Press; 1994; pp. ix-x.

142. Rocha FJ, Kelleher RS, Edwards JA, Pena JDO, Ono M, Sullivan DA. Binding characteristics,

immunocytochemical location and hormonal regulation of androgen receptors in lacrimal tissue. Adv Exp Med Biol 1994;350:157-160.

143. Sullivan DA, Ariga H, Vendramini AC, Rocha FJ, Ono M, Sato EH. Androgen-induced suppression

of autoimmune disease in lacrimal glands of mouse models of Sjögren's syndrome. Adv Exp Med Biol 1994;350:683-690.

144. Rocha FJ, Sato EH, Sullivan BD, Sullivan DA. Comparative efficacy of androgen analogues in

suppressing lacrimal gland inflammation in a mouse model (MRL/lpr) of Sjögren's syndrome. Adv Exp Med Biol 1994;350:697-700.

145. Lambert RW, Kelleher RS, Wickham LA, Gao J, Sullivan DA. Neural-endocrine control of secretory

component synthesis by lacrimal gland acinar cells: specificity, temporal characteristics and molecular basis. Adv Exp Med Biol 1994;350:175-180.

146. Wickham LA, Huang Z, Lambert RW, Sullivan DA. Sialodacryoadenitis virus infection of rat

lacrimal gland acinar cells. Adv Exp Med Biol 1994;350:193-196. 147. Huang Z, Lambert RW, Wickham LA, Sullivan DA. Influence of the endocrine environment on

herpes virus infection in rat lacrimal gland acinar cells. Adv Exp Med Biol 1994;350:189-192. 148. Gao J, Lambert RW, Sullivan DA. Androgen regulation of secretory component mRNA levels in the

rat lacrimal gland. Adv Exp Med Biol 1994;350:219-224. 149. Ono M, Rocha FJ, Sato EH, Sullivan DA. Distribution and endocrine regulation of androgen

receptors in lacrimal glands of the MRL/lpr mouse model of Sjögren’s syndrome. In: Homma M.


Sugai S, Tojo T, Miyasaka N, Akizuki M, editors. Sjögren's Syndrome. State of the Art. Amsterdam, Kugler Press 1994. p. 261-263.

150. Sullivan DA. Possible mechanisms involved in the reduced tear secretion in Sjögren’s syndrome. In:

Homma M. Sugai S, Tojo T, Miyasaka N, Akizuki M, editors. Sjögren's Syndrome. State of the Art. Amsterdam, Kugler Press; 1994. p. 13-19.

151. Sullivan DA, Huang Z, Lambert RW, Wickham LA, Ono M, Pena JDO, Gao J. Androgen regulation

of ocular mucosal- and auto-immunity. In: Szélenyi J, Berczi I, editors. Advances in Psychoneuroimmunology. New York: Plenum Press; 1994. p. 213-222.

152. Sullivan DA, Rocha FJ, Sato EH. Influence of androgen therapy on lacrimal autoimmune disease in

a mouse model of Sjögren's syndrome. Adv Exp Med Biol 1995;371B:1199-1202. 153. Lambert RW, Gao J, Kelleher RS, Wickham LA, Sullivan DA. Neural, endocrine and immune

regulation of secretory component production by lacrimal gland acinar cells. Adv Exp Med Biol 1995;371A:221-224.

154. Wickham LA, Huang Z, Lambert RW, Sullivan DA. Herpes- and corona-virus infection of rat

lacrimal acinar cells. Adv Exp Med Biol 1995;371B:999-1002. 155. Sullivan DA. Preface. Lacrimal Gland, Tear Film and Dry Eye Syndromes 2. Basic Science and

Clinical Relevance. Sullivan DA, Dartt DA, Meneray MM, editors. New York: Plenum Press; 1998; pp. v-vi.

156. Sullivan DA, Wickham LA, Rocha EM, Kelleher RS, Silveira LA, Toda I. Influence of gender, sex

steroid hormones and the hypothalamic-pituitary axis on the structure and function of the lacrimal gland. Adv Exp Med Biol 1998;438:11-42.

157. Sullivan DA, Rocha EM, Ullman MD, Krenzer KL, Gao J, Toda I, Dana MR, Bazzinotti D, Silveira

LA, Wickham LA. Androgen regulation of the meibomian gland. Adv Exp Med Biol 1998;438:327-331.

158. Wickham LA, Rocha AM, Gao J, Krenzer KL, Silveira LA, Toda I, Sullivan DA. Identification and

hormonal control of sex steroid receptors in the eye. Adv Exp Med Biol 1998;438:95-100. 159. Toda I, Wickham LA, Rocha EM, Silveira LA, Sullivan DA. Gender- and androgen-related impact

on the expression of proto-oncogenes and apoptotic factors in lacrimal and salivary glands of mouse models of Sjögren’s syndrome. Adv Exp Med Biol 1998;438:447-452.

160. Rocha EM, Wickham LA, Huang Z, Toda I, Gao J, Silveira LA, Sullivan DA. Presence and

testosterone influence on the levels of anti- and pro-inflammatory cytokines in lacrimal tissues of a mouse model of Sjögren’s syndrome. Adv Exp Med Biol 1998;438:485-491.

161. Sullivan DA. Preface. Lacrimal Gland, Tear Film and Dry Eye Syndromes 3. Basic Science and

Clinical Relevance. Sullivan DA, Tsubota K, Dartt DA, Stern ME, Sullivan RM, Bromberg BB, editors. New York: Kluwer Academic/Plenum Press; 2002; p. xi.


162. Sullivan DA, Yamagami H, Liu M, Steagall RJ, Schirra F, Suzuki T, Krenzer KL, Cermak JM, Sullivan RM, Richards S, Schaumberg DA, Dana MR, Sullivan BD. Sex steroids, the meibomian gland and evaporative dry eye. Adv Exp Med Biol 2002;506:389-399.

163. Richards SM, Liu M, Sullivan BD, Sullivan DA. Gender-related differences in gene expression of the

lacrimal gland. Adv Exp Med Biol 2002;506:121-127. 164. Liu M, Richards SM, Schirra F, Yamagami H, Sullivan BD, Sullivan DA. Identification of androgen-

regulated genes in the lacrimal gland. Adv Exp Med Biol 2002;506:129-135. 165. Sullivan BD, Evans JE, Dana MR, Sullivan DA. Impact of androgen deficiency on the lipid profiles

in human meibomian gland secretions. Adv Exp Med Biol 2002;506:449-458. 166. Sullivan BD, Cermak JM, Sullivan RM, Papas AS, Evans JE, Dana MR, Sullivan DA. Correlations

between nutrient intake and the polar lipid profiles of meibomian gland secretions in women with Sjögren’s syndrome. Adv Exp Med Biol 2002;506:441-447.

167. Steagall RJ, Yamagami H, Wickham LA, Sullivan DA. Androgen control of gene expression in the

rabbit meibomian gland. Adv Exp Med Biol 2002;506:465-476. 168. Yamagami H, Richards SM, Sullivan BD, Liu M, Steagall RJ, Sullivan DA. Gender-associated

differences in gene expression of the meibomian gland. Adv Exp Med Biol 2002;506:459-463. 169. Yamagami H, Schirra F, Liu M, Richards SM, Sullivan BD, Sullivan DA. Androgen influence on

gene expression in the meibomian gland. Adv Exp Med Biol 2002;506:477-481. 170. Suzuki T, Sullivan BD, Liu M, Schirra F, Richards SM, Yamagami H, Sullivan DA. Estrogen and

progesterone effects on the morphology of the mouse meibomian gland. Adv Exp Med Biol 2002;506:483-488.

171. Schaumberg DA, Sullivan DA, Dana MR. Epidemiology of dry eye syndrome. Adv Exp Med Biol

2002;506:989-998. 172. Sullivan RM, Cermak JM, Papas AS, Dana MR, Sullivan DA. Economic and quality of life impact of

dry eye symptoms in women with Sjögren's syndrome. Adv Exp Med Biol 2002;506:1183-1188. 173. Bijlsma WR, Tonino BAR, Richards SM, Liu M, Sullivan BD, Sullivan DA. Androgen influence on

lymphocyte gene expression. Adv Exp Med Biol 2002;506:143-151. 174. Sullivan DA, Sullivan BD, Evans JE, Schirra F, Yamagami H, Liu M, Richards SM, Suzuki T,

Schaumberg DA, Sullivan RM, Dana MR. Androgen deficiency, meibomian gland dysfunction and evaporative dry eye. Ann NY Acad Sci 2002;966:211-222.

175. Suzuki T, Schaumberg DA, Sullivan BD, Liu M, Richards SM, Sullivan RM, Dana MR, Sullivan DA.

Do estrogen and progesterone play a role in the dry eye of Sjögren's syndrome? Ann NY Acad Sci 2002;966:223-225.


176. Sullivan DA, Stern ME. Preface, 4th International Conference on the Lacrimal Gland Tear Film and Dry Eye Syndromes: Basic Science and Clinical Relevance. Ocul Surf 2005; 3 (1) Suppl:S7.

177. Sullivan DA. The endocrine system and the meibomian glands. Proceedings of the Meibom-2000

Symposium on the Meibomian Glands, 2008; in press. Reviews, Editorials and Chapters: 178. Wira CR, Sullivan DA. Effect of estradiol and progesterone on the secretory immune system in the

female genital tract. In: Leavitt WW, editor. Hormones and Cancer. New York: Plenum Press; 1982. p. 99-111.

179. Allansmith MR, Sullivan DA. Books on cornea-external diseases. Ophthalmol 1983;Suppl 229-230. 180. Sullivan DA. Endocrine control of the ocular secretory immune system. In: Berczi, I, editor.

Hormones and Immunity. Lancaster, England: MTP Press Limited; 1987. p. 54-92. 181. Sullivan DA, Hann LE. Mechanisms involved in the endocrine regulation of the ocular secretory

immune system. In: Hadden JW, Masek K, Nistico G, editors. Interactions among Central Nervous System, Neuroendocrine and Immune Systems. Rome, Italy: Pythagora Press; 1989. p. 395-428.

182. Sullivan DA. Hormonal influence on the secretory immune system of the eye. In: Freier S, ed. The

Neuroendocrine-Immune Network. Boca Raton, FL: CRC Press; 1990. p. 199-238. 183. Sullivan DA, Sato EH. Potential therapeutic approach for the hormonal treatment of lacrimal gland

dysfunction in Sjögren's syndrome. Clin Immunol Immunopath 1992;64:9-16. 184. Sullivan DA. Endocrine effects on mucosal immune function. In: Walker WA, Harmatz PR, Wershil

BK, editors. Immunophysiology of the Gut. Orlando, FL: Academic Press; 1993. p. 165-170. 185. Sullivan DA. Research report of the SSF 1992-3 fellowship winner, Zhiyan Huang, MD. The

Moisture Seekers 1993;11:1,5. 186. Sullivan DA, Sato EH: Immunology of the lacrimal gland. In Albert DM, Jakobiec, FA, editors.

Principles and Practice of Ophthalmology: Basic Sciences. Philadelphia, PA: WB Saunders Company; 1994. p. 479-486.

187. Sullivan DA. Ocular mucosal immunity. In: Ogra PL, Mestecky J, Lamm ME, Strober W, McGhee J,

Bienenstock J, editors. Handbook of Mucosal Immunology. Orlando, FL: Academic Press; 1994. p. 569-597.

188. Sullivan DA, Ono M. New research insights into the physiological basis and potential treatment for

dry eye in Sjögren's syndrome. Journal of the Eye, 1994;11:1187-1195. 189. Sullivan DA, Wickham LA, Rocha EM, Silveira LA, Toda I. Role of sex steroid hormones in the

expression and possible treatment of dry eye in Sjögren’s syndrome. In: The Moisture Seekers Newsletter, 1996:14:1,3,4.


190. Sullivan DA, Wickham LA, Krenzer KL, Rocha EM, Toda I. Aqueous tear deficiency in Sjögren’s syndrome: Possible causes and potential treatment. In: Pleyer U, Hartmann C, Sterry W, editors. Oculodermal Diseases - Immunology of Bullous Oculo-Muco-Cutaneous Disorders. Buren, The Netherlands: Aeolus Press; 1997. p. 95-152.

191. Sullivan DA. Sex hormones and Sjögren’s syndrome. J Rheumatol 1997;24 (Suppl 50):17-32. 192. Sullivan DA, Wickham LA, Toda I, Rocha EM, Krenzer KL, Dana MR. Gender and dry eye. In:

Research to Prevent Blindness Science Writers Seminar. New York: Research to Prevent Blindness; 1997. p. 57-60.

193. Zierhut M, Elson CO, Forrester JV, Kijlstra A, Kraehenbuhl J-P, Sullivan DA. Mucosal immunology

and the eye. Immunol Today 1998;19:148-150. 194. Sullivan DA. Ocular mucosal immunity. In: Ogra PL, Mestecky J, Lamm ME, Strober W, McGhee J,

Bienenstock J, editors. Handbook of Mucosal Immunology, 2nd Edition. Orlando, FL: Academic Press; 1999. p. 1241-1281.

195. Sullivan DA, Wickham LA, Rocha EM, Krenzer KL, Sullivan BD, Steagall R, Cermak JM, Dana MR,

Ullman MD, Sato EH, Gao J, Rocha FJ, Ono M, Silveira LA, Lambert RW, Kelleher RS, Tolls BD, Toda I. Androgens and dry eye in Sjögren’s syndrome. Ann NY Acad Sci 1999;876:312-324.

196. Sullivan DA. Immunology of the lacrimal gland and tear film. In Pleyer U, Zierhut M, Behrens-

Baumann W, editors. Developments in Ophthalmology: Immuno-Ophthalmology. Basel, Switzerland: Karger; 1999. p. 39-53.

197. Dartt DA, Sullivan DA. Wetting of the ocular surface. In Albert DM, Jakobiec, FA, editors.

Principles and Practice of Ophthalmology, 2nd Edition. Philadelphia, PA: WB Saunders Company; 2000. vol. 2, p. 960-981.

198. Sullivan DA. Ocular secretory immune system: lacrimal gland and conjunctiva. In Zierhut M,

Forrester JV, editors. Mucosal Immunology and Ocular Diseases. Buren, The Netherlands: Aeolus Press; 2000. p. 53-91.

199. Dana MR, Sullivan DA, Parke AL. Toward optimal health: the experts discuss dry eye syndrome.

Interview by Jodi Godfrey Meisler. J Womens Health Gend Based Med 2001;10:725-729. 200. Sullivan DA, Schaumberg DA, Schirra F, Suzuki T, Liu M, Richards SM, Sullivan RM, Dana MR,

Sullivan BD. Hormone therapy for dry eye. Rev Ophthalmol 2002;9:73-76. 201. Zierhut M, Dana MR, Stern ME, Sullivan DA. Immunology of the Lacrimal Gland and Ocular Tear

Film. Trends Immunol 2002;23:333-335. 202. Sullivan DA. Androgen deficiency and dry eye syndromes. Arch Soc Espanola Oftalmologia.

2004;79:49-50. 203. Sullivan DA. Tearful relationships? Sex, hormones and aqueous-deficient dry eye. Ocular Surface

2004;2:92-123.


204. Sullivan DA. Sex and sex steroid influences on dry eye syndrome. In: Pflugfelder SC, Beuerman RW,

Stern ME, editors. Dry Eye and Ocular Surface Disorders. New York City, NY: Marcel Dekker, Inc. 2004;165-190.

205. O'Sullivan NL, Montgomery PC, Sullivan DA. Ocular mucosal immunity. In: Ogra PL, Mestecky J,

Lamm ME, Strober W, McGhee J, Bienenstock J, editors. Handbook of Mucosal Immunology, 3rd Edition. Orlando, FL: Academic Press;2004;86:1477-1496.

206. Sullivan DA, Schaumberg DA, Schirra F, Suzuki T, Liu M, Richards SM, Sullivan RM, Dana MR,

Sullivan BD. Sex, sex steroids and dry eye syndromes. In Zierhut M, Stern ME, Sullivan DA, eds. Immunology of the Lacrimal Gland, Tear Film and Ocular Surface. London, Great Britain: Taylor & Francis, 2005. pp. 161-181.

207. Sullivan DA. Endocrine Markers in the diagnosis of dry eye syndromes. Diagnostic Template 11

(http://www.tearfilm.org/dewsreport/), Appendix of Methodologies to diagnose and monitor dry eye disease, Report of the International Dry Eye WorkShop (DEWS), Volume 5, Number 2, 2007.

208. Abelson MB, Sullivan DA, Ousler GWIII, Smith L, Maffei C. What you missed at the TFOS

Meeting: A thorough update on the latest research in corneal and external disease. Rev Ophthalmol 2007;14(12):56-61.

209. Sullivan DA. Historical Perspective: Tear Film & Ocular Surface Society Conferences. Ocul Surf

2011;9:2. 210. Nichols KK, Foulks GN, Bron AJ, Sullivan DA. Meibomian gland dysfunction: What is it, why does

it occur, and how do I treat it? Ophthalmology Management, Optometric Management and Contact Lens Spectrum 2011.

211. Gomes JA, Rocha EM, Freitas D, Sullivan DA. Workshop sobre Disfunção das Glândulas

Meimobius. Arq Bras Oftalmol 2011;74:157-160. 212. Sullivan DA. New approaches and challenges for the treatment of dry eye disease. Frontiers Dry Eye

2012;7:48-49. 213. Efron N, Brennan NA, Bright FV, Glasgow BJ, Jones LW, Sullivan DA, Tomlinson A, Zhang J. 2. Contact

lens care and ocular surface homeostasis. Cont Lens Anterior Eye 2013;36 Suppl 1:S9-13. 214. Liu Y, Ding J, Sullivan DA. An additional explanation for azithromycin’s efficacy in treating

meibomian gland dysfunction. Brit J Ophthalmol, Published Online First: 19 August 2014 215. Dewundara S, Wiggs J, Sullivan DA, Pasquale LR. Is estrogen a therapeutic target for glaucoma?

Semin Ophthalmol 2015; in press. Books:


216. Sullivan DA, Bromberg BB, Cripps MM, Dartt DA, MacKeen DL, Mircheff AK, Montgomery PC, Tsubota K, Walcott B, editors. Lacrimal Gland, Tear Film and Dry Eye Syndromes: Basic Science and Clinical Relevance. New York: Plenum Press; 1994.

217. Sullivan DA, Dartt DA, Meneray MM, editors. Lacrimal Gland, Tear Film and Dry Eye Syndromes

2. Basic Science and Clinical Relevance. New York: Plenum Press; 1998. 218. Sullivan DA, Tsubota K, Dartt DA, Stern ME, Sullivan RM, Bromberg BB, editors. Lacrimal Gland,

Tear Film and Dry Eye Syndromes 3. Basic Science and Clinical Relevance. New York: Kluwer Academic/Plenum Press; 2002.

219. Zierhut M, Stern ME, Sullivan DA, eds. Immunology of the Lacrimal Gland, Tear Film and Ocular

Surface. London, Great Britain: Taylor & Francis, 2005. Thesis: Sullivan DA. Pulmonary immaturity in the respiratory distress syndrome and glucocorticoid induced

acceleration of lung maturation [M.S. project]. Minneapolis, MN: University of Minnesota Medical School; 1975.

Sullivan DA. The role of estradiol in the regulation of the secretory immune system of the female

reproductive tract [Ph.D. dissertation]. Hanover, NH: Dartmouth Medical School; 1980. Patents: 1. Ocular Androgen Therapy in Sjögren’s Syndrome. Patent No. 5,620,921, Issued 4/15/97. 2. Ocular Therapy in Sjögren’s Syndrome Using Topically Applied Androgens or TGF-b. Patent No.

5,688,765, Issued 11/18/97. 3. Ocular Therapy in Keratoconjunctivitis Sicca Using Topically Applied Androgens or TGF-b. Patent

No. 5,958,912, Issued 9/28/99. 4. Ocular Therapy in Keratoconjunctivitis Sicca Using Topically Applied Androgens or TGF-b. Patent

No. 6,107,289, Issued 8/22/00. 5. Sullivan B, Schmidt TA, Sullivan DA. Therapeutic replenishment and enrichment of ocular surface

lubrication. Pub. No. WO/2009/137217. 6. Sullivan B, Schmidt TA, Sullivan DA. Therapeutic modulation of ocular surface lubrication. Pub.

No. WO/2009/137602. 7. Sullivan B, Schmidt TA, Sullivan DA. Ophthalmic device, and method of use thereof, for increasing

ocular boundary lubrication. Patent No. 12,940,454, Issued 6/13. 8. Sullivan B, Schmidt TA, Sullivan DA. Replenishment and enrichment of ocular surface lubrication.

Pub. No. WO/2011/050287.


9. Sullivan B, Schmidt TA, Truitt E, Truitt NBJ, Sullivan DA. Application and uses of PRG4 and therapeutic modulation thereof. Pub. No. WO/2010/135736.

10. Truitt E, Sullivan B, Sullivan DA. Therapeutic modulation of vaginal epithelium boundary

lubrication. Pub. No. WO/2010/083239. 11. Sullivan B, Schmidt TA, Sullivan DA. Ophthalmic device, and method of use thereof, for increasing

ocular boundary lubrication. Patent No. 14/032,233, Issued 9/14. 12. Sullivan B, Schmidt TA, Sullivan DA. Therapeutic modulation of ocular surface lubrication. US

Application No. 12/940,425, Issued 6/15. Abstracts: Articles submitted by February 2016 - 1. Liu Y, Sullivan DA, Lost EO, Kopchick JJ, Ding J. Regulation of mouse meibomian gland size by the

growth hormone/insulin-like growth factor-1 axis. Submitted to J Ophthalmol, November 2015. 2. Kam WR, Liu Y, Ding J, Sullivan DA. Do cyclosporine A, anakinra, uridine triphosphate, rebamipide

or bimatoprost influence the proliferation, differentiation or signaling of human meibomian gland epithelial cells? To be submitted, January 2015.

3. Sullivan DA, Cermak JM, Sullivan RM, Papas AS, Dana MR, Krenzer KL. Comparative signs and

symptoms of dry eye in primary and secondary Sjögren’s syndrome and meibomian gland disease. To be submitted, January.

4. Kam WR, Rahimi Darabad R, Suzuki T, Sullivan DA. Suppressive effects of 17β-estradiol on

immortalized human meibomian gland epithelial cells. To be submitted, February 2016. 5. Sullivan DA, Kam WR, Rahimi Darabad R, Sahin A. Lipopolysaccharide induction of pro-

inflammatory gene expression in human corneal, conjunctival and meibomian gland epithelial cells. To be submitted, September 2015.

Abstracts to be converted to original articles - 6. Sullivan DA, Richards SM. Sex and endocrine influence on surfactant protein gene expression in

ocular and salivary tissues. 7. Rocha EM, Sullivan BD, Toda I, Wickham, LA, Silveira LA, Sullivan DA. Sex and androgen effects

on cytokine mRNA levels in lacrimal tissues of mouse models of Sjögren’s syndrome. 8 Sullivan DA, Richards SM. Mechanism(s) involved in the androgen-induced suppression of lacrimal

gland inflammation in Sjögren’s syndrome. 9. Kam WR, Rahimi Darabad R, Sullivan DA. Membrane steroid receptors are expressed by human

meibomian gland epithelial cells.


10. Sullivan DA, Rahimi Darabad, Liu S, Kam WR. Are mice relevant models for understanding sex-related differences in the human meibomian gland?

Part IV: Personal Narrative I am a Ph.D. graduate of Dartmouth Medical School (Hanover, NH), an Associate Professor in the Department of Ophthalmology at Harvard Medical School and a Senior Scientist at the Schepens Eye Research Institute (SERI; Boston, MA). During the past 33 years, my research has focused upon the interrelationships between sex, sex steroids and dry eye disease, and has led to authorship on over 200 scientific articles and 12 patents, as well as to the development of potential therapies for aqueous-deficient and evaporative dry eye disease. I have continually been awarded research grants from NIH throughout my career, and have served as a preceptor for 29 postdoctoral fellows. I have been invited to give presentations at numerous international meetings on ophthalmology, immunology, endocrinology and autoimmunity, as well as at various medical institutions, around the world. I was recently awarded The Carel C. Koch Memorial Medal Award from the American Academy of Optometry for “outstanding contributions to the enhancement and development of relationships between optometry and other professions.” I am a Founder, recent President, and current Chairman of the Board of Directors of the Tear Film & Ocular Surface Society (TFOS), a non-profit organization, which was created to advance the research, literacy, and educational aspects of the scientific field of the tear film and ocular surface throughout the world. I have organized 8 International Conferences, overseen the awarding of more than 225 Young Investigator Awards, and organized the TFOS International Workshops on Dry Eye (“DEWS”), Meibomian Gland Dysfunction, Contact Lens Discomfort and presently, DEWS II. These global Workshops have involved the efforts of 60 to 150 scientific and clinical experts, each required 2 to 3 years to complete, and all led to the publication of major reports. Through TFOS I have helped to promote increased international awareness of external eye diseases, enhance governmental funding for tear film and ocular surface research, stimulate the development of therapeutic drugs and diagnostic devices, and influence the design and conduct of clinical trials of novel treatments for ocular surface disorders. My efforts for TFOS are voluntary, and I receive no compensation from this Society. TFOS has a distribution to ~5,000 basic scientists, clinical researchers and industry representatives in more than 80 countries. Within SERI I have served as the Head of the Research Council (i.e. Faculty Senate), the Director of the Center for Corneal and External Eye Disease Research, the Head of the Immunology Unit, and the Leader of the Immunity, Inflammation and Transplantation Focus Group. I also chaired the SERI Technology Transfer Committee for over 10 years, and helped to create the Joint Clinical Research Center of SERI and the Massachusetts Eye & Ear Infirmary, and the SERI Corporate Alliance Program. Outside SERI I have chaired the Medical and Scientific Advisory Board of the Sjögren's Syndrome Foundation, and was recently a Co-Chair of the Cornea Program Committee of the Association for Research in Vision and Ophthalmology. I have acted as a reviewer for research grant proposals for NIH, the Concerted Action Program of the Ministry of Education of Flanders and the USA Veterans Administration, served on the Fellowship Review Panel for the Fight for Sight Research Division of the National Society to Prevent Blindness, and assisted as an editorial referee for many ophthalmic, immune and endocrine journals.

david a. sullivan, ph.d. 1 curriculum vitae part i: general … · 2015-11-30 · 1 curriculum...

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