dave asprey: if you're a regular listener, you've heard me...

DaveAsprey: Ifyou'rearegularlistener,you'veheardmesharemylistoftop10biohacks.Let'stalkaboutnumbernine,funhacksforthebulletproofmind.Itmaysoundweird,buthangingupsidedownisagreatwaytohackyourbrain.Regularlyinvertingtrainsyourbraincapillaries,makingthemstrongerandmorecapabletobringoxygentoyourbrain.

It'sprettystraightforward,moreoxygeninthebrainmeansbetterperformance.IgetmydailystretchandmydoseofoxygenwithmyTeeterInversionTable,whichissoessentialforoptimumfocus,concentration,andmentalenergy.Thatfullbodystretchelongatesthespineandtakesthepressureoffthediskssotheycanplumpbackup.Lesspressuremeanslesspain.Ifyouhavebackpain,evenifyou'vebeenluckyenoughtoavoiditsofar,youreallywantateetertoinverteverydaytokeepyourbackandjointsfeelinggreat.

Forover35years,Teeterhassetthestandardforqualityinversionequipmentyoucantrust.MyfriendsoveratTeeterhavedecidedtoshowsomelovetoBulletprooflisteners.Foralimitedtime,youcangettheTeeterInversionTablewithbonusaccessoriesandafreepairofgravityboots,soyoucaninvertathome,ortakethebootswithyoutothegym.Togetthisdeal,whichisasavingsofover138bucks,gotogetteeter.com/bulletproof.You'llalsogetfreeshipping,anda60daymoneybackguarantee,andfreereturns.There'sabsolutelynoriskforyoutotryitout.

Remember,youcanonlygettheTeeterwithbonusaccessoriesandafreepairofgravitybootsbygoingtogetteeter.com/bulletproof.Getteeter.com/bulletproof.Checkitout.

Speaker2: BulletproofRadio,astateofhighperformance.

DaveAsprey: YouarelisteningtoBulletproofradiowithDaveAsprey.Today'scoolfactofthedayisthatsweatingdoesmorethanjustcoolyouoff.In2012,areviewof50studiesonsweatingfoundthatsweatingremoveslead,cadmium,arsenic,mercury,especiallyinpeoplewhohaveheavymetaltoxicity,likeIusedtohave.Ihadhighlevelsofmercuryandmoderatelyhighlevelsofleadthatwereaffectingme.SweatingalsoeliminatesBPA,whichisahormonedisrupterfoundinplastics,andthatstuffaccumulatesinyourfatcells.

Ifyoudosomethingliketherapidfatlossprotocol,theBulletproofDiet,orevengoonacrashstarvationdiet,alowcalorie,lowfatthing,ifyoudumpalotoffatallatonce,allofthosetoxinscomeintothebody.You'regoingtowanttosweatmoreifyou'relosingmoreweight.Whatyouwanttodois,youwanttosweat.Saunasaregood,exerciseisgood.Prettymuchanythingthatmakesyousweatcanbegoodfordetoxing,it'sawaytobiohackyourwaytofeelingbetter,performingbetter,justwhenyoueliminatewaste.

BPR-JospehPizzorno of 26

Speakingofeliminatingwaste,beforewegetintotheshow,ifyouhaven'thadachancetotryoutthebrandnewglutathioneforce,it'sworthyourtime.Ifyou'realongtimelistener,youknowthatglutathioneisoneoftheprimarydetoxingantioxidantsinthebody,it'susedupprecipitouslyintheliver,butit'spresentinmostcellsinyourbody.It'salsohighlyrepresentedinyourbrain.Whenyourunoutofglutathioneintheliver,youstartgettingliverdamage,whichiswhyalcohol,andTylenol,thingslikethat,cancausedamagetotheliver.

Takingexogenousglutathioneisawaytojustincreaseyourbody'sdetoxabilities,andthat'swhyI'vebeenusingitformanyyears.Ihaveuseditintravenously,andthat'swhyIstartedmakinganoralformthatwasabsorbed.Youjusthavetoputitunderyourtongue,didn'ttastesogood,butitworkedreallywell.Werecently,afteralotofresearch,cameoutwithanencapsulatedversionoftrueliposomesthatyoucantakeorally.Theytransportwellwithyou,andtheyactuallyabsorb.Theproblemwithglutathionehasalwaysbeengettingittogoinwithoutbeingdigested.We'vegotawayaroundthat,andthenewglutathioneforceiseasytotravelwith,it'sjustcapsules,andit'stotallymadeitaloteasier,andtheTSAdoesn'tlookatyoufunnyforcarryingsyringesofstrangelycoloredgoopliketheyusedto.Thisisabigupgrade,anditdoesn'ttastelikeorangefrostinganymore.Checkitoutonbulletproof.com.

Aswe'regettinggoing,you'reprobablystillontheiTuneswebpage.Domeafavorreallyquickandleaveafivestarreview.I'mgratefulforthat,it'sawayyoucansupporttheshow,andtellotherpeoplethattheshowisgood.Wejustcrossed1500fivestarreviews,soI'mgratefulifyoutakeliterallyfivesecondstodothat.Itmakesmoredifferencethanyoumightimagine.

Today'sguesthasalmostahalfadecadeworkinginfunctionalmedicine.Infact,hewasworkinginfunctionalmedicinebeforeevenwasnamedfunctionalmedicine.Infact,Ithinkbefore,itwasevencalledortho-molecularmedicine,andhe'soneoftheworld'sleadingauthoritiesonsciencebasednaturalmedicine,haswrittenadozenbooksonit,hundredsofpapers.Hewasnamedin2003,theAmericanHolisticMedicalAssociation'stop25pioneersinholisticmedicine.ThefoundingpresidentofSeattle'sBastyrUniversity,PresidentClinton,in2000,appointedhimtotheWhiteHouseCommissiononComplimentaryandAlternativeMedicinePolicy.

Imentionedhe'sanauthor,he'salsoabestsellingauthor,andhehasabrandnewbookthatyou'retotallygonnawanttocheckoutcalledtheToxinSolution,HowHiddenPoisonsinAir,Water,Food,andProductsWeUseareDestroyingOurHealth,andWhatYouCanDoToFixIt.

We'regonnatalkabouttoxinstoday,whichisabigdifferentiatorforjustthewayofthinkingabouttakingcontrolofyourhealth.Maybeifyoudolessofthingsthatmakeyouweak,you'llbestronger.Theguywho'sbeendoingthisactuallylongerthanI'vebeenaliveisnoneotherthanDr.JosephPizzorno.Dr.Pizzorno,welcometotheshow.


JosephPizzorno: Well,thankyouforthekindintroduction.

DaveAsprey: Whatmadeyouwrite,thisisyour13thbook,oristhisyour12thbook?

JosephPizzorno: Okay,soactually,I'mworkingonnumber12,thisisnumber11.

DaveAsprey: It'sonlynumber11,jeez,Ioversoldyou,sorryman.

Workingon12,thisisnumber11,sowhatmadeyouwritethisbook,giventhatyouhaveaprettystrongsetofbooks,includingsomeleadingbooksinthefield,already,what'snewinthetoxinworld?

JosephPizzorno: Ihavebeeninvolvedinmedicinenowforabouthalfacentury,firstasaresearcherinconventionalmedicine,thenasastudentofnaturopathicmedicine,thenasaclinician,thenfoundedBastyrUniversity,andthenwritingbooks,andlecturingliterallyallovertheworld.I'vehadachancetoseewhatmakespeoplesickandhowtohelpthembecomehealthier.

Startingahalfcenturyago,theprimaryreasonspeoplewerehavingchronicdiseasewastypicallynutritionaldeficienciesornutritionalexcesses.But,thensomethingstartedtochange,andmoreandmoreIwasnoticingIwasseeingpatientswhowerebeingtoxicratherthanjustnutritionaldeficient.I'llbeveryclear,I'mnotsayingnutritionaldeficienciesandexcesseshaven'tgoneaway,we'vesimplyaddabiggerproblem.

Iwasstartingtoseemoreandmorepatientsshowingsignsof[inaudible00:06:45]toxicity,andchemicaltoxicity,andintestinaltoxicity.Istartedrealizingthattheyweren'trespondingaswelltonutritionaltherapyliketheyusedto,andIhadtodetoxifytheirbodies.Isaid,"Okay,wellthat'sinteresting,"anditreallygottriggeredformebackin1980whenayoungmancametoseeme,hewas30yearsold,andhehadleukemia.Leukemia'snotrealcommonthen,butkindofanunfortunatecondition,andsoItalkedtohim,andaskedwhathewasdoing,andhesaid,"Well,IworkasafarmeroverinEasternWashington.""Well,that'sinteresting,tellmewhatyou'rebeingexposedtointermsofchemicals,"andhetoldme,andIsaid,"Okay,fine,"soIgavehimsomeadviceonhowtonotgetcanceragain.

Twoweekslater,anotheryoungman,30yearsold,ofcourse,seemsyoungnow,butatthattimehewasaroundmyage.30yearsold,andhehadleukemia,andheworkedonafarm,andIsaid,"Well,that'sinteresting."Iaskedhim,"Whatchemicalsareyouexposedto,"andtheywerethesamechemicals.Atthattime,IwenttoUniversityofWashingtonSchoolofMedicinebookstore,andIboughtthemostcurrentbookontoxicology,andIstartedlookingchemicals[he'dbeen00:07:57]exposedto,andloandbehold,thesechemicalsinducecancer.But,what'sinteresting,thetoxicologybooksaid,onlyinducestoxicityandcancerinpeoplewhohavehighexposurelikefarmers,itdoesn'taffectanybodyelse.


Ithough,"Okay,well,maybethat'strue,becauseeverybodyelsehaslowerdosage,"butthenyoustartlookingatit.We'renotjustbeingexposedtooneortwopesticidesandherbicides,we'rebeingexposedtoalotofthesethings,andnowpeoplearebeingexposedtheirwholelives,soIthough,"Well,that'sinteresting."Then,Istartedlookingattheresearchontoxinsanddisease,andIwasjuststunnedbywhatIfound.Now,I'mmakingtheassertionthattheprimarycauseofchronicdiseasetodayinthewesternworldisthetoxinswe'reexposedto.

Thewondersofcivilization,asmuchasIlovehotshowers,andhavingallthesecomputers,andthingslikethis,thereisapricewe'vebeenpaying,andwehavetobecomemoreawareofthatprice,andrealizethat,indeed,wecanavoidmanyofthesetoxins,wecanhelpourbodygetthetoxinsout,andwecangetthetoxinsout,andbecomehealthier.

DaveAsprey: There'saclassofpeople,andImighthavebeenoneyearsagowhenIwasarawvegan,wherethemindsetis,"Look,Iwanttogetallmynutrientsfrommothernature."WhatIfoundjustinmyowncourseoflosing100poundsandgettingmybrainbackisthat,youshouldonlybeexposedtomothernature'stoxins,ifyouwanttoonlygetnutrientsfrommothernature.Wedon'tliveinthatworldanymore.Itsoundslikeyoureallycamacrossthis35yearsago,andyou'vebeeninclinicalpracticeforagoodportionofthat35years,workingwithtoxins,orisitmoreresearch,what'sthebreakdown?

JosephPizzorno: Idoboth.BeforeIstartedBastyr,Iwasdoingfulltimeprimarycare.Isawalotofpatientsthen,butafterIstartedBastyr,Icouldn'tdoprimarycareanymore,buthavingsaidthat,whatIendupdoingismoreconciergekindofcare.Iwouldseemaybeadozenpatientsayear,andIwouldonlyseethereally,reallysickones,thereallydifficultones,andtypicallypeoplewithlotsofmoney,whichisadvantageous,becausethenIcouldrunallthelabteststhatIwantedtoonthem.

Igottoseeanumberofpeople,butalso,Igotinvolvedinsomeveryinterestingcorporatewellnessprograms,andprobablythemostimportantwasoneIdidinAlberta,Canada,whereIwas[inaudible00:10:22]byoneofthewealthiestmeninCanadatohelpimprovethehealthofhisoilfieldworkers.Isaid,"Well,great,thisisinteresting,"soIsaid,"Ihavesomeideastohowtoimprovetheirhealth,butIwanttodoitobjectively,whichmeansIneedgooddata,soIwanttorunlabtestsonthem,"sohesays,"Okay,"Isaid,"Iwanttotesttheirnutritionalstatus,Iwanttotesttheirtoxicstatus,wanttotesthowtheirmetabolism'sworking,"andIaskedhim,"HowmuchcanIspend,"andhesaid,"Blankcheck,"[inaudible00:10:48]blankcheck,right?

Weresearchers,[inaudible00:10:53]dreams.

DaveAsprey: Weneedit.


JosephPizzorno: Ithenstartedtellinghim,whattestsIwantedtorun,andhesaid,"Well,ifyoucanconvincemeIshouldrunthetest,I'llrunit,"soIran$1500labteston4500oilfieldworkers.Igotahugeamountofdata,andIstartedlookingattheresearch,andlookingatlotsoftoxicity,lotsofindicationoftoxicity,andIstartedlookingat,well,howdoyougetthetoxinsoutofpeople,andwestartedgettingtoxinsoutofpeople,andtheirhealthstartedtoimprove,and,boy,itreallygotmedeeplyintoit.

DaveAsprey: Thatwasn'tBrettWilson,ormaybeyoucan'tsay,he'sonDragon'sDen,butBrettandIhavebecomefriends.Thatsoundslikesomethinghewoulddo,he'saCanadianoilbillionaire,who'sjustconscientiousaboutthingslikethat.Maybeit'sjustpartofbeinginCanada,that'sjustthemindsethere.Thatblowsmymind,$1500times4500peopleforcorporatewellness,thatisabovethepar.

Oilfieldworkersgetexposedtoallsortsofnastyorganicsolids,notjustrawpetroleum.Whatkindofstuffdidyoufindinthesepeople?I'msojustdyingtoknow.

JosephPizzorno: Greatquestion,becauseIactuallyusethisinmylecturetostudents,andIlectureonthisnowallovertheworld.Everybody,ofcourse,immediatelythings,"Oh,oilfieldworkers,alotofchemicalexposurefromworkingtheoilfields."No.Bytheway,wehadofficepeople,notjustoilfieldworkers.Thesearebasicallyguys,typicallyguys,theygetinthepickuptruckinthemorning,haveacowboybreakfast.Acowboybreakfastisacupofcoffee,apee,andalookaround.OneofthesefunnythingsfromtheCanadians.

Theygetintheirpickuptruck,theydriveouttotheprairie,theycheckoutthepump,theymakesureit'sfunctioningproperly,andthentheydothat,andtheygohome.Basically,they'rerarelyexposedtochemicals.

DaveAsprey: Oh,wow,so,thenit'slackofexercise,orwhatdidyoufind?

JosephPizzorno: [crosstalk00:12:46]?

So,whyallthetoxicity?

DaveAsprey: Yeah.

JosephPizzorno: Theydrink,buttheydon'tdrinkalotmorethananybodyelsedoes.Westarttalkingtotheseguysandrealizethatmanyofthemaredoingtwothingsthatareveryproblematicforthem.Oneis,theyfishinthelakesinCanadathathavebeenpoisonedwithlotsofmetaltoxinsfromindustry,andsecond,theyworkintheoilfieldstosubsidizethefamilyfarms.Theyhavefamilyfarmsthathavebeeninthefamilyforgenerations.They,becausethey'reaggrobusiness,now,theycan'tquitecompete,sotheyneedalittleextraincome,andsotheygettheincomefromworkingtheoilfields.


Whataretheydoingonthosefamilyfarms?Herbicides,pesticides,allthesethingsthey'redoingthatarethenexposingthem,showingsignsintheirbloodtest,oftoxicity,andwhoiseatingthefoodsthatthey'remaking,they'repreparing?That'sus.

DaveAsprey: Wow.That'sshocking.Thedatathere,evengoingbackafewyears,isthatsmallfarms,90%ofthemarenotselfsustaining,youhavetohaveajob.I'masmallfarmer,Iliveon32acresonVancouverIsland.Thegoalwastogrowallofourownfood.Icantellyou,there'snothingsprayedeveronthisproperty,andcertainlywedon'tsprayanythingotherthannaturalstuff.There'snowayitpaysforitself.Evenifmywholefamilyworked12hoursaday,itwouldnotpayourcostoflivingoranything.Youhavetodothat,especiallyorganic.

Whatyou'refindingis,theoilindustrywasn'tresponsible,atleast,maybetheoilindustryrunoff,andpollutionintothefish,thatwaswherethemetalswerecomingfrom,andthenthe[endocrine00:14:31]disruptorswerecomingfromwhattheysprayedontheirfields?

JosephPizzorno: Correct.Asyouknow,youmentionedglutathione,whichI'mdelintedtohearyourinterestinit,Ithinkit'safascinatingarea,I'velecturedonthataswell.OneofthetestsIranonthesepeople,wasthetestcallGGT.GGT,GammaGlutamylTransferase,isastandardliverenzymethat'smeasuredtoseeifapersonhashepatitis.Whentheirliversaredamaged,thatenzymegetsreallyhigh,andit'sawaytotrytorecognizewhohashepatitis,andfigureoutwhy.

Itturnsout,asyoumayknow,withinthenormalrange,whichis10to60,GGTgoesupinproportiontochemicalandmetalexposurefor90%ofpopulation-

DaveAsprey: Bytheway,waterdamagedbuildings,toxicmold,willalsoraiseGGT,becausethetoxinstherefrommothernaturewillalsodamageyourliver,right?Anytoxincoulddoit.

JosephPizzorno: [crosstalk00:15:24].

Actually,ifyoulookatresearch,lookingattheVLCsbeingreleasedbythemolds,andthenlookattheeffectsofchemicaltoxinsinthebody,it'salmostidentical.[crosstalk00:15:34].ThethingwithGGTisthat,for90%ofpopulation,itgoesupinproportiontotoxicload.ThereasonforthatisthatGGTistheenzymethatrecyclesglutathione.Oursmartbodies,whenwe'reexposedtotoxins,say,"Ah,IneedmoreglutathionethanIcanproducefromthe[inaudible00:15:49]that'savailableinthediet,"sonowwerecycletheglutathionethat'savailabletohelp...protectsusfromtheoxidativedamage,andhelpgetthetoxinsoutofthebody.Itturnsouttobeveryimportant.

10%ofpeople,unfortunately,however,don'thavethegeneticstohelpregulateGGT,andmyassessmentisthey'retheoneswhoareactuallymostdamagedbythetoxins.


DaveAsprey: Okay,howdopeoplelisteningknowifthey'reonofthe10%?That'sahugethingtounderstand.I'mguessingImightbe,givenmyterriblehealthhistoryfromtoxinexposures,butI'mhealthynowbecauseImonitorthatstuff.But,howdoItell?

JosephPizzorno: Right,soitturnsout23andMewilldoagenetictestforjust$200.Theproblemwiththatisyougethundredsofthousandsofsnips,andwhatdotheymean?Actually,I'vebeenworkingwithmyteamtocreateanartificialintelligenceprogram,whichIthinkyou'llappreciatebasedonyourbackground,thatactuallywillgoto23andMe,downloadtheresultsofthesnips,andthendeterminewhatenzymesthebodyarenotworkingproperly.

Wejustfinishedlastweek,250snips.We'vebeenworkingonforthelastyear,andwenowhave250snipsintothesystem,sonowwecandeterminewhichpeoplearegoingtobemosttoxicsusceptible.

DaveAsprey: ArethesedifferentfromtheMTFHRandtheCBS[crosstalk00:17:02]?

JosephPizzorno: Yes,yes,exactly.

DaveAsprey: Thosearethesame,orthey'redifferent?

JosephPizzorno: No,different,definitelydifferent.

DaveAsprey: Okay.Forlistenerswho'veheardsomepastepisodes,alotofpeople,includingme,Ihavesomeproblemswithmymethylation,andagoodpercentageofpopulationhasatleastsomegenesthatareoffthere.Ihaveaproblemwithmysulfurmetabolismaswell,oneofmyCBSenzymesisoff,soIchangedmyselfontheregimenIt'soneofthereasonsIdon'ttelleveryone,"Here'sallthisstuffItake,"like,don'tcopyme,I'mgeneticallyunique,andsoareyou.Dowhatmatchesyourbiology.Don'tcopymeoranyotherpersonontheirsupplementregimen,ithastobecustom.

JosephPizzorno: Correct.

DaveAsprey: Canpeoplealreadygetthistest?Iwanttodoyourtest,isitavailable?

JosephPizzorno: Yes,soifyougotothetoxinsolution.com,wearemakingaccesstothistest.Idon'tthinkit'sonthatwebsitequiteyet,butit'sgoingtobethereshortly,askindofapromoforpeoplepre-ordering,weactuallygivethemaccesstothistest.

DaveAsprey: Thisissupercool,because23andMeishamstrung.There'salotofreallygooddata,andforalllisteners,youshouldhavethislevelofdata.Iactuallyhavemyfullgenomesequenced,whichisunusual,andnotnecessaryformostpeople,butifyouhavethisdata,it's200bucks,you'llfigureoutthatyouactuallyhaveweirdstuff,like,I'msomethinglike0.1%somenomadicSiberiantribe,whichis


justinteresting,andpotentially0.1%NativeAmerican,too,they'renotreallysure.

Okay,that'sjustcool,theycantellyouthat,becauseit'snotFDAregulated,butallofthegoodstuffinthedata,theFDAhamstrungthemandsaystheycan'ttellyou.But,Dr.Pizzorno,yourwork,you'reallowedtosaywhateveryouwantonsomeoneelse'sdata,sowehavethisweirdseparationthat'sdoneforlegalandregulatoryreasons.Iwouldsay,everyonehere,orderyour23andMe,soyouhavethedata,andthenrunitthroughsoyouknowifyouhavemethylationproblems.Doyoualsodothat,ortheycangetthatonanyotherwebsite?

JosephPizzorno: So,methylationproblemshavebeenwellworkedout,andthereareanumberofsitesyoucangetthatfrom.We'reworkingatthedetoxenzymes,andalltheotherthings,sothisisalevelofevaluation,I'mnotawareofanybodyelsehavingdone.

DaveAsprey: Okay.Wouldyoutellpeopletogotoadifferentwebsiteformethylation,aswell,ordoyoujustcoverthatbecauseit'salreadythere?

JosephPizzorno: Oh,sure.

DaveAsprey: Okay.What'syourfavorite?

JosephPizzorno: Wehavemethylationinthere.

DaveAsprey: Oh,yoursisinthereaswell?Okay.

JosephPizzorno: [crosstalk00:19:08].

Yeah,PureGenomicsdoesagoodjobwiththeMTHFRpolymorphisms.

DaveAsprey: PureGenomicstesting,okay,cool,sothat'sasecondtest,andithinkthat'sprobablyfree.IknowGeneticGenie'soneI'veused,it'sfree,oryoudonatefivebucks,orsomething.

Youowethistoyourself.Intheshownotes,Iwilltellallofyoutheselinks.Itdoesn'ttakealongtimetodothis,youspitinathing,ifyoudon'talreadyhaveyourresults,yougiveyouraccesstoyouraccounttotherightapp,andallofasuddenyouknowyourweaknesses.Imagine,ifyou'reSuperman,andyoudon'tknowyou'reallergictokryptonite,andthen,LoisLanegetsaringwithkryptoniteonit,andsometimesyoufeellikecrap,andsometimesyoudon't,andyoujusthavenoideawhy.Youjustthink,"Maybeit'sbecauseIdidn'ttryhardenough."

Thisisthestoryofmylife.I'mworkingreallyhardandit'snotworking,it'sbecauseofthis.Theknowledgethatyou'reofferingisprecious.Ididn'trealize


youweredoingthatfromlookingthroughyourwork,becauseit'snotonthewebsiteyet,sothankyouforofferingthat.I'mactuallyreallyexcitedaboutthis.

JosephPizzorno: Youmightfindthisinteresting,actuallybefuntohaveacupofhealthycoffeewithyousomeday.I'vebeenworkingfor15yearstodevelopanartificialintelligencesystemthatmapsthehumanbody.

DaveAsprey: Oh,cool.

JosephPizzorno: I'vecreateda...thetechnicaltermis,annotated[inaudible00:20:24]inferencenetwork,wherewehavedonebruteforceaccesstotheresearch,tobasicallymapphysiology,andthenuseinformationabouttheusertodeterminewheretheirphysiology'snotworkingproperly,whyit'snotworkingproperly,whattodoaboutit.So,laboriouslywentthroughallthese,pastcoupledecades,asillustratedyourbook,we'regonnamakethateasierforpeople.

DaveAsprey: There'snoreasonitshould'vecostmeahalfamillion,actuallymorethanthatnow,andallofthisincrediblework,andit'sbecausenoonehadputthedatatogether.It'sfunny,wewillsitdownforthatcupofcoffee,you'restillinSeattle,andI'minVictoria,soit'sclose.Also,myundergraduatedegreeisinasubsetofartificialintelligence,calleddecisionsof[inaudible00:21:11]systems.Theyactuallytoldus,don'tcallitartificialintelligence,becausenoone'severgonnabelieveit'sreal.It'sactuallyrealnow,andI'mreallyexcitedthatyou'reusingthehugeamountofdatathatyouhave,even4500peoplefromonecompany,whereyouknowabouttheirlifestyle,itwasunusable10yearsago.Wejustdidn'thavethedataprocessing,andthemachinelearning,andnowwedo,soIamsuperexcitedtohearaboutthis,becauseweareonthecuspofunravelingmysteriesthathaven'tbeenoutthere.

Let'sgobacktotheseenvironmentalpollutants,thesetoxins.Oneofthethingsthatmakesme...There'stwothingsthatmakemereallyconcerned,andkindofupset.Oneofthemisadosageresponsecurve,andforlisteners,we,ashumans,wehavethisbias,wethink,"Okay,ifsomeofit'sgoodorbad,moreofit'sgood,andlessofitisbad,"wejustimagineastraightlinethatgoesupandtotheright.Inyourexperiencewithtoxins,whatisthedoseresponsecurvelooklike?

JosephPizzorno: Verygoodobservation.Ithinkoneofthereasonswhytheresearchersdidnotearlierrealizethehugeproblemwiththesetoxinswasthatwe'veallassumedyou'dhavelineardoseresponsecurves,whichmeansthemorethetoxin,themorethedamage.Unfortunately,manyofthem[curveor00:22:37]linearones,whereasmallamountcausealotofdamage,mediumamount,notmuchdamage,andahigheramountcausealotofdamage.Oneofthewaysthatresearcherstriedtodeterminehowproblematicatoxinis,theylookatwhathappenstoanimalsatlowdosages,whathappensinmediumdose,whathappensathighdosages.Ifitdoesn'tlooklikethere'salotofdifference


betweenthem,particularlythelowdoseandhighdose,thefigure,"Well,[inaudible00:22:59]notabigproblem."

Unfortunately,what'shappening,isthesethingshavesurprisinglysignificanteffectsatlowdosages,buttheevenbiggerproblemisthatsomuchofthatresearchwasdoneonsingletoxinsatatime.

DaveAsprey: Yes.Thatwasmysecondquestionforyou,youreadmymind,keepgoing.

JosephPizzorno: Oh,yes.

AsItellmystudents...Itjustsohappens,justtaughtmylastclassthismorningatBastyrUniversity,aclassI'vebeenteachingstudentsnowfor40yearscalledhealingsystems.

DaveAsprey: Lovethename.

JosephPizzorno: InhealingsystemsItalktothestudentsabout,you'vegottogetallthepartsoftheirbodyworkingthewaythey'resupposedto.Anyways,asI'dsaidtothem,whenwelookattoxicity,yes,thespecifictoxiceffectsarevery,veryimportant,butyouhavetolookattotaltoxicload,becausewhenyoulookattotaltoxicload,nowyougetveryclearlineareffects.Themoretoxinsyougot,themoredamageitdoestothebody.

Abigreasonthathappens,isbecauseglutathioneplayssuchacriticalroleinbothprotectingusfromtheoxidativestressfromthetoxins,butalsoforgettingthemout.Mercury,andallthese[inaudible00:24:07]organicpollutants,andsuch,thephasetwoconjugationwithglutathione,Iknowit'skindatechnical,butitrequiresglutathione.Themoretoxinsyouget,basicallyyoustartdepletingyourglutathione,andasyoudepleteglutathione,younowcan'tprotectyourDNAfromoxidativedamage,butevenmorecritical,youcan'tprotectyourmitochondriafromoxidativedamage.Yougetolderfaster,yougetsickerfaster,andyougetmorecancerfaster.

DaveAsprey: That'swhyIjustfinishedwritingHeadStrong,whichisallabouthowdoyouprotectandupregulatemitochondrialfunction,andmitochondrialdensity,becausestuff,whetherit'sthemetals,thetoxins,poordiet,stress,badlight,allthatstuffaffectsit.Idon'twanttoage,Iwanttoliveto180.That'smygoal.

Bytheway,isthatagoodgoal?Isitpossiblefora45yearoldtohit180,doyouthink,oramInuts?

JosephPizzorno: Mybestassessmentis,notwithourcurrenttechnology.

DaveAsprey: Agreed.


JosephPizzorno: Ithinkhumanbeings,ourtopendisgoingtobearound120.Ifyoudoeverythingright,thebestyoucandois120.Havingsaidthat,though,IthinktherearesometechnologiesevolvingthatwillhelpusstartrepairingsomeofthedamagedDNA,andextendthatalong.But,untilwecanactuallybetterrepairthedamagedDNA,Ithinkwe'vegotatimelimithere.

DaveAsprey: We'reinfullagreement,Ithink120,currently,isreasonable,I'mjustbettingthatsomethingcoolwillhappenoverthenext80years,becausewhenIgoback80years,thingswereprettydifferent.

JosephPizzorno: Yes,yes,Ihopeso,aswell.Also,Ihavethegreatfortuneofbeingfromarelativelylonglivedfamily.Iknewmygreatgrandfather.Mygreatgrandfatherlivedtoage95,neversawadoctorinhislife,hadnoapparentdisease,nolimitations.Iusedto,asaprecociousyoungster,Iusedtoplaystrategycardgameswithhim,andhe'dbeatmeallthetime.I'mthinking,"There'smygreatgrandfather,he'sdoingeverything..."Helived,basically,themediterraneantypelifestyle,butwhatI'vecalledahealthymediterraneantypelifestyle,withlowtoxicexposure.Hedidincrediblywell.

Then,Ilookedatwhathappenedinmygrandfather,andmyfather,andasitwentfromamediterraneanlifestyleofhealthyfoodsandlowtoxins,toamore,andmoreoftheNorthAmericantypedietandlifestyle,youcanseethemstarttodegenerate,startdevelopingdisease,andstartdevelopingdementia,andalltheseotherthings.Iwanttobelikemygreatgrandfather.Iwanttohaveahealthy,fulllife,andnotmuchdisease.

DaveAsprey: Thebigdifferentiatorthere,whenIsaythings,andI'mnottheonlyonetalkingaboutlivingbeyondwhatpeoplethinkispossiblerightnow,butI'moneofthefurtheroutnumberofpeopleinthepubliceye.Everyonesays,"Well,whywouldyouwanttolooklikeaturtleandbeinawheelchairfor60years?"That'snotwhatI'm[crosstalk00:26:54].

JosephPizzorno: Exactly.

DaveAsprey: IwanttolooklikethiswhenI'm180,Idon'tknowifIcandothat,butIhopewithtechnology,andavoidingthetoxinsthatyourightaboutintheToxinSolution,thatthere'shope,anyway.

JosephPizzorno: Yes,yes.

DaveAsprey: Youtalkedaboutthisdoseresponsecurve,andhowtoxins,atverylowdoses,canhavejustterribleeffects,andthenbadeffectsathighdoses,butsinceit'snotastraightline,researchersjustkindathrowitoutassayingitdoesn'treallymatter.There'salsothisissuethatsafelevelsofonetoxinwillnotbesafewhenpresentwithanotherone,andyousimplifythatastotaltoxinload.That'ssomethingthatIlearnedaboutbecause,asIwasunravelingmyownproblems,I


certainlyhadthemercuryandleadproblem.Ialsohadlimeexposure,whichmakesnaturaltoxins,andalotofthetoxinmoldexposure.

Iamallergictoeightofthetop10toxicmolds,whichmeansI'venotonlybeenexposed,Ihaveanallergicresponsetothem,whichisproofofexposure.WhenIdugintotheliterature,bothonthechemicalsidethatyouwriteabout,andonthenatural,naturemadetoxinside,safelevelsofonemicrotoxin,whenyouputthemwithsafelevelsofanothermicrotoxin,equalswayunsafe.Nogovernmentonearthhasmulti-microtoxinstandards,andthat'swhyIdiditfortheBulletproofCoffee,there'sreallyprobablyaboutsixorseventhatarereallyimportantincoffee,butwetestfor25thatcanoccur,andsomeofthemhavenogovernmentregulationatall,otheronesaresingletoxinlevels.

I'mgenuinelyconcerned,becausewhenyoutakemothernature'stoxins,whichcomefromeatingprocessedfoodthat'sbeenstoredforalongtime,infact,incorn,thetoxins,wesprayitwithglyphosate,wesprayitwithalltheseotherthings,andoneofthosethings,infactIbelieveit'sglyphosate,causes[fusarium00:28:48],thetoxicmold,togointotherootstock.Youcanhavepristinelookingcornthat'sbeencontaminatedbyitsroots,becausethemoldnowlivesintherootsbecauseofthechemicalsweuse.Now,you'regettingmothernaturetoxinsstackedwithmanmadetoxins,onsomethingthatlookslikeit'sapristineearofcorn.

Ifeelthesymptomsyouwriteaboutinyourbook,thingsliketremors,dizziness,Idon'tgetelevatedbloodpressure,Igetlowbloodpressure,whichistheoppositesideofthat,insomnia,forsure,fatigue,andjustbrainfog.IfIeatameal,Ifeelthis,probablybecauseofmitochondriadamage.Whataboutpeoplewhodon'treallyfeelthosetoomuch?Shouldtheyworryaboutthis?

JosephPizzorno: Ah.Youcoveredalotofgreatterritorythere.

DaveAsprey: Alotofquestions,sorry.

JosephPizzorno: Letmestartwiththe...Ithinkaveryimportantfactor,Itaughtmystudents,lastweek,actually,ishumanshaveabout1000foldvariationintheactivityofeachoftheirdetoxenzymes.That'sverysignificant.Significantnotjustwhenthey'relow,butsometimesitcanbeaproblemwhenthey'rereallyactive.[inaudible00:29:56]youhaveinyourliver,kindofatwostageprocessforgettingridoftoxins.Wehavewhat'scalledphaseone,thatbothdirectlydetoxifiesmanyofthesethings,buttypically,forthereallytoughones,itconvertsthemintowhat'scalledanactivatedintermediate,which,then,phasetwo,bindstoanothermoleculecalledconjugation,tothenneutralizeit,makeitwatersoluble,getitoutthroughthekidneys.

Thatintermediate,thatactivatedintermediate,isfarmoretoxicthanthechemicalthatwasbeenactivatedbyphaseone.Ifyou'vegotahighphaseone,andalowphasetwo,you'reactuallymakingyourselfworsebecauseofthatliver


enzymeworkingbetter.Normally,youwantyourliverenzymesallworkingreallywell,butgenetically,wehavethesepolymorphisms,andtheyvaryquitealot.Itturnsout,thatindeed,youhavesituationswhere,forexample,you'reexposedtoonetoxin,andyou'reproducingallthisactiveintermediate,it'snowusingupalltheglutathioneavailableinphasetwoforneutralization,andthenyouexposeyourselftoanothertoxinthatneedsphasetwoglutathionetoneutralizeit,andnowyoucan'tneutralizeit,becauseyou'veusedupallyourglutathione.

Therearetons,andtonsofexamplesofhowmultipletoxinsmakeyoufarworse,farmoretoxic,andfarmoredamaged,thanthejustsingleonesatatime.Anotherfactorthat'sreallyimportant,iswestartlookingattheclinicalresearchontoxicity.Upuntilabouttheageof40to45,youdon'tseealotofeffectswithtoxinsexceptforpeoplewhoareparticularlysusceptible.Butthen,onceyouhittheageofabout40,45,ifyou'venotbeentakingcareofyourself,ifyou'dbeenbuildinguptoxicload,ifyou'vedamagedyourDNA,then,frankly,allhellbreaksloose.Then,allthischronicdiseasestartshappeningwherepeoplesay,"Oh,Iwasfine,butthenIwasage50andIgotdiabetes,Igotheartdisease,"or,"Oh,god,justsounlucky,Igotcancer."

Well,no.Youjustspentyourwholelifesettingyourselfupforit.Whenyou'reyoung,yougetawaywitheverything,asyougetolder,no,youcannotgetawaywithit,butnowyou'restartingtopaythepricefornottakingcareofyourself.

DaveAsprey: DuringthecourseofresearchforHeadStrong,Ilookedatmitochondrialfunction,andIknowthatmymitochondrialfunction,atleast,it'smuchbetternowafteralltherepairstuffI'vedone,butitwasprettybad,whichiswhyIwasgettingbrainfog,youhavealotofmitochondriainthebrain.Icameacrosssomeworkthatsaidabout48%ofpeopleunderage40haveearlyonsetmitochondrialdysfunctiontoday,andprettymucheveryoneoverage40,it'scalledaging.

JosephPizzorno: Yes.

DaveAsprey: Ibelievethattheincreaseinthatearlyonsetmitochondrialdysfunctionisdirectlycorrelatedtotoxinload,justlikeinyourbook,andIdon'tcarewherethetoxinscomeform,whetherwemadethem,ormothernaturemadethem,orthey'remadebythebacteriainyourgut,they'realltoxins,theyallaffectmitochondriaonewayoranother.Someofthemaffecthigherlevelorgansystems,butwhenyoukeepdigging,youalwaysfind,attheendoftheday,ithitthemitochondria.

If48%ofpeoplearegettingthisearlyonset,someofthemaregoingtofeeltremors,dizziness,theseothersymptoms,andIguessthosearetheoneswhoshouldworrythemost.Igetmaybe5%ofpeople,Icantakeeverymitochondrialenhancerthatyoumake,Icandrinkpizzasmoothies,beer,ice


cream,stayupallnight,itdoesn'tmatter.Thesearewalkingsupermen,asfarasIcantell,Iwanttheirmitochondria.

JosephPizzorno: Right,pickadifferentmotherhere.

DaveAsprey: Exactly.IactuallybelievethatImightbeoneofthefirstpeopletogetamitochondrialtransplant,Idon'tseewhyyoushouldn'thavemitochondriafromthreedifferentpeopleintome,that'dbereallycoolforredundancy.

JosephPizzorno: Thatmightbeoneofthosetechnologiesthatwillincreaseouractualhumanlongevity.

DaveAsprey: Ihopeso.

JosephPizzorno: Because,you'reright.Oncethemitochondriaaredone,you'redone.

DaveAsprey: Justhavingamixofthem,Icomefromabackgroundofmakinghighlyfaulttolerantcomputersystems,sowhenthedifferentcomponentsdon'tbreakforthesamereason,then,"Great,somebodytookouthalfmymitochondria,buttheotherhalfarestillpartying,whichgivesmeachancetoreplacetheotherones."I'msuperhopefulthat'soneofthe5000avenuesofanti-agingthatmightsavebothofourlives.

JosephPizzorno: Youmayknowthisdata,butnotasingleaudienceI'vespokentohasbeenabletoanswerthisquestioncorrectly.HowmuchATPdoyouproduceeverydayatrest?

DaveAsprey: Theatrestmightmakeittough.Myresearchsaysthatthe50or60gramswenormallyhavegetrecycledtoabout600poundsofATPonadailybasis.

JosephPizzorno: You'rethefirstpersontoanswerthatcorrectly.

DaveAsprey: Oh,wow,cool.

JosephPizzorno: Mydata'salittledifferent,butyou'retheclosestofanybodysofar.ItturnsoutthatwebasicallyproduceourbodyweightinATPeverydayatrest.Now,ifyougooutandsprint,runawayfromthatsabretoothtiger'stryingtoeatyou,weproduceahalfapoundofATPeveryminute,togivepeopleanideaofhowmuch...Ourmitochondria,wedon'tstoreATP,yourATPgoesaway,you'redead,pureandsimple,rightaway,becausewedon'tstoreanyATPinourbodies.

YouthinkabouttheincrediblemetabolicactivitynecessaryinthemitochondriatoproduceallthatATPeveryday,andofcourse,we'renotjustsittingdown,we'removingaroundandbeingactive,thenindeed,werequirehundredsofpoundsofATPeveryday.Thathelpsexplainwhythemitochondriaaresosusceptibletoenvironmentaltoxinsandnutritionaldeficiencies.


I'manavidbasketballplayer,soI'vebeenplayingbasketballatthesameplaceandtime,thesamegame,forover30yearsnow.Everybodyintheagegroupbelowmearenowgone[crosstalk00:35:52]...

DaveAsprey: [crosstalk00:35:52]about70,I'mguessing?

JosephPizzorno: Yeah,yougotitright.Iwasbornin1947.Iplaywithguyshalfmyage.WhatI'venoticed,isthatwhenguyshitabouttheageof50,theyalldisappear,becausewhat'shappenedis,well,afteryouplay...Doyouplaybasketballyourself?

DaveAsprey: Ah,tootall.

JosephPizzorno: Okay,tootall.

DaveAsprey: Ihaveascrewinmyknee,soIwatchbasketball,Idon'tplayit.

JosephPizzorno: Iamonthemoreshorterside,well,averageheight,Iguess.Ilovethegamenonetheless.Anyway,whenplayingwiththeseguys,afteryouplayacouplehoursoffullcourtbasketball...Ofcourse,youwanttodoitonawoodcourt,becauseyoudoitonasphaltyoudestroyyourjoints,butyou'rereallysoreafterwards,sowhataretheseguysdoing?Well,they'repoppingtheiribuprofen,and[inaudible00:36:41]anti-inflammatorydrugs,andthingslikethat,whichtakeawaythepain,buttheydotwothings,whichiscriticallyimportant.Numberoneis,theyactuallyimpaircartilageregenerationintheknees,andtheypoisonthemitochondria.

DaveAsprey: Yes.

JosephPizzorno: What'shappeningistheyburnouttheirbodiesmorequickly.It'sinteresting,Ilookattheseguys,Iloveplayingwiththem,andIknowthatthey'reonlygonnabetherefor10or20years,becauseafterthatthey'vewreckedtheirbodiesandthey'redone.

DaveAsprey: Becauseyouunderstandhumansystems,thecoursethatyouteach,youdon'tmakethosenotobviousdecisions.Feelinggoodthenextdayseemstomakesense,andtherearenaturalthingsliketurmeric,youmightconsider,thatdon'tcausemitochondrialdamagethatalsohelpwithswellingandallowyourbodytostillheal.

JosephPizzorno: It'dbefuntositdownandcomparenotes,becauseI'vebeenprettyaggressiveabouttakingcareofmymitochondriaforaverylongperiodoftimenow.I'veaprettygoodideaofwhatittakesforthemitochondriatofunctionproperly,andwhatdamagesitmorequickly.Thesethingsarelargelyunderourcontrol.

DaveAsprey: Iamabsolutelyfascinated.I'llgetyouacopyofHeadStrong,andthenwhatwe'lldoiswe'llsitdownforlunchinSeattle,theBulletproofheadquartersisinBellevue,soit'seasyformetocomedownthere.Maybewe'llrecordour


conversationandmakeitabonusthinghereforyourbook,orforthepodcast,andwe'lljusttalkabout,howdoyouhackyourmitochondria,becausenotalotofpeoplearedoingit,especially,becauseyou'vebeendoingitforlongerthanIhave,andyou'refurtheralonginlife,andthedifferenceislike...Youlookatmitochondria,they're10%ofyourbodyweight,maybe,andyouthinkaboutyouriPhone,whichisagoodthingforlisteners.Ifthebatterydischargesfaster,yourphonestopsworkinghalfwaythroughtheday.Ifyoucandosomethingtomakethebatterylastlonger,yourphoneworksbetterandyougetmoreoutofit.

Ifyoulookatthemitochondriainyou,10%ofyouisyourbattery,youputatoxininthere,thebatterywon'ttakeacharge.Athirdofthecapacityisgone.Youchargeit,anditdoesn'twork.Howdoyouchargeamitochondria?Youeat.

JosephPizzorno: MayIusethatanalogyinoneofmylectures?That'sagreatanalogy.

DaveAsprey: Please,useanythinginyourlectures.Thewholepointistogetthisknowledgeoutthere.IfonlysomeonehadtoldmethiswhenIwas20,andIunderstoodthatwhatIwasdoingwasharmingmymitochondria,especiallyasIgotfatter,whichisamitochondrialdysfunction,andasigotmore,andmorebrainfog,andtothepointwhere...IwastothepointwhereIwouldn'thavehiredmyself,eventhoughIhadahighpoweredSiliconValleyjob,andmadeallkindsofmoneythatIthenlost.Iwasbarelyhangingon,andIwasgenerallyfearfulformyabilitytocareformyself.

Iknowsomanyotherpeoplewhogetthere.Igetcelebritiesnow,musicians,andfamousactors,andall,whoarethere,becausethey'relivingahighlytoxiclifestylewithskincareproductspaintedonthemonsetsfullofformaldehyde,andit'shittingthem.Wetalkaboutthatstuffprivately,andthey'rescaredbecausenotonlydotheyhavetofeelgood,theyhavetolookgood.Forme,I'monlya300poundcomputerhacker,allIhavetodoisbeabletothink.

I'mgenuinelyinterestedinyourprogram,andwe'llseeifthere'sanyupgradestotherecommendationshere.Whatwouldyouofferforpeoplelistening,whonowtheyknow,becauseofwhatwejusttalkedabout,they'regettingthesepollutants,eveniftheyeatmostlyorganic,whichisagoodchoice,they'restillgettingsomebecausetheybreathe,andbecausetheyshowerandthings.Topthreemitochondrialenhancing,orjustdetoxenhancingthings,whatshouldyoudorightnowifyou'relisteninggoing,"Oh,mygod,IthoughtthiswasallBS,thisguy'scredible,it'snotBS,whatdoIdo?"

JosephPizzorno: BeforeIanswerthat,letmegoback,andsomethingyoumentionedearlier.Firstone,let'shavethatlunch,talkaboutmitochondria,andlet'srecordit.

DaveAsprey: Wewill.


JosephPizzorno: Whenyoustartedtheprogramyoumentionedhowsweatinggetsridoftoxins.Iassumeyou'vebeenreadingtheworkofSteven[Genuis00:40:41]upinEdmonton,Alberta.

DaveAsprey: Thatnameisn'tfamiliar,Ireadalotofpapers,though,sodotellme.

JosephPizzorno: He'stheguywhogotpeoplesweating,andthenhetooktheirsweatandmeasuredwhatwasinit,andhealsocomparedwhatwasintheirsweattowhatwasintheirblood,whatwasintheirurine.AcoupleyearsagoIhadachancetomeethim.Weateataorganicvegetarianrestaurant,andI'mnotexaggerating,wesatdown,startedtalking,whenInextlookedupitwastwohourslater.IwishI'dhavetapedthatconversation,becauseitwasjustfascinating,becausehecamefromthe...asaclinician,asaresearcher,hisperspectives,andIcameasaclinician,researcher,withmyperspectives,anditwasfuntoseewhereweagree,wherewedidn'tagree,howwecouldlearnfromeachother.Itwassomuchfun,solet'srecordit.

DaveAsprey: Okay,we'lldefinitelyrecordit,andataminimumwe'lldoatranscript,sometimesthesoundqualityisnogoodforapodcast.Thisisthesortofstuff,that'swhyIdoBulletproofRadio,istogetachancetotalkwithguyslikeyou,becauseyou'vegotawealthofexperienceoutthere,andwehavethisunfortunatehabitof,weonlyarewillingtolookatdoubleblindclinicaltrialdata,buttherealknowledge,andthestuffthatyou'remininginyourAIstuff,itcomesfromclinicalexperience,andlookingatwhatworks,andnoticingthingsthatshouldn'tbe,andasking,"Why?"

Wehavethese,Icallthemsciencetrolls.There'speopleouttherethatsay,"Well,Idon'tlikethat,thereforeit'snottrue,thereforehere'sastudythatIGoogledinfiveminutesonPubMedthatdisagrees,therefore,you'reaconartist."It'scompletelyillogical,fallacy,adhominemattacks,it'sallBS,butit'sonlythreeto5%ofpeople,andwhensomeonewithyourknowledgeandexperiencetakesthetimeandtroubletowriteabookaboutit,thatsignalssomethingforpeoplelistening.

You'renotgoingtowasteyourtime,you'rerunninguniversity,youhavestufftodowithyourtime.Fewpeopleunderstandtheamountofenergyittakestoputallofthatknowledgeintoonly,whatever,80,000words.It'sthousandsofhoursof,like,"DoIreally?DoIneedtocutthat?"We'renotgoingtowasteourtimeonthatstuff,andthen,tobeabletohearyou,Ithinkisadifferentway.

Anyway,that'swhyIstartedthisshow,isIjustwantedtobeabletopickyourbrain,and[crosstalk00:43:00].

JosephPizzorno: That'sagreatpublicservice.OneofthereasonsIstartedBastyrwasbecausethere'sthishugebodyofknowledgethatthepioneersofnaturalmedicinehavelearnedoverthecenturiesabouthowtobehealthy,anditwassystematicallyremovedfromthepopulacebyconventionalmedicine.


Anyway,let'sgobacktoyourquestionaboutmitochondria.Mitochondrialstrategyisbasicallythreeparts.Numberoneis,oneofthemostimportantthingsyoucandotonotdamageyourmitochondria...Alwaystellstudents,wehaveallthesegreatherbsandnutrients,andthingswecanuseforpatients,butyoufirsthavetostopthedamage.Idon'tcarehowgoodyourherbsare,vitaminsare,you'restillcausingdamage,it'snotgoingtodomuchgood.

Thesecondthingwewanttodo,isto,youmightsay,facilitatemitochondriatoworkthewaythey'resupposedtowiththerightkindofnutrients,andinparticular,akey,key,keyapproachisprotectingthemitochondriafromthemselves,becausethemitochondriaproduceahugeamountofoxidativestresseverydayjustproducingATP.Ifyou'renotproducingthatATPefficiently,you'releakingalotofhighenergyelectrons,andoxygen,anditcausesalotofdamage.

Thethirdfactoris,howdoyoumakethemitochondriaworkevenbetter?

DaveAsprey: Ilovethewayyouthink,thisisexactlyit.

JosephPizzorno: Okay,good.I'llsaysomethingoneachofthosethreecategories.

DaveAsprey: Yeah.

JosephPizzorno: Numberone,intermsofthingsthatdamagethemitochondria,letmetaketwothatpeopleprobablydon'toftenthinkabout.Thatis,doyoudrinkalcohol.Now,whetheryoudrinkalcoholornot,it'stotallyuptoyou.Ifyoudrinkalcohol,itdoesdamagemitochondria,because,asyoumentionedearlier,depletesglutathione.Now,ifyoudrinkalcoholintheformofbeerorwine,interestinglyenough,itdoesn'tdepletetheglutathione.Withregularalcohol,likevodka,forexample,youseeadropinATPproduction.Givethesameamountofalcoholintheformofbeerorwine,youdon'tgetadecreaseinATPproduction.

DaveAsprey: Wow.Doyouknowwhythatis?I'veneverheardthis.

JosephPizzorno: Somegreatdatadone,forexample,astudywasdoneinnunsinacloister,neverdrankalcohol.Theygavethemdealcoholizedbeer,justonequartaday,andtheyincreasedtheirglutathionelevelsandtheirRBCsbyabout30%.

DaveAsprey: So,it'saBvitaminthing?

JosephPizzorno: Maybe,butsomethinginbeer,clearlyincreases.

DaveAsprey: SincebeerisalsohighinochratoxinA,it'soneofthethingsthatcausesthebiggesthangoverinpeople.


JosephPizzorno: Theremaybealotofotherthingsthatareproblematic,butifwe'relookingattheATP,turnsoutthere'ssomethingthathelpsthem.

DaveAsprey: Gotit.

JosephPizzorno: Withwine,ofcourse,the[resveratrol00:45:38]increasesglutathionelevels.Conversely,ifyoualsothendrinkalcoholintheformofagedthingslikewhiskey,andscotch,andthingslikethat,youactuallydamagemitochondriamore.So,ifyou'regoingtobedrinkingalcohol,it'syourchoicewhatyoudo,well,drinkthealcoholintheformofbeerorwine,don'tdrinkintheformofscotch,andyouwon'tdamageyourmitochondria.

DaveAsprey: Allright,I'mgoingtohavetodiginonthat.I'vegotaninfographicthatIofferpeoplethatsays,nomatterwhatalcoholisn'tagoodchoiceforyourmitochondria,butifyoudrinkthestuffthat'salreadybeencharcoalfilteredanddistilled,atleastyoudidn'thavetotakeallthebyproductsoutalongwithit,soit'slessofaloadontheliver,andthenyoushouldtakevitaminC,orglutathione,andyoushouldconsidertakingactivatedcharcoalwithittoundothedamagefromtheacetalaldehydethatformsinthefirststepofbreakingitdown.

JosephPizzorno: Makesurezinclevelsaregood,etcetera.

DaveAsprey: Right.Theproblemis,issomuchwineandbeerisfullofglyphosate,especiallyAmericanwine,andit'sfullofochratoxinA,becauseourgovernmentlevelsherearenotverygood.I'lldrinkanorganicfrenchwinewherethelevelsaretwopartsperbillion,butIdon'treallyfeelgoodonmostAmericanwine,becauseit'sgotglyphosateinit.You'regivingmefoodforthoughthere,I'mgoingtodosomeresearch,andit'spossible,peoplelistening,Imaytweetthealcoholinfographic,basedonDr.Pizzorno'sstuffhere,becauseI'veneverheardthatbefore,sothankyouforthat.

JosephPizzorno: Interestinglyenough,thatstudyIquotedtoyou,wasdoneinEurope.

DaveAsprey: Ah,thatmakessense.

JosephPizzorno: [crosstalk00:47:08],soit'sinteresting.Maybe,thebeertheyweredrinkingdidnothaveasmuchcontamination,[crosstalk00:47:14].

DaveAsprey: Theyalsousetraditionalspeciesofyeastintheirmaking,whentheymakestuffinEurope.TheAmericanspeciesofyeastarehyperaggressive,they'rebreadthatway,sotheremightbeadifferencethere.Fascinatingstuff.Youblewmeawayonthatone,thatwasstepone,don'tdrink,basically.

JosephPizzorno: Okay,so,thenextoneis,steptwo,then,isprotectyourmitochondriafromthemselves.Iwon'tgetintoalotofdetail,butthere'salotmitochondrial[inaudible00:47:38]damagethathappenswhenyou'renotcontrollingthose


highenergyelectrons.Itturnsoutthereareseveralstrategiesthatareimportant.Numberoneisyouwanttogetyourglutathionelevelsupasmuchasyoucan,andyoucaneithertakeittopically,takeitlypozomally,orglutathionebyitselfisnotveryeffectivebecauseitgetsbrokendownto[systane00:47:56],soyourglutathionewillstillgoupbutit'sanexpensivewayofdoingit.Mypreferenceis[anacilisystane00:48:03],because[anacilisystane00:48:05]willgetyourglutathionelevelsupquitenicely.

Inaddition,critical,critical,critical,iscoenzymeQ10.CoenzymeQ10carriesthehighenergyelectronsfromthevariouspartsofthemitochondriasothatthehighenergyelectronsarebeingconvertedintoATP.IfyouhavelowcoQ10,like,forexample,you'retakingastatindrug,nowyou'regoingtolosemoreofthosehighenergyelectrons,you'regoingtoburnoutyourmitochondriamorequickly.

ThethirdfactorIthinkisvery...Well,there'ssomanynutrientswecantalkaboutbeingimportantformitochondria.Yousaid,limitednumber,let'sjuststickwiththat.CoQ10,and[inaudible00:48:42].Now,thethirdaspect,getyourmitochondriatoproducemoreATP.There'sbeensomefascinatingresearchdoneinanimals,andsome[inaudible00:48:52]inreproductioninhumansaswell,andtherearesupplementsyoucantakelike[acetylcarnitine00:48:57].Whatthe[acetylcarnitine00:48:59]does,isithelpstransportthefattyacidsinmitochondriamoreefficiencysoyoucanproducemoreATP.It'sresearchthat'sbeendonewheretheylookathowfarananimalcanrun,ayounganimal,comparedtoanoldanimal,andtheoldanimalcanonlyrunhalfasfarastheyounganimal.Ifyougivethatoldanimal[acetylcarnitine00:49:17],alongwith[alphalipoic00:49:19]acid,theycanrunasfarastheyounganimal.

HereIam,I'mthisoldratwhoplaysbasketballwithguyshalfmyage,soI'mdoingallthesethingstogetmymitochondriatoworkaswellaspossible,becauseIwanttokeeprunningthecourt,Iwanttokeepenjoyingthisgamethatissomuchfunformetoplay.

DaveAsprey: Thoseareawesomerecommendations.ThosearesimilartosomeoftheonesinHeadStrong.There'sabunchofotherthingsaroundmodifyingtheKrebCycle,reducingelectronleakage,increasingefficiency.Oneofmyfavoritesissomethingthatwemanufacture,justcameoutwithit,calledKetoPrime.It'sthelaststepoftheKrebCyclebeforeyoutakemoreelectronsinfromfood,whetherit'sfromketones,orfrom[pyruvate00:50:03],whichcomesfromcarbsorproteinbreakdown.Theideais,ifyouhaveanyelectronleakage,yourunoutofthisthingcalledketosuccinicacid,soifthat'slow,thenyournextcycleoftheKrebCyclewon'twork,soyoubasicallytopupthelaststepoftheKrebCyclesoyoucanefficientlyusefood,evenifthere'selectronleakage,youbasicallyneverlosetheabilitytorunthefullKrebs.

JosephPizzorno: Ihavenotrunacrossthat,that'sinteresting.Ilookforwardtolearningmoreaboutit.


DaveAsprey: I'llsendsomethingtoyou.That'ssomethingthatI'venoticedhugechangesinmyenergy,especiallyaroundexercise,andcognitivefunctionfromdoingit.It'saketone,butit'snotthenormalketonesthatwegetfromgoingintoketosis,kindofcyclicaldiet.

JosephPizzorno: Interesting.

DaveAsprey: That'soneofthemanythings,likeyousaid,wecouldtalkprobablyforsixhoursaboutallthedifferentnutrients.Ithinkforpeoplelistening,theygetalittlebitoverwhelmed,like,"Okay,I'mgonnaspend$2000amonthonmitochondrialenhancingsupplements,andIdon'tknowwhichoneswork,andI'mafraidI'mgoingtohaveexpensivepee,andyougothroughallthisstuff,butIlikeit.Whatyou'resayingthereis,somethingforglutathione,youlikeNAC.Ihaveconcernsabouttheratelimiting,like,youcanonlyconvertsomuchNACbeforeyourunoutofcofactors,butyeah,NACworkstoacertainlevel.

Thenyou'resayingcoQ10,whichyouandIwouldtotallyagreeon.Everyonelistening,youcangetcoQ10allovertheplace,it'skindofacommoditything.IbuyintocoQ10toanunusualacidbaseformofPQQ...

JosephPizzorno: PQQ,yes.

DaveAsprey: ...andthenwemakelittlenanoparticles,or,they'reactuallymicroparticles,suspendedinwaterforbetterabsorption,whichissomethingcalledUnfairAdvantage,thatwemanufacture,butthat'snotthatmuchcoQ10.There'snoreasonthatpeopleshouldn't...Irecommend100milligramsaday.What'syournumberfor...

JosephPizzorno: Ipersonallyhavebeentaking100milligramsofcoQ10aday,for20years,and10to20milligramsperdaydependinguponhowthecosthaschanged,ofthePQQ,foralmost10years.Goodtoseeourthinkingisquitecongruent.

DaveAsprey: IstartedPQQat30milligrams,andIdidthatfortwoyears,about10yearsago,whentheresearchfirstcameout,butIcouldneverfeelanydifference,andIfeelwhenmymitochondriaworkbetter.ThatwaswhywecameupwithadeliverysysteminUnfairAdvantage,becausethatstuff,ithitsme,like,"Okay,somethingjusthappened,"andIthinkithastodowiththeonlymanufacturerofPQQouttheremakesadisodiumsaltformthatprecipitatesoutinyourstomach,sotheabsorptionofthatisalmostasbadasglutathione,ifit'snotproperlypackaged.It'soneofthethingsthat,ifyou'refeelingit,youshoulddoit.Eatitwithahighfatmeal,thatmighthelp.Idon'thavegreatlabdataonit,butthescienceisthatstomachacid'sgonnakillit,soyoutakeitwithahighfatmeal,thestomachacid,youtakeitonanemptystomach,itdoesn'tabsorbwell,butatleastitdoesn't...Idon'tknow.

I'mafanofPQQ,Iwoulddoitintravenouslyiftherewasagoodway.


JosephPizzorno: Interesting,interesting.

DaveAsprey: DoyoubelieveinIVvitamins,andotherthingslikethat?

JosephPizzorno: Goodquestion.Asaclinician,Iofcourse,haveseenpeopleatwiderangeofhealthanddiseasestatus.Ingeneral,Ialwaysprefertogetitthroughfood,numberone,ifthepersonisnotabletogetthenutrientsadequatelyfromfood,Ithendosupplementation.Butthen,iftheirdigestivesystemissodamaged,thenIwilldoIVvitamins.

YouhavetobeprettycarefulwithIVvitamins,becauseyouhavetorealizethatwhenyoudoahighdoseofasingle,orjustafewmolecules,youmightsay,youhavetolookatwhatelseitdoesinthebody.Yes,Idoit,butIonlydoitasmylastresort,notasafirstresort.

DaveAsprey: Itendto,abouteverytwoorthreeweeks,Igeta[Myer's00:53:58]cocktailwithamethylatedformsofvitaminsandsomeglutathione,andalittlebitofB-12,andallthat.

JosephPizzorno: [crosstalk00:53:59],yes,right.

DaveAsprey: Ifoundthatworksforme,butIalsotravel125daysayear.I'madad,andaCEOofacompany,andanauthor,andaradioshowhost,I'mpushinglimits,andIfindthathelpsmetoberesilient,butIthinkfortheaverageperson,thatcouldbeoverkill.Whoknows,maybeI'mimbalancingsomething.

JosephPizzorno: Yes.Ithinkwhatyousaid,whichismostimportant,thatisunderstandingwhatyourbodyneeds,whatyouruniqueneedsare,andthenmeetthose.Ingeneral,theycanbemetwithsupplementation,butsometimesyouneedtheIVapproach.I'mnotopposedtoit,Iprefertodotheotherthingsfirst,andthenifyoudon'tgettheresults,then,likeyousaid,dotheIVs.

DaveAsprey: Beautiful.Ifeellikewecouldhaveanothertwohoursofinterview,butwe'recomingupontheendofthis,andthegoodthingiswe'lldoaninpersonone,becausewe'regeographicallyclose,andbecauseyou'retoointerestingnottodothat.

IwantlistenerstounderstandthatintheToxinSolution,Ididn'tkindawalkthroughallpartsofit,butyoubasicallyhaveanineweekthingwhereyousteppeoplethroughthedifferentpartsofdetox,whichisaneffectivewaytodoit.Ireallylikethewayyou'rethinkingaboutthesystemofthebody,andIwouldencourageyou,ifyou'relisteningtothis,andthisisresonatingwithyou,it'sworthcheckingouttheToxinSolution.Thetoxinsolution.com.

JosephPizzorno: CanIjust,realquickly,justacoupleminutes,oroneminute.

DaveAsprey: Yeah.


JosephPizzorno: So,whatIdowiththeToxinSolution,is,firstoffsay,"Here'showtoxinsdamageyourbody.Here'swherethey'recomingfrom,here'showyouavoidthem,andthenhowdoyouprepareyourbodytogetridofthetoxins?Howdoyougetyourgutcleanedup,howdoyougetyourliverfunctioningproperly,howdoyougetyourkidneysfunctioningproperly?"Because,Idon'tthinkdoingadetoxprogramwithoutpreparingyourbodyfordetoxisaverygoodidea,becauseyoureleasethetoxinsfromthetissues,andthere'snoplaceforthemtogotogetoutofyourbody,you'rejustgoingtoredistributethemandcausedamageaswell.

So,stopthetoxinscomingin,prepareyourbodyforit,andthenIprovideareallyintenseprogramfornowgettingthetoxinsout.Then,thefinalchapterissomethingIthinkyou'dreallyenjoy,andthatis,howdoyouliveatoxinfreelife?Howdoyouchoosethehouseholdcleaningagents,andhowdoyouchoosehealthandbeautyaids,andhowdoyouchooseyourfood,howdoyouprepareyourfood,whatkindofpackagingmaterialsdoyouuse?Allthesethingswegottado...

DaveAsprey: Howdoyouprepareyourfood,tellmethatyou'retellingpeopletoavoidcharringandgrillingandfrying,isthatpartofit.

JosephPizzorno: Absolutely.

DaveAsprey: Yes,that'sinmybookaswell,allright,noonedoesthatinpaleo.Thewholepaleo,we'relike,"Deepfriedwhatever."No,itdoesn'tmatterifit'sgrassfedbeefifyouburnthecrap,it'sgoingtobebadforyourmitochondria.[crosstalk00:56:41].

JosephPizzorno: [inaudible00:56:43]ages,andyouproduceallthisoxidizedlycinethat'scarcinogenic,it'sjustterrible.

DaveAsprey: Iloveitthatyou'retalkingaboutthat,becausethesearethingsthatreallymatterthatwedoeverysingledaythatpeoplejustdon'tknowabout,like,"Butittastedgood."Itdoesn'tmatterifittastesgoodifit'sknockingyouout10yearsfromnow,youstilldon'twanttodoit.Findsomethingelsethattastesgood.

JosephPizzorno: Yes,yes.Haveyouheardofthehealthystirfrycreatedbymyfriend[inaudible00:57:08]?

DaveAsprey: Ihaven't,I'mguessingsomewaterisinit,aswell,orhowdoesitwork?

JosephPizzorno: Yeah,nooil.Youputwaterinthepansoitdoesn'tgettoohot,yousauteyourvegetablesinthewater,andthen,afteryou'vecookedthem,thenaddoil.

DaveAsprey: That'sexactlyhowIcook,toaT.Youneverwanttocookinoil.Oil'sprecious,andwhenyouheatit,evenifit'sbutterandall,it'sjustnotagoodthing


becausetheheattransferstoomuchheattothefood,andwaterratelimitsat212whenitturnsintosteam.Iloveit,andthisisinyourbookaswell?

JosephPizzorno: Itis.IthinkImentionitinthebook.It'sbeenawhilesinceIwroteit.IbelieveItalkabouthealthystirfries,butI'mnotsureifIremember,sorry.

DaveAsprey: Okay.Yeah,thestandardBulletproofTechniques,Ihaveacookbookaswell,andit's,youalwayscookwithalittlebitofwater,andyoudon'twanttocaramelize,andchar,andbrown,becausethose,theytriggerinflammation,andyes,theytastegood,butit'sokaytoeatthingsthatalsotastegoodthatdon'tcauseinflammation.

Allright,Ihaveonemorequestionforyou,andthisisaquestionthatI'veaskedeveryguestonthisshow.It'sbasedonyourwork,notjustyourwork,justyourwholelife'sprogress.Ifsomeonecametoyoutomorrowandsaid,"Look,IwanttoperformbetterateverythingIdoinlife."Whatarethethreemostimportantpiecesofadviceyouwouldgiveme?Whatwouldyouofferthem?

JosephPizzorno: I'vebeen[inaudible00:58:28]askthatquestion,I'llgiveyouthesimplestthings.Numberone,eatrealfoodthathasbeenorganicallygrownandproperlyprepared.Numbertwo,becomemuchmoreawareofhowtoxinsgetintoyourbody.Numberthree,buildmusclemass.WhileIthinkexerciseisimportant,Ithinkmusclemassisevenmoreimportant,andwecangetallthosereasons,butyouhavetorealizethatI'vegotmoremusclemass,thosemusclescellsareproducingATP,andevenwhenyou'renotusingthosemusclesthey'reproducingmoreATPandmakeseverythingelseinyourbodyworkbetter.

DaveAsprey: Ilovethatlastone.Idon'tthinkanyone'severtalkedaboutmusclemass,thatmight'vebeenananswerI'veheardonceoutof350episodes.It'sinteresting,Ijusttookaresearchcompoundtwomonthsago,thatinanimalsincreasesskeletalmitochondriaby50%infourweeks.Ifeltahugedifference,asin,Istoppedneedingtowearajacketinsnowstorms.Ijustradiatingheat,Ihadtobackoffmythyroidmeds,andIputon19poundsofmusclewithfourworkouts.It'skindofridiculous.

JosephPizzorno: Thatisprettystunning.

DaveAsprey: It'sa[inaudible00:59:37],selectiveandrogenreceptormodulator.There'sawholebunchofmitochondrialhackingcomingdownthepipe,whereIhavenoideawhatthelongtermseffectsofthat'llbe,butI'mbettingthey'regood.Wedon'tknow,butIloveyourlastoneaboutmusclemass,becauseitdoesmatter,anditdoesn'tmeanyouworkouteverysingledayhard,itmeansyoudowhatittakestogetyourmusclemassback.

JosephPizzorno: Ithoughtitwasinterestinginyourbook,becauseIlookedatwhatyousaidthere,andifIunderstoodyouproperly,youdowhatIdo,andthatisI,oncea


week,dorealintense,highweightwork.Veryshortperiodoftime,realintense,andit'sincrediblyeffective.

DaveAsprey: Itsavestime,anditworksbetterthanbeatingyourselfupeverydaylikeIusedtodowhenIweighed300poundsIworkedoutanhourandahalfadayandIcouldn'tlosetheweight.

JosephPizzorno: Ididtwoyearsofstandard[inaudible01:00:22]trainingwithatrainer.Itgavemesomebenefit,andthenIdidthehighintensitytraining,andinsixweeks,Iincreasedmyverticalleapbyfourinches.

DaveAsprey: Yeah.

JosephPizzorno: Whatthatmeantwas,Iactuallyhada25to50%increaseinstrength.Itwasjustincrediblehowmuchmoreeffectiveitwas.

DaveAsprey: Whenyougetitright,youcanquantifythemeasurement,anditsavesyoutime,andIalsojustbelievebyfreeinguptime,everyone'stoobusy,theywantmoretimewiththeirkids,theywantmoretimeforwork,ortheirfamily.Ifyou'resavinganhouradayofworkingout,andyou'regettingbetterresults,thatkindofmakestheworldabetterplace.

JosephPizzorno: Ifyoudoitright20minutesaweekisallyouneedtodo.

DaveAsprey: Thisissocool.We'reupontheendoftheshow.Peoplecanlearnmoreaboutyou,andIthinkanyonewholistenedtothisshowforthewholelengthunderstandsthatyouspentsometimethinkingaboutthesethings,andthatyou'realivingexampleofwhatyou'retalkingabout.You'veputthisdown,yournewbookisverywellthoughtout,andittotallypassesthebar,frommyperspective,aroundthewaytothinkaboutit,andjustthewaytoapproachthetoxinproblem,whichisunderrecognizedinalmostallhealthliterature,especiallythepopularstuff.

It'scalledtheToxinSolution,andyoucangetitat,funnyenough,thetoxinsolution.com,andforlisteners,you'relisteningtoDr.JosephPizzorno,who'safounderofBastyrUniversityinSeattle,andoneofthetop,probably,25mostinfluentialexpertsinthefieldoffunctionalalternativemedicine.ThisisaprettyspecialinterviewforBulletproofRadio.It'sbeenalotoffunforme,andDr.Pizzorno,thanksforbeingontheshow.

JosephPizzorno: Thankyou,it'sbeengreattalkingwithyou,andIlookforwardtoourlunch.There'salotmoretoexplorehere.

DaveAsprey: Metoo.

Ifyoulikedtoday'sepisode,youknowwhattodo.HeadonovertotheToxinSolution,andpickupacopyofDr.Pizzorno'sbook,becauseit'sactuallygoingto


makeadifferenceforyou,andBulletproofRadio'saboutmakingadifference.Whileyou'reatit,sinceyou'reinbookbuyingmode,youmightalsoheadovertoorderheadstrong.com,andpickupacopyofthattoo.You'llfindthatifyoudothetoxinavoidancestrategiesintheToxinSolution,yourmitochondriawillworkbetter.DosomeofthemitochondriaupgradestrategiesinHeadStrong,andyourmitochondriawillworkbetter.

Moremitochondriaequalsmorecognitivefunction,becauseyouhavethemostmitochondriainyourneurons,sothesethingsstackreallynicely,andifyouonlybuyoneofthetwobooks,that'stotallycool,too.Eitheroneisgoingtobenefityou,andIamcertainyougotvalueforyourtimethisepisode,andiftherewasmoreweshould'vetalkedabout,tellmeinthecomments,andI'llmakesuretotalkaboutthosethingsnexttimeDr.PizzornoandImeetandwerecorditforyou.

Haveagreatday.

dave asprey: if you're a regular listener, you've heard me...

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